RU2205842C2 - Илиды фосфора, способ их получения и промежуточные соединения - Google Patents

Илиды фосфора, способ их получения и промежуточные соединения Download PDF

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RU2205842C2
RU2205842C2 RU99128084/04A RU99128084A RU2205842C2 RU 2205842 C2 RU2205842 C2 RU 2205842C2 RU 99128084/04 A RU99128084/04 A RU 99128084/04A RU 99128084 A RU99128084 A RU 99128084A RU 2205842 C2 RU2205842 C2 RU 2205842C2
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formula
compounds
intermediate compounds
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preparing
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Ги БЕРТРАН (FR)
Ги Бертран
Денни БИГ (FR)
Денни БИГ
Жан-Бернар КАЗО (FR)
Жан-Бернар Казо
Стефани ГУМРИ (FR)
Стефани ГУМРИ
Оливье ГЕРРЕ (FR)
Оливье ГЕРРЕ
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Сосьете Де Консей Де Решерш Э Д'Аппликасьон Сьентифик (С.К.Р.А.С.)
Сантр Насьональ Де Ля Решерш Сьентифик (Снрс)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D227/00—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00
    • C07D227/02—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D227/06—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D227/08—Oxygen atoms
    • C07D227/087—One doubly-bound oxygen atom in position 2, e.g. lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/535—Organo-phosphoranes
    • C07F9/5352—Phosphoranes containing the structure P=C-
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/082—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing phosphorus
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/40—Introducing phosphorus atoms or phosphorus-containing groups

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

Изобретение относится к новым илидам фосфора ф-лы (I)
Figure 00000001

в которой R1, R2 и R3 представляют аминогруппу R'R''N, где R' и R'' - представляют С1-С6 алкил; R4 - Н, Ме; R5 - полимерный носитель полистиролового типа ф-лы (S)
Figure 00000002

где n, n' и m - целые числа, большие или равные 1. Соединения ф-лы (I) могут быть использованы в качестве слабонуклеофильных сильных оснований. Описаны также промежуточные соединения ф-лы (3)
Figure 00000003

где R1-R5 имеют вышеуказанные значения, Y⊖ - анион. 3 с.п. ф-лы, 1 табл.

Description

Текст описания в факсимильном виде (см. графическую часть). Тс

Claims (3)

1. Илиды фосфора общей формулы (1)
Figure 00000007
(l)
в которой R1, R2 и R3 представляют собой аминогруппу R'R''N, где R' и R'' - C1-C6 алкил;
R4 - H, Me;
R5 - полимерный носитель полистиролового типа формулы (S)
Figure 00000008

где n, n' и m - целые числа, большие или равные 1.
2. Способ получения соединений по п.1, отличающийся тем, что фосфин общей формулы (1)
PR1R2R3, (1)
где R1, R2 и R3 имеют указанные в п.1 значения,
подвергают взаимодействию с соединением общей формулы (2)
Figure 00000009

где R4 и R5 имеют указанные в п.1 значения;
Y - такой, что Y⊖ представляет собой анион,
для получения соли фосфония формулы (3)
Figure 00000010

которое обрабатывают сильным основанием для получения соединения формулы (1).
3. Соединения формулы (3)
Figure 00000011

в которой R1-R5 и Y⊖ имеют указанные в п.2 значения.
RU99128084/04A 1997-05-26 1998-05-26 Илиды фосфора, способ их получения и промежуточные соединения RU2205842C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97401142.1 1997-05-26
EP97401142A EP0881235A1 (fr) 1997-05-26 1997-05-26 Nouveaux ylures de phosphore, leur préparation et leurs utilisations notamment en tant que bases fortes faiblement nucléophiles

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RU99128084A RU99128084A (ru) 2001-09-10
RU2205842C2 true RU2205842C2 (ru) 2003-06-10

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US (1) US6222032B1 (ru)
EP (2) EP0881235A1 (ru)
JP (1) JP2002504900A (ru)
AT (1) ATE235520T1 (ru)
AU (1) AU7776598A (ru)
CA (1) CA2291345A1 (ru)
DE (1) DE69812614D1 (ru)
NO (1) NO995771L (ru)
RU (1) RU2205842C2 (ru)
WO (1) WO1998054229A1 (ru)

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Publication number Priority date Publication date Assignee Title
PT984777E (pt) * 1997-05-12 2004-01-30 Ortho Mcneil Pharm Inc Piperazinas arilsubstituidas uteis no tratamento da hiperplasia benigna da prostata
GB9911152D0 (en) * 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
FR2833602B1 (fr) * 2001-12-14 2004-03-12 Rhodia Chimie Sa Procede de preparation de polyorganosiloxanes (pos) par polycondensation/redistribution d'oligosiloxanes, en presence d'une superbase et superbases employees
KR20090045233A (ko) 2006-07-10 2009-05-07 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1003730B (de) * 1954-09-24 1957-03-07 Basf Ag Verfahren zur Herstellung von Yliden des Phosphors
US3274228A (en) * 1963-07-29 1966-09-20 Interchem Corp Triphenylphosphinemethylene compounds
GB1277736A (en) * 1968-09-30 1972-06-14 British Petroleum Co Catalyst support
US3681428A (en) * 1968-10-24 1972-08-01 Reynolds Tobacco Co R Synthesis of phosphorane compounds
GB1312611A (en) * 1969-05-09 1973-04-04 British Petroleum Co Catalyst supports
US3725365A (en) * 1971-04-08 1973-04-03 Dow Chemical Co Resins with phosphorane pendant groups and process for preparing same
US4043948A (en) * 1973-08-23 1977-08-23 The Dow Chemical Company Insoluble polyalkyl phosphonium salt resins having carbon-carbon crosslinked backbone
US3919126A (en) * 1973-08-23 1975-11-11 Dow Chemical Co Insoluble polyalkyl phosphonium salt resins having crosslinked backbone
US4092466A (en) * 1976-07-19 1978-05-30 Nasa Heat resistant polymers of oxidized styrylphosphine
CA1139318A (en) * 1979-12-03 1983-01-11 Dane K. Parker Process for preparing primary alkyl chlorides
GB2301104B (en) * 1995-05-23 1998-11-11 Ethyl Petroleum Additives Ltd Process for the preparation of polyalkene-substituted succinic acylating agents

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JP2002504900A (ja) 2002-02-12
CA2291345A1 (fr) 1998-12-03
AU7776598A (en) 1998-12-30
EP0881235A1 (fr) 1998-12-02
WO1998054229A1 (fr) 1998-12-03
ATE235520T1 (de) 2003-04-15
DE69812614D1 (de) 2003-04-30
EP0986585A1 (fr) 2000-03-22
NO995771D0 (no) 1999-11-25
EP0986585B1 (fr) 2003-03-26
US6222032B1 (en) 2001-04-24
NO995771L (no) 1999-11-25

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