RU2234267C2 - Method for vaccine prophylaxis of epidemic parotitis in far north - Google Patents

Abstract

FIELD: medicine, pediatrics.

SUBSTANCE: children in Far North are subjected for immunization with live parotitis vaccine in attainment vaccination age in children. Vaccinations are carried out from May to August being independently of baby birthday date. Children with medicinal contraindications are vaccinated also. Method provides enhancing the effectiveness of primary vaccination and to reduce number of repeated vaccination.

EFFECT: enhanced effectiveness of vaccine prophylaxis.

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Description

The invention relates to medicine, namely to pediatrics, and can be used for the vaccination of mumps among the newcomer population of the Far North.

A known method of mass vaccination with live mumps vaccine (VZP) during the year, depending on the age of the child [1]. However, the adaptation of the newcomer population in the Far North is slow and depends on the season of the year. In such cases, the effectiveness of immunization is reduced. In addition, material and labor costs are required year-round.

The purpose of the invention is to increase the efficiency of vaccination of ZHPV.

The goal is achieved by the fact that children of the alien population living in the Far North are vaccinated with a lively mumps vaccine from May to August, upon reaching the vaccination age, regardless of the date of birth of the child, including during medical withdrawal. In the period from May to August, which coincides with the "polar day", the immunological reactivity of the body reaches its highest levels due to an increase in titers of antipartite antibodies.

The method is as follows. They constitute a group of alien children living in the High North and subject to vaccination. After each child reaches the vaccination age of 12 months, he is vaccinated with a lively mumps vaccine from May to August. In cases of withdrawal for medical reasons, the vaccination is transferred to the next period from May to August.

Example 1. A child at the age of 1 year was vaccinated with VHP in January. One year after immunization, antipartite antibodies were detected in a titer of 1:10.

Example 2. A child at the age of 1 year was vaccinated with ZHV in February. One year after immunization, anti-mumps antibodies were detected in titers of 1:10.

Example 3. A child at the age of 1 year was vaccinated with ZHV in March. One year after immunization, anti-mumps antibodies were detected in titers of 1:10.

Example 4. A child at the age of 1 year was vaccinated with EPA in April. One year after immunization, anti-mumps antibodies were detected in titers <1:10.

Example 5. A child at the age of 1 year was vaccinated with HPV in May. One year after immunization, anti-mumps antibodies were detected in titers <1: 640.

Example 6. A child at the age of 1 year was vaccinated with HPV in June. One year after immunization, anti-mumps antibodies were detected in titers 1: 160.

Example 7. A child at the age of 1 year was vaccinated with ZHV in July. One year after immunization, anti-mumps antibodies were detected in titers of 1: 320.

Example 8. A child at the age of 1 year was vaccinated with ZHV in August. One year after immunization, anti-mumps antibodies were detected in titers of 1: 640.

Example 9. A child at the age of 1 year was vaccinated with ZHV in September. One year after immunization, anti-mumps antibodies were detected in titers of 1:10.

Example 10. A child at the age of 1 year was vaccinated with ZHV in October. One year after immunization, anti-mumps antibodies were detected in titers of 1:10.

Example 11. A child at the age of 1 year was vaccinated with VZP in November. One year after immunization, anti-mumps antibodies were detected in titers of 1:10.

Example 12. A child at the age of 1 year was vaccinated with ZHV in December. One year after immunization, anti-mumps antibodies were detected in titers of 1:10.

In all, in the Far North, 508 people were vaccinated with HPV. The highest vaccination efficacy was shown between May and August. After vaccination with VHP in this period (first group), 6.2 ± 2.3% seronegative were detected, while the geometric mean titer of antibodies was determined at the level of 5.8 ± 0.05 log ₂ . At the same time, after vaccination with VZP in other months of the year, from September to April (second group), 15.9 ± 3.2% of seronegative ones were revealed, while the differences with the first group were statistically significant (P <0.01). The geometric mean shooting index of antibodies was determined at 4.7 ± 0.04 log ₂ , which was statistically significantly lower than in the first group (P <0.001).

The proposed method allows to increase the effectiveness of primary vaccination (there remains a significantly lower percentage of seronegative ones), while the number of booster vaccinations is reduced by more than half.

Sources of information

1. Order of the Ministry of Health of the Russian Federation No. 229 dated 06/27/2001. “National calendar of vaccinations.”

Claims (1)

A method of vaccine prophylaxis of mumps in children of the newcomer population of the Far North, which consists in vaccinating a live mumps vaccine after reaching the vaccination age, characterized in that they are vaccinated from May to August, regardless of the date of birth of the child, including medical appointments.