RU2145209C1 - Curative-prophylactic dental paste - Google Patents

Abstract

FIELD: medicine, stomatology. SUBSTANCE: invention relates to agents used for mouth cavity care. Curative-prophylactic dental paste has synthetic finely dispersed amorphous silicon dioxide, purified carboxymethylcellulose sodium, distilled glycerol, sorbitol, pigmented titanium dioxide, sodium fluoride, saccharin, sodium lauryl sulfate, aromatic composition, water and, additionally, paste has troclozan, nettle and plantain aqueous-alcohol-glycerol extracts. Components are taken at the definite quantitative ratio. Paste protects teeth from caries and inhibits different inflammatory processes arising in gum tissues. EFFECT: enhanced effectiveness of paste. 1 cl, 2 tbl

Description

 The invention relates to medicine, in particular to means for caring for the oral cavity.

Recently, triclosan has been widely used abroad in the production of toothpastes. Examples of toothpastes with triclosan:
- Corsodil, UK. Contains triclosan, sodium fluoride, calcium glycerophosphate:
- Macleans, UK. Contains triclosan, sodium monofluorophosphate, calcium glycerophosphate;
- Colgate total, USA. Contains triclosan, sodium fluoride [1].

 The introduction of triclosan into the composition of these toothpastes helps to prevent the occurrence of inflammatory processes in the oral mucosa, as well as reduce the formation of plaque and tartar.

 The introduction of sodium fluoride, sodium monofluorophosphate and calcium glycerophosphate into toothpastes gives them anticaries properties.

The closest in composition to the claimed therapeutic and prophylactic toothpaste is a therapeutic and prophylactic composition for treating teeth [2] containing traditional components: an abrasive — synthetic finely dispersed amorphous silicon dioxide, a forming thickener — sodium carboxymethyl cellulose, water-retaining substances — glycerol and sorbitol, and anti-caries - sodium fluoride, preservative - sodium benzoate food, sweetener - saccharin, dye - titanium dioxide pigment, cleansing and foaming total - sodium lauryl sulfate, aromatic composition and water in the following proportions, wt.%:
Fine-dispersed synthetic amorphous silica - 17.40 - 22.60
Purified sodium carboxymethyl cellulose - 0.85 - 1.95
Distilled glycerin PK-94 - 19.20 - 25.30
Sorbitol - 15.20 - 23.10
Sodium fluoride - 0.20 - 0.24
Sodium benzoate food - 0.30 - 0.52
Saccharin - 0.06 - 0.10
Pigment Titanium Dioxide - 0.31 - 0.60
Sodium lauryl sulfate (in terms of 100%) - 0.90 - 1.60
Fragrance - 0.90 - 1.00
Water - Else
However, the known paste does not inhibit the growth of microorganisms that can cause disease of the gums and oral mucosa.

 The claimed therapeutic and preventive toothpaste with triclosan contains, in addition to triclosan and sodium fluoride, also extracts of medicinal herbs - nettle and plantain.

 Nettle and plantain extracts include vitamin K, which has a pronounced hemostatic effect, ascorbic acid, pantothenic acid, carotenoids, chlorophyll and flavonoids, tannins. Due to such a rich chemical composition, the extracts have a hemostatic, wound healing, bacteriostatic effect, accelerate the growth of granulation and epithelization of the mucous membranes.

 The multifunctionality of triclosan in combination with the action of active fluoride and herbal extracts effectively protects teeth from caries and prevents the development of various kinds of inflammatory processes that occur in the gum tissue.

The claimed therapeutic and preventive toothpaste in addition to the traditional components: synthetic finely dispersed amorphous silicon dioxide, sodium carboxymethyl cellulose, glycerin, sorbitol, sodium fluoride, sodium benzoate food, saccharin, titanium dioxide pigment, sodium lauryl sulfate, aromatic composition and water additionally contains triclorosilane extracts of nettle and plantain in the following ratio of components, wt.%:
Fine-dispersed synthetic amorphous silica - 13.50 - 25.00
Purified sodium carboxymethyl cellulose - 0.50 - 2.00
Distilled glycerin PK-94 - 6.00 - 18.00
Sorbitol - 15.50 - 43.00
Triclosan - 0.05 - 0.30
Pigment Titanium Dioxide - 0.20 - 1.00
Water-alcohol-glycerin nettle extract (leaf) - 0.20 - 2.50
Water-alcohol-glyceric plantain extract - 0.20 - 2.50
Sodium fluoride - 0.10 - 0.27
Saccharin - 0.02 - 0.15
Sodium lauryl sulfate in terms of 100% - 0.50 - 2.00
Aromatic composition - 0.60 - 1.30
Drinking Water - Else
Triclosan - C ₁₂ H ₁₇ C ₁₂ O ₂
2,4,4'-trichloro-2'-hydroxy-diphenyl ether
Trademark Irgakar MP
Powder with a pleasant faint odor. It is characterized by high antimicrobial activity against oral microbes. Passed rigorous tests for toxicity and environmental friendliness. Easily soluble in most organic solvents.

