RU2322238C2 - Лечение ревматоидного артрита - Google Patents
Лечение ревматоидного артрита Download PDFInfo
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- RU2322238C2 RU2322238C2 RU2004126447/15A RU2004126447A RU2322238C2 RU 2322238 C2 RU2322238 C2 RU 2322238C2 RU 2004126447/15 A RU2004126447/15 A RU 2004126447/15A RU 2004126447 A RU2004126447 A RU 2004126447A RU 2322238 C2 RU2322238 C2 RU 2322238C2
- Authority
- RU
- Russia
- Prior art keywords
- treatment
- salt
- formula
- pharmaceutically acceptable
- benzamide
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- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 description 1
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- JDOZJEUDSLGTLU-VWUMJDOOSA-N prednisolone phosphate Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COP(O)(O)=O)[C@@H]4[C@@H]3CCC2=C1 JDOZJEUDSLGTLU-VWUMJDOOSA-N 0.000 description 1
- 229960002943 prednisolone sodium phosphate Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 208000005069 pulmonary fibrosis Diseases 0.000 description 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960000371 rofecoxib Drugs 0.000 description 1
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000000192 social effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- AGHLUVOCTHWMJV-UHFFFAOYSA-J sodium;gold(3+);2-sulfanylbutanedioate Chemical compound [Na+].[Au+3].[O-]C(=O)CC(S)C([O-])=O.[O-]C(=O)CC(S)C([O-])=O AGHLUVOCTHWMJV-UHFFFAOYSA-J 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 201000004595 synovitis Diseases 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960002871 tenoxicam Drugs 0.000 description 1
- WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- 229950006782 triamcinolone benetonide Drugs 0.000 description 1
- GUYPYYARYIIWJZ-CYEPYHPTSA-N triamcinolone benetonide Chemical compound O=C([C@]12[C@H](OC(C)(C)O1)C[C@@H]1[C@@]2(C[C@H](O)[C@]2(F)[C@@]3(C)C=CC(=O)C=C3CC[C@H]21)C)COC(=O)C(C)CNC(=O)C1=CC=CC=C1 GUYPYYARYIIWJZ-CYEPYHPTSA-N 0.000 description 1
- 229960004221 triamcinolone hexacetonide Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 229960002004 valdecoxib Drugs 0.000 description 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0201882.8 | 2002-01-28 | ||
| GBGB0201882.8A GB0201882D0 (en) | 2002-01-28 | 2002-01-28 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004126447A RU2004126447A (ru) | 2005-07-10 |
| RU2322238C2 true RU2322238C2 (ru) | 2008-04-20 |
Family
ID=9929858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004126447/15A RU2322238C2 (ru) | 2002-01-28 | 2003-01-27 | Лечение ревматоидного артрита |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20060264443A1 (enExample) |
| EP (1) | EP1471916B1 (enExample) |
| JP (1) | JP4398731B2 (enExample) |
| KR (1) | KR101030416B1 (enExample) |
| CN (1) | CN1646130A (enExample) |
| AT (1) | ATE399555T1 (enExample) |
| BR (1) | BR0307286A (enExample) |
| CA (1) | CA2473158C (enExample) |
| DE (1) | DE60321888D1 (enExample) |
| DK (1) | DK1471916T3 (enExample) |
| ES (1) | ES2309299T3 (enExample) |
| GB (1) | GB0201882D0 (enExample) |
| IL (1) | IL162983A (enExample) |
| MX (1) | MXPA04007309A (enExample) |
| NO (1) | NO328255B1 (enExample) |
| NZ (1) | NZ534137A (enExample) |
| PL (1) | PL212137B1 (enExample) |
| PT (1) | PT1471916E (enExample) |
| RU (1) | RU2322238C2 (enExample) |
| SI (1) | SI1471916T1 (enExample) |
| WO (1) | WO2003063844A2 (enExample) |
| ZA (1) | ZA200405323B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2580656C1 (ru) * | 2014-11-20 | 2016-04-10 | Закрытое Акционерное Общество "БИОКОМ" | Твердая лекарственная форма гидроксихлорохина немедленного высвобождения и способ ее получения |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003226209B2 (en) * | 2002-03-21 | 2008-10-23 | Dana-Farber Cancer Institute, Inc. | Inhibition of cell death responses induced by oxidative stress |
| US20050130986A1 (en) * | 2003-11-21 | 2005-06-16 | Eklund Kari K. | Treatment of spondylarthropathies |
| US20080248022A1 (en) * | 2004-09-08 | 2008-10-09 | Immunaid Pty Ltd | Therapeutic Strategy for Treating Autoimmune and Degenerative Diseases |
| US20080032989A1 (en) * | 2006-05-31 | 2008-02-07 | Robinson William H | Method of treating inflammatory diseases using tyroskine kinase inhibitors |
| CN102512421B (zh) * | 2011-10-28 | 2013-11-06 | 中国科学院广州生物医药与健康研究院 | 哌嗪酰胺类化合物在制药中的应用 |
| KR101386697B1 (ko) | 2012-06-18 | 2014-04-18 | 아주대학교산학협력단 | 이매티닙 또는 이의 약학적으로 허용되는 염을 유효성분으로 포함하는 혈관 투과성 관련 질환의 치료 또는 예방용 조성물 |
