RU2798337C1 - Agent for the treatment and prevention of postpartum endometritis and cervicitis in cows - Google Patents

Abstract

FIELD: veterinary medicine.

SUBSTANCE: invention relates to an agent for the treatment and prevention of postpartum endometritis and cervicitis in cows. The agent contains components in the following ratio, wt.%: red clover — 25–30; ortilia lopsided — 10–15; chamomile — 5–10; stinging nettle — 5–10; common yarrow — 5–10; Lugol's solution with glycerin — 15–20; coconut oil — 5–10; 40% water-alcohol solution — up to 100%.

EFFECT: above tool allows for the treatment and prevention of postpartum endometritis and cervicitis in cows with a therapeutic efficacy of 100%.

1 cl, 3 tbl, 1 ex

Description

The tool relates to veterinary medicine, in particular to veterinary obstetrics, and can be used for the treatment and prevention of postpartum endometritis and cervicitis in cows.

The agent has a high therapeutic efficacy, anti-inflammatory effect, suppresses bacterial, fungal and viral infections.

Treatment of diseases of the reproductive system is mainly carried out with the help of antimicrobial drugs. Pathogen resistance to antibiotics, their abuse and accumulation in animals affects the effectiveness of conventional drugs and causes problems in milk production. Therefore, treatment based on more natural ingredients is a good alternative and plays an important role in restoring the reproductive dysfunction of cows.

A known remedy for the treatment of postpartum endometritis in cows contains licorice root and lozeval as active substances, and water as an auxiliary substance, in the following ratios, wt. %: licorice root 59-60, lozeval - 29-30, water - the rest (Patent RU 2251418 C1, 2005).

The disadvantages of this method are long and expensive treatment, which does not give a 100% positive effect, in which the transition of an acute inflammatory process to a chronic form is possible.

Known means for the treatment and prevention of acute postpartum endometritis in agricultural animals, which contains active substances and a foaming base, including sodium bicarbonate, citric acid, sodium sulfate, calcium stearate, potato starch, as active substances ceftriaxone, carbacholin, yarrow extract in the form of a powder and aloe extract in the following ratio, wt. %: ceftriaxone - 1.0; carbacholin - 0.05; yarrow extract (powder) - 10.0; aloe extract - 8.0; sodium bicarbonate - 38.95; citric acid - 32.0; sodium sulfate - 2.0; calcium stearate - 2.0; potato starch - 16.0 (Patent RU 2672250 C1, 2018).

The disadvantages of this tool are side effects due to the presence of antibiotics, and therefore, restrictions on the use of animal products.

The prototype is a remedy that includes angelica root, nettle leaf, fresh sea buckthorn fruit, oregano herb, motherwort herb, coriander fruit, dandelion root aqueous extract, marshmallow root aqueous extract, licorice syrup, borneol, taken in a certain amount. The invention relates to medicine, namely to gynecology, and is a tool that is used for therapeutic and prophylactic purposes to suppress bacterial gynecological infections (Patent RU 2682643 C1, 2019).

The main disadvantage of this tool is the use of licorice syrup, which serves as a favorable environment for microorganisms.

The technical result is the development of an improved agent for the treatment and prevention of postpartum endometritis and cervicitis in cows, which has antimicrobial, antifungal and antiviral activity, which is phytotampons.

The technical result is achieved through the use of phytocomponents in the composition, due to which the internal genital organs are cleansed of pathogenic microflora, viruses, fungi and their metabolic products. The use of phytocomponents in the composition of the tampon makes it possible to avoid the rejection of dairy products.

The claimed agent for the treatment and prevention of postpartum endometritis and cervicitis in cows contains dry herbs of red clover, ortilia unilateral, chamomile, nettle, yarrow, as well as a solution of Lugol with glycerin, coconut oil, 40% aqueous-alcoholic solution in the following ratio of components , wt. %:

red clover - 25-30;

ortilia lopsided - 10-15;

chamomile - 5-10;

stinging nettle - 5-10;

common yarrow - 5-10;

Lugol's solution with glycerin - 15-20;

coconut oil - 5-10;

40% water-alcohol solution - up to 100%.

Optimally selected components of phytotampon provide suppression of bacterial, fungal and viral infections, have an anti-inflammatory effect. The method of obtaining is simple in the implementation of obtaining the final product.

Red clover promotes a special effect on the animal organism through the mechanism of the estrogen-like (hormone-modulating) action of isoflavones.

Ortilia one-sided effectively has an anti-inflammatory effect by inhibiting the processes of lipid peroxidation, caused by the action of a complex of biologically active substances.

The therapeutic effect of chamomile is due to the presence in it of a complex of substances, primarily essential oil, flavonoids, coumarins, as well as sesquiterpene lactone matrix, which, under the action of acids, alkalis, water vapor, turns into chamazulene - a substance of anti-inflammatory and anti-allergic action.

