RU2355446C1 - Method of biocontrolled magnetic therapy of patients with prostatitis and device for its realisation - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: course exposure of prostate gland to electromagnetic radiation is carried out after endorectal inductor introduction. After inductor introduction correction of said radiation parametres is realised depending on dynamics of change of hemodynamics indices in area surrounding prostate gland. As hemodynamics indices, area of photoplehysmogram S, obtained from photoelectric sensor installed on inductor case surface, pulse wave amplitude, dichrotic wave index, ripple factor index are used. Device for realising method of magnetic therapy of patients with prostatitis contains successively connected control unit, audio amplifier and inductor. Inductor is made with possibility of introduction into patient's rectum. It has sensor, amplifier, connected with filter of low frequencies. Phitoelectric sensor is installed on inductor case surface and is connected to amplifier inlet. Outlet of filter of low-frequencies is connected to control unit inlet.

EFFECT: adaptive change of frequency range and intensity of electromagnetic radiation depending on change of microcirculation parametres in place of exposure during treatment process.

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Description

The invention relates to medicine, specifically to urology and physiotherapy, and is intended for the adapted treatment of patients with diseases of the prostate gland by exposure to an electromagnetic field of a sound frequency range. In the pathogenesis of chronic prostatitis, a leading role is played by a violation of microcirculation. Restoring microcirculation in the prostate is difficult and not always effective.

A known method of treating patients with prostatitis, including a course exposure to the prostate gland with a source of electromagnetic radiation, characterized in that in the course of a single and course exposure, blood circulation in the prostate is assessed by means of rheographic studies and the subsequent exposure regimen is adjusted depending on the dynamics of changes in the rheographic index (see A method for the treatment of patients with chronic prostatitis and a device for its implementation. Patent of the Russian Federation No. 2203109).

The disadvantages of this method are:

1. Rheographic index is not a sufficient indicator for the implementation of adequate correction of therapeutic effects.

2. Rheographic studies are not an indicator of microcirculation in the vicinity of the prostate gland, but reflect the integral blood supply in the area of the probing current, which covers the deep areas of the biological tissue and cannot be unambiguously assessed.

3. Monitoring the effectiveness of the therapeutic effect does not have the necessary efficiency, since either the "therapy" mode or the "control" mode are possible, which requires appropriate switching over during the therapeutic procedure.

The objective of the proposed method is to increase the effectiveness of therapeutic effects through adaptive changes in the frequency range and intensity of electromagnetic radiation, depending on changes in microcirculation in the vicinity of the radiation source during therapeutic exposure.

A device is known for electromagnetic stimulation in the sound range of electromagnetic oscillations AROPAK 614 (see Universal Medical Device PUMA. Operating Instructions 2089001 OM), containing a microphone, an audio amplifier, and an inductor for connecting to the patient’s rectum, as well as a control unit connected to the second input of the audio amplifier, and a control unit connected to the output of the inductor.

The device has the following disadvantages.

1. When operating the device, an external source of acoustic vibrations is required.

2. The device does not allow you to select the optimal parameters of electromagnetic waves of the acoustic frequency range for each individual patient, as well as to biofeedback these parameters.

3. The effectiveness of the therapeutic effect cannot be controlled during the adoption of the treatment procedure.

The objective of the claimed device is the implementation of biocontrolled magnetotherapy with simultaneous monitoring of the effectiveness of magnetotherapy effects.

The problem in the "Method ..." is solved by the fact that when treating patients with prostatitis with a method that includes a course exposure to electromagnetic radiation on the prostate after endorectal induction of the inducer and subsequent correction of the parameters of this radiation depending on the dynamics of changes in hemodynamic parameters in the vicinity of the prostate gland, as the parameters of hemodynamics use the area of the photoplethysmogram S obtained from the photoelectric sensor mounted on the surface inductor housing, defined as

where a _i is the value of the i-th sample of the photoplethysmogram, N is the number of samples in the analyzed photoplethysmogram in the interval [0, B5 _t ], B1 _a , B5 _a and B5 _t are the coordinates of the coding points of the volume pulse along the axes a and t, and point B1 corresponds to the beginning of the period of exile, point B2 corresponds to the moment of maximum expansion of blood vessels in the phase of forced exile, point B3 corresponds to the protodiastolic period, point B4 corresponds to the beginning of diastole, point B5 corresponds to the end of the diastole and indicates the end of the cardiac cycle;

pulse wave amplitude, defined as

dicrotic wave index, defined as

and a notch index defined as

where Δa _i = a _{i + 1} -a _i ,

.

