RU2240819C2 - Method for vaccinoprophylaxis of pertussis, diphtheria and tetanus in the far north - Google Patents

Abstract

FIELD: medicine, pediatrics.

SUBSTANCE: the suggested vaccinoprophylaxis should be performed due to periodic injection of diphtheria, tetanus toxoids and pertussis vaccine by taking into account calendar's graph, but, moreover, the next vaccination should be carried out not less than 2 mo before leaving the areas of Far North and other climatic areas and not earlier than 3 mo after entering the regions of Far North being from other climatic areas. The method provides high titers of antidephtheritic, antitetanic antitoxins and antipertussic antibodies for 12 min in this group of vaccinated children.

EFFECT: higher efficiency.

6 ex

Description

The invention relates to medicine, namely to pediatrics, and can be used for vaccination of pertussis, diphtheria and tetanus during adaptation to the Far North.

A known method of mass vaccine prophylaxis of pertussis, diphtheria and tetanus by introducing the associated pertussis-diphtheria-tetanus vaccine to children aged 3; 4,5, 6 and 18 months [1].

The disadvantage of this method of vaccination of pertussis, diphtheria and tetanus is that the processes of adaptation of the population to the conditions of the Far North are not taken into account. Children of maternity age are vaccinated, regardless of the length of time that has elapsed since the arrival of vaccinees from other regions. At the same time, most newcomers to the Far North regularly travel to other climatic regions of the country. After a few months, these residents return to the Far North. A change in the region of residence, even temporary, leads to a disruption in the process of adaptation of the functional systems of the human body to the conditions of the Far North.

The objective of the present invention is to increase the effectiveness of vaccine prophylaxis of pertussis, diphtheria and tetanus for children of maternity age and reduce the cost of its implementation.

The essence of the invention lies in the fact that according to a known method for the vaccination of pertussis, diphtheria and tetanus by periodic administration of DTP vaccine to children aged 3; 4,5; For 6 and 18 months, the next vaccination is carried out no later than 2 months before departure from the Far North regions to other climatic zones and no earlier than 3 months after arrival in the Far North regions from other climatic zones. If a child arrives in the Far North at the age of 18 months, he is vaccinated at the age of 21 months, that is, 3 months after arrival.

With the proposed approach to the prevention of pertussis, diphtheria and tetanus, the adaptation of functional systems that occurs in the child’s body when changing latitudinal belts is taken into account.

The method is as follows.

When scheduling the calendar vaccine prophylaxis of pertussis, diphtheria and tetanus in the Far North, data are collected on the likely departure of other individuals to be immunized with DTP vaccine and form a group of people traveling from the Far North regions. Members of this group are given DTP vaccine no later than 2 months prior to departure from the Far North regions to other climatic zones. After arriving in the Far North, immunization with DTP vaccine is carried out no earlier than 3 months later.

Example 1. Child A. aged 3; 4.5 and 6 months inoculated with DTP vaccine. The last immunization with DTP vaccine was done at the age of 6 months - 2 months before leaving the Far North region. 12 months after immunization, anti-diphtheria and tetanus antitoxins and anti-pertussis antibodies were determined in titers 1: 640, 1: 1280 and 1: 640.

Example 2. Child M. aged 3; 4.5 and 6 months inoculated with DTP vaccine. The last immunization with DTP vaccine was done at the age of 6 months - 1 month before departure from the Far North region. 12 months after immunization, anti-diphtheria, tetanus antitoxin and anti-pertussis antibodies were determined in titers 1:10, 1:10 and 1:10 (seronegative).

Example 3. Child C. aged 3; 4.5 and 6.5 months. vaccinated with DTP vaccine. The last immunization with DTP vaccine was made at the age of 6.5 months - 2 months after arrival in the Far North. 12 months after immunization, anti-diphtheria, anti-tetanus antitoxins and anti-pertussis antibodies were determined in titers <1:10, <1:10 and 1:10 (seronegative).

Example 4. Child C. aged 3; 4.5 and 7.5 months inoculated with DTP vaccine. The last immunization with DTP vaccine was made at the age of 7.5 months - 3 months after arrival in the Far North. 12 months after immunization, anti-diphtheria, anti-tetanus antitoxins, anti-pertussis antibodies were determined in titers 1: 640, 1: 1280 and 1: 320.

Example 5. Child G. at the age of 18 months. immunized with DTP vaccine 3 months after arrival in the Far North. Twelve months after immunization, anti-diphtheria, tetanus antitoxin and anti-pertussis antibodies were detected in titers 1: 1280, 1: 320 and 1: 640.

Example 6. Child N., aged 18 months, was immunized with DTP vaccine 2 months after arrival in the Far North. 12 months after immunization, anti-diphtheria, anti-tetanus antitoxins and anti-pertussis antibodies were determined in titers <1:10, <1:10 and 1:10 (seronegative).

In total, in the conditions of the Far North, 618 people were immunized with DTP vaccine according to the proposed method. The highest vaccination efficacy was obtained no later than 2 months before departure and no earlier than 3 months after arrival in the Far North.

The technical result from the use of the proposed method:

1. The vaccination of diphtheria, tetanus and pertussis increases;

2. The method of vaccination of diphtheria, tetanus and pertussis is simplified, since the immunization season among the newcomers is significantly reduced and the costs of operating helicopters and medical teams are accordingly reduced.

Sourse of information

1. The Ministry of Health of the Russian Federation. The new calendar of vaccinations in Russia. Order No. 229. - M .: 06/27/2001.

Claims (1)

A method of vaccination for pertussis, diphtheria, tetanus in the Far North by periodically administering DTP vaccine taking into account the calendar schedule, characterized in that when scheduling it is taken into account that the next vaccination should be carried out no later than 2 months before leaving the Far North regions to other climatic zones, and not earlier than 3 months after arriving in the regions of the Far North from other climatic zones.