| US12173065B2 (en) * | 2018-10-18 | 2024-12-24 | Sinomab Bioscience Limited | Fusion proteins comprising extracellular domain of human CD22 |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000073279A1 (en) * | 1999-05-31 | 2000-12-07 | F. Hoffmann-La Roche Ag | 4-phenyl-pyrimidine derivatives |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4316884A (en) * | 1979-01-25 | 1982-02-23 | Adria Laboratories, Inc. | Sustained release pharmaceutical formulation |
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| US5792476A (en) * | 1996-12-19 | 1998-08-11 | Abigo Medical Ab | Sustained release glucocorticoid pharmaceutical composition |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| CO5200760A1 (es) * | 1999-06-16 | 2002-09-27 | Smithkline Beecham Corp | Antagonistas del receptor de la il-8 ceptor il-8 |
| GB0108606D0 (en) * | 2001-04-05 | 2001-05-23 | Novartis Ag | Organic compounds |
| WO2002083075A2 (en) * | 2001-04-16 | 2002-10-24 | Uab Research Foundation | Akt and regulation of ra synovial fibroblast apoptosis |
| PT1392313E (pt) * | 2001-05-16 | 2007-07-17 | Novartis Ag | Combinação que compreende n - ( 5- [ 4- ( metil-piperazinomrtil ) - benxoilamido ] - 2 -metilfenil ) - 4 -( 3 - piridil ) - 2 - pirimidina-amina e um agente quimioterapêutico |
| EP1401415B1 (en) * | 2001-06-29 | 2006-06-21 | AB Science | Use of n-phenyl-2-pyrimidine-amine derivatives for treating inflammatory diseases |
-
2002
- 2002-01-28 GB GBGB0201882.8A patent/GB0201882D0/en not_active Ceased
-
2003
- 2003-01-27 MX MXPA04007309A patent/MXPA04007309A/es active IP Right Grant
- 2003-01-27 NZ NZ534137A patent/NZ534137A/en not_active IP Right Cessation
- 2003-01-27 JP JP2003563538A patent/JP4398731B2/ja not_active Expired - Fee Related
- 2003-01-27 US US10/502,534 patent/US20060264443A1/en not_active Abandoned
- 2003-01-27 DE DE60321888T patent/DE60321888D1/de not_active Expired - Lifetime
- 2003-01-27 EP EP03704474A patent/EP1471916B1/en not_active Expired - Lifetime
- 2003-01-27 RU RU2004126447/15A patent/RU2322238C2/ru not_active IP Right Cessation
- 2003-01-27 DK DK03704474T patent/DK1471916T3/da active
- 2003-01-27 WO PCT/EP2003/000802 patent/WO2003063844A2/en not_active Ceased
- 2003-01-27 SI SI200331369T patent/SI1471916T1/sl unknown
- 2003-01-27 ES ES03704474T patent/ES2309299T3/es not_active Expired - Lifetime
- 2003-01-27 CN CNA038028808A patent/CN1646130A/zh active Pending
- 2003-01-27 BR BR0307286-0A patent/BR0307286A/pt not_active IP Right Cessation
- 2003-01-27 CA CA2473158A patent/CA2473158C/en not_active Expired - Fee Related
- 2003-01-27 KR KR1020047011580A patent/KR101030416B1/ko not_active Expired - Fee Related
- 2003-01-27 PL PL370264A patent/PL212137B1/pl unknown
- 2003-01-27 PT PT03704474T patent/PT1471916E/pt unknown
- 2003-01-27 AT AT03704474T patent/ATE399555T1/de active
-
2004
- 2004-07-05 ZA ZA2004/05323A patent/ZA200405323B/en unknown
- 2004-07-12 IL IL162983A patent/IL162983A/en not_active IP Right Cessation
- 2004-08-27 NO NO20043585A patent/NO328255B1/no not_active IP Right Cessation
-
2008
- 2008-12-04 US US12/328,013 patent/US20090131382A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000073279A1 (en) * | 1999-05-31 | 2000-12-07 | F. Hoffmann-La Roche Ag | 4-phenyl-pyrimidine derivatives |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2580656C1 (ru) * | 2014-11-20 | 2016-04-10 | Закрытое Акционерное Общество "БИОКОМ" | Твердая лекарственная форма гидроксихлорохина немедленного высвобождения и способ ее получения |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1646130A (zh) | 2005-07-27 |
| EP1471916A2 (en) | 2004-11-03 |
| RU2004126447A (ru) | 2005-07-10 |
| US20090131382A1 (en) | 2009-05-21 |
| PT1471916E (pt) | 2008-10-03 |
| KR20040086301A (ko) | 2004-10-08 |
| GB0201882D0 (en) | 2002-03-13 |
| ES2309299T3 (es) | 2008-12-16 |
| PL370264A1 (en) | 2005-05-16 |
| ZA200405323B (en) | 2005-08-31 |
| BR0307286A (pt) | 2004-12-28 |
| HK1072192A1 (en) | 2005-08-19 |
| ATE399555T1 (de) | 2008-07-15 |
| KR101030416B1 (ko) | 2011-04-20 |
| IL162983A (en) | 2010-06-16 |
| DE60321888D1 (enExample) | 2008-08-14 |
| PL212137B1 (pl) | 2012-08-31 |
| SI1471916T1 (sl) | 2008-12-31 |
| JP2005526022A (ja) | 2005-09-02 |
| EP1471916B1 (en) | 2008-07-02 |
| US20060264443A1 (en) | 2006-11-23 |
| MXPA04007309A (es) | 2005-09-12 |
| WO2003063844A2 (en) | 2003-08-07 |
| WO2003063844A3 (en) | 2004-04-01 |
| NO328255B1 (no) | 2010-01-18 |
| DK1471916T3 (da) | 2008-10-20 |
| JP4398731B2 (ja) | 2010-01-13 |
| CA2473158C (en) | 2013-06-11 |
| NZ534137A (en) | 2007-03-30 |
| NO20043585L (no) | 2004-10-21 |
| CA2473158A1 (en) | 2003-08-07 |
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| JP2005531622A5 (enExample) |
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