.

The problem in the "Device ..." part is solved by the fact that in the device for magnetotherapy of prostatitis containing a serially connected control unit, an audio amplifier and an inductor designed to enter the patient’s rectum, a photo-electric sensor mounted on the surface of the inductor housing is additionally introduced, an amplifier and a low-pass filter, the output of which is connected to the input of the control unit, and the control unit includes a microcontroller, the analog input of which It is intended for connection to a low-pass filter, a display connected to the first digital port of the microcontroller, a keyboard connected to the second digital port of the microcontroller, a serial interface controller connected to the third digital port of the microcontroller, a flash memory connected to the fourth digital port of the microcontroller, and a digital-to-analog a converter connected to the fifth digital port of the microcontroller, the output of which is designed to connect to the input of an audio amplifier.

The operation of the method and device is illustrated by the following figures.

Figure 1 presents the structural diagram of the proposed device.

Figure 2 presents a diagram of the algorithm of the device.

Figure 3 presents a diagram of the algorithm of operation of a random process generator block.

Figure 4 presents a graph of photoplethysmogram with the main coding points of the volume pulse.

Figure 5 presents a diagram of the algorithm of the unit for correction of magnetotherapy parameters.

A device for biocontrolled magnetotherapy of prostatitis (Figure 1) contains a control unit 1, including a microcontroller 2, a display 3 connected to the first digital port of the microcontroller 2, a keyboard 4 connected to the second port of the microcontroller 2, a serial interface 5 connected to the third digital port of the microcontroller 2, a flash memory 6 connected to the fourth digital port of the microcontroller 2, and a digital-to-analog converter 7 connected to the fifth digital port of the microcontroller 2, an audio amplifier 8 connected th to the output of the digital-to-analog converter 7, an inductor 9, designed to affect the bioobject 13 and connected to the output of the audio amplifier 8, a photoelectric sensor 10, designed to control the blood supply of the bioobject 13 in the vicinity of the inductor 9, an amplifier 11, the input of which is connected to the output of the sensor 10, and a low-pass filter 12, the input of which is connected to the output of the amplifier 11, and the output is designed to connect to the analog port of the microcontroller 2.

The method is as follows.

They lay the patient on his side with his knees pressed to his stomach and a curved back. The inductor body 9, Fig. 1, is inserted into the rectum, connected by a cable with an audio amplifier 8 and an amplifier 11 (Fig. 1). Control the correct placement of the inductor strictly above the prostate gland. The initial photoplethysmogram is obtained from the photosensor 10 (Fig. 1) mounted on the inductor body 9 (Fig. 1). Set the parameters of the "average" mode of magnetotherapy and carry out a therapeutic effect for 1 ... 2 minutes. Then get photoplethysmogram and calculate the following informative signs of the effectiveness of magnetotherapy:

where t2-tl = T _BK , T _BK - the time interval (1 ... 2 minutes), determined by the frequency of biofeedback correction of therapeutic effects;

The intensity of electromagnetic radiation is increased until one of the informative parameters changes in a favorable direction, that is, in the direction of increase. If one of the parameters changes in a favorable direction, then the electromagnetic radiation intensity remains at the achieved level, and the “floating” spectral window mode is implemented, the essence of which is to select in the sound frequency range such an amplitude-frequency characteristic of electromagnetic radiation that would deflect informative signs of the effectiveness of magnetotherapy in a favorable direction with a constant intensity of electromagnetic radiation or with its decrease.

