RU2240995C2 - Аминобензофеноны в качестве ингибиторов интерлейкина il-1бета и фактора некроза опухолей tnf-альфа - Google Patents

Аминобензофеноны в качестве ингибиторов интерлейкина il-1бета и фактора некроза опухолей tnf-альфа Download PDF

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RU2240995C2
RU2240995C2 RU2002103876/04A RU2002103876A RU2240995C2 RU 2240995 C2 RU2240995 C2 RU 2240995C2 RU 2002103876/04 A RU2002103876/04 A RU 2002103876/04A RU 2002103876 A RU2002103876 A RU 2002103876A RU 2240995 C2 RU2240995 C2 RU 2240995C2
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group
compound
phenyl
alkyl
chloro
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RU2002103876/04A
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RU2002103876A (ru
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Эрик Рюттер ОТТОСЕН (DK)
Эрик Рюттер Оттосен
Хайнц Вильхельм ДАННАХЕР (DK)
Хайнц Вильхельм ДАННАХЕР
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Лео Фармасьютикал Продактс Лтд.А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб)
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    • C07C271/06—Esters of carbamic acids
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    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C271/38—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
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    • C07C2601/00—Systems containing only non-condensed rings
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    • C07C2601/14—The ring being saturated

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  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2002103876/04A 1999-07-16 2000-07-11 Аминобензофеноны в качестве ингибиторов интерлейкина il-1бета и фактора некроза опухолей tnf-альфа RU2240995C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14406399P 1999-07-16 1999-07-16
US60/144,063 1999-07-16

Publications (2)

Publication Number Publication Date
RU2002103876A RU2002103876A (ru) 2003-09-27
RU2240995C2 true RU2240995C2 (ru) 2004-11-27

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RU2002103876/04A RU2240995C2 (ru) 1999-07-16 2000-07-11 Аминобензофеноны в качестве ингибиторов интерлейкина il-1бета и фактора некроза опухолей tnf-альфа

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Country Link
EP (1) EP1202959B1 (enExample)
JP (1) JP2003505362A (enExample)
KR (1) KR20020022774A (enExample)
CN (1) CN1167667C (enExample)
AT (1) ATE277897T1 (enExample)
AU (1) AU768512B2 (enExample)
CA (1) CA2379286A1 (enExample)
DE (1) DE60014394T2 (enExample)
ES (1) ES2230118T3 (enExample)
HU (1) HUP0201911A3 (enExample)
NZ (1) NZ516825A (enExample)
PL (1) PL353646A1 (enExample)
PT (1) PT1202959E (enExample)
RU (1) RU2240995C2 (enExample)
WO (1) WO2001005749A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2270194C2 (ru) 2000-05-22 2006-02-20 Лео Фарма А/С Бензофеноны как ингибиторы il-1бета и tnf-альфа, фармацевтическая композиция и способ лечения
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
KR100896667B1 (ko) * 2001-08-28 2009-05-14 레오 파마 에이/에스 신규한 아미노벤조페논 및 이를 포함하는 약제학적 조성물
US20030225089A1 (en) * 2002-04-10 2003-12-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors
DE60310730T2 (de) 2002-07-09 2007-05-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege
AU2003262911A1 (en) 2002-08-29 2004-03-19 Scios Inc. Methods of promoting osteogenesis
PL377377A1 (pl) * 2002-12-20 2006-02-06 Leo Pharma A/S Nowe związki aminobenzofenonu
ZA200510137B (en) 2003-07-24 2007-04-25 Leo Pharma As Novel aminobenzophenone compounds
US7244441B2 (en) 2003-09-25 2007-07-17 Scios, Inc. Stents and intra-luminal prostheses containing map kinase inhibitors
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
JP5015005B2 (ja) 2004-12-13 2012-08-29 レオ ファーマ アクティーゼルスカブ トリアゾール置換アミノベンゾフェノン化合物
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
WO2010014276A1 (en) * 2008-07-31 2010-02-04 3M Innovative Properties Company Azide compositions and methods of making and using thereof
JP2011529977A (ja) 2008-07-31 2011-12-15 スリーエム イノベイティブ プロパティズ カンパニー フルオロポリマー組成物並びにその製造及び使用方法
EP2206534A1 (de) 2008-10-09 2010-07-14 c-a-i-r biosciences GmbH Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1535401A (en) * 1977-07-28 1978-12-13 Holliday & Co Ltd L Nitrodiphenylamine carboxylic acid disperse dyes
US4981970A (en) * 1986-11-21 1991-01-01 Ricoh Company, Ltd. Coloring phthalide compounds
WO1998032730A1 (en) * 1997-01-24 1998-07-30 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) Aminobenzophenones as inhibitors of interleukin and tnf

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1535401A (en) * 1977-07-28 1978-12-13 Holliday & Co Ltd L Nitrodiphenylamine carboxylic acid disperse dyes
US4981970A (en) * 1986-11-21 1991-01-01 Ricoh Company, Ltd. Coloring phthalide compounds
WO1998032730A1 (en) * 1997-01-24 1998-07-30 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) Aminobenzophenones as inhibitors of interleukin and tnf

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KR20020022774A (ko) 2002-03-27
ES2230118T3 (es) 2005-05-01
CN1167667C (zh) 2004-09-22
AU5806900A (en) 2001-02-05
WO2001005749A1 (en) 2001-01-25
DE60014394D1 (de) 2004-11-04
PT1202959E (pt) 2005-01-31
EP1202959B1 (en) 2004-09-29
HUP0201911A2 (en) 2002-10-28
DE60014394T2 (de) 2005-12-22
CN1371359A (zh) 2002-09-25
AU768512B2 (en) 2003-12-18
JP2003505362A (ja) 2003-02-12
HUP0201911A3 (en) 2002-11-28
HK1048303A1 (zh) 2003-03-28
EP1202959A1 (en) 2002-05-08
CA2379286A1 (en) 2001-01-25
NZ516825A (en) 2004-05-28
ATE277897T1 (de) 2004-10-15
PL353646A1 (en) 2003-12-01

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