RU2188047C2 - Method for correcting human body desynchronosis due to air flight into another time zone - Google Patents

Abstract

FIELD: prophylactic medicine. SUBSTANCE: method deals with correcting desynchronosis as a result of broken daily human biorhythms due to rapid transportation (air flights) for two and more time zones both in the western and eastern directions. During the post-flight period a man is affected with an artificial light of not less than 300 lux for 40 min or natural daylight at duration of not less than 2 h in any combination with the following factors: physical, psychoemotional or alimentary ones. Impact is conducted every day for 4 h to reach the control time T_cw for western air flight or for 4 h after the onset of the control time T_ce for eastern air flight according to a time zone of destination point. Time of impact is determined by the formulas:

where t - the number of crossed time zones, t_n - usual time of getting up (awakening) in the morning in departure point, n - an ordinal number of the day after arrival to destination point; impact should be continued to achieve the matching of t_n in destination point with t_n in departure point at calculating the time according to corresponding time zones in destination and departure points. The method provides more physiological and less painful transition for the mode of new time zone at shortened terms. EFFECT: higher efficiency of correction. 1 tbl

Description

 The invention relates to the field of preventive medicine and can be used to correct desynchronoses caused by violations of human daily biorhythms and formed as a result of rapid movement (air travel) to 2 or more time zones in the western or eastern directions.

 The basis of desynchronosis is a violation of the circadian rhythms of the activity of various body systems, intersystem and intra-parameter desynchronization.

 The main signs of desynchronosis are: fatigue, insomnia, decreased physical performance, appetite, impaired intestinal excretory function, memory impairment, headache, loss of sexual interest, decreased muscle tone and neuromuscular coordination.

 The time required to normalize these functions without using methods and means of correcting desynchronosis is quite large and ranges from 1 to 3 weeks, depending on the number of crossed time zones and individual characteristics of the body. This is an obstacle to the normal work or proper rest of people going on a business trip for shift work. on vacation, etc. by plane.

 There is a method of correcting desynchronosis of the human body caused by air travel to another time zone, including a directed effect on sleep mode by a single use of sleeping pills during a flight (Moiseeva N.I. et al., 1975). The disadvantage of this method is that the use of sleeping pills violates the structure of sleep, reduces efficiency, does not allow you to quickly normalize other functional disorders of the body.

 There is also a method of correcting desynchronosis of the human body caused by air travel to another time zone, including directed daily exposure to sleep using a pharmacological agent - quiadone (Aschoff J. et al., 1975). The specified method has the same disadvantages.

 There is also known a method of correcting desynchronosis of the human body caused by air travel to another time zone, which includes a directed effect on sleep and wakefulness using physical factors: warm baths, soothing bedtime exercises and physical activity during wakeful hours (Stepanova S.I., 1977) . The disadvantage of this method is a sufficiently long period of restoration of physiological functions, which is due to the weak efficiency of the used correction factors due to their lack of specificity.

 Closest to the claimed is a method of correcting desynchronosis of the human body caused by air travel (CF Ehret. LW Scanlon. 1985), including exposure to physical (physical activity), psycho-emotional (mental activity) factors, nutritional factors (foods high in protein, methylxanthines) in in the first half of the day according to the time of the departure point in the pre-flight time, according to the time of the destination point in the flight and after-flight time.

 The disadvantage of this method is that they begin to carry out the correction in the pre-flight time, “shaking” the natural daily biorhythms of a person in advance, and then rigidly imposing on him the regime of the day at the time of the destination, starting from the day of the flight. In this case, the effect is carried out by factors that are not specific enough for the reconstruction of biorhythms. This delays the restructuring of the body for a new standard time up to 4-6 days, does not provide its sufficient effectiveness, because after this period, a reduced level of the functional reserves of the body, efficiency labor activity.

The task to which the invention is directed is to increase the efficiency of correction, which consists in ensuring a more physiological and less painful for a person to switch to a new time zone mode in a shorter time. The solution to this problem is achieved by the fact that in the post-flight time a person is exposed to artificial light for at least 3,000 lux for 40 minutes or natural daylight for at least 2 hours in any combination with other activating physical, psychoemotional and alimentary factors, while the effect is carried out daily for 4 hours before the reference time T _kOe when flying westward or within 4 hours after the onset of the control time T _q on the way to the east-hour destination, the exposure time is determined by the formulas
T _KZ = (t _p -t) + 24 + 2n
T _q = (t _p + t) -2n.

where t is the number of crossed time zones. t _n - the usual rise time (wake up in the morning) at the departure point, n - ordinal number of the day after arrival at the destination: the impact continues until the day of a match t _n at destination t _n at the point of departure in calculating the time of the relevant data points time zone.

Description of the invention
The method is as follows.

Starting from the first day after the flight to the destination, every day within 4 hours before the control time T _KZ during the flight to the West or within 4 hours after the control time T _square during the flight to the east in the time zone of the destination, the person is not exposed to artificial light less than 3000 lux for 40 minutes or natural daylight lasting at least 2 hours in any combination with the following factors:
- intake of drinks or food containing methylxanthines (for example, 2-3 cups of black coffee or strong tea or chocolate);
- intake of protein-rich foods (proteins, fats);
- active physical and / or mental stress;
- invigorating water procedures (cool showers) at a water temperature of 10-20 ^o C.

The exposure time is determined by the formulas
T _KZ = (t _p -t) + 24 + 2n
T _sq = (t _p + t) -2n,
where t is the number of crossed time zones, t _p is the usual time of ascent (wake up in the morning) at the departure point, n is the ordinal number of the day after arrival at the destination.