Upon reaching the optimal amplitude-frequency characteristics of electromagnetic radiation, they return to the procedure for increasing the intensity of electromagnetic radiation while monitoring the trend of changes in informative features. The next session of magnetotherapy begins with the installation of such parameters of magnetotherapy, which were achieved in the previous session.

Thus, the plan of the following procedure and the duration of the course as a whole is determined by the dynamics of changes in the informative signs of the effectiveness of magnetotherapy, that is, taking into account the role of vascular changes in the pathogenesis of inflammation of the prostate gland and the adaptation mechanisms of the organ circulatory system, the degree of reserve capacity for improving the circulation of the prostate and the need for an individual, pathogenetically based approach to the treatment of prostatitis.

Thus, the presented method allows to reduce the effect of adaptation of the organism to the electromagnetic field due to the use of electromagnetic radiation with non-stationary spectral characteristics and to prevent negative reactions to therapeutic electromagnetic radiation by controlling the intensity of electromagnetic radiation through biological feedback on microcirculation.

A device that implements this method works as follows.

The functioning of the device is determined by the program, flashed in the memory of the control unit 1 (figure 1). The algorithm diagram, according to which this program works, is presented in Fig.2. After turning on the power, the microcontroller 2 sets the output of the digital-to-analog converter 7 to zero voltage (block 14 of figure 2), that is, de-energizes the inductor 9 (figure 1), and goes into waiting for the input of magnetotherapy parameters and the Start command, which puts the device into mode magnetotherapy (blocks 15 and 16 of figure 2).

The input of the magnetotherapy parameters is carried out from the keyboard 4 and is controlled by the display 3. The input parameters include the time of the therapeutic effect T _MT , the center frequency of the spectrum of electromagnetic radiation F _C , the spectral range of electromagnetic radiation 2Δf _sd , the frequency of biocontrolled correction of the parameters of electromagnetic radiation 1 / T _BC . When calculating the parameters of therapeutic signals, it is assumed that their sampling rate is 10,000 Hz, i.e., the upper frequency range of electromagnetic radiation is 5,000 Hz.

When implementing magnetotherapy, it is necessary to use two timers, the states of which are determined by Flag 1 and Flag 2. The first timer counts the time interval T _MT from the beginning to the end of the therapeutic procedure and the state Flag 1 = 1 indicates that this time has expired. The second timer counts the time interval T _BK between two adjacent biocontrolled procedures for the correction of electromagnetic radiation parameters and the state Flag 2 = 1 indicates that this time has expired. In the initial state, the timers are set in blocks 17 and 18 of figure 2.

Biofeedback of the magnetotherapeutic procedure is carried out by analyzing the photoplethysmogram obtained from biological tissue located at the surface of the inductor 9. The biofeedback process is based on the analysis of changes in the integral characteristic of the photoplethysmogram over the time interval T _BC in a favorable or unfavorable direction. Therefore, during the first pass of the block 19 of FIG. 2, recording in the memory of the control unit 1 of FIG. 1 the photoplethysmogram readings before the magnetotherapy effect is carried out. Therefore, during the first pass of block 19, block 20 is ignored, and control is transferred to the block of the random process generator 8.

The task of the random process generator block 8 is to form a variational series whose spectrum satisfies the statistical parameters F _C and Δf _sd . Moreover, we believe that in a certain time window the spectral coefficients of the series satisfy the normal distribution law, therefore, F _C can be considered as the mathematical expectation, and Δf _sd / 3 as the standard deviation of the normal distribution law. Since magnetotherapy is carried out in the sound range of electromagnetic waves, the width of this window is selected in the range of 20 ... 40 ms, as is customary for the window Fourier transform of acoustic signals (see L. Rabiner Theory and the use of digital signal processing [Text]: [trans. from English.] / L. Rabiner, B. Gould. M.: Mir, 1978. P.116), which corresponds to a maximum frequency resolution of 25 Hz. In this case, at a sampling frequency of 10 kHz, 400 samples are obtained in a window with a width of 40 ms.

