RU2252012C1 - Insecticidal gel-attractant - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: he present innovation deals with eliminating harmful insects and ticks due to preparing poisoned attractants. As an active substance the suggested insecticidal gel-attractant contains chloropyriphos and a food foundation, additionally, it contains didecyldimethylammonium bromide of efficient amount being fused with chloropyriphos. The desirable content of didecyldimethylammonium bromide and chloropyriphos for eliminating cockroaches corresponds to 0.01-0.45%. Moreover, food foundation contains water, food attractant, water-retaining additive, gel-forming agent, emulsifier and conserving agent, additionally - hydrotropic additive and aromatizing agent. At the content of didecyldimethylammonium bromide and chloropyriphos being 0.01-0.3% it is useful to apply them to eliminate certain kinds of ants and wasps. Moreover, food foundation contains sorbitol, food attractant, gel-forming agent, emulsifying agent, oxidizing agent and conserving agent and, additionally, hydrotropic additive and aromatizing agent. The innovation is toxicologically safe and economical.

EFFECT: higher efficiency of desired result.

5 cl, 3 ex, 2 tbl

Description

The invention relates to medical pest control, household chemicals and plant protection products, in particular to insecticidal preparations of contact and intestinal action, which can be used in the practice of medical pest control, agriculture, personal farms and household life for the destruction of harmful insects and ticks by preparing poisoned baits .

Known drugs of contact and intestinal action for the destruction of a wide range of harmful insects (bugs, bugs, herbivorous and blood-sucking ticks, flies, wood lice, etc.) containing QAC of the formula [RR ¹ R ² R ³ N] ⁺ X ^- (where RR ³ = alkyl, halogen-containing alkyl, alkenyl or halogen-containing alkenyl and X = halogen), which have chemosterilant activity [1]. Among the specific HOURs listed in this patent, iodides with an allyl, 2-chlorallyl, or 2-chlorobutenyl radical, which are the most active chemosterilants, predominate. Examples of their use are sugar syrup food baits supplemented with 1% allyltrimethylammonium iodide [CH ₂ = CHCH ₂ N (CH ₃ ) ₃ ] ⁺ I ^- or 0.5% 2-chloroallyl trimethyl ammonium iodide [CH ₂ = CClCH ₂ N (CH ₃ ) ₃ ] ⁺ I effective against the meat fly Cochliomya hominovorax. The disadvantages of such an HOUR are inaccessibility on an industrial scale, chemical instability in the compositions and high toxicity to warm-blooded animals.

Known means of contact action for the destruction of cockroaches and other household insects based on synergistic combinations of pyrethroid insecticides with lipophilic salts of benzalkonium and didecyldimethylammonium type [C ₁₂ H ₂₅ N (CH ₃ ) ₂ CH ₂ C ₆ H ₅ ] ⁺ X ^- and [(C ₁₀ H _2l ) ₂ N (CH ₃ ) ₂ ] ⁺ X ^- (where X is the remainder of stearic, stearylphosphoric, lauric or dodecylbenzenesulfonic acids) [3]. The experimental data given in this patent show that the claimed HOURs are equivalent as synergists to the corresponding chlorides. Their disadvantages are a weak synergistic effect (working emulsions tested on cockroaches contained 0.5% tetramethrin in combination with a huge amount of HOURS - 20%), the difficulty of production and the lack of industrial production.

Described insecticides for killing termites and soil-borne pests containing combinations of didecyldimethylammonium chloride, dioctyl dimethyl ammonium chloride or octyl decyl dimethyl ammonium chloride with organophosphate insecticides - phenithrothione or pyridafention [4]. These drugs are alcohol solutions with a very high content of active components (for example, 64% didecyldimethylammonium chloride, 5% phenitrothione and 31% methanol), which leads to their low profitability and high toxicity to warm-blooded animals.

