RU2205625C1 - Curative-prophylactic composition for treating teeth - Google Patents

Abstract

FIELD: medicine, stomatology. SUBSTANCE: the suggested curative-prophylactic composition contains synthetic finely dispersed amorphous silicon dioxide, purified sodium carboxymethyl cellulose, distilled glycerol PK-94, decahydrate sodium diphosphate, triclozane, sodium fluoride, pigmentary titanium dioxide, saccharin, sodium laurylsulfate, aromatic composition, drinking water, additionally, it contains polydon, watery-alcoholic- glycerol extracts of calendula and sage, components should be taken at certain quantitative ratio. The suggested composition enables to remove dental plaque, prevents the development of dental calculus and caries, strengthens dental enamel and decreases gingival inflammation. EFFECT: higher efficiency. 2 tbl

Description

 The invention relates to medicine, in particular to means for caring for the oral cavity.

 Colgate total toothpaste is widely known, manufactured by Colgate Palmolive, which contains, in addition to traditional ingredients, sodium fluoride and triclosan.

 The closest in composition to the claimed composition is a therapeutic and prophylactic toothpaste "New Pearl Total", manufactured by CJSC "Nevskaya Cosmetics", St. Petersburg. The paste contains: abrasive - silicon dioxide, a thickener, water-retaining substances - glycerin and / or sorbitol, polyethylene glycol, a component that prevents the formation of tartar, - sodium pyrophosphate, an antibacterial additive - triclosan, an anti-caries additive - sodium fluoride, a dye - titanium dioxide, preservatives - sodium benzoate and thymol, the sweetener is saccharin, the cleaning component is sodium lauryl sulfate, an aromatic additive and water.

 The task of the inventors was to create a highly effective therapeutic and prophylactic toothpaste with a wide and prolonged spectrum of action: preventing the formation of tartar, preventing tooth decay, strengthening tooth enamel, promoting healing of gums.

The problem is solved in that the composition of the therapeutic and prophylactic composition for treating teeth containing synthetic finely dispersed amorphous silicon dioxide, purified sodium carboxymethyl cellulose, distilled glycerin PK-94, sodium diphosphate 10-water, triclosan, sodium fluoride, titanium dioxide pigment, saccharin lauryl sulfate, aromatic composition and drinking water, additionally introduced polydone, water-alcohol-glycerin extracts of calendula and sage, in the following ratios of components, wt.%:
Fine-dispersed synthetic amorphous silicon dioxide - 15.20-31.50
Purified sodium carboxymethyl cellulose - 0.62-1.87
Distilled glycerin PK-94 - 21.00-57.00
Sodium diphosphate 10-water - 0.50-5.10
Polydon - 0.20-1.50
Triclosan - 0.20-0.30
Sodium fluoride - 0.10-0.27
Pigment titanium dioxide - 0.20-1.00
Water-alcohol-glycerin marigold extract - 0.10-3.00
Water-alcohol-glycerin sage extract - 0.10-3.00
Saccharin - 0.02-0.15
Sodium lauryl sulfate in terms of 100% - 0.5-2.00
Aromatic composition - 0.60-1.30
Drinking Water - Else
Compared with the prototype of the claimed composition has a wider spectrum of action (see table. 1). Polydon, forming a film on the surface of the teeth, not only protects the teeth from external influences for a long time, but also accumulates on its surface a complex of biologically active substances (triclosan, extracts of calendula and sage) in combination with an anti-caries supplement - sodium fluoride and an additive against education tartar - 10-aqueous sodium diphosphate. As a result of longer exposure to teeth and gums, the therapeutic and antibacterial effect of toothpaste is enhanced.

 POLIDONE is an aqueous solution of high molecular weight polyvinylpyrrolidone. Due to the strong solubilizing and complexing effect, polydon binds all the components that make up the composition and prolongs their physiological effect.

 Polyvinylpyrrolidone helps to dissolve the protein-lipid base of dental plaque, which provides a significant improvement in cleaning teeth from plaque, and therefore, eliminates plaque microflora toxins and enhances trophism of periodontal and oral mucosa tissues, which enhances the preventive effect of the proposed composition.

 A number of compositions are known for the prevention of diseases of the oral cavity [1, 2] and therapeutic and prophylactic toothpastes [3, 4] based on chalk and aerosil containing polyvinylpyrrolidone.

 Water-alcohol-glycerin extract of sage (leaves) contains starch, resin, gum, protein, tannins and bitter substances, alkaloids, ursolic, oleanolic acid, mineral salts and essential oil up to 2.5%. Sage oil contains cineol, thujone, pinene, camphor, borneol. Fresh leaves contain volatile and have a strong bactericidal effect.

 Sage has a disinfectant, astringent, anti-inflammatory effect. It is used for various catarrhal conditions of the mucous membranes, tonsillitis, gum disease [5].