The scheme of the algorithm of the block 21, which implements the synthesis of the variational series, is presented in figure 3. The generator unit 21 (FIG. 2) includes two main software modules: a white noise generator in the acoustic frequency range 24 (FIG. 3) and a digital filter 27 (FIG. 3). The samples of the frequency response of the digital filter are obtained by tabulating a Gaussian function having the parameters F _C and Δf _sd / 3. The order of the filter is determined by the number of samples that hit the window. The window driver 14 (Fig. 3) generates a vector of digital samples, which interacts with the "mask" of the digital filter 28 (Fig. 3).

Thus, at the output of block 21 (Fig. 2), a sequence of samples is formed - a frame, the number of elements in which is determined by the order of digital filter 28 (Fig. 3). After the frame with the samples is issued to the digital-to-analog converter (block 23 of FIG. 2), the state of Flag 2 is checked. If Flag 2 is in state 1, then transition to block 6 takes place, in which the photoplethysmogram is recorded. In this case, several photoplethysmograms are recorded and a photoplethysmogram with parameters that are closest to the average in the analyzed set is selected for analysis.

The analysis of photoplethysmogram is carried out by block 20 of figure 2. The basis of biocontrol is the thesis that the pathogenesis of most diseases is impaired microcirculation (see Microcirculation [Text]: / AM Chernukh, PN Aleksandrov, OV Alekseev. M .: Medicine, 1984. - 432 p. ) Based on this position, from the photoplethysmogram, the figure of which with characteristic points is shown in Fig. 4, it is necessary to highlight informative signs that would characterize the improvement of microcirculation in adjacent tissues. Four signs are used as such signs: X1, X2, X3, X4. They are determined by the formulas (5-8).

Informative signs are selected in such a way that in case of a favorable effect of magnetotherapy on microcirculation they increase. Thus, the doctor has the opportunity, after each interval of T _BK, to evaluate the effectiveness of the therapeutic effect according to four indicators and change the parameters of magnetotherapy in the necessary direction. The program also allows you to use the automatic mode of correction of magnetotherapy parameters when a regression model of therapeutic effect effectiveness is used.

in which the coefficients b1, b2, b3 and b4 are selected as a result of statistical studies on one patient or on a set of patients and are entered into the memory of the microcontroller from the keyboard 4 of figure 1.

The algorithm of the operation of block 20 of FIG. 2 for correction of magnetotherapy parameters is presented in FIG. 5. The presented algorithm diagram assumes an interactive mode of correction of magnetotherapy parameters (block 32). Automatically, the process of increasing the intensity of electromagnetic radiation (EMR) occurs, provided that none of the informative signs has changed significantly after the expiration of time T _BC (blocks 36, 39, 40, 42, 45, and 47 of FIG. 5) or a decrease in the intensity of EMR, provided if at least one of the informative signs has changed in an unfavorable direction after the expiration of time T _BK (blocks 37, 39, 41, 43, 48 and 49 of figure 5).

The objective of the claimed device is the implementation of biocontrolled magnetotherapy with simultaneous monitoring of the effectiveness of magnetotherapy effects.

Thus, the presented device allows you to implement a negative feedback loop on the parameters of microcirculation and through this feedback to control the parameters of the therapeutic electromagnetic field during the treatment procedure so as to minimize the negative effect of magnetotherapy by reducing the radiation intensity and maximize the therapeutic effect of electromagnetic radiation on the pathological organ by reducing the adaptive reactions of the body to this radiation uw.

An example of a specific implementation of the method.

Patient G., 37 years old, complained of aching pains in the inguinal-scrotal area, frequent urination, decreased erection, rapid ejaculation, discharge from the white urethra during defecation. From the anamnesis of the disease it was found that chronic prostatitis suffers for 8 years, worsening of the condition notes 2 ... 3 times a year. When examining the secretion of the prostate gland: white blood cells up to 30 in sight, no lecithin grains. With a manual examination of the prostate gland, the tonus of the prostate is reduced, its outline is blurred, palpation is painful, with a light massage of the prostate from the urethra, the secretion of the prostate gland is liberated. Ultrasound examination of the prostate gland tissue is not homogeneous, its contours are enlarged. The initial photoplethysmogram indicated pronounced hemodynamic impairment of the prostate gland.

