RU2317822C2 - Means and method for carrying out chronobiological correction - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: means comprises two complexes. Morning complex comprises soft tonic and biostimulating vegetable ingredients and vegetable adaptogen complex. Evening complex comprises soft vegetable ingredients of tranquilizing and sedative action stimulating cellular resources recovery. Beside that, the evening and morning complex comprise vitamins, mineral substances, antioxidants and specific biologically active substances directed to correction of specific organ or system disorders arising as a result of chronic desynchronosis. Method involves applying chronobiological correction means selecting their application time to match individual biorhythm phase peaks.

EFFECT: improved tolerance to transmeridional flight loads.

7 cl

Description

The invention relates to medicine and can be used to correct desynchronism of functions of various organs and systems of the human body caused by professional and technogenic factors (air travel to a different time zone, night shift and shift work, living in the polar regions of the Arctic, chronic light conditions and sleep and wakefulness), as well as related health disorders.

One of the most important factors in the deterioration of the health of a modern person is chronic desynchronosis of various organs and systems of the body due to the mismatch of daily (circadian) biorhythms in connection with the influence of such inalienable factors of modern life as transmeridial flights, shift working methods and constant interference of factors of the urban environment leading to chronic sleep disturbance and wakefulness. Violation of the natural structure of biorhythms leads to disruption of the processes of restoration of organs and systems, their overstrain and premature depletion of biological resources, which is currently considered to be one of the most important pre-painful human conditions. With prolonged persistence of desynchronosis and the absence of measures for its prevention and correction, this pre-painful condition can go into chronic diseases, primarily of the nervous, cardiovascular, endocrine systems.

Currently, for the prevention and correction of desynchronosis, pharmacological and physiotherapeutic effects are used, mainly aimed at regulating the nervous and endocrine systems.

Known means and method of correcting desynchronosis of the human body caused by air travel to another time zone (F.A. Iordanskaya. Features of temporary adaptation during flights to the east and west. Means of correction and prevention of desynchronosis. Theory and practice of physical culture. - 2000. - No. 3 . -C.6-13). The essence of this approach is the use of various physiotherapeutic methods of a two-phase correction scheme, which, depending on the condition, includes either tonic or sedatives in combination with restorative drugs. With a fairly broad integrated approach, this method has a number of limitations that narrow the spectrum of its application. Firstly, the described means and method are intended solely for correcting short-term desynchronosis caused by transmeridial flights, and does not meet the characteristics of chronic desynchronosis due to professional or urban factors. Secondly, these funds are aimed only at correcting the general structure of circadian rhythms and do not take into account the characteristics of individual biorhythms of individual organs and systems. Thirdly, these funds are aimed at increasing the general biological resistance of the body and do not take into account painful disorders in the functioning of organs and systems of the body developing as a result of chronic desynchronosis.

The objective of the present invention is to develop a means of chronobiological correction of two-phase action based on plant materials, vitamins and minerals, taking into account the organotropic manifestation of desynchronosis and a method of chronobiological correction using a tool that takes into account the characteristics of individual biorhythms of organs and systems.

The task in relation to the means of chronobiological correction is solved by the fact that five variants of the means of chronobiological correction of two-phase action are proposed taking into account the five most common organotropic manifestations of desynchronosis: somatic, cardiovascular, neurological, hepatological, articular. All variants of the claimed means of chronobiological correction consist of two complexes. The morning complex includes plant components of a mild tonic and bio-stimulating effect and a complex of plant adaptogens, the evening complex includes plant components of a mild sedative and sedative effect and stimulate the restoration of cellular resources. In addition, the morning and evening complexes include vitamins, minerals, antioxidants and specific biologically active substances aimed at correcting specific organ or systemic disorders that develop as a result of chronic desynchronosis.

