RU2420582C2 - Модулирование экспрессии 11бета-гидроксистероидной дегидрогеназы 1 для лечения глазных болезней - Google Patents

Модулирование экспрессии 11бета-гидроксистероидной дегидрогеназы 1 для лечения глазных болезней Download PDF

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RU2420582C2
RU2420582C2 RU2008120702/10A RU2008120702A RU2420582C2 RU 2420582 C2 RU2420582 C2 RU 2420582C2 RU 2008120702/10 A RU2008120702/10 A RU 2008120702/10A RU 2008120702 A RU2008120702 A RU 2008120702A RU 2420582 C2 RU2420582 C2 RU 2420582C2
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sirna
use according
11beta
eye
expression
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АНТОН Ана Изабель ХИМЕНЕС (ES)
АНТОН Ана Изабель ХИМЕНЕС
Анхела Сесто ЯГЕ (ES)
Анхела Сесто ЯГЕ
ГОМЕС Ма Консепсьон ХИМЕНЕС (ES)
ГОМЕС Ма Консепсьон ХИМЕНЕС
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Силентис С.А.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01146—11-Beta-hydroxysteroid dehydrogenase (1.1.1.146)
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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RU2008120702/10A 2005-10-25 2006-10-25 Модулирование экспрессии 11бета-гидроксистероидной дегидрогеназы 1 для лечения глазных болезней RU2420582C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0521716.1A GB0521716D0 (en) 2005-10-25 2005-10-25 Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases
GB0521716,1 2005-10-25

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RU2008120702A RU2008120702A (ru) 2009-12-10
RU2420582C2 true RU2420582C2 (ru) 2011-06-10

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US (1) US8188057B2 (enExample)
EP (2) EP1941037B1 (enExample)
JP (2) JP5398262B2 (enExample)
CN (1) CN101346467B (enExample)
AU (1) AU2006307690B2 (enExample)
CA (1) CA2627272C (enExample)
ES (1) ES2403305T3 (enExample)
GB (1) GB0521716D0 (enExample)
IN (1) IN2015DN03331A (enExample)
MX (1) MX2008005409A (enExample)
RU (1) RU2420582C2 (enExample)
WO (1) WO2007049074A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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RU2662967C2 (ru) * 2013-09-13 2018-07-31 Ионис Фармасьютикалз, Инк. Модуляторы фактора в комплемента

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US20070049543A1 (en) * 2001-05-18 2007-03-01 Sirna Therapeutics, Inc. RNA interference mediated inhibition of 11 beta-hydroxysteroid dehydrogenase-1 (11 beta-HSD-1) gene expression using short interfering nucleic acid siNA
WO2009073460A2 (en) * 2007-12-03 2009-06-11 Bausch & Lomb Incorporated Inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 for ocular neuroprotection
CN101976979A (zh) * 2010-10-25 2011-02-16 北京印刷学院 抛物柱面聚光半圆柱面闭合腔体采光太阳能发电装置
CN101969282A (zh) * 2010-10-25 2011-02-09 北京印刷学院 抛物柱面聚光凹形闭合腔体采光太阳能发电装置
MA44908A (fr) * 2015-09-08 2018-07-18 Sylentis Sau Molécules d'arnsi et leur utilisation dans des procédés et des compositions pour inhiber l'expression du gène nrarp
CN106702003B (zh) * 2017-02-28 2021-02-12 固安博健生物技术有限公司 Hsdl1在诊治骨肉瘤中的应用
CN109022436B (zh) * 2018-06-07 2021-04-09 深圳市疾病预防控制中心（深圳市卫生检验中心、深圳市预防医学研究所） 特异抑制3β-HSD基因表达的shRNA重组载体构建与应用
JP6617191B1 (ja) * 2018-12-03 2019-12-11 三井金属鉱業株式会社 溶液中の目的成分を分離又は分析するための方法及び装置
CN120204234B (zh) * 2025-05-28 2025-08-19 温州医科大学附属眼视光医院 11β-HSD1通路活性抑制剂在制备治疗青光眼睫状体炎综合征药物上的应用

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RU2662967C2 (ru) * 2013-09-13 2018-07-31 Ионис Фармасьютикалз, Инк. Модуляторы фактора в комплемента

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JP2013176395A (ja) 2013-09-09
CN101346467B (zh) 2013-03-13
MX2008005409A (es) 2008-11-26
EP2354229A2 (en) 2011-08-10
US8188057B2 (en) 2012-05-29
WO2007049074A3 (en) 2007-08-02
EP1941037B1 (en) 2013-01-16
RU2008120702A (ru) 2009-12-10
JP2009513617A (ja) 2009-04-02
CA2627272A1 (en) 2007-05-03
EP2354229A3 (en) 2012-12-05
JP5398262B2 (ja) 2014-01-29
US20110160277A1 (en) 2011-06-30
EP1941037A2 (en) 2008-07-09
CA2627272C (en) 2015-12-01
CN101346467A (zh) 2009-01-14
HK1120830A1 (en) 2009-04-09
IN2015DN03331A (enExample) 2015-10-23
GB0521716D0 (en) 2005-11-30
AU2006307690A1 (en) 2007-05-03
AU2006307690B2 (en) 2012-07-12
WO2007049074A2 (en) 2007-05-03
ES2403305T3 (es) 2013-05-17

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