Known means of contact action for the destruction of ticks of house dust, which contain the usual insectoacaricide (pyrethroid, organophosphorus or other) in combination with an antiseptic that can kill bacteria and molds that serve as food for these ticks [5]. A solution of 0.75% cygalotrin (pyrethroid insectoacaricide) and 8% benzalkonium chloride with the addition of isothiazolinones in diethylene glycol is given as an example. When applying this preparation (without dilution) on the filtering surfaces of the air conditioner, the death of the house dust mites living on them was 94.66% after 1 hour and 100% after 2 hours. The synergistic effect of HOUR is not mentioned in this patent. The disadvantages of the above funds is a narrow scope and a very high content of active components, which leads to its low efficiency and relatively high toxicity to humans and domestic animals. In addition, diethylene glycol has pronounced narcotic properties, which is why it is undesirable to use it as part of sawed preparations.

Thus, of the above-mentioned HOURs, only benzalkonium chloride and didecyldimethylammonium chloride are available, which have a less favorable price: effectiveness ratio than traditional insecticides. In addition, benzalkonium chloride always contains an admixture of benzyl chloride - a substance with a tear smell, which makes it impossible to use it in insecticidal food lures.

Known insecticidal gel preparations and methods for their preparation. (6, 7). These drugs are gels, including pyrethrodes - phenotropin, allethrin. The preparation of gels is based on the use of organic solvents such as ethanol, isopropyl alcohol, n-methylpyrrolidone.

The closest technical solution is an insecticidal bait containing an insect bait, an effective amount of insecticide, emulsion gel-forming additives and other additives. Chlorpyrifos, carbamates, pyrethroids can be used as an insecticide (RF patent application 96121385) (7). There is no industrial production of these lures.

The technical result of the present invention is the creation of an insecticidal gel-bait, which contains an industrially available HOUR in combination with conventional insecticides, increased efficiency in comparison with known similar drugs, superior to them in terms of cost and toxicological safety.

The technical result is achieved in that the insecticidal gel bait, including technical chlorpyrifos and a food base, according to the invention contains a food attractant as a food base and additionally contains didecyldimethylammonium bromide or didecyldimethylammonium clathrate with an effective amount of carbamide fused with chlorpyrifosome.

Preferably, the content of didecyldimethylammonium bromide and chlorpyrifos in an amount of 0.01-0.45% for the destruction of cockroaches.

Moreover, the insecticidal gel bait may additionally contain water, a water-retaining additive, a gelling agent, an emulsifier and a preservative.

To destroy house and garden ants and wasps, the content of didecyldimethylammonium bromide or didecyldimethylammonium clathrate with carbamide in an amount of 0.01-0.3%, chlorpyrifos in an amount of 0.01-0.3% is preferable.

Moreover, the gel bait may additionally contain sorbitol, a gelling agent, an emulsifier, an acidifier and a preservative.

The insecticidal gel bait may additionally contain a hydrotropic additive and flavor.

The didecyldimethylammonium bromide used in the gel [(C ₁₀ H ₂₁ ) ₂ N (CH ₃ ) ₂ ] ⁺ Br ^- (DDAB) (RF patent 2155186, 08/27/00) can be used as a free compound (chemically pure substance or technical product) or in form of clathrates with urea [8, 9]. DDAB and its clathrates are odorless, which allows it to be introduced into insecticidal food lures.

Due to the extremely high and diverse antimicrobial activity of DDAB, the products we offer destroy not only harmful insects and ticks, but also the pathogens that they carry, fungi and viruses. This eliminates the need for special additional treatments, which further increases the economic benefit from the use of the claimed drugs.

Until now, DDAB was mainly known as a component of disinfectants such as Veltolen (RF patent 2095086, 10/10/97), Velodez (RF patent 2189834,27.09.02), Veltolen-extra (RF patent 2158142, 10.27.00).

The toxicity of DCAB is at about the same level as that of didecyldimethylammonium chloride and benzalkonium chloride, all of these HOURs, and especially DCAB clathrates, are less toxic to warm-blooded than traditional insecticides.

EXAMPLE 1. Insecticidal gel bait for the destruction of cockroaches.

A method of obtaining the proposed gel for the destruction of cockroaches is carried out in several stages. In the first of these, an active synergistic complex is obtained by fusion of 0.055% chlorpyrifos with 0.075% DCAB at a temperature of 45 ° C. Then 0.87% emulsifier, 3.5% hydrotropic additives and 0.1% flavor are added to it.