The chronobiological correction tool intended for the correction of chronic desynchronosis, according to the first option, is a morning and evening complex, while the morning complex includes spirulina - from 4 to 7%, eleutherococcus roots - from 7 to 10%, rhizomes and roots of the left-handed - from 7 to 10% rhizomes and angelica roots - from 7 to 10%, needles of Siberian fir - from 3 to 5%, nettle leaves - from 7 to 10%, raspberry leaves - from 6 to 8%, vitamin C - from 10 to 15%, Vitamin A - from 0.25 to 0.5%, Vitamin D3 - from 0.001 to 0.002%, Vitamin E - from 3 to 5%, Vitamin B1 - from 0.3 to 0.7%, Vitamin B2 - from 0, 5 to 1%, vitamin B6 - from 0.5 to 1%, vitamin B12 - from 0.0005 to 0.001%, vitamin PP (niacinamide) - from 5 to 7%, folic acid - from 0.05 to 0.1%, pantothenic acid - from 1 to 2%, biotin - from 5 to 7%; and the evening complex includes spirulina - from 5 to 7%, rhizomes and valerian roots - from 7 to 10%, motherwort grass - from 5 to 7%, peppermint leaf - from 4 to 6%, oregano grass - from 4 to 6% , burdock roots - from 4 to 7%, calendula flowers - from 7 to 10%, calcium - from 10 to 15%, potassium - from 8 to 10%, magnesium - from 8 to 10%, iron from 4 to 6%, iodine - from 0.03 to 0.1%, selenium - from 0.01 to 0.02%, zinc - from 2 to 4%, copper - from 0.2 to 0.5%, manganese - from 0.2 up to 0.5%.

The chronobiological correction tool intended for the correction of chronic desynchronosis, according to the second option, is a morning and evening complex, while the morning complex includes hawthorn fruit extract - from 20 to 25%, astragalus root extract - from 15 to 20%, green tea extract - from 5 to 7%, citrus bioflavonoids from 15 to 20%, raspberry leaf extract from 2 to 5%, blueberry leaf extract from 2 to 5%, grape seed extract from 0.2 to 0.5%, vitamin C - from 10 to 15%, vitamin A - 0.08 to 0.12%, vitamin E - from 6 to 10%, selenium - from 0.008 to 0.012%; and the evening complex includes hawthorn fruits - from 30 to 40%, calendula flowers from 7 to 10%, creeping grass - from 10 to 15%, clover grass - from 8 to 10%, hemophilus root - from 7 to 10%, grass zizifora from 10 to 15%, motherwort grass - from 6 to 8%, lemon balm leaves - from 5 to 7%.

The chronobiological correction tool intended for the correction of chronic desynchronosis, according to the third option, is a morning and evening complex, while the morning complex includes an extract of ginkgo leaves - from 12 to 16%, an extract of Asian thyme leaves - from 15 to 17%, an extract of astragalus roots - from 7 to 10%, citrus bioflavonoids - from 15 to 20%, bilberry leaf extract - from 2 to 5%, golden root - from 2 to 3%, eleutherococcus root - from 2 to 3%, rhizomes and roots of leuzea - from 2 up to 3%, aralia root - from 2 to 3%, vitamin C - from 10 to 15%, vit m A - 0.08 to 0.12%, Vitamin E - from 6 to 10%, selenium - from 0.008 to 0.012%; and the evening includes a penny root - from 6 to 8%, St. John's wort grass - from 10 to 12%, angelica root - from 8 to 10%, hawthorn fruits from 25 to 30%, eyebright herb from 20 to 25%, marigold flowers - from 7 to 10%, chaga - from 7 to 10%.

The chronobiological correction tool intended for the correction of chronic desynchronosis, according to the fourth option, is a morning and evening complex, while the morning complex includes extract of hodgepodge - from 15 to 20%, extract of rastoroshi fruits - from 15 to 20%, extract of St. John's wort - from 6 to 8%, volcano saussure extract - from 1 to 2%, citrus bioflavonoids - from 15 to 20%, raspberry leaf extract - from 2 to 5%, vitamin C - from 10 to 15%, vitamin A - 0.08 to 0.12%, vitamin E - from 6 to 10%, selenium - from 0.008 to 0.012%; and the evening complex includes a grass of a repeshka - from 4 to 6%, thistle fruits - from 20 to 25%, immortelle flowers - from 20 to 25%, beet root - from 12 to 16%, corn stigmas - from 6 to 8%, leaves nettles - from 10 to 13%, dandelion root - from 8 to 10%.

