RU2791325C1 - Therapeutic and preventive agent for farm animals - Google Patents

Abstract

FIELD: veterinary medicine.

SUBSTANCE: invention can be used as a therapeutic and prophylactic agent for normalizing the water and electrolyte balance and regulating the pH of the digestive tract in animals, in particular in young animals, such as calves. Therapeutic and prophylactic agent for the normalization of water and electrolyte balance for farm animals, containing sodium chloride, potassium chloride, glycine, sodium bicarbonate, citric acid, talc and lactose in the following ratio of initial components, % by weight: sodium chloride — 3.5–5.5, potassium chloride — 1.5–2.3, glycine — 3.3–5.0, sodium bicarbonate — 12.2–18.4, citric acid — 7.2–10.8, talc — 0.4–0.6, lactose — 57.4–71.9.

EFFECT: proposed therapeutic and prophylactic agent for normalizing water and electrolyte balance for farm animals has a high degree of restoration of water and electrolyte balance, stimulates digestion, increases overall tone and improves consumption of the therapeutic and prophylactic agent by animals due to its taste.

1 cl, 1 ex

Description

The invention relates to veterinary medicine and can be used as a therapeutic and prophylactic agent for normalizing the water and electrolyte balance and regulating the pH of the digestive tract in animals, in particular in young animals such as calves, lambs, goats, etc.

Known therapeutic and prophylactic Nutrisan containing protein, betaine, fat, fiber, ash, lactose, dextrose; vitamins: A, D3, E; minerals: Na, K, Mg, plant extracts, etc., and Diarax Light containing diatomite, bentonite, acid complex, anticaking agent, sweetener, electrolytes, vitamins, macronutrients, flavor. However, these agents have shown low therapeutic efficacy during production trials.

Known therapeutic and prophylactic agent for farm animals "Rumisol" (patent for the invention of the Russian Federation No. 2547423, IPC A23K 1/175, A61K 33/00, publ. 03/27/2014), containing sodium salts, potassium salts, potassium chloride and an excipient. As sodium and potassium salts, the product contains sodium chloride, potassium chloride, as well as sodium and potassium salts of one or more organic acids selected from the group of ascorbic, formic, acetic, valeric, caprylic, enanthic, malic, tartaric, lactic, oxalic, succinic , propionic, citric, malonic, glutaric acid, and as an auxiliary substance - glucose and / or propylene glycol. The use of a therapeutic and prophylactic agent ensures the restoration of water and electrolyte balance, energy metabolism and the regulation of the pH of the digestive tract in case of animal dyspepsia, ketosis and acidosis of the rumen in cows, sheep and goats, diarrhea of various etiologies, feed intoxications, mycotoxicoses, dehydration, heat stress, water disturbances. -salt balance, provides stimulation of digestion, increase in general tone and increase in milk production.

However, this product contains glucose, which does not have the proper effect on the growth of calves compared to lactose. Glucose breaks down quickly, not providing the body with the necessary energy supply. Also, the disadvantage of the invention is that during the first hour after consumption, organic acid salts are dissolved, and the highest level of volatile acids in the rumen after eating food occurs after 4-6 hours or more. By this time, the added salts of organic acids are utilized in the rumen. Therefore, the effectiveness of the use of small doses of such compounds is minimal, and high doses significantly inhibit feed intake due to the deterioration of its taste properties and adversely affect the growth of microflora and the condition of the rumen mucosa.

Known therapeutic and prophylactic agent for farm animals and birds "Libekrin" (patent for the invention of the Russian Federation No. 2513557, IPC A23K 1/16, publ. 20.04.2014), containing lysine, methionine, zinc, citric acid, chlorides and excipient . The agent additionally contains betaine, fumaric acid, succinic acid, sorbitol and propylene glycol, sodium chloride and potassium chloride as chlorides, and benzyl alcohol and/or purified water as an auxiliary substance.

The disadvantage of this tool is the complexity of the drug from a production point of view, the energy consumption associated with the need for heating during manufacture. The product contains benzyl alcohol, a highly volatile substance, the evaporation of which can irritate the mucous membranes of the eyes and nose. Amino acids (methionine, lysine) and organic acids (succinic and fumaric acid) present in the composition can prevent the absorption of zinc, which is part of the composition, forming complexes with polydentate ligands.

The closest analogue is the therapeutic and prophylactic agent for farm animals and birds "Electrosol" (catalog of veterinary drugs, Interkhimiya, 2007, p. 32), containing glucose, sodium chloride, glycine, sodium phosphate, potassium chloride and sodium citrate.

The disadvantage of this tool is the presence of glucose in the composition, which does not have the proper effect on the growth of calves compared to lactose. Glucose breaks down quickly, not providing the body with the necessary energy supply.

