RU2440995C2 - Производные бензотиазола, фармацевтическая композиция, обладающая свойством связывать амилоид, и способ детекции отложений амилоида у млекопитающего - Google Patents
Производные бензотиазола, фармацевтическая композиция, обладающая свойством связывать амилоид, и способ детекции отложений амилоида у млекопитающего Download PDFInfo
- Publication number
- RU2440995C2 RU2440995C2 RU2005131872/04A RU2005131872A RU2440995C2 RU 2440995 C2 RU2440995 C2 RU 2440995C2 RU 2005131872/04 A RU2005131872/04 A RU 2005131872/04A RU 2005131872 A RU2005131872 A RU 2005131872A RU 2440995 C2 RU2440995 C2 RU 2440995C2
- Authority
- RU
- Russia
- Prior art keywords
- amyloid
- brain
- compound
- benzothiazole
- binding
- Prior art date
Links
- 0 Cc1ccc2nc(-c(cc3)cc(*)c3N)[s]c2c1 Chemical compound Cc1ccc2nc(-c(cc3)cc(*)c3N)[s]c2c1 0.000 description 6
- ZTKDUAATMRBDMG-UHFFFAOYSA-N CNc(cc1)ccc1-c([s]c1c2)nc1ccc2OC Chemical compound CNc(cc1)ccc1-c([s]c1c2)nc1ccc2OC ZTKDUAATMRBDMG-UHFFFAOYSA-N 0.000 description 1
- DPRRSJADKXEBPN-UHFFFAOYSA-N CNc(cc1)ccc1-c([s]c1c2)nc1ccc2[N+]([O-])=O Chemical compound CNc(cc1)ccc1-c([s]c1c2)nc1ccc2[N+]([O-])=O DPRRSJADKXEBPN-UHFFFAOYSA-N 0.000 description 1
- CJXJTZXIMFUEOY-SECBINFHSA-N C[C@H]1SCCN(CC2)N1[N]2(CCS)C(C)=O Chemical compound C[C@H]1SCCN(CC2)N1[N]2(CCS)C(C)=O CJXJTZXIMFUEOY-SECBINFHSA-N 0.000 description 1
- CHNLPLMAXNTNTE-UHFFFAOYSA-N Cc(c1c(cc2)nc(-c(cc3)ccc3OC)[s]1)c2N Chemical compound Cc(c1c(cc2)nc(-c(cc3)ccc3OC)[s]1)c2N CHNLPLMAXNTNTE-UHFFFAOYSA-N 0.000 description 1
- XRTJYEIMLZALBD-UHFFFAOYSA-N Cc1ccc2nc(-c(cc3)ccc3N)[s]c2c1 Chemical compound Cc1ccc2nc(-c(cc3)ccc3N)[s]c2c1 XRTJYEIMLZALBD-UHFFFAOYSA-N 0.000 description 1
- WKRCOZSCENDENK-UHFFFAOYSA-N Nc(cc1)ccc1-c1nc2ccccc2[s]1 Chemical compound Nc(cc1)ccc1-c1nc2ccccc2[s]1 WKRCOZSCENDENK-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/388,173 US7270800B2 (en) | 2000-08-24 | 2003-03-14 | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
US10/388,173 | 2003-03-14 | ||
US10/645,847 | 2003-08-22 | ||
US10/645,847 US20050043523A1 (en) | 2003-08-22 | 2003-08-22 | Benzothiazole derivative compounds, compositions and uses |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2005131872A RU2005131872A (ru) | 2006-02-27 |
RU2440995C2 true RU2440995C2 (ru) | 2012-01-27 |
Family
ID=35057877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2005131872/04A RU2440995C2 (ru) | 2003-03-14 | 2004-03-15 | Производные бензотиазола, фармацевтическая композиция, обладающая свойством связывать амилоид, и способ детекции отложений амилоида у млекопитающего |
Country Status (16)
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0113470B8 (pt) * | 2000-08-24 | 2021-05-25 | Univ Pittsburgh | composto de ligação amilóide, composição farmacêutica e métodos de síntese de composto, de detecção in vivo de depósitos amilóides num indivíduo e em tecido humano ou animal, de quantificação de depósito amilóide em tecido de biópsia ou postmortem e de distinção de um cérebro de doença de alzheimer de um cérebro normal |
US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
CN101198598A (zh) * | 2004-05-20 | 2008-06-11 | 弗尔德里克斯制药股份有限公司 | 2-((杂)芳基)-苯并噁唑化合物及其衍生物、组合物以及用于稳定和抑制甲状腺素转运蛋白错重叠的方法 |
GB0516564D0 (en) * | 2005-08-12 | 2005-09-21 | Ge Healthcare Ltd | Fluorination process |
CA2675228A1 (en) * | 2007-01-30 | 2008-07-07 | Ge Healthcare Limited | Tools for aiding in the diagnosis of neurodegenerative diseases |
CN101293878B (zh) * | 2007-04-25 | 2010-12-15 | 中国科学院上海应用物理研究所 | 苯并噻唑苯胺类化合物及其制备方法和应用 |
US8420052B2 (en) * | 2008-07-24 | 2013-04-16 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying AD pathology |
WO2010034982A1 (en) * | 2008-09-23 | 2010-04-01 | Wista Laboratories Ltd. | Ligands for aggregated tau molecules |
CN105579453B (zh) | 2013-09-26 | 2017-12-22 | 豪夫迈·罗氏有限公司 | 作为成像工具的咪唑并[1,2‑a]吡啶‑7‑胺类 |
JP6260967B2 (ja) * | 2013-11-06 | 2018-01-17 | 国立大学法人京都大学 | 放射性ヨウ素標識化合物、及び、これを含む放射性医薬 |
CN103613589B (zh) * | 2013-11-29 | 2016-03-30 | 江苏华益科技有限公司 | 一种用于神经退行性疾病领域的新型pet显像剂前体及标准品的合成方法 |
MX2017002705A (es) * | 2014-08-29 | 2017-12-20 | Chdi Foundation Inc | Sondas para la proyección de imagen de la proteína huntingtina. |