The chronobiological correction tool intended for the correction of chronic desynchronosis, according to the fifth variant, is a morning and evening complex, while the morning complex includes citrus bioflavonoids - from 8 to 12%, raspberry leaf extract - from 1 to 2%, vitamin C - from 5 to 7%, vitamin A - 0.04 to 0.06%, vitamin E - from 3 to 5%, glucosamine sulfate - from 70 to 80%, manganese - from 0.1 to 0.2%, zinc - from 0, 3 to 0.5%, copper - from 0.04 to 0.06%, selenium - from 0.004 to 0.006%; and the evening complex includes flowers of meadowsweet - from 35 to 45%, horsetail grass - from 5 to 7%, licorice root - from 10 to 15%, saber grass - from 18 to 22%, blackcurrant leaves - from 2 to 5% , the root of the penny - from 3 to 5%, the root of the incense - from 4 to 6%, the leaves of birch - from 2 to 5%, the grass of the succession - from 2 to 5%.

The inventive options funds can be obtained as follows. Whole plant materials - grass, leaves, roots, flowers, fruits, needles are dried and chopped. The resulting powders are mixed until a homogeneous mixture with a particle size of not more than 0.5 mm To obtain extracts, the plant material is extracted in a conventional manner, the aqueous extracts are subjected to vacuum evaporation, followed by drying. Vitamins and trace elements are used in the form of dry powders. Vitamin E is used as an oil solution. All components of the tool are mixed in the stated proportions in the mixers. Powdered mixtures after their preparation are packaged in gelatin capsules weighing 0.35-0.65 g - morning complex and weighing 0.3-0.45 g - evening complex. Thus obtained variants of the means of chronobiological correction were produced under the name dietary supplement (BAA) "Health Rhythms".

The problem in relation to the claimed method of chronobiological correction is solved by the fact that the proposed method using chronobiological correction means, in which the time of receipt of the funds is selected in accordance with the selected peak phases of the individual biorhythms.

The method is as follows. The morning complex of chronobiological correction means in the form of 2 capsules weighing 0.35-0.65 g is taken in the morning with food, the evening complex in the amount of 1 capsule weighing 0.3-0.45 g is taken in the evening with food, and the time for morning reception T _y and the time of evening intake of T _in is determined by the formulas:

T _y = t _p +0.5 hour

T _in = (1 _p +12 hours) -0.5 hours,

where t _g is the average time of habitual arbitrary waking for at least three days outside the period of intensive work; the duration of taking the drug is from 1 to 12 months.

The proposed options for chronobiological correction provide the desired effect of chronobiological correction as follows. Firstly, all variants of the claimed funds consist of two complexes. The morning complex includes biologically active substances that have a mild tonic effect and stimulate energy metabolism in cells. These substances are contained in plant components such as extracts of green tea and raspberry leaves, the golden root, the rhizomes and roots of the leuzea, the roots of aralia, the roots of Eleutherococcus. The evening complex includes biologically active substances that have a calming effect and contribute to the processes of recovery and regeneration in cells. To do this, the composition of the product options includes such plant components as lemon balm leaves, valerian roots, oregano grass, motherwort grass, marigold flowers, frankincense leaves, grass seedlings. As a result of a two-phase effect based on the calculated peaks and acrophase of biorhythms, exogenous correction and stabilization of biological rhythms is achieved, the violation of the natural structure of which is the main cause of desynchronosis.

Secondly, all variants of the claimed funds contain a wide range of plant adaptogens, such as the roots of a penny root, the golden root, the rhizomes and roots of the levzea, the roots of aralia, the roots of eleutherococcus, the grass of zizifora, the grass of repes, the roots of angelica, which increase the non-specific resistance of cells to various damaging environmental factors, including desynchronosis of various nature.

