RU2324496C1 - Method of treatment of diseases caused by abnormality of cartilagenous and/or bone tissues - Google Patents

Abstract

FIELD: medicine; pharmacology.

SUBSTANCE: invention relates to the method of treatment of diseases caused by abnormality of cartilaginous and/or bone tissue; the method includes the treatment course of applications of hydrolysed collagen and cosmetic clay to the painful area, when the KollAmin-80 or Epydermat-0 are rubbed into the painful area, and then the diluted cosmetic clay is applied, the area is covered with the polyethylene film or compressor paper and warmth-keeping for 30-40 min once daily, with course of 30-60 days 3-6 times annually.

EFFECT: high therapeutic efficiency is achieved.

2 cl, 9 ex

Description

The invention relates to the field of medicines and can be used to treat arthrosis, osteoporosis and other diseases caused by a pathological change in the structure of cartilage and / or bone tissue.

Today, joint diseases are one of the most common reasons for going to the doctor. Arthritis and arthrosis are extremely common diseases that take second place after cardiovascular disease. Joint diseases are accompanied by pain, swelling of the affected joint, cartilage degeneration and often lead to disability and a decrease in the quality of life.

Osteoporosis is a metabolic disease of the skeleton associated with impaired bone quality and decreased bone mass, which leads to bone fractures even due to minor injury, and sometimes even for no apparent reason. Osteoporosis affects 15% of women aged 50-65 years, up to 70% over the age of 65 years. Every second patient who has had a hip fracture becomes disabled. In 50% of patients after a fracture, their activity is never restored. 10-20% of elderly patients die in the first year after a hip fracture. All bones are affected in osteoporosis, however, the femur (its neck), spine and radius in the wrist are the most common lesion. Thus, the search for new effective approaches to the treatment of diseases associated with pathological changes in bone and / or cartilage tissue is one of the most urgent tasks facing scientists around the world.

Currently, for the treatment and prevention of the above diseases, various ointments, nutritional supplements, homeopathic, phyto- and aromatherapy drugs, as well as anti-inflammatory drugs are used.

One of the most common, simple and painless procedures is the application of drugs. Application tools can be divided into the following groups:

1. Means of annoying, distracting and warming effects.

These include ointments based on bee (apisartron) and snake (vipratox) poisons, as well as synthetic warming agents (finalgon and others) (Mashkovsky M.D. Medicines, M., Medicine, part 2, p.163 -167; Radar, Encyclopedia of Medicines, 7th edition, editor Yu.F. Krylov, 2000, p. 976). Traditionally used ointment preparations containing:

menthol as a painkiller and coolant;

pepper extracts of an irritating nature;

turpentine - a component that has a local irritating and analgesic effect;

derivatives of nicotinic acid, causing the expansion of blood vessels.

These drugs are used for joint diseases once to relieve pain with unexpressed synovitis.

2. Means containing non-steroidal anti-inflammatory drugs (NSAIDs), Mashkovsky MD, Medicines, M., Medicine, part 2, pp. 187-200, 202).

Butadiene, indomethacin, voltaren ointment, cream dolit, fastum gel and many others have a pathogenetic justification in the treatment of joints. Local NSAIDs are indicated in the acute stage of the disease to relieve inflammation. They penetrate the joint cavity with an adequate duration and frequency of treatment. The use of ointments with NSAIDs in practical use:

has no contraindications

used at any age

independent of concomitant diseases,

It does not depend on the drugs taken in other groups, combined with oral administration of painkillers, including PNVC.

3. Dimethyl sulfoxide (dimexide, DMSO).

Dimexide has a pronounced anti-inflammatory effect and is a good conductor for other drugs. Treatment is carried out in exacerbation courses.

4. Means that improve trophic tissue.

These include bischofite, naphthalan, medical bile, and others. The drugs are used mainly during the period of disease remission (MD N.A. Khitrov, 2005).

As the closest analogue of the present invention, a method of treating arthrosis, osteochondrosis, degenerative diseases of the joints and spine using the ointment "Chondroxide 5%", which is used to relieve inflammation by rubbing into the affected area with arthrosis, osteochondrosis, degenerative diseases of the joints and spine, can be adopted (Radar, Encyclopedia of Medicines, 7th edition, editor Yu.F. Krylov, 2000, pp. 1028-1029).

However, the effectiveness of the application of drugs of the above groups does not always lead to the achievement of the desired results, even in combination with systemic drugs.

In accordance with the invention, a method for treating diseases caused by a pathological change in cartilage and / or bone tissue is described, in which an application course effect is applied to the painful area with hydrolyzed collagen and cosmetic clay by rubbing into the painful area a solution (preparation) of hydrolyzed collagen in water in the form of CollAmin- 80 or Epidermate-O with subsequent application of cosmetic clay diluted in water to the indicated area, covering with plastic wrap or compressor Umag and insulation for 30-40 minutes. Treatment is carried out in courses of 30-60 days 3-6 times a year.

CollAmin-80 is an enzymatic hydrolyzate of collagen in cattle and contains all the amino acids of this protein, and in the ratio that is optimal for normal life.

