RU2420582C2 - Модулирование экспрессии 11бета-гидроксистероидной дегидрогеназы 1 для лечения глазных болезней - Google Patents

Модулирование экспрессии 11бета-гидроксистероидной дегидрогеназы 1 для лечения глазных болезней Download PDF

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RU2420582C2
RU2420582C2 RU2008120702/10A RU2008120702A RU2420582C2 RU 2420582 C2 RU2420582 C2 RU 2420582C2 RU 2008120702/10 A RU2008120702/10 A RU 2008120702/10A RU 2008120702 A RU2008120702 A RU 2008120702A RU 2420582 C2 RU2420582 C2 RU 2420582C2
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sirna
use according
11beta
eye
expression
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АНТОН Ана Изабель ХИМЕНЕС (ES)
АНТОН Ана Изабель ХИМЕНЕС
Анхела Сесто ЯГЕ (ES)
Анхела Сесто ЯГЕ
ГОМЕС Ма Консепсьон ХИМЕНЕС (ES)
ГОМЕС Ма Консепсьон ХИМЕНЕС
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Силентис С.А.
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01146—11-Beta-hydroxysteroid dehydrogenase (1.1.1.146)
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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RU2008120702/10A 2005-10-25 2006-10-25 Модулирование экспрессии 11бета-гидроксистероидной дегидрогеназы 1 для лечения глазных болезней RU2420582C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0521716.1A GB0521716D0 (en) 2005-10-25 2005-10-25 Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases
GB0521716,1 2005-10-25

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RU2008120702A RU2008120702A (ru) 2009-12-10
RU2420582C2 true RU2420582C2 (ru) 2011-06-10

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US (1) US8188057B2 (enExample)
EP (2) EP2354229A3 (enExample)
JP (2) JP5398262B2 (enExample)
CN (1) CN101346467B (enExample)
AU (1) AU2006307690B2 (enExample)
CA (1) CA2627272C (enExample)
ES (1) ES2403305T3 (enExample)
GB (1) GB0521716D0 (enExample)
IN (1) IN2015DN03331A (enExample)
MX (1) MX2008005409A (enExample)
RU (1) RU2420582C2 (enExample)
WO (1) WO2007049074A2 (enExample)

Cited By (1)

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RU2662967C2 (ru) * 2013-09-13 2018-07-31 Ионис Фармасьютикалз, Инк. Модуляторы фактора в комплемента

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CN101969282A (zh) * 2010-10-25 2011-02-09 北京印刷学院 抛物柱面聚光凹形闭合腔体采光太阳能发电装置
CN101976979A (zh) * 2010-10-25 2011-02-16 北京印刷学院 抛物柱面聚光半圆柱面闭合腔体采光太阳能发电装置
WO2017042238A1 (en) * 2015-09-08 2017-03-16 Sylentis Sau Sirna and their use in methods and compositions for inhibiting the expression of the nrarp gene
CN106702003B (zh) * 2017-02-28 2021-02-12 固安博健生物技术有限公司 Hsdl1在诊治骨肉瘤中的应用
CN109022436B (zh) * 2018-06-07 2021-04-09 深圳市疾病预防控制中心（深圳市卫生检验中心、深圳市预防医学研究所） 特异抑制3β-HSD基因表达的shRNA重组载体构建与应用
JP6617191B1 (ja) * 2018-12-03 2019-12-11 三井金属鉱業株式会社 溶液中の目的成分を分離又は分析するための方法及び装置
CN120204234B (zh) * 2025-05-28 2025-08-19 温州医科大学附属眼视光医院 11β-HSD1通路活性抑制剂在制备治疗青光眼睫状体炎综合征药物上的应用

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Publication number Priority date Publication date Assignee Title
RU2662967C2 (ru) * 2013-09-13 2018-07-31 Ионис Фармасьютикалз, Инк. Модуляторы фактора в комплемента

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MX2008005409A (es) 2008-11-26
CA2627272A1 (en) 2007-05-03
CN101346467A (zh) 2009-01-14
GB0521716D0 (en) 2005-11-30
JP2009513617A (ja) 2009-04-02
US20110160277A1 (en) 2011-06-30
IN2015DN03331A (enExample) 2015-10-23
ES2403305T3 (es) 2013-05-17
JP2013176395A (ja) 2013-09-09
EP2354229A2 (en) 2011-08-10
RU2008120702A (ru) 2009-12-10
WO2007049074A2 (en) 2007-05-03
EP1941037B1 (en) 2013-01-16
AU2006307690B2 (en) 2012-07-12
JP5398262B2 (ja) 2014-01-29
EP2354229A3 (en) 2012-12-05
CN101346467B (zh) 2013-03-13
US8188057B2 (en) 2012-05-29
AU2006307690A1 (en) 2007-05-03
HK1120830A1 (en) 2009-04-09
EP1941037A2 (en) 2008-07-09
CA2627272C (en) 2015-12-01
WO2007049074A3 (en) 2007-08-02

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