RU2448098C2 - Производные 2-пиразинона для лечения заболевания или состояния, при которых полезно ингибирование активности нейтрофильной эластазы - Google Patents

Info

Publication number

RU2448098C2

RU2448098C2 RU2008143457/04A RU2008143457A RU2448098C2 RU 2448098 C2 RU2448098 C2 RU 2448098C2 RU 2008143457/04 A RU2008143457/04 A RU 2008143457/04A RU 2008143457 A RU2008143457 A RU 2008143457A RU 2448098 C2 RU2448098 C2 RU 2448098C2

Authority

RU

Russia

Prior art keywords

phenyl

compound

trifluoromethyl

oxo

pharmaceutically acceptable

Prior art date

2006-05-08

Links

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• 201000010099 disease Diseases 0.000 title claims abstract description 22
• 230000000694 effects Effects 0.000 title claims abstract description 13
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• 150000001875 compounds Chemical class 0.000 claims abstract description 151
• 150000003839 salts Chemical class 0.000 claims abstract description 78
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 41
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• 238000000034 method Methods 0.000 claims abstract description 29
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• 229910052801 chlorine Inorganic materials 0.000 claims abstract description 18
• 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 18
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• 125000002947 alkylene group Chemical group 0.000 claims abstract description 14
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 13
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• 150000002431 hydrogen Chemical class 0.000 claims abstract description 6
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims abstract description 4
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims abstract 2
• 125000001424 substituent group Chemical group 0.000 claims description 39
• 229910052736 halogen Inorganic materials 0.000 claims description 18
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• SGUPMZFLRHPHQI-UHFFFAOYSA-N 6-[2-(5-cyanopyridin-2-yl)pyrazol-3-yl]-n,5-dimethyl-3-oxo-4-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide Chemical compound CC=1N(C=2C=C(C=CC=2)C(F)(F)F)C(=O)C(C(=O)NC)=NC=1C1=CC=NN1C1=CC=C(C#N)C=N1 SGUPMZFLRHPHQI-UHFFFAOYSA-N 0.000 claims description 3
• CHRGDTSVXIPUHY-UHFFFAOYSA-N 6-[2-(6-cyanopyridin-3-yl)pyrazol-3-yl]-n,5-dimethyl-3-oxo-4-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide Chemical compound CC=1N(C=2C=C(C=CC=2)C(F)(F)F)C(=O)C(C(=O)NC)=NC=1C1=CC=NN1C1=CC=C(C#N)N=C1 CHRGDTSVXIPUHY-UHFFFAOYSA-N 0.000 claims description 3
• OBMLGXKIHVSLHG-UHFFFAOYSA-N 6-[3-(4-cyanophenyl)triazol-4-yl]-n,5-dimethyl-3-oxo-4-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide Chemical compound CC=1N(C=2C=C(C=CC=2)C(F)(F)F)C(=O)C(C(=O)NC)=NC=1C1=CN=NN1C1=CC=C(C#N)C=C1 OBMLGXKIHVSLHG-UHFFFAOYSA-N 0.000 claims description 3
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