 The anti-inflammatory effect of sage is achieved by reducing the permeability of the walls of blood vessels and capillaries.

 The antimicrobial activity of the plant is most pronounced in relation to gram-positive strains of bacteria.

 Water-alcohol-glycerin extract of calendula (flower baskets) contains essential oil, carotenoids, carotene, flavonoids, organic acids - malic, pentadecyl and traces of salicylic.

 Calendula preparations have pronounced bactericidal properties against a number of microbes (especially staphylococci and streptococci) and are used to treat inflammatory diseases of the oral cavity (stomatitis, gingivitis, alveolar pyorrhea, ulcers of the mucous membrane) [6].

 The compositions of the therapeutic composition for treating teeth for several examples are given in table. 2.

 The inventive therapeutic and prophylactic composition for treating teeth is prepared as follows: the components in a prescription amount are loaded into a reactor with a stirrer: first, glycerol, then sodium carboxymethyl cellulose and titanium dioxide pigment are loaded with a vacuum, and the reactor is sealed. After stirring for 10 min, water is added and, after stirring for 40 min, water-alcohol-glycerin extracts of sage and calendula, sodium diphosphate 10-water, sodium fluoride, triclosan, silicon dioxide, sodium benzoate, polydone and saccharin. Then the mass is homogenized for 150 minutes, dispersed, vacuum at a residual pressure of 50-60 mm Hg. and sodium lauryl sulfate and aromatic composition are added.

The whole process of obtaining toothpaste is carried out without heating at a temperature of 18-25 ^o C.

 After pumping the resulting toothpaste into the hopper of the tube filling machine, the paste is packaged in tubes.

 The quality of the toothpaste must comply with the requirements of GOST 7983-99.

 In laboratory and semi-industrial conditions, studies were conducted that showed that going beyond the declared amounts of the components used in the direction of reduction will not allow you to get a toothpaste with the desired properties, and going beyond the claimed amounts of the components used in the direction of increasing concentrations leads to a deterioration in the consumer properties of the proposed composition .

 An experimental batch of toothpaste has been released.

 The declared toothpaste received permission and approval of the Scientific Center for Preventive Dentistry "Profident". The tests were carried out in accordance with the requirements of SanPiN 1.2.676-97.

 The test results of the inventive toothpaste for microbial purity showed a complete absence of bacteria, yeast and molds.

 Toxicological tests showed the absence of acute toxicity when administered orally, the absence of irritating effects on the mucous membranes of the oral cavity and gastrointestinal tract.

 Clinical studies have shown that the claimed composition does not have a locally irritating and allergenic effect. With a single application, the Green Vermillion index of the cleansing action is 60%, with repeated use, the cleansing effect of the paste is 46%.

 As a result of tests, it was shown that toothpaste is safe for health, helps to remove plaque, prevents the formation of tartar, provides effective protection of teeth from caries, strengthens tooth enamel and reduces gum inflammation.

Literature
1. RF patent 2005466 5, A 61 K 6/02, 7/26. Publ. in bull. January 1, January 15, 1994.

 2. RF patent 20062123, A 61 K 6/02, 7/26. Publ. in bull. 2, 1/30/94.

 3. RF patent 2090181, A 61 K 7/16. Publ. in bull. 09/26/97.

 4. RF patent 2090182, A 61 K 7/16. Publ. in bull. 09/26/97.

 5. V. G. Volynsky et al. Plants in Medicine, Ed. Saratov University, 1989, p. 199-200.

 6. V. G. Volynsky et al. Plants in Medicine, Ed. Saratov University, 1989, p. 168-170.

Claims (1)

A therapeutic and prophylactic composition for treating teeth containing synthetic finely dispersed amorphous silicon dioxide, purified sodium carboxymethyl cellulose, distilled glycerin PK-94, sodium diphosphate 10-water, triclosan, sodium fluoride, titanium dioxide pigment, saccharin, sodium lauryl sulfate and sodium lauryl sulfate , characterized in that it further comprises polydone, water-alcohol-glycerin extracts of calendula and sage, in the following ratios of components, wt.%:
Synthetic finely dispersed amorphous dioxide - 15.20-31.50
Purified sodium carboxymethyl cellulose - 0.62-1.87
Distilled glycerin PK-94 - 21.00-57.00
Sodium diphosphate 10-water - 0.50-5.10
Polydon - 0.20-1.50
Triclosan - 0.20-0.30
Sodium fluoride - 0.10-0.27
Pigment titanium dioxide - 0.20-1.00
Water-alcohol-glycerin marigold extract - 0.10-3.00
Water-alcohol-glyceric sage extract - 0.10-3.00
Saccharin - 0.02-0.15
Sodium lauryl sulfate in terms of 100% - 0.5-2.00
Aromatic composition - 0.60-1.30
Drinking Water - The Rest

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