Thirdly, each of the variants of the claimed funds includes specially selected plant and biologically active substances that have a specific therapeutic and prophylactic effect in relation to the main organ manifestations of desynchronosis.

For this, the composition of the chronobiological correction tool according to the first option, intended for the correction of chronic desynchronosis, mainly manifested by a decrease in the general biological resistance of the body and the development of general somatic diseases, includes such components as multivitamin and multimineral complexes, as well as spirulina, nettle leaves, raspberry leaves, fir needles , burdock roots as sources of natural vitamins and mineral compounds with corrective and normalizing effects and all kinds of exchange.

The composition of the chronobiological correction tool according to the second option, designed to correct chronic desynchronosis, mainly manifested by disorders of the cardiovascular system, includes the following components that have protective properties against the heart muscle and blood vessels, as well as normalizing lipid and cholesterol metabolism:

vitamin-mineral antioxidant complex (vitamin A, vitamin C, vitamin E, selenium, bioflavonoids), as well as raspberry leaf extract, astragalus root extract and hawthorn fruit extract as a means of cardiotonic, vasodilating and anticoagulation action; green tea extract, anchor grass and clover grass as a means of capillary-strengthening and anti-atherosclerotic action; motherwort herb as a hypotensive and sedative; grape seed extract as an antithrombotic agent.

The composition of the chronobiological correction tool according to the third option, designed to correct chronic desynchronosis, mainly manifested by disorders of the central nervous system, includes components that stimulate cerebral circulation, energy metabolism and antioxidant protection of the central nervous system: ginkgo leaf extract, thyristol leaf extract, root extract astragalus as a means of improving microcirculation in the cerebral vessels; vitamin-mineral antioxidant complex (vitamin A, vitamin C, vitamin E, selenium, bioflavonoids); grass euphorbia and hawthorn fruits as vasodilator and antithrombotic agents; St. John's wort herb as a mild sedative and antidepressant.

The composition of the chronobiological correction tool according to the fourth embodiment, intended for the correction of chronic desynchronosis, mainly manifested by disorders in the liver and biliary tract includes the following components: vitamin-mineral antioxidant complex (vitamin A, vitamin C, vitamin E, selenium, bioflavonoids); extracts of hodgepodge and milk thistle as hepatoprotective agents; Sossurei extract, immortelle flowers, corn stigmas, hair roots and dandelion roots as a choleretic and cholekinetic complex; St. John's wort herb extract, raspberry leaf extract and nettle leaves as anti-inflammatory drugs.

The composition of the chronobiological correction tool according to the fifth embodiment, designed to correct chronic desynchronosis, mainly manifested by disorders of the musculoskeletal system, includes the following components: glucosamine sulfate as a chondroprotector; grass meadowsweet and licorice as anti-inflammatory drugs; raspberry leaf extract, manganese, copper and a series of herbs as collagen synthesis stimulating agents; saber grass, birch leaves, horsetail and currant leaves as a means of normalizing water-salt metabolism; as well as a vitamin-mineral antioxidant complex (vitamin A, vitamin C, vitamin E, selenium, bioflavonoids).

The proposed options for chronobiological correction, used as an additional treatment for diseases accompanied by a violation of the biorhythms of organs and body systems, provide a more effective treatment of major diseases, which is confirmed by the following examples.

Example 1

The study was conducted on the basis of the medical institution "Sanatorium" Krasnoozersky "(Novosibirsk region). The clinical effectiveness of the proposed means of chronobiological correction was studied in workers working on a rotational basis at the circumpolar oil producing enterprises. A total of 40 people were observed, of which 22 people made up the main group (general rehabilitation methods + the claimed remedy according to the first option) and 18 people - a control group that received only traditional rehabilitation.

All observed had signs of chronic desynchronosis associated with prolonged exposure to the polar day and manifested by sleep disturbance, dyspeptic disorders, fatigue, emotional irritability, as well as signs of an immunodeficiency state. As an additional therapy in the main group, a chronobiological correction tool according to the first option was chosen, intended for the correction of chronic desynchronosis, mainly manifested by a decrease in the general biological resistance of the body and the development of general somatic diseases.

