RU2233099C1 - Fodder additive for farm animals and poultry - Google Patents

Abstract

FIELD: fodder production.

SUBSTANCE: as a fodder additive it is suggested to apply either succinate salt of 2-amino-4-methylthio-(S-oxo-S-imino)-butyric acid or phosphate salt with succinic acid at weight ratio of components being 1 : (0.5-2), correspondingly. The results obtained indicate fodder's high efficiency that enables to safe livestock that leads to increased average daily weight gain having positive impact upon meat characteristics in swine that stimulates immune protection and favors animal adaptation towards stress-factors.

EFFECT: higher efficiency.

8 ex, 13 tbl

Description

The invention relates to the field of agriculture, specifically to feed additives that increase the productivity of farm animals and birds.

The use of succinic acid with feed is known to prevent a decrease in productivity in birds under stress exposure. (USSR Author's Certificate No. 553965, A 23 K 1/16, 1977).

It is known to use succinate premix (succinic acid and wheat bran) with feed to stimulate egg production in laying hens. (USSR author's certificate 743669, A 23 K 1/22, 1980).

It is known to use succinic acid calcium as a mineral feed additive for young pigs. (USSR author's certificate No. 1375230, A 23 K 1/16, 1988).

It is known to use succinic acid in the diet of pigs as an anti-stress drug in order to reduce the loss of animal productivity. (USSR Author's Certificate No. 1503731, A 23 K 1/16, 1989).

It is known to use succinic acid sodium salt in an amount of 100-500 mg / kg body weight as a means for increasing body weight, thymus, spleen, red bone marrow in animals. (RF patent No. 2029466, A 01 K 67/02, A 61 K 31 / 00.1995).

It is known to use the sodium salt of succinic acid as a feed additive to increase the egg production of laying hens. (RF patent No. 2088110, A 23 K 1/16, 1997).

It is known to use succinic acid with food or in the form of an aerosol to stimulate the growth, development, viability and productivity of poultry. (RF patent No. 2102063, A 61 K 9/12, A 23 K 1/00, 1998).

Known feed additive that increases the gain in live weight of farm animals and birds, containing succinic acid, succinic acid, citric acid iron, citric acid copper, ascorbic acid. (RF patent No. 2086149, A 23 K 1/16, 1997).

Known feed additive to increase the gain in live weight of farm animals and birds, containing iron succinate, copper succinate, zinc succinate, manganese succinate, cobalt succinate, ascorbic acid. (RF patent No. 2092074, A 23 K 1/16, 1997).

Known premix, which is introduced into the diet of dry cows to increase milk productivity and reproductive function of cows containing succinic acid, folic acid, selenium, zinc, copper, cobalt, iodine, manganese, magnesium, vitamin D. (RF Patent No. 2145479, A 23 K 1/16, 2000).

Known premix for farm animals and poultry, which helps to increase the growth rate of young pigs, reduce feed costs for the growth of young pigs and egg production of laying hens, improve meat quality, increase the content of vitamins A and C in the liver, containing chelating compounds of zinc citric acid salt, iron, manganese, copper, cobalt; potassium iodide, sodium selenite, succinic acid, lysine, methionine, defluorinated phosphate, ascorbic acid, citric acid mycelium, wheat bran. (RF patent No. 2156080, A 23 K 1/16, 2000).

Known protein-vitamin-mineral feed additive for farm animals and poultry, contributing to an increase in the egg production rate of laying hens, reducing feed costs for the growth of pigs and egg productivity of laying hens, increasing the content of vitamins A and C in the liver and meat, reducing toxic elements in the liver, containing protein components, vitamins, as well as chelating compounds of citric acid salts: zinc, iron, copper, manganese, cobalt citrates, citric acid mycelium, amino acids, succinic acid lot. (RF patent No. 2162287, A 23 K 1/16, 2001).

It is known to use sulfoximine methionine sulfate as a feed additive for farm animals to increase calf weight. (RF patent No. 2033053, A 23 K 1/16, 1995).

It is known to use 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid and its sodium, potassium, phosphoric acid salts as a feed additive, which increases the productivity of farm animals and birds. (RF patent №2154951, А 23 К 1/16 /, 2000, RF patent №2161983, А 23 К 1/16, 2001).