The diagnosis of chronic non-specific prostatitis, stage of exacerbation.

The patient underwent complex therapy, including anti-inflammatory, general strengthening therapy, a course of treatment with prostamol-Uno was administered 1 capa × 1 time per day for a month, α - adrenergic blockers, vitamin therapy, vitaprost rectally.

Against the background of the treatment, positive dynamics were noted, but the photoplethysmography of the prostate showed a violation of the hemodynamics in the prostate gland. Therefore, at the final stage, the patient underwent a course of magnetotherapy. In this case, the magnetotherapy procedures were carried out according to the claimed method using the claimed device.

They laid the patient on his side with his knees pressed to his stomach and a curved back. An inductor was introduced into the rectum with a photoelectric converter mounted on its body, connected by cables with an audio amplifier and amplifier, respectively. Controlled the correct placement of the inductor strictly in the projection of the prostate gland. The magnetic field intensity on the inductor surface was set to 0.6 mT, and the amplitude-frequency characteristics of the Gaussian "white" noise F _C = 1000 Hz, Δf _sd = 600 Hz.

After 10 minutes of magnetotherapy with such parameters, a significant increase in the informative sign of XI by 10% was found. In this case, the magnetic field intensity increased to 1.1 mT. After that, they began to shift F _C toward higher frequencies while maintaining the achieved intensity of electromagnetic radiation. When F _C = 1350 Hz, a significant increase in the informative sign X3 was found. Since the procedure time has ended, the achieved parameters were used as initial parameters in the next procedure.

The duration of the procedure was 20 minutes. Photoplethysmograms were analyzed after 0.5 minutes (T _BK ). The plan for the next procedure and the duration of the course as a whole was determined by the dynamics of changes in hemodynamic parameters of previous procedures.

If the hemodynamic parameters worsened during subsequent procedures, then in a similar way (the algorithm diagram of FIG. 5), the electromagnetic radiation intensity was reduced and F _{C was} moved to the right and left along the frequency axis until at least one of the informative signs changed in a favorable direction in the absence of significant changes in other informative signs.

The prescribed treatment was carried out daily for 10 days.

That is, the treatment was carried out taking into account the role of vascular changes in the pathogenesis of inflammation of the prostate gland and the adaptation mechanisms of the organ circulatory system, the degree of reserve capacity for improving the circulation of the prostate and the need for an individualized, pathogenetically based approach to the treatment of prostatitis.

Results of the analysis of monitoring photoplethysmogram of the prostate gland.

Prior to the start of magnetotherapy on 02.11.2006, photoplethysmograms of the prostate gland (initially) showed a weakly expressed subcritical tooth, pulse blood filling was reduced (S and AR parameters are small), which makes it impossible to assess the state of vascular tone and peripheral resistance, and venous outflow is difficult.

After the 1st magnetotherapy procedure (exposure time of 20 minutes, Gaussian “white” noise at the inductor input, magnetic field intensity 1.1 mT), a significant increase in peripheral resistance and difficulty in venous outflow were observed, i.e. the procedure served as a stress test, revealing latent insufficiency of the vascular bed of the prostate.

Before the start of the 2nd procedure of magnetotherapy on November 3, 2006, photoclet plethysmograms of the prostate gland show a more pronounced subcritical tooth, and vascular tone is restored.

After the 2nd procedure (exposure time of 20 minutes, Gaussian “white” noise at the inlet of the inductor, magnetic field intensity of 1.1 mT), pulse blood supply (S and AR) increased by an average of 2 times, but the geariness increased, which led to a decrease electromagnetic radiation intensity up to 0.8 mT.