Epidermate-O is a collagen hydrolyzate of mammalian skin, the dry skin enzyme contains a complete set of free amino acids (including all essential for humans), low molecular weight biologically active polypeptides, has an anti-inflammatory, regenerating effect and improves cell proliferation.

The application effect is as follows: the preparation of hydrolyzed cattle collagen is placed in a non-metallic container, slowly added 10 ml of water, kept without stirring for 20 minutes, then mixed until a homogeneous mass is obtained and rubbed dropwise into the area of the diseased joint or spine until the skin sticks fingers to the treated surface of the skin. Clay is placed in a non-metallic container, 20 ml of water is added, with a spatula diluted to a homogeneous mass - sour cream consistency, applied to a surface rubbed with hydrolyzed collagen, covered with plastic wrap or compress paper, insulated for 30-40 minutes, then the clay is removed with a damp soft cloth . After the procedure, the treated surface is lubricated with a moisturizer.

In the treatment of arthrosis, the duration of the application of these active ingredients should be approximately 30 minutes. The application effect on the painful area must be carried out daily 1 time per day for 30 days. Treatment is carried out in courses 6 times a year.

In the treatment of osteoporosis, the duration of the application of the active ingredients should be approximately 40 minutes. Application exposure is carried out daily 1 time per day for 60 days. Treatment is carried out in courses 3 times a year.

The number of applications and the duration of exposure can easily be determined by the attending physician on the basis of the information given in this description, taking into account the gender, age of the patient, the severity of the lesion and general health.

The proposed method for the treatment of diseases of the joints has no contraindications and is easily carried out at home.

The effectiveness of the method is illustrated by the following examples.

Example 1

Patient T., 62 years old.

Over the past 3-4 years, the patient has been bothered by joint pain, especially in the left knee and right hip. According to densitometry, a decrease in bone density was found. She took various treatments without a long therapeutic effect. Then the pain intensified, the legs hurt, not only when walking, but also at rest. The patient was held 60 applications using the described method with a duration of exposure to the active components of 40 minutes, daily. After the first procedure at night, pain was not disturbed. After the 3-4th procedure, pain in the knee joint when walking was gone. After 10 procedures, the condition is stable, joint pain does not bother, sleep has become much better and calmer.

Example 2

Patient F, 58 years old.

The patient complained of pain in the toes of the left leg of a muscle nature and in the hip joint on the left. The patient received 30 applications using the described method with a duration of exposure of the active components of 30 minutes daily. After treatment, the pain in the toes eased, the pain in the hip joint did not bother.

Example 3

Patient I., 50 years old.

Complained of pain in the wrist and joint of the thumb. Joint swelling was observed. After 10 applications daily for 30 minutes, the pain and swelling have passed. The movement of the arm became painless.

Example 4

Patient R., 67 years old.

For more than 20 years, she suffered from pain in the small joints of the hands and 2 years from pain in the elbow joints. I didn’t go to the doctors. After applying daily for 30 minutes, I felt a noticeable improvement. Ceased to disturb pain at night, edema slept.

Example 5

Patient J., 65 years old.

For a long time suffers from pain in the ankle joint of the left leg. The patient received 30 applications daily, lasting 30 minutes. After the 3rd procedure, the patient felt relief. Pain ceased to bother at the end of the procedure.

Example 6

Patient V., 59 years old.

Complained of pain in the right hand after injury. The patient received 12 applications daily for 30 minutes. The pain ceased to bother, sleep improved, and the amplitude of motion in the joint increased.

Example 6

Patient P., 67 years old.

For many years, she suffered from arthrosis of the knee joints. The patient began to receive treatment with applications using the described method. After the 4th procedure, the pain noticeably subsided. Joint mobility has improved. The patient continues to receive treatment with applications.

Example 7

Patient A., 59 years old.

She complained of pain in the left thigh and left foot. Biochemically diagnosed with preopeoporosis. The patient was treated with applications using the proposed method (2 months, 1 time per day with a duration of exposure of 40 minutes). The condition has improved markedly, the pain has passed.

Example 8

Patient N., 67 years old.

The patient complained of back pain with radiation to the thigh. X-ray: osteoporosis, right-sided coxarthrosis. The patient received 15 applications using the described method daily, lasting 40 minutes each, the improvement came after the 3rd session. The treatment is ongoing.

Example 9

Patient L., 67 years old.

She complained of pulling back pain. Diagnosis: generalized osteoporosis, especially the spine. 15 applications were performed daily, lasting 40 minutes. Relief was noted after 2 sessions. The treatment is ongoing.

Claims (2)

1. A method for the treatment of diseases caused by a pathological change in cartilage and / or bone tissue by course application of a hydrolyzed collagen and cosmetic clay to a painful area, in which a solution of hydrolyzed collagen CollAmin-80 or Epidermate-O in water is rubbed into the painful area, followed by applying to the indicated area cosmetic clay diluted in water, covering with plastic wrap or compressor paper and warming for 30-40 minutes. 2. The method according to claim 1, where the application effect is carried out 1 time per day daily in courses of 30-60 days 3-6 times a year.