RU2426744C2 - Антитела к ox40l и способы их применения - Google Patents
Антитела к ox40l и способы их применения Download PDFInfo
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- RU2426744C2 RU2426744C2 RU2008129111/10A RU2008129111A RU2426744C2 RU 2426744 C2 RU2426744 C2 RU 2426744C2 RU 2008129111/10 A RU2008129111/10 A RU 2008129111/10A RU 2008129111 A RU2008129111 A RU 2008129111A RU 2426744 C2 RU2426744 C2 RU 2426744C2
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- antibody
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- ox40l
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11208469B2 (en) | 2016-03-18 | 2021-12-28 | Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet | Antiviral immunotherapy by membrane receptor ligation |
| RU2773427C2 (ru) * | 2016-03-18 | 2022-06-03 | Эберхард Карлс Универзитет Тюбинген Медицинише Факультет | Противовирусная иммунотерапия посредством лигирования мембранных рецепторов |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291331B1 (en) | 2002-09-11 | 2007-11-06 | La Jolla Institute For Allergy And Immunology | Methods of treating OX40 medicated recall immune responses |
| EP2041756B1 (en) | 2006-07-14 | 2015-05-13 | FEI Company | A multi-source plasma focused ion beam system |
| BRPI0807269A2 (pt) * | 2007-02-27 | 2014-04-29 | Genentech Inc | "anticorpo antagonista isolado, molécula de ácido nucléico isolada, vetor, célula hospedeira, composição, método de tratamento, método para tratamento, método para reduzir a severidade da asma, método para produzir um anticorpo, hibridoma, uso do anitocrpo, método para detectar ox40, kits e aparelhos médicos" |
| US20090309617A1 (en) * | 2007-08-24 | 2009-12-17 | Ye Fang | Biosensor antibody functional mapping |
| WO2009141239A1 (en) * | 2008-05-20 | 2009-11-26 | F. Hoffmann-La Roche Ag | A pharmaceutical formulation comprising an antibody against ox40l, uses thereof |
| US8518405B2 (en) * | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
| FI3309176T3 (fi) | 2009-12-14 | 2026-01-09 | Ablynx Nv | Immunoglobuliinin yksittäinen vaihteleva domeeni -vasta-aineita ox40l:ää vastaan, konstrukteja ja niiden terapeuttinen käyttö |
| WO2012015696A1 (en) * | 2010-07-26 | 2012-02-02 | Baylor Research Institute | Thymic stromal lymphopoietin (tslp) and ox40 ligand in cancer |
| NZ716369A (en) | 2010-08-23 | 2017-05-26 | Univ Texas | Anti-ox40 antibodies and methods of using the same |
| US9845362B2 (en) | 2010-10-08 | 2017-12-19 | The University Of North Carolina At Charlotte | Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same |
| AR083847A1 (es) * | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
| SMT201800228T1 (it) | 2011-04-21 | 2018-07-17 | Bristol Myers Squibb Co | Polipeptidi anticorpali che antagonizzano cd40 |
| AU2012299421B2 (en) * | 2011-08-23 | 2016-02-04 | Board Of Regents, The University Of Texas System | Anti-OX40 antibodies and methods of using the same |
| ES2777939T3 (es) | 2013-09-09 | 2020-08-06 | Canimguide Therapeutics Ab | Moduladores del sistema inmunitario |
| GB201403775D0 (en) * | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| JP2017165652A (ja) * | 2014-06-30 | 2017-09-21 | 国立大学法人東北大学 | 新規抗ヒトｏｘ４０リガンド抗体、及びこれを含む抗インフルエンザ薬 |
| CN107074951B (zh) * | 2014-08-04 | 2021-08-03 | 贝勒研究院 | 拮抗性抗-ox40l抗体及其使用方法 |
| US11554181B2 (en) | 2014-09-05 | 2023-01-17 | The University Of North Carolina At Charlotte | Tumor specific antibody conjugates and uses therefor |
| US9434785B1 (en) * | 2015-04-30 | 2016-09-06 | Kymab Limited | Anti-human OX40L antibodies and methods of treating graft versus host disease with the same |