The study found that in individuals with somatic manifestations of chronic desynchronosis, the use of the claimed drug significantly enhanced the clinical effectiveness of standard rehabilitation methods. So, in persons who received the claimed remedy in addition to the main rehabilitation scheme, a faster restoration of the immune status was observed, which was manifested by an increase in resistance to colds and an improvement in the state of the respiratory organs compared with the control group. In addition, in the main group, by the end of the month-long rehabilitation course, there was an increase in general tone, a decrease in fatigue and irritability, and also restoration of sleep. In the control group, recovery was much slower.

Example 2

The study was conducted by employees of the Department of Human Ecology with a course of occupational diseases of the Novosibirsk State Medical Academy in the clinic of occupational pathology of the Novosibirsk Research Institute of Hygiene of the Ministry of Health of the Russian Federation. The clinical effectiveness of the proposed means of chronobiological correction was studied in workers with initial signs of vibrational disease. The object of the study was not chosen by chance, because at present, in the etiology of vibrational disease, great importance is attached to the factor of the desynchronous effect of technogenic factors on the body. And since the main organotropic manifestation of desynchronosis during the development of a vibrational disease is damage to the cardiovascular system, a chronobiological correction tool was chosen for the study, intended to correct chronic desynchronosis, which is mainly manifested by disorders of the cardiovascular system.

A total of 72 patients with vibrational disease were observed: 32 people made up the main group, whose patients, along with the traditional treatment complex, received the claimed drug according to the second option, 40 people - the control group, whose patients received only traditional therapy.

The study found that in patients with vibrational disease, the use of the claimed means of chronobiological correction significantly enhanced the clinical effectiveness of the standard treatment regimen, which was confirmed by objective clinical, laboratory and functional methods. So, after a course inpatient treatment in the main group of patients with vibrational disease, a significant positive clinical effect was noted - in the form of improved overall health, normalization of sleep, normalization and stabilization of blood pressure, reduction in the frequency and severity of cardialgia and headaches. In the patients of the main group, after the course of treatment according to the control ECG examinations, there is an improvement in the metabolic processes in the myocardium and a tendency toward normalization of the processes of repolarization. In addition, according to rheovasography of the hands and feet, a significant improvement in rheovasographic parameters was noted. In the control group of patients, significant changes in rheovasographic and ECG indices were not observed. In general, the obtained results confirm that drug cardiotropic therapy in combination with the claimed drug helps to correct the cardiotropic manifestations of desynchronosis due to vibration, which is manifested by the restoration of systemic microcirculation and improvement of the general somatic state in patients with vibrational disease.

Example 3

The study was conducted on the basis of the medical institution "Sanatorium" Krasnoozersky "(Novosibirsk region). The clinical effectiveness of the proposed means of chronobiological correction was studied in workers working on a rotational basis at the circumpolar oil producing enterprises, with signs of disadaptive liver damage in conditions of chronic desynchronosis. A total of 28 people were observed, of which 16 people made up the main group (general treatment methods + the claimed drug according to the fourth option) and 12 people - a control group that received only traditional therapy. Disadaptation disorders of the functional state of the liver were manifested by signs of biliary dyskinesia and a change in the biochemical parameters of the liver, namely a moderate increase in the levels of total bilirubin, alanine aminotransferase and aspartate aminotransferase. As an additional therapy in the main group, a means of chronobiological correction was chosen, intended for the correction of chronic desynchronosis, mainly manifested by disorders in the liver and biliary tract.

As a result of treatment, positive dynamics were noted in both groups. All observed noted the disappearance of pain, nausea, belching, restoration of regular bowel movement. The inclusion of the claimed drug in therapy made it possible to achieve an improvement in 94.4% of cases, which is 19.4% higher than the same indicator in the control group. In the main group, indicators reflecting bilirubin metabolism improved more significantly and transaminase activity decreased.