Separately, 30% of a water-retaining additive, 30% of a food attractant and 0.5% of a preservative are dissolved in water. Mixtures of the active complex with an emulsifier, hydrotropic additive and flavor are gradually added to this solution. 0.5% gelling agent is added. The mixture is homogenized and the following composition is obtained.

Insecticidal gel bait for the destruction of cockroaches.

Technical MAB (counting at 80%) 0.075%

Technical chlorpyrifos (98%) 0.055%

Emulsifier 0.87%

Hydrotropic supplement 3.5%

Gelling agent 0.5%

Food Attractant 30%

Water-retaining additive 30%

Flavor 0.1%

Preservative 0.5%

Water up to 100%

Chlorpyrifos is an organophosphorus insecticide [2], which is most often used in bait gels against cockroaches and ants intended for use in medical disinfestation and everyday life. Usually its content in them is 0.5% ("Absolute-gel", "Anchar-gel", "Globol gel-paste", "Brownie-gel", "Zorro-gel", "Liquidator gel-paste", " Tornado-gel "," Fumitox-gel "," Elpas ", etc.). Due to the powerful synergistic effect of the BCAB, the proposed gel contains almost 10 times less chlorpyrifos, which makes it cheaper than the known gels and much safer than them. In addition, it is effective against cockroach populations resistant to chlorpyrifos. This advantage is also very important due to the widespread use of chlorpyrifos in the practice of medical pest control and household chemicals.

Technical chlorpyrifos is a solid with a melting point of 41.5-44 ° C, and technical DDAB is a viscous semi-liquid mass. Both of them dissolve slowly in all solvents. Fusion between them allows you to immediately get an active synergistic complex, the addition of an emulsifier and a hydrotropic additive (ethyl alcohol or acetone) ensures its uniform distribution in the gel volume with the formation of a stable microemulsion. The flavor is introduced to increase the nutritional attractiveness of the gel.

The food attractant used in the third stage of the process is necessary to mask the repellency of chlorpyrifos and DDAB. As it can be taken, for example, a mixture of dry dog food with sugar and beer grains. A moisture-retaining additive is introduced to slow the drying of the gel on the treated surfaces, since cockroaches prefer moist food. Such an additive may be glucose, sorbitol, maltitol and other polyhydric alcohols. A preservative (sodium benzoate or sorbic acid) is administered to prevent microbial damage to the gel.

At the final stages of the process, a gelling agent (neutralized carbopol or sodium carboxymethyl cellulose) is added and the finished formulation is homogenized.

Food attractant, water-retaining additive, gelling agent, emulsifier and preservative are mandatory components of the food base of the gel, while the hydrotropic additive and flavoring can be omitted.

The insecticidal effectiveness of the gel according to [11, method 3.4] corresponds to the normative indicator [12] - death of at least 70% after 48 hours (see table 1).

EXAMPLE 2. Insecticidal gel bait for the destruction of house and garden ants and wasps.

Technical DDAB (counting at 80%) 0.075%

Technical chlorpyrifos (98%) 0.055%

Emulsifier 0.87%

Hydrotropic supplement 3.5%

Gelling agent 0.5%

Food Attractant 40%

Flavor 0.1%

Acidifier 0.1%

Preservative 0.5%

Sorbitol up to 100%

The method of obtaining the proposed gel is carried out as in example 1. Instead of water, sorbitol (70% sorbitol syrup) is used, in which the food attractant, acidifier (buffer system with pH 4-5) and preservative are dissolved. These changes are dictated by the fact that ants and wasps love sour-sweet foods high in carbohydrates. The use of sorbitol as the main component of insecticidal food lures for ants is known. Food attractant, gelling agent, emulsifier, acidifier and preservative are mandatory components of the food base of the gel, while the hydrotropic additive and flavoring can be omitted.

The test results of the gel according to method 3.4 [11] are presented in table.2.

During field tests of the gel against black garden ants, their complete disappearance was observed the day after laying out on the paths of movement of insects.

Among the known commercial gels on chlorpyrifos listed in Example 5, Absolute-Gel, Brownie-Gel, Zorro-Gel, and Elpas were recommended for exterminating ants. All of them contain 0.5% chlorpyrifos, which is why it is more expensive than the gel we offer and more toxic for warm-blooded animals.