The listed additives are intended only for a certain type of animal or bird, or have a specifically limited effect, or are multicomponent, which affects the cost of feed, or are not effective enough, or they require a complex feeding system, or large dosages of the feed additive.

The aim of the invention is to expand the range of feed additives with increased efficiency, contributing to an increase in the productivity of farm animals and birds, increasing the safety of the livestock.

The goal is achieved in that as a feed additive it is proposed to use the succinic acid salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid or its sulfuric acid salt or its phosphoric acid salt in a mixture with succinic acid or its salts. The drug is used in an amount of 2 mg / kg body weight for poultry, 3 mg / kg body weight for pigs, 5 mg / kg body weight for cattle, based on the salt of 2-amino-4-methylthio- (S-oxo-S -imino) -butyric acid. Succinic acid has low toxicity and versatile physiological activity in the body of animals, for which it is a normal metabolite. The manifestations of the physiological activity of succinic acid known from the literature are favorable for the body.

Sulfur-containing amino acids are involved in many processes to activate vitamins, hormones, enzymes and other substances that affect nitrogen, carbohydrate and fat metabolism.

The feed supplement can be supplemented with the elements necessary for the development of the body: iron, zinc, iodine, selenium, cobalt, manganese.

The proposed feed additive is easily digested, has high consumer properties.

For feeding animals and poultry, the additive is mixed with the main feed in solid form. Given the small dosage of the drug, for convenience of mixing with the feed, fillers can be used, for example, natural aluminosilicates such as bentonite, or flour of cereal plants, or bran. In this case, it is easier to achieve uniform distribution of the drug in the feed. It is possible to irrigate the feed with an aqueous solution of the drug in the drum, or the feed additive is given to the bird with a drink, or other acceptable methods are used. For better feed eatability, it is possible to use flavors such as vanillin, citric acid, menthol, aspartame, saccharin and others.

The invention is illustrated by the following examples.

Example 1. The experiments were conducted on pigs in the pig farm "Industrial" Timashevsky district of the Krasnodar Territory. The feed additive was used in the form of a phosphoric acid salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid and succinic acid in a mass ratio of 1: 0.5, respectively, on piglets of 45 days old live weight 14 -16 kg at a dose of 3 mg / kg per day, based on the phosphoric acid salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid.

The results of the experiments are presented in table 1.

Example 2. The experiments were conducted on broiler chickens in the laboratory of veterinary pharmacy of the Krasnodar Research Veterinary Institute. We studied the effect on the safety of the livestock feed additive - sulfate salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid in a mixture with succinic acid at a mass ratio of 1: 1. The feed additive was given at a dose of 2 mg / kg per body weight per day based on the sulfuric acid salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid.

The results of the experiments are presented in table.2.

The data obtained confirm that the use of feed additives leads to an increase in the safety of the broiler population.

Example 3. Feeding pigs was carried out in the state unitary farm “Roshchinsky” of the Republic of Bashkortostan from May 8, 2001 to August 17, 2001. The number of animals in the groups was 29. The phosphoric acid salt 2-amino-4- was used as a feed additive. methylthio- (S-oxo-S-imino) -butyric acid and sodium salt of succinic acid in a mass ratio of 1: 0.5. The feed additive was given with a dry feed daily at a dose of 3 mg / kg body weight calculated on the phosphoric acid salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid.

The results of the experiments are presented in table.3.

Thus, the use of a feed additive causes an increase in the average daily gain for the entire period of fattening compared to the control of 98 g.

Example 4. The experiments were conducted in agrofirm “Maximovskaya” of the Republic of Bashkortostan on large white pigs. Six groups of pigs were formed, one of which was a control. There were 14 pigs in each group. The feed additive was given daily with a feed at a dose of 3 mg / kg body weight, based on the corresponding salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid.

The results of the experiments are presented in table.4.

Thus, the average daily gains in the experimental groups significantly exceed the control, and the drug allows you to achieve a stable result over a long time of feeding.

Example 5. The experiments were carried out on ducks in the Blagovarsky state plant of the Republic of Bashkortostan. According to the principle of analogues, two groups of ducks of 50 animals were formed, one of the groups was a control. The control group received a normal diet based on grain mix. The amber acid salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid, carefully mixed with food, was daily administered to the experimental group at the rate of 2 mg / kg body weight per day. Feeding was carried out for 20 days.