The main group showed more significant changes in the characteristics of bile (according to duodenal sounding): a decrease in the number of cholesterol crystals and the absence of C-reactive protein in bile in 16 patients (53.3%). Similar changes in the control group were detected only in 10 patients (33.3%).

Indicators Main group Control group before treatment after treatment before treatment after treatment Common bilirubin 19.1 ± 1.5 13.0 ± 1.2 15.9 ± 1.3 13.4 ± 1.4 Direct bilirubin 4.2 ± 1.0 2.1 ± 1.0 3.6 ± 1.2 2.3 ± 1.3 Indirect bilirubin 14.9 ± 2.1 12.9 ± 1.3 13.6 ± 1.6 13.3 ± 1.1 ALT 0.62 ± 0.16 0.25 ± 0.10 0.61 ± 0.16 0.43 ± 0.1 ACT 0.41 ± 0.1 0.27 ± 0.09 0.35 ± 0.1 0.32 ± 0.1

In general, the obtained results confirm that drug therapy in combination with the claimed drug helps to correct the hepatotropic manifestations of desynchronosis and disadaptation disorders of the functional state of the liver.

Example 4

The study was conducted at the clinical base of the State Health Institution TsGSEN No. 25 (Novosibirsk). The clinical effectiveness of the proposed means of chronobiological correction was studied in university students during the winter session. A total of 22 people were observed, of which 12 people made up the main group (general rehabilitation methods + the claimed remedy according to the third option) and 10 people - a control group that received only traditional rehabilitation. All those observed before the recovery course had signs of functional discirculatory encephalopathy associated with session desynchronosis: headache, dizziness, noise in the head, distraction, memory impairment, poor general health and mood, emotional lability. According to a radioisotope study, there was a decrease in total cerebral blood flow and a mosaic of blood supply to various areas of the brain. As an additional therapy in the main group, a means of chronobiological correction was chosen, intended for the correction of chronic desynchronosis, mainly manifested by disorders of the central nervous system.

As a result of rehabilitation measures, positive dynamics was noted in both groups. However, the inclusion in the rehabilitation complex of the claimed means allowed to achieve a more complete and faster recovery of the central nervous system. In addition, according to a repeated radioisotope study, there was an increase in total cerebral blood flow by 2.4% and a decrease in the mosaic blood supply to various areas of the brain by 15.3% (in the control group - 1.2 and 10.1%, respectively). In general, the obtained results confirm that rehabilitation measures in combination with the claimed means of chronobiological correction contribute to a more rapid correction of signs of functional encephalopathy due to sessional desynchronosis.

Example 5

The study was conducted on the clinical base of the Children's and Youth Sports School No. 2 (Novosibirsk). The clinical effectiveness of the proposed means of chronobiological correction was studied in athletes, football players, whose professional activity is associated with frequent transmeridial flights. A total of 36 people were observed, of which 20 people made up the main group (general rehabilitation methods + the claimed remedy according to the fifth option) and 16 people - a control group that received only traditional rehabilitation. All observed before the recovery course had signs of functional damage to the knee joints, manifested by some restriction of mobility, moderate pain and swelling. As an additional therapy in the main group, a means of chronobiological correction was chosen, intended for the correction of chronic desynchronosis, mainly manifested by disorders of the musculoskeletal system.

The use of the claimed means in combination with traditional methods of rehabilitation not only significantly improved the tolerance of transmeridial flights, but also had a pronounced therapeutic and prophylactic effect in relation to exacerbation of the articular syndrome caused by sports injuries against the background of constant desynchronosis associated with frequent flights of athletes. At the same time, in the control group, the traditional rehabilitation methods did not have a significant protective effect on the musculoskeletal system, despite the improvement in the overall health of the athletes.

In general, the results obtained indicate that rehabilitation measures in combination with the claimed means of chronobiological correction contribute to the prevention of exacerbations of the articular syndrome provoked by chronic desynchronosis.

