RU2281098C1 - Method for treatment of chronic tonsillitis decompensated form - Google Patents

Abstract

FIELD: medicine, otorhinolaryngology.

SUBSTANCE: method involves administration to a patient 1% solution of emoxipine in volume 5 ml in the treatment course 3-4 procedures in each other day by intralacunar route. Method provides the curative effect based on deeper penetration and rapid absorption of medicinal agent possessing with antioxidant effect by palatine tonsil surface of lacunas.

EFFECT: improved treatment method.

2 tbl, 1 ex

Description

The method relates to medicine, namely to otorhinolaryngology.

Known methods for washing the lacunae of the tonsils with antiseptic solutions in chronic tonsillitis (1).

The lacunae of the palatine tonsils were washed with solutions of various antiseptics (furacilin) using the distal end of the cannula of the syringe for washing the lacunae of the tonsils. In this case, the distal end was introduced into the lumen of the lacuna of the palatine tonsil and under pressure a 0.2% solution of furatsillin was fed into it, which ensured the mechanical removal of the contents of the lacuna of the palatine tonsil. The course of treatment ranged from 5 to 10 procedures 2-3 times a year.

The disadvantages of the analogue is the following.

1. Intralacunar administration of antiseptics, in contrast to the administration of antioxidants, does not suppress the peroxidation process in tissues.

2. Furacilin, being an antiseptic, does not, in contrast to an antioxidant, contribute to the improvement of metabolic processes in tissues, does not improve the functioning of enzyme systems and does not increase tissue immunity.

As a prototype, a method of washing the gaps of the tonsils with a solution of miramistin was taken (2). Miramistin solution was injected into the gaps of the tonsils using the distal end of the cannula of the syringe for washing the gaps of the tonsils.

The disadvantages of the prototype is the following.

1. The wide antimicrobial spectrum of action of miramistin does not help to reduce the destructive effect of free radicals and peroxide compounds.

2. When using miramistin, it is necessary to repeatedly wash the lacunae of the tonsils.

The aim of this invention is a deeper penetration and faster absorption by the surface of the lacunae of the palatine tonsils of a drug having an antioxidant effect (1% solution of emoxipin).

This goal is solved by the fact that a drug with an antioxidant effect (1% emoxipine solution) up to 5 ml is injected into the cavity of the lacuna of the palatine tonsil through the distal end of the cannula of the syringe to rinse the lacunae of the tonsils. The course of treatment consists of 3-4 procedures, washing is carried out with an interval of 1 day directly in the viewing room.

Concrete example

Under observation were 12 children aged 7 to 16 years with a decompensated form of chronic tonsillitis, previously who had repeatedly washed the lacunae of the tonsils with solutions of various antiseptics (miramistin, furatsillin).

Example. Patient S., 12 years old, was outpatient in the ENT department of the AODKB with a diagnosis of Chronic tonsillitis, decompensated form. Hypertrophy of palatine tonsils of the II degree. A child has a history of relapses of angina up to 2 times a year with a temperature reaction of up to 37.5-37.9 ° C, frequent colds and viral infections. Previously, the child was washed lacunae of the tonsils with 1% solution of ascorbic acid and miramistin every other day with courses up to 10 times. Against the background of the treatment, the sizes of the tonsils did not decrease, caseous masses remained in the gaps of the tonsils, the regional lymph nodes were enlarged to 1.5 cm in diameter.

The technique of intra-lacunar administration of a 1% solution of emoxipin was carried out every other day in the amount of 3-4 procedures directly in the viewing room. The system of crypts of the tonsils was washed through the gaps, which pursued the removal of all pathological contents of the tonsils and saturation of the cavities of the tonsils with a drug with antioxidant effect (1% solution of emoxipin).

At the same time, a study of blood biochemical parameters was carried out to assess the effectiveness of the treatment in comparison with patients who were flushed with lacunae of the tonsils with miramistin (Table 1).

The antioxidant solution introduced into the palatine tonsil cavity inhibited lipid peroxidation and increased the level of antioxidant protection, which is important in the treatment of pathology of pharyngeal lymphadenomas in children (Table 2).

The dynamics of lipid peroxidation after treatment (table 1).

Table 1. Indicators in nmol / l Indicators before treatment in nmol / l Miramistin Emoxipin Lipid hydroperoxides (normal - 28.5 ± 0.6) 29.83 ± 0.35 28.95 ± 0.31 28.59 ± 0.37 Diene conjugates (norm - 29.98 ± 0.61) 30.87 ± 0.53 30.42 ± 0.81 29.99 ± 0.59 Malondialdehyde (normal - 5.79 ± 0.12) 6.84 ± 0.30 6.20 ± 0.27 5.82 ± 0.29

The dynamics of antioxidant protection after treatment (table. 2).

Table 2. Indicators in mcg / ml Indicators before treatment in mcg / ml Miramistin Emoxipin Tocopherol acetate (normal - 22.05 ± 0.55) 20.74 ± 0.15 21.21 ± 0.11 22.03 ± 0.21 Ceruloplasmin (normal - 22.0 ± 0.37) 20.61 ± 0.19 21.12 ± 0.27 21.96 ± 0.15

Information sources

1. Palchun V.T., Polyakova T.S., Romanova O.N. Therapeutic and diagnostic approaches to the problem of chronic tonsillitis // Bulletin of otorhinolaryngology. - 2001. - No. 1. - p. 4-7.

2. Feigina V.M. Prevention and treatment of tonsillitis in children // Attending physician. - 2002. - 9. - p. 1-4.

Claims (1)

A method of treating a decompensated form of chronic tonsillitis, including intra-lacunar administration of a drug, characterized in that a 1% solution of emoxipin up to 5 ml is used as a drug, the course of treatment is 3-4 procedures with an interval of 1 day.