RU2390558C2 - Гемопоэтическая клетка cd34+ и ее применение - Google Patents

Гемопоэтическая клетка cd34+ и ее применение Download PDF

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RU2390558C2
RU2390558C2 RU2007107369/13A RU2007107369A RU2390558C2 RU 2390558 C2 RU2390558 C2 RU 2390558C2 RU 2007107369/13 A RU2007107369/13 A RU 2007107369/13A RU 2007107369 A RU2007107369 A RU 2007107369A RU 2390558 C2 RU2390558 C2 RU 2390558C2
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cells
trail
cell
tumor
apoptosis
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RU2007107369/13A
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RU2007107369A (ru
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Алессандро М. ДЖАННИ (IT)
Алессандро М. ДЖАННИ
Кармело КАРЛО-СТЕЛЛА (IT)
Кармело КАРЛО-СТЕЛЛА
Франческо КОЛОТТА (IT)
Франческо Колотта
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ДОМПЕ ФА.Р.МА С.п.А.
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    • A61K40/4232Tumor necrosis factors [TNF] or CD70
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RU2007107369/13A 2004-07-29 2005-07-21 Гемопоэтическая клетка cd34+ и ее применение RU2390558C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04017907A EP1621550A1 (en) 2004-07-29 2004-07-29 Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
EP04017907.9 2004-07-29

Publications (2)

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RU2007107369A RU2007107369A (ru) 2008-09-10
RU2390558C2 true RU2390558C2 (ru) 2010-05-27

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US (1) US20070264231A1 (https=)
EP (2) EP1621550A1 (https=)
JP (1) JP5042826B2 (https=)
KR (1) KR20070047757A (https=)
CN (1) CN101076540B (https=)
AT (1) ATE455847T1 (https=)
AU (1) AU2005266543B2 (https=)
BR (1) BRPI0513855A (https=)
CA (1) CA2571426A1 (https=)
DE (1) DE602005019050D1 (https=)
DK (1) DK1771468T3 (https=)
ES (1) ES2340400T3 (https=)
HR (1) HRP20100227T1 (https=)
IL (1) IL180233A (https=)
MX (1) MX2007001152A (https=)
NO (1) NO20070956L (https=)
NZ (1) NZ552223A (https=)
PL (1) PL1771468T3 (https=)
PT (1) PT1771468E (https=)
RS (1) RS51381B (https=)
RU (1) RU2390558C2 (https=)
SI (1) SI1771468T1 (https=)
WO (1) WO2006010558A1 (https=)
ZA (1) ZA200701231B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080199423A1 (en) * 2004-06-18 2008-08-21 Genentech, Inc. Methods of Using Apo2l Receptor Agonists and Ink Cell Activators
DE102006020307A1 (de) * 2006-05-03 2007-11-08 Martin-Luther-Universität Halle-Wittenberg TNF-related apoptosis-including (TRAIL)stabil transgen exprimierende mesenchymale Stammzellen, Verfahren zu ihrer Herstellung und zu ihrer Verwendung
EP2163250B1 (en) * 2007-05-18 2013-01-09 National University Corporation Asahikawa Medical University Anticancer therapy by transplanting vascular endothelial progenitor cells
CN102154213B (zh) * 2011-01-19 2012-07-25 郑骏年 一种运载荷载细胞因子的双调控溶瘤腺病毒的新型cik细胞
JP2015506697A (ja) * 2012-02-01 2015-03-05 ポステック アカデミー‐インダストリー ファウンデーション 12量体trail及びhsv−tk自殺遺伝子を同時に発現するベクター並びにそれを用いた抗癌幹細胞治療剤
CN103288966B (zh) * 2013-05-17 2015-01-21 华侨大学 一种融合受体及其用于治疗大肠癌的基因药物
RU2552609C1 (ru) * 2013-10-28 2015-06-10 Федеральное государственное бюджетное учреждение науки Институт молекулярной биотехнологии им. В.А. Энгельгардта Российской академии наук (ИМБ РАН) Способ получения системы направленной доставки белковых молекул (онколитических белков) в опухолевые ткани на основе активированных лимфоцитов
AU2015335607B2 (en) 2014-10-24 2020-04-23 Calidi Biotherapeutics (Nevada), Inc. Combination immunotherapy approach for treatment of cancer
US10906951B2 (en) 2015-07-29 2021-02-02 Onk Therapeutics Limited Modified natural killer cells and natural killer cell lines having increased cytotoxicity
JP6974681B2 (ja) * 2015-07-29 2021-12-01 オーエヌケー セラピューティクス リミテッド 細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株
WO2019232631A1 (en) * 2018-06-06 2019-12-12 Stemcell Technologies Canada Inc. Kits, compositions and methods for myeloid-derived suppressor cell enrichment
US12220465B2 (en) 2018-11-28 2025-02-11 Washington University Compositions and methods for targeted treatment and imaging of cancer or tumors
JP2022526504A (ja) * 2019-03-21 2022-05-25 オーエヌケー セラピューティクス リミテッド 細胞死に対する耐性が増大した改変免疫エフェクター細胞
EP3712257A1 (en) 2019-03-21 2020-09-23 ONK Therapeutics Limited Modified natural killer cells with increased resistance to cell death
WO2021209625A1 (en) 2020-04-17 2021-10-21 Onk Therapeutics Limited High potency natural killer cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2232812C2 (ru) * 1994-10-07 2004-07-20 Ридженерон Фармасьютикалз, Инк. Выделенная молекула нуклеиновой кислоты, кодирующая tie-2 лиганд, tie-2 лиганд и способ получения, плазмида (варианты), антитело, конъюгат, лигандное тело, фармацевтическая композиция, способ стимулирования неоваскуляризации, способ поддержания клетки, способ идентификации антагониста tie-2 рецептора