CN109400615B (zh) * | 2017-08-18 | 2021-07-16 | 上海交通大学医学院附属新华医院 | 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用 |
GR1009516B (el) * | 2018-03-22 | 2019-05-02 | Εκεφε Δημοκριτος | Τρικαρβονυλο-συμπλοκα μεταλλων μεταπτωσεως με βενζο-ετεροκυκλικο παραγωγο του κυκλοπενταδιενυλικου ανιοντος με υψηλη διαπερατοτητα του αιματοεγκεφαλικου φραγμου για εφαρμογες στη διαγνωση και θεραπεια νοσων του κνς |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5354398A (en) * | 1996-11-22 | 1998-06-10 | Elan Pharmaceuticals, Inc. | N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions compri sing same, and methods for inhibiting beta-amyloid peptide release and/or it s synthesis by use of such compounds |
GB9919673D0 (en) * | 1999-08-20 | 1999-10-20 | Cancer Res Campaign Tech | 2-Arlybenzazole compounds |
BRPI0113470B8 (pt) * | 2000-08-24 | 2021-05-25 | Univ Pittsburgh | composto de ligação amilóide, composição farmacêutica e métodos de síntese de composto, de detecção in vivo de depósitos amilóides num indivíduo e em tecido humano ou animal, de quantificação de depósito amilóide em tecido de biópsia ou postmortem e de distinção de um cérebro de doença de alzheimer de um cérebro normal |
JP2004524289A (ja) * | 2000-12-22 | 2004-08-12 | アストラゼネカ・アクチエボラーグ | 治療化合物 |
DE60217090T2 (de) * | 2001-04-23 | 2007-07-12 | The Trustees Of The University Of Pennsylvania | Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittel |
GB0229686D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase fluorination of benzothiazoles |
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2004
- 2004-03-15 RU RU2005131872/04A patent/RU2440995C2/ru not_active Application Discontinuation
- 2004-03-15 EP EP04720788A patent/EP1611115B1/en not_active Expired - Lifetime
- 2004-03-15 JP JP2006507179A patent/JP4875487B2/ja not_active Expired - Lifetime
- 2004-03-15 BR BRPI0408274A patent/BRPI0408274B8/pt active IP Right Grant
- 2004-03-15 CN CNA2004800125035A patent/CN1784392A/zh active Pending
- 2004-03-15 ES ES04720788T patent/ES2393921T3/es not_active Expired - Lifetime
- 2004-03-15 CN CN201110437182.5A patent/CN102532055B/zh not_active Expired - Lifetime
- 2004-03-15 DK DK04720788.1T patent/DK1611115T3/da active
- 2004-03-15 SI SI200431952T patent/SI1611115T1/sl unknown
- 2004-03-15 PT PT47207881T patent/PT1611115E/pt unknown
- 2004-03-15 AU AU2004221897A patent/AU2004221897B2/en not_active Expired
- 2004-03-15 PL PL04720788T patent/PL1611115T3/pl unknown
-
2005
- 2005-10-11 NO NO20054674A patent/NO330861B1/no active Protection Beyond IP Right Term
-
2006
- 2006-07-04 HK HK06107502.0A patent/HK1086270A1/xx not_active IP Right Cessation
-
2011
- 2011-02-16 AU AU2011200667A patent/AU2011200667B2/en not_active Expired
- 2011-07-06 NO NO20110980A patent/NO20110980L/no not_active Application Discontinuation
-
2012
- 2012-11-16 CY CY20121101106T patent/CY1113334T1/el unknown
-
2015
- 2015-01-27 BE BE2015C005C patent/BE2015C005I2/fr unknown
- 2015-02-18 NO NO2015005C patent/NO2015005I1/no not_active IP Right Cessation
- 2015-02-18 HU HUS1500006C patent/HUS1500006I1/hu unknown
- 2015-03-04 CY CY2015007C patent/CY2015007I1/el unknown
Non-Patent Citations (2)
Title |
---|
CHESTER A. MATHIS ET AL: "A LIPOPHILIC THIOFLAVIN-T DERIVATIVE FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING OF AMYLOID IN BRAIN" BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, vol.12, p.295-298. * |
WANG YANMING ET AL: "SYNTHESIS AND EVALUATION OF 2-(3'-IODO-4'-AMINOPHENYL)-6-HYDROXYBENZOTHIAZOLE FOR IN VIVO QUANTITATION OF AMYLOID DEPOSITS IN ALZHEIMER'S DISEASE'' JOURNAL OF MOLECULAR NEUROSCIENCE, 2002, vol.19, №1/2, p.11-16. * |
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Legal Events
Date | Code | Title | Description |
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FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20080114 |
|
FZ9A | Application not withdrawn (correction of the notice of withdrawal) |
Effective date: 20081106 |
|
FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20100125 |
|
FZ9A | Application not withdrawn (correction of the notice of withdrawal) |
Effective date: 20101228 |
|
PD4A | Correction of name of patent owner |