Stinging nettle has a very rich biological composition. It contains formic acid, tannins, vitamins A, C and K, so nettle is considered a multivitamin plant. It has vitaminizing, anti-inflammatory properties, increases the processes of regeneration of mucous membranes.

Yarrow does not have a sensitizing effect, it has an antimycobacterial and immunocorrective effect.

Lugol's solution with glycerin has an antiseptic and local irritating effect, as well as a bacterial effect against gram-negative and gram-positive flora, pathogenic fungi. Actively affects the metabolism, enhances the processes of dissimilation, participates in the synthesis of T3 and T4, has a proteolytic effect.

Coconut oil reduces inflammation, fights fungi, bacteria and viruses, strengthens the immune system, and has an antioxidant effect. Contains lauric, oleic, myristic, palmitic acids, as well as phytosterols, vitamins E and K, iron.

A 40% water-alcohol solution is an antimicrobial agent; when applied topically, it has an antiseptic effect (denatures the proteins of microorganisms). Antiseptic activity is manifested in relation to gram-positive and gram-negative bacteria and viruses. Alcohol is an excellent solvent and very effectively “sucks out” all useful components from the starting material.

The proposed remedy for the treatment and prevention of postpartum endometritis and cervicitis in cows fitotampon receive as follows. Pre-dry herbs (red clover, unilateral ortilia, chamomile, stinging nettle, common yarrow) are crushed to a powder form. Lugol's solution with glycerin, coconut oil and 40% water-alcohol solution are added to the resulting powder. The resulting product in the aggregate makes it possible to preserve the necessary biologically active substances in herbs, as well as to give the maximum amount of active substances when using it. After that, the wet mixture is formed under pressure into a tampon 1.5 × 5 cm, a thin layer of cotton wool is applied along the diameter and tightly covered with a sterile gauze shell with a density of 36 g/m ² (GOST 9412-93) in 3 layers until the dense external state of the formed tampon. The top of the gauze swab is fixed with a bandage 5 × 65 cm in size, so that the end of the bandage comes out for further extraction of the phytotampon. Subsequently, the swab is cooled to +10 C° and placed in a vacuum package. Phytotampons are used throughout the entire period of the inflammatory process in the cervical canal with their replacement every 8 hours. With preventive measures in the postpartum period, the tampon is administered for 8 hours every 2 days for 14 days. The product is stored at a temperature of +2 C° to +5C° for 1 month.

The resulting remedy for the treatment and prevention of postpartum endometritis and cervicitis in cows is a light green gauze swab with a pleasant herbal smell. Phytotampon is not toxic.

Before use, the phytotampon should have room temperature + 20-25 degrees.

Example 1

To select the optimal ratio of components in the product for the treatment and prevention of postpartum endometritis and cervicitis in cows, 8 groups of animals were formed according to the principle of pairs of analogues at the age of 2 to 4 years, red-and-white breed with postpartum endometritis and cervicitis, 5 animals each. Phytotampons were changed every 8 hours.

Prior to treatment, the general condition of the animals was depressed. An external examination of the animals showed light brown discharge from the genitals with an unpleasant odor. Vaginal examination revealed swelling and hyperemia of the mucous membrane of the vagina and cervix. On rectal palpation, pain and enlargement of the uterus were noted. In the leukocyte formula, inflammatory processes were noted, in the smear - staphylococci, streptococci, fungus, Escherichia coli were found.

Animals were treated with the formulations shown in Table 1.

In two experimental groups in animals, improvements occurred on the 5th day of treatment, discharge from the genital organs had a translucent grayish tint, the smell became less sharp, improvements in the mucous membrane of the vagina and cervix were observed, and uterine soreness was not observed. Clinical recovery occurred on the 7th day.

In five experimental groups, the well-being of animals improved on day 6, and complete clinical recovery occurred on day 8.

In one group, improvements were observed on day 7, complete recovery occurred on day 9.

Table 2 shows the indicators of the therapeutic efficacy of the treatment.

In all experimental groups, after the treatment, the general condition of the animals was within the physiological norm, the leukocyte formula returned to normal, only saprophytic microorganisms were found in the smear.

To confirm the effectiveness of the phytotampon, blood was taken from the animals before and after the treatment (Table 3).

According to biochemical blood tests, all groups of animals showed complete clinical recovery.

These studies have shown that the combination of compounds in certain ratios has 100% therapeutic efficacy.

Claims (2)

Means for the treatment and prevention of postpartum endometritis and cervicitis in cows, which is a phytotampon and contains dry herbs of red clover, ortilia unilateral, chamomile, nettle, yarrow, as well as Lugol's solution with glycerin, coconut oil, 40% water-alcohol solution with the following ratio of components, wt. %: red clover 25-30 ortilia lopsided 10-15 pharmaceutical camomile 5-10 stinging nettle 5-10 yarrow 5-10 Lugol's solution with glycerin 15-20 Coconut oil 5-10 40% water-alcohol solution up to 100%