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852703B1 (en) * 1997-06-04 2005-02-08 Oxford Biomedica (Uk) Limited Tumor targeted vector
AU2001290720A1 (en) * 2000-09-11 2002-03-26 Musc Foundation For Research Development Method and composition for treating tumors by selective induction of apoptosis
JP2004529102A (ja) * 2000-10-24 2004-09-24 イミュネックス・コーポレーション 併用療法を用いて、腫瘍を治療する方法
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
JP4493882B2 (ja) * 2001-06-19 2010-06-30 株式会社カネカ 抗原およびこの抗原を識別するモノクローナル抗体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2232812C2 (ru) * 1994-10-07 2004-07-20 Ридженерон Фармасьютикалз, Инк. Выделенная молекула нуклеиновой кислоты, кодирующая tie-2 лиганд, tie-2 лиганд и способ получения, плазмида (варианты), антитело, конъюгат, лигандное тело, фармацевтическая композиция, способ стимулирования неоваскуляризации, способ поддержания клетки, способ идентификации антагониста tie-2 рецептора

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEE J. et al., Cellular and genetic characterization of human adult bone marrow-derived neural stem-like cells: a potential antiglioma cellular vector. Cancer Res., 2003, v.63, n.24, p.8877-8889. UCUR E. et al., Induction of apoptosis in experimental human В cell lymphomas by conditional TRAIL-expressing Т cells, J. Br. J. Cancer, 2003, Dec 1; v.89, n.11, p.2155-2162. GARSIA-CASTRO J. et al., Antitumoral cell-based therapies, CANCER THERAPY, 2003, v.1, p.163-171. SMYTH M.J. et al., Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis, J. Exp. Med., 2001, v.193, n.6, p.661-670. *

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PL1771468T3 (pl) 2010-07-30
HRP20100227T1 (hr) 2010-07-31
CN101076540A (zh) 2007-11-21
MX2007001152A (es) 2007-04-18
RS51381B (sr) 2011-02-28
WO2006010558A8 (en) 2006-08-24
ATE455847T1 (de) 2010-02-15
IL180233A0 (en) 2007-07-04
IL180233A (en) 2010-12-30
NZ552223A (en) 2009-01-31
AU2005266543B2 (en) 2012-02-02
SI1771468T1 (sl) 2010-07-30
WO2006010558A1 (en) 2006-02-02
EP1771468B1 (en) 2010-01-20
ZA200701231B (en) 2008-08-27
PT1771468E (pt) 2010-04-20
CA2571426A1 (en) 2006-02-02
CN101076540B (zh) 2012-10-24
EP1621550A1 (en) 2006-02-01
NO20070956L (no) 2007-02-20
JP2008507961A (ja) 2008-03-21
DK1771468T3 (da) 2010-05-25
KR20070047757A (ko) 2007-05-07
EP1771468A1 (en) 2007-04-11
DE602005019050D1 (de) 2010-03-11
RU2007107369A (ru) 2008-09-10
HK1110874A1 (en) 2008-07-25
US20070264231A1 (en) 2007-11-15
BRPI0513855A (pt) 2008-05-20
JP5042826B2 (ja) 2012-10-03
ES2340400T3 (es) 2010-06-02
AU2005266543A1 (en) 2006-02-02

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