RU2173556C1 - Method for treating the cases of mass scale new born kettle dyspepsia - Google Patents

Abstract

FIELD: veterinary medicine. SUBSTANCE: method involves administering 1 l of decimolar glycine (7.5 g/l) heated to body temperature to calf for drinking on empty stomach instead of colostrum (milk, milk substitutes). The animal state is observed during the following day. Diarrhea fails to be stopped until the following feeding, 0.5-0.7 l of the same solution is additionally given to the calf. The calf receives one half of the prescribed ration at the next feeding and then it is allowed to eat the usual ration. EFFECT: enhanced effectiveness in stopping diarrhea of various severity degrees.

Description

 The invention relates to veterinary medicine and is intended to carry out therapeutic measures for mass dyspepsia of young animals in cattle farms and enterprises for the cultivation of factory breeds of cattle.

 Known methods of treating dyspepsia of a newborn young infectious etiology, mainly these methods include: the use of antimicrobials, in particular antibiotic therapy, treatment with sulfonamides and nitrofurans; the use of astringents (tannin, decoction of oak bark), adsorbent substances (activated carbon, dried cuticle powder of the muscular stomach of chickens) in combination with anti-dehydration measures [Mityushin, 1989; Karput, 1990]. Recently, ecologically safe means, for example, probiotics, have become especially popular [Zhirkov, Bratukhin, 1999].

 The action of the above drugs is aimed at the destruction of pathogenic intestinal microflora or at its correction (with probiotic drugs); the effect of binders and adsorbents on the binding and "neutralization" of toxins, in large quantities generated during the disease. Anti-dehydration measures occur in all treatment regimens and are aimed at restoring the body’s water-salt balance.

 However, it should be noted the low effectiveness of astringents and adsorbents, as well as antimicrobial agents, since the intestinal microflora tends to adapt to the latter. When using antibiotics, sulfonamides and nitrofurans, as well as other chemotherapeutic agents, the entire microflora (both pathogenic and normal) of the intestine is partially or completely destroyed, which can be replaced by microscopic fungi (for example, the genus Candidamyces); in addition, the effect of the above drugs is exclusively on the pathogenesis of the disease, in particular on the destruction of the second infection, which appears during the development of diarrhea.

 Dyspeptic disorders of young animals associated with technological stress are usually observed in calves of highly productive (factory) breeds of dairy cattle, poorly adapted to local conditions. Etiopathogenesis in such cases begins with general excitation of the body, which causes excitation of the sympathoadrenal system and, as a result, achlorhydria of the abomasum, which does not lead to the activation of pepsinogen, and feed proteins do not undergo rennet proteolysis. Milk (or its substitute), not having passed the "primary processing" in the abomasum, enters the small intestine. As a result, there is an accelerated evacuation of the semi-digested contents into the intestine and stagnation of the chyme in non-functioning abomasum, and then its decay. All this creates favorable conditions for dysbiosis and intoxication of the body. Moreover, according to Khayrutdinov (1967), rennet juice with a high content of hydrochloric acid has bactericidal properties. Thus, all drugs that do not cause excitation of the abomasum during dyspepsia caused by technological stresses are ineffective.

 Antibiotics, probiotics and various chemotherapeutic drugs alter the microbial spectrum of the intestinal contents, but they do not stimulate the secretion of hydrochloric acid in the abomasum. Ultimately, the healing process is delayed and the calf loses weight. Moreover, it is known that overcoming dyspepsia at an early age further affects the productivity of the animal and its susceptibility to various diseases.

The closest analogue of the proposed method is treatment with probiotics. The latter do not cause the destruction of microorganisms that inhabit the intestines, but only correct the resulting dysbiosis. On top of that, probiotics are immunomodulating agents, since, being introduced into the bloodstream, they contribute to the activation of nonspecific immunity. However, as can be seen from the test results, the use of the probiotic "RAS" alone is not able to relieve the severity of the problem. Although it should be noted the rather high effectiveness of this drug [Zhirkov, Bratukhin, 1999]. The disadvantages of using even highly effective probiotics include their inability to stimulate the activity of ointment cells, the relatively high cost of their production, special storage conditions (at a temperature of 3 - 6 ^o C) and a limited shelf life. All this makes the treatment of dyspepsia of calves probiotics economically disadvantageous.

 The main disadvantage of using antibiotics and other chemotherapeutic drugs (sulfonamides, nitrofurans, etc.) is the relatively fast adaptability of pathogenic intestinal microflora, which makes their use ineffective, and the destruction of normal microflora can lead to further deepening of dysbiosis. Many chemotherapeutic drugs also have cumulative properties (i.e., they can accumulate in the tissues of an animal), which is unsafe from an environmental point of view.

 The aim of the invention is to create the most optimal treatment regimen for newborn young cattle using an environmentally friendly means for mass dyspepsia.