The results of the experiments are presented in table.5.

The experimental results indicate a pronounced growth-promoting effect of the drug by 26.5%.

Example 6. The experiments were conducted at the Turbaslinsky poultry factory of the Republic of Bashkortostan. The succinic acid salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid was used on broilers with a cell content of 2 mg / kg body weight daily for 42 days of feeding. The comparison was carried out with a group of broilers contained in similar conditions, receiving similar food, but without the drug. In the cells was populated (see table 6):

After slaughtering and weighing, the following results were obtained (see table 7):

Thus, despite the fact that the initial mass of small chickens of 1 caliber (up to 38 g) in the experiment with the feed additive was 56.7% versus 21.2% in the control, during the slaughter period the average weight of the carcass in the experiment was 1.801 kg against 1.772 kg in the control, which clearly indicates a greater growth rate of experimental chickens compared with the control group. In addition, the output of meat of a higher quality category is greater than in the control.

Example 7. The experiments were conducted in the experimental farm "Ufa" of the Republic of Bashkortostan on large white pigs. The composition of the feed additive: phosphoric acid salt of 2-amino-4-methylthio- (S-oxo-S-imino) butyric acid and succinic acid in a mass ratio of 1: 1, respectively. 2 groups were formed in the amount of 12 animals each, taking into account the age, live weight, and physiological state of the piglets. The feeding conditions were the same. The supplement was given with food once a day for 180 days. The dosage of the feed additive was 3 mg / kg body weight calculated on the phosphoric acid salt of 2-amino-4-methylthio- (S-oxo-S-imino) butyric acid.

The results of the effect of the drug on various indicators, including the slaughter characteristics of pigs are presented in tables 8-12.

The protein index of the longest muscle of the back of pigs in the experiment using the feed additive exceeds the control, the color of the meat of the experimental group also exceeds the control, which indicates the beneficial effect of the additive on the chemical composition of the meat.

As follows from the data presented, the feed additive has an immunostimulating effect, which is expressed in a significant increase in blood leukocytes, including T and B lymphocytes, and in an increase in phagocyte activity indicators. Thus, the use of a feed supplement causes a steady tendency to stimulate cellular and phagocytic immune defense mechanisms.

The concentration of the hormone ATKG slightly exceeds the control, which helps to increase the adaptation of the animal organism to stress factors as a result of feeding them with the addition of the drug.

However, changes in the hormone do not statistically go beyond the normal values in this population.

The data obtained indicate that the yield of pulp during the slaughter of pigs that received the drug during feeding exceeds that for keeping animals on a normal diet. The area of the skins of experimental animals is also 6.6–9.84 larger than the skins of control animals, which is of great practical importance.

Considering that with an increase in the endocrine part of the pancreas, the meat productivity of the animal increases, good fattening characteristics and meat qualities of pigs receiving the supplement can be expected.

Example 8. The feed additive was tested on a livestock farm experimental farm "Ufa" of the Republic of Bashkortostan. Two groups of calves of 15-20 days of age were formed, 12 pieces each of a hypotrophic physical condition. One of the groups was a control. The experimental group received a daily feed additive in the form of a succinic acid salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid at a dose of 5 mg / kg body weight.

The results of the experiments are presented in table.13.

In animals receiving the feed supplement, by the end of the second month the clinical condition was normalized, characterized by good appetite and activity. In addition, the safety of livestock in the experimental group is 30% higher than in the control.

In the above examples, the dosage of succinic acid or its salts in the composition of the feed additive corresponds to 0.5-6.0 mg / kg of body weight.

The test results of the feed additive testify to its high efficiency, contributing to the safety of the livestock, leading to an increase in the increase in average daily growth, having a beneficial effect on the meat characteristics of pigs, causing stimulation of the immune defense, contributing to the adaptation of animals to stress factors.

Claims (1)

A feed additive for farm animals and birds containing a salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid, characterized in that as a salt of 2-amino-4-methylthio- (S-oxo It contains the succinic salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid, or a mixture of the sulfate salt of 2-amino-4-methylthio- (S-oxo- S-imino) -butyric acid with succinic acid, or a mixture of phosphoric acid salt of 2-amino-4-methylthio- (S-oxo-S-imino) -butyric acid with succinic acid in a mass ratio of 1: (0.5-2 ) correspondence veno.