| US9512229B2 (en) | 2015-03-03 | 2016-12-06 | Kymab Limited | Synergistic combinations of OX40L antibodies for the treatment of GVHD |
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| PH12017502013B1 (en) | 2015-05-07 | 2022-07-22 | Agenus Inc | Anti-ox40 antibodies and methods of use thereof |
| TWI717432B (zh) | 2015-12-02 | 2021-02-01 | 美商艾吉納斯公司 | 抗體和使用彼之方法 |
| EP3443984A4 (en) * | 2016-04-15 | 2019-04-10 | Pontificia Universidad Católica De Chile | PHARMACEUTICAL COMPOSITION FOR REDUCING THE SYMPTOMS AND THE SERIOUS DEGREE OF RESPIRATORY INFECTION BY human metapneumovirus (hMPV) WITH AT LEAST ONE FUNCTION OF TSLP- AND / OR TSLPR- AND / OR OX40L- AND / OR CD177-MOLECULE neutralizing agent AND PHARMACEUTICAL ACCEPTABLE ALTERNATIVE FUEL AND USE THEREOF |
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| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| WO2018089628A1 (en) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
| GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
| KR102634374B1 (ko) | 2017-11-24 | 2024-02-06 | 유큐(베이징) 바이오파마 코., 엘티디 | 항―ｏｘ４０ 항체 및 그의 용도 |
| EP3728314A1 (en) | 2017-12-19 | 2020-10-28 | Kymab Limited | Bispecific antibody for icos and pd-l1 |
| GB201721338D0 (en) | 2017-12-19 | 2018-01-31 | Kymab Ltd | Anti-icos Antibodies |
| GB202012331D0 (en) * | 2020-08-07 | 2020-09-23 | Petmedix Ltd | Therapeutic antibodies |
| CN114437228B (zh) * | 2020-10-30 | 2024-02-06 | 中国科学院生物物理研究所 | 一种il-2与抗体亚单位构成的双功能融合蛋白 |
| CN117440967A (zh) * | 2020-12-09 | 2024-01-23 | 怡诺安有限公司 | 抗OX40L抗体、抗OX40L/抗TNFα双特异性抗体及其用途 |
| TW202330023A (zh) * | 2021-08-10 | 2023-08-01 | 英商科馬布有限公司 | 異位性皮膚炎之治療 |
| KR20240139085A (ko) * | 2022-02-09 | 2024-09-20 | 펫메딕스 리미티드 | 치료 항체 |
| WO2025090570A1 (en) * | 2023-10-23 | 2025-05-01 | Abcellera Biologics Inc. | Anti-ox40l antibodies and methods of use |
| TW202540204A (zh) * | 2024-01-26 | 2025-10-16 | 西班牙商阿爾米雷爾有限公司 | 雙特異性分子及使用其的治療方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457035A (en) * | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
| US5821332A (en) | 1993-11-03 | 1998-10-13 | The Board Of Trustees Of The Leland Stanford Junior University | Receptor on the surface of activated CD4+ T-cells: ACT-4 |
| US6242566B1 (en) | 1994-02-10 | 2001-06-05 | Board Of Trustees Of The Leland Stanford Junior University | Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells |
| JP3914342B2 (ja) | 1997-09-25 | 2007-05-16 | 武田薬品工業株式会社 | ｇｐ３４結合阻害物を有効成分として含有する医薬組成物 |
| CA2410188A1 (en) * | 2000-06-06 | 2001-12-13 | Idec Pharmaceutical Corporation | Non-agonistic antibodies to human gp39, compositions containing, and therapeutic use thereof |
| FR2822846B1 (fr) * | 2001-04-03 | 2004-01-23 | Technopharm | Procede de preparation et de selection d'anticorps |
| GB0123276D0 (en) | 2001-09-27 | 2001-11-21 | Imp College Innovations Ltd | Uses of agents that bind immune-system components |
| JP3926596B2 (ja) | 2001-09-28 | 2007-06-06 | 独立行政法人科学技術振興機構 | Ｏｘ４０ｌ遺伝子を導入した自己免疫疾患モデル非ヒト哺乳動物 |
| AU2002365814A1 (en) * | 2001-12-18 | 2003-07-30 | J And J Research Pty Ltd | Method of treating asthma |
| IL164376A0 (en) | 2002-04-03 | 2005-12-18 | Applied Research Systems | Ox4or binding agents, their preparation and pharmaceutical compositions containing them |
| MXPA05002219A (es) | 2002-08-28 | 2005-07-05 | Immunex Corp | Composiciones y metodos para tratar una enfermedad cardiovascular. |
| US7291331B1 (en) | 2002-09-11 | 2007-11-06 | La Jolla Institute For Allergy And Immunology | Methods of treating OX40 medicated recall immune responses |
| AU2005229009A1 (en) * | 2004-03-23 | 2005-10-13 | Amgen, Inc. | Monoclonal antibodies specific for human OX40L (CD 134L) |
