RU2127120C1 - Method for ozone vaccine-prophylaxis of diphtheria and rigor nervorum in extreme north conditions - Google Patents

Abstract

FIELD: pediatrics. SUBSTANCE: method consists in that children of new-comers are immunized with adsorbed diphtheria-rigor nervorum-M anatoxin since May until September. EFFECT: reduced sick rate among children population. 3 ex

Description

 The invention relates to medicine, namely to pediatrics, and can be used for vaccination of diphtheria and tetanus among the alien population of the Far North.

 A known method of mass vaccination with adsorbed diphtheria-tetanus-M toxoid (ADS-M toxoid) in different seasons [1]. However, in the applied method there is no regional approach in the tactics of its implementation. In this case, vaccination against diphtheria and tetanus is necessary throughout the year. The regional approach to vaccination is very important especially in the Far North, as the processes of adaptation of the population coming from other geographical areas take a long period of time and can continue for several generations. The inexpediency of vaccination with ADS-M toxoid among the newcomers of the Far North during the period from October to April is proved to be inadvisable, since otherwise the effectiveness of immunoprophylaxis is significantly reduced. When carrying out throughout the year, more significant material and labor costs are required than when vaccinating in a shorter period of time (from May to September).

 The purpose of the invention: simplification of the method of vaccination with ADS-M toxoid. This is achieved by the fact that children of the alien population of the Far North are vaccinated against diphtheria and tetanus in the period from May to September.

 The method is carried out in the following way.

 Children are selected in a group, which is represented by the alien population of the Far North. This group primarily includes children who came to the Far North and lived there at different times, as well as children who were born in the Far North, but their parents also came to the Far North at different times. In the future, a group of children of the newcomer population of the Far North will be vaccinated with ADS-M toxoid when they reach the vaccination age in accordance with the calendar of preventive vaccinations of the Russian Federation from May to September.

 Example 1. A child aged 6.5 years old was vaccinated with ADS-M toxoid (1 vaccination in January, 2 vaccination in the month of March). Eight months after immunization, diphtheria antitoxins and tetanus antibodies were detected in titers of 1:10 and 1:10, respectively.

 Example 2. A child aged 6 years 9 months was vaccinated with ADS-M toxoid (1 vaccination in June, 2 vaccination in the month of September). Eight months after immunization, diphtheria antitoxins and tetanus antibodies were detected in titers of 1: 640 and 1: 320, respectively.

 Example 3. A child aged 6 years old was vaccinated with ADS-M toxoid (1 vaccination in May, 2 vaccination in the month of July). 8 months after immunization, diphtheria antitoxins and tetanus antibodies were detected in titers of 1: 320 and 1:80, respectively.

 Example 4. A child aged 7 years old was vaccinated with ADS-M toxoid (1 vaccination in November, 2 vaccination in the month of January) 8 months after immunization with anti-diphtheria antitoxins and anti-tetanus.

 - In total, in the Far North, 204 people were vaccinated with ADS-M toxoid. The highest vaccination efficacy was shown between May and September.

Using the proposed method has the following advantages:
1. The method of vaccination of diphtheria and tetanus in the settlements of the Far North is simplified, since the vaccination season is significantly reduced (the operation of helicopters and medical teams).

 2. The number of booster vaccines is reduced by more than 2 times since the effectiveness of primary vaccination is significantly increased (a much lower percentage of seronegative ones remains).

Sourse of information
1. On making changes to the diphtheria immunization schedule. The order of the Ministry of Health and honey. prom RF and State. Com SEN RF, 1994, N 235/130.

Claims (1)

 A method for seasonal vaccine prophylaxis of diphtheria and tetanus in the High North, which consists in immunizing against diphtheria and tetanus with an adsorbed diphtheria-tetanus-M toxoid, characterized in that children belonging to the newcomer population of the High North are vaccinated with adsorbed diphtheria-tetanus-M anatoxin in May.