Before the start of the 3rd procedure on November 4, 2006, the blood supply to the prostate was 1.5 times higher than the baseline. Indicators of elastonic properties of blood vessels and the state of venous outflow within the normal range.

After the 3rd procedure of magnetotherapy (exposure time of 20 minutes, Gaussian “white” noise at the inlet of the inductor, magnetic field intensity 0.8 mT), the blood filling rate is moderately increased, the elastotonic state of the vessels is at the upper border, i.e. there is a "training" of the vascular bed of the prostate to subsequently increase the reserve capacity of organ blood flow.

Before the beginning of the 4th procedure on November 5, 2006, the blood supply index was reduced, the elastotonic state of the vessels was gradually normalizing.

After the 4th procedure (exposure time 20 min, Gaussian “white” noise at the inductor input, F _C = 1150 Hz, Δf _sd = 450 Hz, magnetic field intensity 0.9 mT), a stereotypical depression of hemodynamic parameters was noted, which is very common in magnetotherapy in general, associated with a sharp limitation of the reserve capacity of the vascular bed of a pathologically altered prostate. This dictated the need to reduce exposure to 15 minutes.

By November 6, 2006 (5th procedure) (exposure time 18 min, Gaussian “white” noise at the inductor input, F _C = 1250 Hz, Δf _sd = 650 Hz, magnetic field intensity 0.85 mT), the highest possible levels were reached for this the patient’s indicators of pulse blood supply (blood supply indicators are on average 3 times higher than the baseline before the procedure and 6 times higher after the procedure). At the same time, peripheral resistance indices are normalized, and vascular tone decreases, and the venous outflow rate decreases.

By the time of the 6th procedure on November 7, 2006 (exposure time 18 min, Gaussian “white” noise at the inductor input, F _C = 1200 Hz, Δf _sd = 600 Hz, magnetic field intensity 0.9 mT), pulse blood filling remains in a stationary state , peripheral resistance and vascular tone increase slightly, remaining within the normal range, IDE is approaching normal, and the dentate index is decreasing.

On the 7th procedure, November 8, 2006 (exposure time of 20 minutes, Gaussian “white” noise at the inductor input, F _C = 1200 Hz, Δf _sd = 760 Hz, magnetic field intensity 0.8 mT), a moderate increase in the blood supply index is observed at the beginning of the session , accompanied by an increase in both peripheral vascular resistance and IDV, at the end of the session and after the end of the procedure, there is a sharp increase in pulse blood supply and normalization of the index of the dicrotic wave in the prostate gland.

In this dynamics, the essence of the “training” effect of magnetotherapy procedures is manifested, since as a result of increasing the boundaries of reserve capabilities for adapting blood flow, changes in the vascular bed of the prostate are compensated.

After the 8th procedure, November 9, 2006 (exposure time 18 min, Gaussian “white” noise at the inductor input, F _C = 1200 Hz, Δf _sd = 700 Hz, magnetic field intensity 0.7 mT), against the background of a stably increased pulse blood supply a significant decrease in peripheral resistance and vascular tone and a decrease in difficulties for venous outflow from the prostate gland (ie, there was sufficient “training” of the vascular walls and an increase in the reserve capacity of the vascular bed of the prostate, favorable for the perception of therapeutic factors and A prediction of treatment outcomes).

11/10/2006 - 9th procedure. Before and after the procedure (exposure time of 20 min, Gaussian “white” noise at the inductor input, F _C = 1100 Hz, Δf _sd = 650 Hz, magnetic field intensity 0.8 mT), a decreased pulse blood filling was observed, which was close to the values before treatment. Apparently, this indicates a depletion of the reserve capacity of blood flow, in other words, a symptom of "fatigue" of the vascular bed. This is also evidenced by a decrease in peripheral resistance and vascular tone. In general, relaxation of the vascular walls is assessed as a positive therapeutic effect, but a break is needed in treatment.