 Reduces gum infection, eliminates bad breath, does not affect taste, does not change the color of teeth.

 The effectiveness of the use of triclosan in dental products to prevent the formation of plaque and stones is described in numerous studies. Triclosan has a wide spectrum of antimicrobial action on gram-positive and gram-negative bacteria, and is also effective against eukaryotic microorganisms. The anti-inflammatory effect of this active ingredient is associated with its ability to reduce the cytotoxic reactions of sodium lauryl sulfate to human gingival fibroplasts. Thus, the introduction of triclosan into toothpaste helps to reduce gum infection, to eliminate bad breath, without adversely affecting the taste and without changing the color of the teeth.

 The inventive treatment and prophylactic toothpaste is prepared as follows: the components in a prescription amount are loaded into a reactor with a stirrer: first, glycerol, then sodium carboxymethyl cellulose and titanium dioxide are loaded using a vacuum, and the reactor is sealed. After stirring for 10 minutes, sorbitol and water are added, and after stirring for 40 minutes, triclosan, water-alcohol-glycerol extracts of nettle and plantain, sodium fluoride, silicon dioxide, sodium benzoate and saccharin are added to the resulting mixture. Then the mass is homogenized for 150 minutes, dispersed, vacuum at a residual pressure of 50-60 mm RT. Art. and sodium lauryl sulfate and aromatic composition are added.

 Flavoring for toothpaste has a fruity - mint smell.

The whole process of obtaining toothpaste is carried out without heating at a temperature of 18-25 ^o C.

 After pumping the resulting toothpaste into the hopper of the tube filling machine, the paste is packaged in tubes.

 The quality of the toothpaste must comply with the requirements of TU 9158-07-00333776-95.

 The compositions of the therapeutic and prophylactic toothpaste for several examples are shown in table 1.

 In laboratory and semi-industrial conditions, studies were conducted that showed that going beyond the declared amounts of the components used in the direction of reduction will not allow you to get a toothpaste with the desired properties, and going beyond the claimed amounts of the components used in the direction of increasing concentrations leads to a deterioration in the consumer properties of the proposed composition .

 Due to the optimal selection of components, a toothpaste tape is created that has high consumer properties: monolithic, plastic and well cut off.

 An experimental batch of toothpaste has been released.

 On the claimed toothpaste received the conclusion of the Center for preventive dentistry "Profident". The tests were carried out in accordance with the requirements approved by the State Sanitary and Epidemiological Supervision of the Ministry of Health of the Russian Federation.

 The test results of the inventive toothpaste for microbial purity showed a complete absence of bacteria, yeast and molds.

 Toxicological tests showed the absence of acute toxicity when administered orally, the absence of irritating effects on the mucous membranes of the oral cavity and gastrointestinal tract.

 Clinical trials were conducted for 21 days on a group of probans aged 18-25 in the amount of 25 people with the same level of hygiene skills and the absence of organ pathology.

 Selected faces were provided with the same toothbrushes.

 Toothpaste is safe for health, helps to remove plaque, provides effective protection of teeth from caries and strengthens tooth enamel.

Literature
1. US patent N 3911102, CL. A 61 K 7/16
2. RF patent N 2108775, cl. A 61 K 7/16, 1998 (prototype).

 3. Dentistry for everyone. International Dental Review, N 3 - 1998, p. 27l

Claims (1)

Treatment-and-prophylactic toothpaste containing synthetic finely dispersed amorphous silicon dioxide, purified sodium carboxymethyl cellulose, distilled glycerin PK-94, sorbitol, pigment titanium dioxide, sodium fluoride, saccharin, sodium lauryl sulfate, aromatic composition and additionally, it contains three other water-alcohol-glycerin extracts of nettle and plantain in the following ratios of components, wt.%:
Fine-dispersed synthetic amorphous silica - 13.50 - 25.00
Purified sodium carboxymethyl cellulose - 0.50 - 2.00
Distilled glycerin PK-94 - 6.00 - 18.00
Sorbitol - 15.50 - 43.00
Triclosan - 0.05 - 0.30
Pigment Titanium Dioxide - 0.20 - 1.00
Water-alcohol-glycerin nettle extract (leaf) - 0.20 - 2.50
Water-alcohol-glyceric plantain extract - 0.20 - 2.50
Sodium fluoride - 0.10 - 0.27
Saccharin - 0.02 - 0.15
Sodium lauryl sulfate in terms of 100% - 0.50 - 2.00
Aromatic composition - 0.60 - 1.30
Drinking Water - Else

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