 As a source of artificial light can be used fixtures from SunBox Co., Inc. (for example, like SunSquare or SunRay, capable of providing illumination of 3000 lux.

The correction course is continued until the day when the usual rise time t _p at the destination coincides with t _p at the departure point when calculating the time according to the time zone corresponding to these points.

 Exposure to bright light is the leading specific factor that “triggers” the daily biorhythm, shifts the acrophase of the rhythm in the direction of local time.

 From the above formula for determining the exposure time, it follows that the exposure on each subsequent day is carried out with a shift of 2 hours, which provides a gradual adjustment of the acrophase of the circadian rhythm.

Along with the aforementioned activating effect, the following inhibitory effects on humans can also be applied:
- water procedures (warm shower or warm baths t ^o = 25-30 ^o C);
- mainly carbohydrate food;
- relaxation exercises, sleep.

This exposure was carried out for 4 hours after the onset of the control time T _kOe when flying westward or within 4 hours before the reference time T _q on the way to the east in the time zone of destination.

 The inhibitory effect does not significantly affect the achievement of the claimed technical result, but can somewhat mitigate the restructuring of the body.

The proof of the operability of the method
To test the method for correcting desynchronosis, special studies were conducted on volunteer subjects in the amount of 12 people. after the flight from Novosibirsk to Vladivostok (zone difference - 3 time zones). Observations were carried out within 14 days after the flight. The following physiological parameters were evaluated in the subjects: well-being, activity, mood - according to the SAN test, muscle strength of the hand according to the dynamometer, body temperature using an electrothermometer, palpation heart rate, respiration rate - visually. Measurement of physiological parameters was carried out once a day. The subjects were divided into 2 groups: 1st group - without correction (6 people), 2nd group using correction according to the claimed method (6 people).

In group 2, 4 subjects were exposed to 3000 lux artificial light using a Sunbox Co. lamp. Inc. type Sunsquare for 40 min. 2 subjects at a predetermined time determined by the above formula were exposed to natural daylight for 2 hours per day. Exposure to other factors was carried out in a different combination:
- 2-3 cups of coffee, intake of protein-rich foods;
- 2-3 cups of strong tea, intellectual load;
- a cool shower, physical and intellectual stress (including the latter could be associated with the performance of official duties on work), etc.

 During hours free of procedures for correcting desynchronosis, subjects were allowed to take carbohydrate foods, a warm shower or warm baths, and perform relaxation or sleeping exercises.

The differences between the pre-flight and post-flight values of the indicators in the 1st and 2nd groups were evaluated by the criterion of signs for 14 days. The correction results were considered successful if deviations in acrophase and amplitude of the measured physiological parameters did not go beyond the limits of diplet values. This was an objective confirmation of the coincidence of t _p at the destination and t _p at the departure point for the time zone corresponding to these points, after which the exposure was stopped. The test results are presented in the table.

 Based on the obtained data, it can be argued that the use of the correction method reliably accelerated the restructuring of physiological parameters, muscle performance and the emotional state of the subjects 2-3 times faster, and facilitated the rapid restoration of the body's functional reserves, as well as labor efficiency. As can be seen from the table, the achievement of the claimed correction effect was obtained already on the second day after the flight, in the following days the effect persisted. Significant differences in the effectiveness of the method for various combinations of light with other factors (coffee or tea, protein-rich foods, cool showers, physical or mental stress) were not detected. This confirms the role of light as a specific factor in achieving a technical result.

 It is known that in the absence of correction, natural resynchronization after a flight proceeds at a constant average speed of 92 min per day when moving west and 57 min per day when moving east, regardless of the number of time zones (Aschoff J. et. Al., 1975). On this basis, it can be argued that the claimed method, which allowed to obtain a technical result when flying to 3 time zones, will be effective when flying to any number of zones from 2 to 12.

Sources of information
1. Moiseeva N.I., Simonov M.Yu., Tonkova N.V., Shaposhnikova V.I. Self-regulation of sleep rhythm in a sudden change in the temporary environment. - In the book: Man and the environment. L .: Nauka, 1975, p.194-199.

 2. Aschoff J., Hoffman K., Pohl H., Wever R. Re-entraiment or circadian rhythms after phase-shifts of the zeitgeber. - chronobiologia, 1975, v. 2, N 1, p.23-78.

 3. Stepanova S.I. Actual problems of space biorhythmology. - In the book. : Problems of space biology. T. 32, M .: Nauka, 1977.

 4. Ch.F. Ehret, L.W. Scanlon Overcoming Jet Lag / Berkley Books, New York, 1985, p. 74-123.

Claims (1)

A method for correcting desynchronosis of a human body caused by air travel to a different time zone, including exposure to physical, psychoemotional and nutritional factors, characterized in that the person in the after-flight is exposed to artificial light for at least 3000 lux for 40 minutes or natural daylight for at least 2 h in any combination with other factors, the effect is carried out daily for 4 hours before the control time T _KZ during the flight to the west or within 4 hours after infusion of control time T _kv when flying eastward according to the time zone of the destination, the exposure time is determined by the formulas
T _KZ = (t _p -t) + 24 + 2n
T _sq = (t _p + t) -2n,
where t is the number of crossed time zones;
t _p - the usual time of ascent (awakening in the morning) at the point of departure;
n is the serial number of the day after arrival at the destination,
the impact continues until t _p at the destination coincides with t _p at the point of departure when calculating the time for the time zone corresponding to these points.

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