JP5527739B2 - 好中球エラスターゼ活性の阻害が有益である疾患または状態の処置のための２−ピリドン誘導体 - Google Patents
好中球エラスターゼ活性の阻害が有益である疾患または状態の処置のための２−ピリドン誘導体 Download PDFInfo
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- JP5527739B2 JP5527739B2 JP2009509486A JP2009509486A JP5527739B2 JP 5527739 B2 JP5527739 B2 JP 5527739B2 JP 2009509486 A JP2009509486 A JP 2009509486A JP 2009509486 A JP2009509486 A JP 2009509486A JP 5527739 B2 JP5527739 B2 JP 5527739B2
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- phenyl
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- trifluoromethyl
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Pulmonology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79878406P | 2006-05-08 | 2006-05-08 | |
| US60/798,784 | 2006-05-08 | ||
| PCT/SE2007/000442 WO2007129963A1 (en) | 2006-05-08 | 2007-05-07 | 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009536197A JP2009536197A (ja) | 2009-10-08 |
| JP2009536197A5 JP2009536197A5 (https=) | 2010-06-03 |
| JP5527739B2 true JP5527739B2 (ja) | 2014-06-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009509486A Expired - Fee Related JP5527739B2 (ja) | 2006-05-08 | 2007-05-07 | 好中球エラスターゼ活性の阻害が有益である疾患または状態の処置のための２−ピリドン誘導体 |
Country Status (20)
| Country | Link |
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| US (2) | US8114881B2 (https=) |
| EP (1) | EP2018377A4 (https=) |
| JP (1) | JP5527739B2 (https=) |
| KR (1) | KR101429303B1 (https=) |
| CN (1) | CN101490040B (https=) |
| AR (1) | AR060874A1 (https=) |
| AU (2) | AU2007248951B2 (https=) |
| BR (1) | BRPI0711362A2 (https=) |
| CA (1) | CA2650553C (https=) |
| CL (1) | CL2007001283A1 (https=) |
| CO (1) | CO6140058A2 (https=) |
| EC (1) | ECSP088869A (https=) |
| IL (1) | IL194949A0 (https=) |
| MX (1) | MX2008013837A (https=) |
| NO (1) | NO20084845L (https=) |
| RU (2) | RU2448098C2 (https=) |
| SG (1) | SG170101A1 (https=) |
| TW (1) | TW200808771A (https=) |
| UY (1) | UY30327A1 (https=) |
| WO (1) | WO2007129963A1 (https=) |
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| SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| TW200808763A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| JP5140154B2 (ja) | 2007-06-27 | 2013-02-06 | アストラゼネカ・アクチエボラーグ | ピラジノン誘導体および肺疾患の処置におけるそれらの使用 |
| WO2009058076A1 (en) * | 2007-11-02 | 2009-05-07 | Astrazeneca Ab | 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| EP2217591A4 (en) | 2007-11-06 | 2011-10-26 | Astrazeneca Ab | CERTAIN 2-PYRAZINONE DERIVATIVES AND THEIR USE AS NEUTROPHILES ELASTASE INHIBITORS |
| AR073711A1 (es) | 2008-10-01 | 2010-11-24 | Astrazeneca Ab | Derivados de isoquinolina |
| TW201036957A (en) * | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| AU2010302420B2 (en) | 2009-10-02 | 2013-07-04 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| WO2011110852A1 (en) | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Polymorphic forms of 6- [2- (4 -cyanophenyl) - 2h - pyrazol - 3 - yl] - 5 -methyl - 3 - oxo - 4 - (trifluoromethyl - phenyl) 3,4-dihydropyrazine-2-carboxylic acid ethylamide |
| DE102010030187A1 (de) | 2010-06-16 | 2011-12-22 | Bayer Schering Pharma Aktiengesellschaft | 4-Cyan-2-sulfonylphenyl)pyrazolyl-substituierte Pyridinone und Pyrazinone und ihre Verwendung |
| JP2013177318A (ja) * | 2010-06-30 | 2013-09-09 | Dainippon Sumitomo Pharma Co Ltd | ジヒドロピリミジノン誘導体およびその医薬用途 |
| GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| TW201247631A (en) | 2011-04-28 | 2012-12-01 | Du Pont | Herbicidal pyrazinones |
| US9102624B2 (en) | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057926A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057920A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| KR20180074793A (ko) * | 2015-11-13 | 2018-07-03 | 바이엘 파마 악티엔게젤샤프트 | 만성 상처 치료를 위한 4-(4-시아노-2-티오아릴)다이하이드로피리미디논 |
| WO2017207430A1 (en) * | 2016-05-31 | 2017-12-07 | Chiesi Farmaceutici S.P.A. | Imidazolone compounds as human neutrophil elastase inhibitors |
| EP3749697A4 (en) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE |
| CN108440508B (zh) * | 2018-04-04 | 2020-03-20 | 河南科技大学第一附属医院 | 吡嗪药物及其制备方法、组合物及在胃肠病人护理的应用 |
| JP7672641B2 (ja) | 2019-09-17 | 2025-05-08 | メレオ バイオファーマ ４ リミテッド | 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット |
| IL297211B2 (en) | 2020-04-16 | 2025-12-01 | Mereo Biopharma 4 Ltd | Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency |
| KR20240090272A (ko) | 2021-10-20 | 2024-06-21 | 메레오 바이오파마 4 리미티드 | 섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제 |
| EP4447960A1 (en) * | 2021-12-16 | 2024-10-23 | Orixa Therapeutics LLC | Small molecule inhibitors of pr3 and hne and uses thereof |
| CN118724801B (zh) * | 2024-09-03 | 2024-12-03 | 中节能万润股份有限公司 | 一种甲苯磺酸艾多沙班中间体的制备方法 |
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| AU2007248951A1 (en) | 2007-11-15 |
| CN101490040A (zh) | 2009-07-22 |
| RU2011131170A (ru) | 2013-02-10 |
| US20120108610A1 (en) | 2012-05-03 |
| US20090209555A1 (en) | 2009-08-20 |
| EP2018377A4 (en) | 2011-03-30 |
| RU2008143457A (ru) | 2010-06-20 |
| WO2007129963A1 (en) | 2007-11-15 |
| AR060874A1 (es) | 2008-07-16 |
| CL2007001283A1 (es) | 2008-01-18 |
| ECSP088869A (es) | 2008-12-30 |
| BRPI0711362A2 (pt) | 2011-12-06 |
| TW200808771A (en) | 2008-02-16 |
| AU2010236027A1 (en) | 2010-11-18 |
| CA2650553C (en) | 2014-07-08 |
| RU2448098C2 (ru) | 2012-04-20 |
| KR101429303B1 (ko) | 2014-08-12 |
| JP2009536197A (ja) | 2009-10-08 |
| US8410114B2 (en) | 2013-04-02 |
| KR20090009956A (ko) | 2009-01-23 |
| MX2008013837A (es) | 2008-11-10 |
| IL194949A0 (en) | 2009-08-03 |
| AU2007248951B2 (en) | 2011-05-19 |
| NO20084845L (no) | 2009-02-03 |
| EP2018377A1 (en) | 2009-01-28 |
| SG170101A1 (en) | 2011-04-29 |
| AU2010236027B2 (en) | 2011-08-18 |
| UY30327A1 (es) | 2008-01-02 |
| CN101490040B (zh) | 2013-06-12 |
| CA2650553A1 (en) | 2007-11-15 |
| US8114881B2 (en) | 2012-02-14 |
| CO6140058A2 (es) | 2010-03-19 |
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