RU2251418C1 - Method for treating puerperal endometritis in cows - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: the suggested preparation for treating puerperal endometritis in cows contains licorice root and loseval as active substances and water as an additional substance at the following ratio of components, weight%: licorice root 59-60, loseval 29-30, water - the rest. Curative effect of the suggested preparation at treating acute puerperal and purulent endometritis in cows corresponds to 96% and 90%, correspondingly. The preparation is of antiseptic and antiphlogistic activity, as well.

EFFECT: higher efficiency of therapy.

Description

The invention relates to veterinary medicine, namely to drugs for the treatment of pathology of the reproductive organs of cows in the postpartum period.

In the pathology of cattle, one of the leading places is occupied by acute postpartum endometritis in cows, which upon transition to a chronic form of the course causes their symptomatic infertility, which causes large losses to farms.

A known drug for intrauterine use is the suppository “geomycin” (antibiotic) [1], manufactured abroad (Croatia), which requires the expenditure of foreign currency funds. Due to the significant spread of antibiotic-resistant strains of conditionally pathogenic microflora, there has been a decrease in the effectiveness of treatment of cows with endometritis using widely used antibiotics and preparations containing them.

Known drug for the treatment of postpartum endometritis in cows "Furopen" - furazolidone sticks used intrauterine. Their effectiveness is low, since the drug contains only furazolidone, which does not completely eliminate the microflora of the uterus of cows, as a result of which endometritis takes a chronic form [2, 3].

The release of domestic complex chemotherapeutic agents (or medicines) containing components of plant origin for the treatment of endometritis in cows is limited, especially for ready-made forms for intrauterine use - suppositories, sticks, etc., which creates certain difficulties in practice.

EFFECT: development of a domestic remedy in the form of a plant-based cyppository, increase in the activity of regenerative processes in pathological tissues of the uterus of cows, expanding the range of products.

The above is achieved by the fact that the proposed suppository, which as active substances (synergistic effect) contains licorice root and lozewal, as well as an auxiliary substance - water, with the following ratios of the starting components, wt.%:

Licorice Root (Radix Glycyrrizae) 59-60

Lozeval 29-30

Water rest

The active substance (licorice root) is crushed, the calculated amounts of licorice and lozewal and water are thoroughly mixed until homogeneous.

Suppositories are formed by known methods in such a way that the mass of one suppository is 9-10 g, and dried in the open air.

Each suppository contains, g:

Licorice Root 5.9-6.1

Lozewal 2.9-3.0

Water 1.0-1.1

In the proposed suppository, the active ingredients are selected so as to provide the maximum bactericidal and anti-inflammatory effect in the indicated ratio.

Licorice root contains a set of biologically active substances: glycyrrhizin, glucose, protein, tannins, emulsifying substances. Lozewal, a triazole heterocyclic compound containing morpholinium (3-methyl-1,2,4-triazole-5-thio) acetate, 1,2-ethylenebis (N-dimethyl-carbacyloxymethyl) - ammonium dichloride mixed with dimethyl sulfoxide, polyethylene glycol and water, is a yellowish liquid with a specific odor. Lozewal has antiviral, bactericidal properties with respect to gram-positive and gram-negative microflora, helps increase animal resistance by stimulating cellular and humoral immunity, increasing lysozyme level [4].

The use of funds in amounts greater than the above limits is not economically feasible, and in amounts less than those indicated, the effectiveness decreases.

The tool in the amount of 1 kg is prepared as follows. The powdered licorice root is sieved through a sieve with a mesh size of 0.25 mm, then, for example, 600 g of licorice root are weighed in a porcelain cup, 290 g of lozewal and 110 g of distilled water are added, mixed to a uniform uniform mass and 10 g suppositories are formed from the mass drying to constant weight.

The product according to its physical properties is an oval suppository 4-5 mm thick with a specific odor. Stability is maintained in a dark, cool place for 12 months.

The therapeutic efficacy of the proposed tool was tested in comparison with the basic tool known drug - furozolidone sticks.

The test was performed on cows with acute postpartum and purulent endometritis, after surgical separation of the delayed afterbirth.

After surgical separation of the placenta, 1 suppository 1 time per day was administered into the uterus for 4 days in the treatment of acute postpartum endometritis and 2 suppositories for purulent endometritis.

Furazolidone sticks were administered in 4-6 pieces.

It was found that in the treatment of cows (n = 16) with acute postpartum and purulent (n = 15) endometritis, the therapeutic effect is 96 and 90%, respectively, and in the control groups using the basic preparation, the efficacy was 42 and 45%, respectively.

The therapeutic efficacy of the proposed drug is significantly higher than in the control version. The proposed tool has a therapeutic effect, is harmless, has antiseptic and anti-inflammatory activity, does not cause microorganisms to get used to it. Achieving the expansion of the range of medicines.

SOURCES OF INFORMATION

1. Kiryutkin G.V., Timofeev B.A., Sozinov V.A. Directory of veterinary drugs. Kirov, 1987. P.364.

2. Polyantsev N.I., Sinyavin A.N. Obstetric and gynecological examination on dairy farms. M., Rosanpromizdat, 1989. S.134-154.

3. Bezborodin VV Bacterial contamination of the uterus of cows and its effect on reproductive function after childbirth. Abstract of Cand. diss. M., 1982, S.8-24.

4. Onishchuk F. D., Sazhnev V. N., Taymyasuhov A. A. Lozeval - a new therapeutic drug // Poultry, 1999, No. 1. S.27-28.

Claims (1)

An agent for treating postpartum endometritis in cows, containing active and auxiliary substances, characterized in that it contains licorice root, lozewal as active substances, water as an auxiliary substance, in the following ratios of components, wt.%: licorice root 59-60 Lozeval 29-30 water rest