Claims (6)

1. A means of chronobiological correction, which consists of morning and evening complexes, while the morning complex includes spirulina, eleutherococcus roots, rhizomes and roots of leuzea, rhizomes and angelica roots, Siberian fir needles, nettle leaves, raspberry leaves, vitamin C, vitamin A, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B 12, vitamin PP (niacinamide), folic acid, pantothenic acid, biotin, and the evening complex includes spirulina, rhizomes and roots of valerian, motherwort grass, peppermint leaf, oregano grass burdock roots, calendula flowers, calcium, potassium, magnesium, iron, iodine, selenium, zinc, copper, manganese in the following ratio, wt.%: morning complex: spirulina - from 4 to 7%, eleutherococcus roots - from 7 to 10%, rhizomes and roots of leuzea - from 7 to 10%, rhizomes and angelica roots - from 7 to 10%, Siberian fir needles - from 3 to 5 %, nettle leaves - from 7 to 10%, raspberry leaves - from 6 to 8%, vitamin C - from 10 to 15%, vitamin A - from 0.25 to 0.5%, vitamin D3 - from 0.001 to 0.002% Vitamin E - from 3 to 5%, Vitamin B1 - from 0.3 to 0.7%, Vitamin B2 - from 0.5 to 1%, Vitamin B6 - from 0.5 to 1%, Vitamin B12 - from 0 , 0005 to 0.001%, vitamin PP (niacinamide) - from 5 to 7%, folic acid - from 0.05 to 0.1%, pantothenic acid - from 1 to 2%, biotin - from 5 to 7%; evening complex: spirulina - from 5 to 7%, rhizomes and valerian roots - from 7 to 10%, motherwort grass - from 5 to 7%, peppermint leaf - from 4 to 6%, oregano grass - from 4 to 6%, burdock roots - from 4 to 7%, calendula flowers - from 7 to 10%, calcium - from 10 to 15%, potassium - from 8 to 10%, magnesium - from 8 to 10%, iron from 4 to 6%, iodine - from 0.03 to 0.1%, selenium - from 0.01 to 0.02%, zinc - from 2 to 4%, copper - from 0.2 to 0.5%, manganese - from 0.2 to 0.5%. 2. A means of chronobiological correction, which consists of morning and evening complexes, while the morning complex includes hawthorn fruit extract, astragalus root extract, green tea extract, citrus bioflavonoids, raspberry leaf extract, blueberry leaf extract, grape seed extract, vitamin C, vitamin A , vitamin E, selenium, and the evening complex includes hawthorn fruits, calendula flowers, creeping grass, clover grass, bloodthirst root, zizifora grass, motherwort grass, lemon balm leaves as follows m ratio of components, wt.%: morning complex: hawthorn fruit extract - from 20 to 25%, astragalus root extract - from 15 to 20%, green tea extract - from 5 to 7%, citrus bioflavonoids - from 15 to 20%, raspberry leaf extract - from 2 to 5 %, blueberry leaf extract - from 2 to 5%, grape seed extract - from 0.2 to 0.5%, vitamin C - from 10 to 15%, vitamin A - 0.08 to 0.12%, vitamin E - from 6 to 10%, selenium - from 0.008 to 0.012%; evening complex: hawthorn fruits - from 30 to 40%, calendula flowers from 7 to 10%, creeping grass - from 10 to 15%, clover grass - from 8 to 10%, hemoptysis root - from 7 to 10%, ziziphora grass from 10 to 15%, motherwort grass - from 6 to 8%, lemon balm leaves - from 5 to 7%. 3. A means of chronobiological correction, which is the morning and evening complexes, while the morning complex includes an extract of ginkgo leaves, an extract of Asiatic seaworm leaves, an extract of astragalus roots, citrus bioflavonoids, blueberry leaf extract, golden root, eleutherococcus root, rhizome and root of the levzea root Aralia, Vitamin C, Vitamin A, Vitamin E, Selenium, and the evening complex includes Lycaena root, St. John's wort, Angelica root, Hawthorn fruits, Eyebright herb, Marigold flowers, Chaga p In the following ratio of components, wt.