This gel can also be used to destroy wasps, since they are close to ants in biology and taste preferences.

Example 3. Insecticidal gel bait for the destruction of cockroaches.

Didecyldimethylammonium bromide clathrate

with urea 0.01%

Technical chlorpyrifos (98%) 0.45%

Emulsifier 0.6%

Hydrotropic supplement 2.5%

Gelling agent 0.35%

Food Attractant 35%

Moisture-retaining additive 45%

Flavor 0.15%

Preservative 0.45%

Water up to 100%

The method of obtaining the proposed gel is carried out as in example 1.

Example 4. Insecticidal gel bait for the destruction of house and garden ants and wasps.

Didecyldimethylammonium bromide clathrate

with carbamide 0.3%

Technical chlorpyrifos (98%) 0.01%

Emulsifier 0.8%

Hydrotropic supplement 3%

Gelling agent 0.55%

Food Attractant 30%

Flavor 0.1%

Acidifier 0.1%

Preservative 0.5%

Sorbitol up to 100%

The method of obtaining the proposed gel is carried out as in example 1.

Table 1. Table 1. The object of the test Insecticidal efficacy * (%) when controlled through 24 hours 48 hours 72 hours Laboratory culture of a red cockroach 50% bend + 50% steam 70% die + 10% n.a. + 20% steam 100% flexible ** Conditional abbreviations: par. - paralysis, n. - knockdown, n.n. - irreversible knockdown, perish. - death. The standard efficiency indicator for pyrethroid and organophosphorus contact insecticides is not less than 100% bend. after 24 hours [14].

Table 2. Test object Insecticidal efficacy * (%) when controlled through 1 day 2 days 3 days 4 days 7 days Laboratory culture of red house ants 30 gib. 55 gib. 70 gib. 81 bends 100 gib. * Conditional abbreviations are the same as in table. 1. The standard efficiency indicator [14] is the death of at least 70% after 7 days.

Literature

1. US patent 3397275, 13.08.68.

2. N.N. Melnikov, K.V. Novozhilov, S.R. Belan. Pesticides and plant growth regulators. Directory. - M., "Chemistry", 1995.

3. Japan patent 09-059109, 03/04/97.

4. Japanese Patent 61-57506, 03.24.86.

5. UK patent 2359023, 08/15/01.

6. RF patent 2077200, 04/20/1997.

7. Application for a patent of the Russian Federation 961211385, 01/27/2000.

8. Israeli patent 58586, 10.30.79.

9. Italian Patent 1,132,629.02.07.86.

11. Test methods for disinfectants to assess their safety and effectiveness. Approved Ministry of Health of the Russian Federation No. 01-12 / 75-97. - M., 1998, part 3.

12. Regulatory safety and efficacy indicators of disinfectants to be monitored during mandatory certification. Approved Ministry of Health of the Russian Federation No. 01-12 / 75-97.- M., 1998.

Claims (6)

1. Insecticidal gel bait, including technical chlorpyrifos and a food base, characterized in that it contains a food attractant as a food base and additionally contains didecyldimethylammonium bromide or didecyldimethylammonium clathrate with an effective amount of carbamide fused with chlorpyrifos. 2. The insecticidal gel bait according to claim 1, characterized in that it contains didecyldimethylammonium bromide or didecyldimethylammonium clathrate with carbamide in an amount of 0.01-0.45% and chlorpyrifos in an amount of 0.01-0.45% to destroy cockroaches. 3. The insecticidal gel bait according to claim 2, characterized in that it further comprises water, a water-retaining additive, a gelling agent, an emulsifier and a preservative. 4. The insecticidal gel bait according to claim 1, characterized in that it contains didecyldimethylammonium bromide or didecyldimethylammonium clathrate with carbamide in an amount of 0.01-0.3%, chlorpyrifos in an amount of 0.01-0.3% for the destruction of house and garden ants and wasps. 5. The insecticidal gel bait according to claim 4, characterized in that it further comprises sorbitol, a gelling agent, an emulsifier, an acidifier and a preservative. 6. Insecticidal gel bait according to claim 3 or 5, characterized in that it additionally contains a hydrotropic additive and flavor.