On the 10th procedure, November 14, 2006 (exposure time of 20 min, Gaussian “white” noise at the inductor input, F _C = 1300 Hz, Δf _sd = 400 Hz, magnetic field intensity 0.7 mT) was repeatedly noted, as well as on 5- procedure, a significant increase in pulse blood supply, increasing even more after the end of the session, but while maintaining within the normal values of the indices of peripheral resistance and vascular tone and with a decrease in the dentate index. This completes the course of magnetotherapy.

The patient was examined 10 days after the end of the course of magnetotherapy. After such treatment, the patient noted the complete disappearance of pain, improved sexual function, and secretion of the prostate gland from the urethra stopped. In the study of prostatic secretion: leukocytes 2 ... 3 in the field of view, a lot of lecithin grains. With a finger examination of the prostate gland, it was noted that it became an elastic consistency, with a smooth contour, the longitudinal groove began to differentiate well. During ultrasound examination of the prostate gland, the structure was homogeneous, its contours became smooth and distinct.

Photoplethysmogram testified to the normalization of hemodynamics in the prostate gland.

For 6 months, the patient did not receive treatment for chronic prostatitis. Examined 6 months after the end of magnetotherapy. On examination, it does not show complaints; there are no changes in the analysis of the secretion of the prostate gland. But the photoplethysmography performed testified to the developing stagnant circulation in the prostate gland. Therefore, the patient was carried out with the preventive purpose of 5 sessions of magnetotherapy according to the proposed method. Against the background of magnetotherapy, normalization of hemodynamic indications in the prostate gland was noted.

The patient was examined after a month. When examining data for exacerbation of chronic prostatitis was not obtained.

Thus, as a result, a new fundamental opportunity appeared to conduct a controlled, pathogenetically substantiated, dosed treatment of chronic prostatitis, and the prophylactic course of magnetotherapy avoids the clinical manifestations of exacerbation of prostatitis.

The proposed method and device can improve the quality of treatment while reducing treatment time, have good tolerance and provide stable remission during treatment. The device can also be used to diagnose chronic prostatitis.

Claims (3)

1. A method for magnetotherapy of patients with prostatitis, including a course of exposure to electromagnetic radiation on the prostate after endorectal induction of the inductor, characterized in that after the introduction of the inducer, the parameters of this radiation are adjusted depending on the dynamics of changes in hemodynamic parameters in the vicinity of the prostate gland, while as hemodynamic indicators use the area of the photoplethysmogram S obtained from the photoelectric sensor mounted on the surface of the induct ora defined as

where a _i is the value of the i-th sample of the photoplethysmogram, N is the number of samples in the analyzed photoplethysmogram in the interval [0, B5 _t ], B1 _a , B5 _a , B5 _t are the coordinates of the coding points of the volume pulse along the axes a and t, and point B1 corresponds to the beginning of the period of exile, point B2 corresponds to the moment of maximum expansion of blood vessels in the phase of forced exile, point B3 corresponds to the protodiastolic period, point B4 corresponds to the beginning of diastole, point B5 corresponds to the end of the diastole and indicates the end of the cardiac cycle; pulse wave amplitude, defined as
AR = B2 _a -B1 _a ;
dicrotic wave index, defined as
IDV = (B3 _a- B5 _a ) / (B2 _a -B1 _a );
and a notch index defined as

where Δa ₁ = a _{i + 1} + a _i ,

2. Device for magnetotherapy of patients with prostatitis, containing a serially connected control unit, an audio amplifier and an inductor configured to enter the patient’s rectum, on which there is a sensor, an amplifier connected to a low-pass filter, characterized in that the photoelectric sensor is mounted on the surface of the housing inductor and is connected to the input of the amplifier, and the output of the low-pass filter is connected to the input of the control unit. 3. The device according to claim 2, characterized in that the control unit includes a microcontroller, the analog input of which is an input for connecting a low-pass filter, a display connected to the first digital port of the microcontroller, a keyboard connected to the second digital port of the microcontroller, and a digital-to-analog converter, connected to the third digital port of the microcontroller, the output of which is the output for connecting an audio amplifier.

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