%: morning complex: extract of ginkgo leaves - from 12 to 16%, extract of leaves of Asiatic seaworm - from 15 to 17%, extract of astragalus roots - from 7 to 10%, citrus bioflavonoids - from 15 to 20%, blueberry leaf extract - from 2 to 5%, golden root - from 2 to 3%, eleutherococcus root - from 2 to 3%, rhizomes and roots of leuzea - from 2 to 3%, aralia root - from 2 to 3%, vitamin C - from 10 to 15%, Vitamin A - 0.08 to 0.12%, Vitamin E - from 6 to 10%, Selenium - from 0.008 to 0.012%; evening complex: penny root - from 6 to 8%, St. John's wort grass - from 10 to 12%, angelica root - from 8 to 10%, hawthorn fruits from 25 to 30%, euphrasia officinalis herb from 20 to 25%, marigold flowers - from 7 to 10%, chaga - from 7 to 10%. 4. A means of chronobiological correction representing morning and evening complexes, while the morning complex includes extract of hodgepodge, thistle fruit extract, St. John's wort herb extract, volcano saussure extract, citrus bioflavonoids, raspberry leaf extract; vitamin C, vitamin A, vitamin E, selenium; and the evening complex includes grass, thistle, thistle flowers, immortelle flowers, beet root, corn stigmas, nettle leaves, dandelion root in the following ratio, wt.%: morning complex: hillwort extract - from 15 to 20%, milk thistle fruit extract - from 15 to 20%, St. John's wort herb extract - from 6 to 8%, willow herb saussure extract - from 1 to 2%, citrus bioflavonoids - from 15 to 20 %, raspberry leaf extract - from 2 to 5%, vitamin C - from 10 to 15%, vitamin A - 0.08 to 0.12%, vitamin E - from 6 to 10%, selenium - from 0.008 to 0.012%; evening complex: grass, repeshka - from 4 to 6%, milk thistle - from 20 to 25%, immortelle flowers - from 20 to 25%, beet root - from 12 to 16%, corn stigmas - from 6 to 8%, nettle leaves - from 10 to 13%, dandelion root - from 8 to 10%. 5. A means of chronobiological correction, which is the morning and evening complexes, while the morning complex includes citrus bioflavonoids, raspberry leaf extract, vitamin C, vitamin A, vitamin E, glucosamine sulfate, manganese, zinc, copper, selenium; and the evening complex includes the flowers of meadowsweet, horsetail, licorice root, cinquefoil, blackcurrant leaves, penny root, frangipani, birch leaves, succession grass in the following ratio, wt.%: morning complex: citrus bioflavonoids - from 8 to 12%, raspberry leaf extract - from 1 to 2%; vitamin C - from 5 to 7%, vitamin A - 0.04 to 0.06%, vitamin E - from 3 to 5%, glucosamine sulfate - from 70 to 80%, manganese - from 0.1 to 0.2% , zinc - from 0.3 to 0.5%, copper - from 0.04 to 0.06%, selenium - from 0.004 to 0.006%; evening complex: flowers of meadowsweet - from 35 to 45%, horsetail grass - from 5 to 7%, licorice root - from 10 to 15%, saber grass - from 18 to 22%, blackcurrant leaves - from 2 to 5%, the root of the penny - from 3 to 5%, the root of the incense - from 4 to 6%, the leaves of birch - from 2 to 5%, the grass of the succession - from 2 to 5%. 6. A method of chronobiological correction, characterized in that the morning complex of chronobiological correction means in the form of 2 capsules weighing 0.35-0.65 g is taken in the morning with food, the evening complex in the amount of 1 capsule weighing 0.3-0.45 g is taken in the evening with food, and the time of the morning intake of Tu and the time of evening reception of Tv are determined by the formulas: T _y = t _p +0.5 h T _in = (1 _p +12 h) -0.5 h where t _p is the average time of the usual arbitrary waking up for at least three days outside the period of intensive work; the duration of taking the drug is from 1 to 12 months.