| JP2006081061A (ja) * | 2004-09-13 | 2006-03-23 | Alpine Electronics Inc | 音声出力装置及び音声／映像出力装置 |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| BRPI0807269A2 (pt) | 2007-02-27 | 2014-04-29 | Genentech Inc | "anticorpo antagonista isolado, molécula de ácido nucléico isolada, vetor, célula hospedeira, composição, método de tratamento, método para tratamento, método para reduzir a severidade da asma, método para produzir um anticorpo, hibridoma, uso do anitocrpo, método para detectar ox40, kits e aparelhos médicos" |
-
2006
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- 2006-12-15 BR BRPI0621065-1A patent/BRPI0621065A2/pt not_active IP Right Cessation
- 2006-12-15 EP EP06851330A patent/EP1973949A2/en not_active Withdrawn
- 2006-12-15 CA CA002633602A patent/CA2633602A1/en not_active Abandoned
- 2006-12-15 AR ARP060105564A patent/AR057253A1/es not_active Application Discontinuation
- 2006-12-15 WO PCT/US2006/062173 patent/WO2007133290A2/en not_active Ceased
- 2006-12-15 TW TW095147231A patent/TW200732349A/zh unknown
- 2006-12-15 RU RU2008129111/10A patent/RU2426744C2/ru not_active IP Right Cessation
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- 2006-12-15 JP JP2008545995A patent/JP2009519718A/ja not_active Withdrawn
- 2006-12-15 KR KR1020087017186A patent/KR20080080639A/ko not_active Withdrawn
- 2006-12-15 ZA ZA200804868A patent/ZA200804868B/xx unknown
- 2006-12-15 AU AU2006343459A patent/AU2006343459A1/en not_active Abandoned
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- 2008-07-11 MA MA31104A patent/MA30153B1/fr unknown
- 2008-07-15 NO NO20083147A patent/NO20083147L/no not_active Application Discontinuation
-
2010
- 2010-07-12 US US12/834,748 patent/US20100272738A1/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| WANG et al., "Characterization and functional study of five novel monoclonal antibodies against human OX40L highlight reverse signalling: enhancement of IgG production of В cells and promotion of maturation of DCs", Tissue Antigens 2004, Vol.64, no. 5, реферат. * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2838031C1 (ru) * | 2015-03-03 | 2025-04-08 | Кимаб Лимитед | Антитела, их применение и способы применения |
| US11208469B2 (en) | 2016-03-18 | 2021-12-28 | Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet | Antiviral immunotherapy by membrane receptor ligation |
| RU2773427C2 (ru) * | 2016-03-18 | 2022-06-03 | Эберхард Карлс Универзитет Тюбинген Медицинише Факультет | Противовирусная иммунотерапия посредством лигирования мембранных рецепторов |
| RU2854454C1 (ru) * | 2020-04-01 | 2026-01-13 | Ф. Хоффманн-Ля Рош Аг | Биспецифические антигенсвязывающие молекулы, нацеливающиеся на ox40 и fap |
| RU2853336C1 (ru) * | 2020-12-09 | 2025-12-23 | ЭйчКей ИННО.Эн КОРПОРЕЙШН | АНТИТЕЛО К OX40L, БИСПЕЦИФИЧЕСКОЕ АНТИТЕЛО К OX40L/TNFα И ИХ ПРИМЕНЕНИЕ |
Also Published As
| Publication number | Publication date |
|---|---|
| IL191820A0 (en) | 2008-12-29 |
| US20100272738A1 (en) | 2010-10-28 |
| CN101374865A (zh) | 2009-02-25 |
| AR057253A1 (es) | 2007-11-21 |
| TW200732349A (en) | 2007-09-01 |
| MA30153B1 (fr) | 2009-01-02 |
| ZA200804868B (en) | 2009-10-28 |
| WO2007133290A3 (en) | 2008-01-10 |
| KR20080080639A (ko) | 2008-09-04 |
| CA2633602A1 (en) | 2007-11-22 |
| EP1973949A2 (en) | 2008-10-01 |
| NO20083147L (no) | 2008-09-16 |
| US7812133B2 (en) | 2010-10-12 |
| WO2007133290A2 (en) | 2007-11-22 |
| RU2008129111A (ru) | 2010-01-27 |
| CR10069A (es) | 2008-10-10 |
| AU2006343459A1 (en) | 2007-11-22 |
| BRPI0621065A2 (pt) | 2011-11-29 |
| JP2009519718A (ja) | 2009-05-21 |
| US20090053230A1 (en) | 2009-02-26 |
| WO2007133290A8 (en) | 2008-03-27 |
| ECSP088543A (es) | 2008-07-30 |
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