 As noted above, dysbiosis can be a consequence of various causes. But the etiopathogenesis of this disease of a newborn young is often based on achlorhydria, in which proteases of rennet juice (rennin and pepsin) are not activated, as well as inactivation of foreign microflora, which penetrated the digestive tract with food. Therefore, a search was made for a means that can naturally excite the lining cells of the digestive glands of the stomach and thereby normalize rennet proteolysis and prevent intestinal dysbiosis.

 The essence of the proposed method of treatment is that a sick calf at the first sign of an indigestion (refusal to feed, depression, and then frequent bowel movements and diarrhea) on an empty stomach drink 1 liter of decimolar (7.5 g / l) glycine solution, heated to body temperature. This natural amino acid takes the first place in the molar ratio among other amino acids and colostrum amines of the first milk yield [Bakradze, Medvedev, 1977]. If diarrhea cannot be stopped by the next feeding (which is extremely rare), the animal is fed another 0.5 - 0.7 liters of the same solution. In the next feeding, the calf receives half the diet and then it is transferred to a normal diet.

 During the test, the most unfavorable period for this disease was chosen, when only traces of carotene were found in the blood of calves (February - April). The experiments were carried out on newborn black-and-white calves belonging to MTF-2 USP "LUCH" of the Gorodishchensky district of the Volgograd region. Animals in both the experimental and control groups were recruited as they were born; calves were observed until 11 days of age.

 Control group I was treated with methods accepted at the farm: 1. antibiotic therapy (trimerazine, tetracycline); 2. A decoction of horse sorrel prepared in an isotonic NaCl solution. Control group II was treated with probiotic ASD according to the previously described scheme (Zhirkov, Bratukhin, 1999).

 The results were processed by the student method.

 EXAMPLE 1. Calves born from heifers (see table. 1), as a rule, are ill with dyspepsia heavier than animals born from previously lactated cows. A conditional group of calves born from heifers (as they were born) was formed in the amount of 52 animals. When the first signs of dyspepsia appeared, all animals were fed a decimolar glycine solution twice. According to the duration of the disease (in terms of 100 calves), the treatment efficiency in the experimental group was on average 140.0% higher than in control group I, and 83.8% than in control group II; by gain in live weight at 10 days of age, respectively, by 50.8 and 16.4%. Moreover, only 1 calf fell in the experimental group (or 1.9 in terms of 100 goals), which is significantly less than in control groups (15.0 per 100 calves).

 EXAMPLE 2. A conditional group of calves born from previously lactating cows was formed (see Table 2) (as they were born) in the amount of 105 animals. When the first signs of dyspepsia appeared, all animals were fed a decimolar glycine solution once, hypotrophic calves (8 animals) - twice. According to the duration of the disease (in terms of 100 calves), the effectiveness of treatment in the experimental group was higher on average by 124.1% than in control group I, and by 48.7% than in control group II; by increase in live weight at 10 days of age, respectively, by 52.9 and 13.2%. Moreover, in the experimental group there were no cases, while in control groups I and II, 4 (5.3 in terms of 100 animals) and 2 (5.3 in terms of 100 animals) fell.

 Significant advantages of the proposed method for the treatment of dyspepsia of newborn calves caused by technological stress over known analogues include the fact that an environmentally friendly substance acting on etiopathogenesis, glycine, is used as a therapeutic agent. The latter, stimulating the secretion of hydrochloric acid in the abomasum, is metabolized later in the biosynthesis of body proteins.

 Thanks to the proposed method, it was possible to stop diarrhea of varying severity in the bulk of the animals observed. In the event that during the observed period (11 days) there will be a threat of recurrence of dyspepsia, then additional use of antimicrobial or other agents according to known treatment regimens is possible.

Sources of information
1. Mityushin V.V. Dyspepsia of newborn calves. M., "Rosagropromizdat", 1989.

 2. Karput IM Prevention of non-communicable diseases of young animals. M., "Agropromizdat", 1990.

 3. Zhirkov I.N., Bratukhin I.I. The use of the probiotic "PAC" for the correction of dysbiosis in calves. // Veterinary medicine, 1999, N 4. P. 40-42.

 4. Bakradze D.S., Medvedev I.K. Dynamics of the content of free amino acids in colostrum of cows. // Bull. VNIIIFBiP, 1977. Issue. 2 (45), pp.21-23.

 5. Khayrutdinov H.Sh. Rennet secretion of cattle. Tashkent, 1967.

Claims (1)

 A method for the treatment of massive dyspepsia of newborn young cattle, including the correction of achlorhydria of the abomasum, characterized in that with the appearance of the first signs of the disease (depressed state, refusal of food, preceding an increase in bowel movements and diarrhea in the first 10 days of life), animals are treated with an etiopathogenetic agent: instead colostrum (milk, milk replacers) on an empty stomach is drunk 1 liter of decimolar solution of glycine (7.5 g / l), heated to body temperature, and over the next day, monitor the condition eating an animal, if it is not possible to stop diarrhea at the next feeding, then 0.5 - 0.7 l of the same solution is additionally fed, the calf receives half of the diet in the next feeding and then it is transferred to a normal diet and monitored for 11 days, by the end of the observation, stable remission sets in.

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