The problem to be solved by the claimed invention is to expand the range of highly effective and safe drugs for veterinary medicine.

The technical result is to obtain a highly effective agent for restoring water and electrolyte balance, as well as providing stimulation of digestion, increasing the overall tone and improving the consumption of the therapeutic and prophylactic agent by animals due to its palatability.

The technical result is achieved by the fact that the therapeutic and prophylactic agent for farm animals contains sodium chloride, potassium chloride, glycine, and additionally includes sodium bicarbonate, citric acid, talc and lactose, in the following ratio of components, in wt.%: sodium chloride - 3, 5-5.5, potassium chloride - 1.5-2.3, glycine - 3.3-5, sodium bicarbonate - 12.2-18.4, citric acid - 7.2-10.8, talc - 0 ,4-0.6 and lactose - 57.4-71.9.

Therapeutic and prophylactic agent for farm animals contains sodium chloride in the ratio of 3.5-5.5 wt.%, potassium chloride - 1.5-2.3 wt.%, sodium bicarbonate - 12.2-18.4 wt.% , glycine - 3.3-5 wt.%, citric acid - 7.2-10.8 wt.%, talc - 0.4-0.6 wt.% and filler - lactose - 57.4-71.9 wt.%.

The most optimal ratio of components is: 4.3 wt.% sodium chloride, 1.9 wt.% potassium chloride, 15.3 wt.% sodium bicarbonate, 4.2 wt.% glycine, 9 wt.% citric acid, 0, 5 wt.% talc and 64.8 wt.% lactose.

Sodium and potassium chloride ensure the normalization of the electrolyte balance. Sodium, chloride and potassium are essential elements for many physiological processes. Sodium is the main cation in extracellular fluid and plays a key role in maintaining osmotic pressure and regulating fluid levels in animals. Other processes, such as neuroconduction and growth, are also highly dependent on the level of sodium and potassium in the blood. Chloride helps to maintain the electrolyte balance of fluids in the body of animals.

Sodium bicarbonate also ensures the normalization of electrolyte balance and regulates the pH of the digestive tract, knocking down acidity.

Glycine stimulates digestion, regulates metabolism and has a protective effect on the intestines. The gut plays a key role in barrier defense in addition to digestion, absorption, and nutrient metabolism.

Citric acid activates the Krebs cycle, which speeds up metabolism, improving metabolism during intoxication, and helps to stimulate digestion.

Against the background of the restoration of water and electrolyte balance and the restoration of the digestive tract, there is an increase in the overall tone.

Talc slows down intestinal motility and promotes water absorption. Also, talc is used for uniform mixing of the powder, reducing the moisture absorption capacity from the outside, maintaining the crumbly form of the powder and quickly dissolving it in water.

Lactose is used as an excipient (filler). Lactose is an energy component, when creating a slightly alkaline environment when the agent is dissolved in water, lactose isomerizes to the main product of lactulose. Lactulose is fermented by lactic acid bacteria in the colon, thereby preventing the growth and reproduction of pathogenic and putrefactive, protein-eating microorganisms.

A method for manufacturing a therapeutic and prophylactic agent for farm animals. The therapeutic and prophylactic agent is prepared by successively mixing the filler, potassium chloride, sodium chloride, sodium bicarbonate, glycine, citric acid and talc, and has a powdery consistency.

A method of using a therapeutic and prophylactic agent for farm animals. Therapeutic and prophylactic agent is given during an illness or during the recovery period after it, individually, orally, mixed with water for drinking. Recommended input rate: 100 g of powder dissolved in 2 liters of pure water.

Production tests of the claimed therapeutic and prophylactic agent and Diaraks Light (Organiko LLC) were carried out in the conditions of Tukaevsky LLC against the background of animal husbandry technologies adopted in the economy, feeding and maintenance conditions.

For the experiment, 2 groups of animals were formed (experimental-15 and control-15). During the experiment, all animals were in the same conditions of feeding and maintenance. The group included calves, which contained animals with signs of dyspepsia, dehydration against the background of diarrhea and disturbances in the water-salt balance. The experiments were carried out on 30 animals.

To test the effectiveness of the use of a feed additive for therapeutic and prophylactic purposes, the calves in the experimental group were orally administered the claimed therapeutic and prophylactic agent (1 time per day at a dose of 100 g per 2 liters of water for 2 days), and the animals of the control group were administered the Diarax Light ", in accordance with the instructions for its use.

The composition of the proposed therapeutic and prophylactic agent, in wt.%: sodium chloride in the ratio of 3.6 wt.%, potassium chloride - 1.6 wt.%, sodium bicarbonate - 12.3 wt.%, glycine - 3.4 wt. %, citric acid - 7.3 wt.%, talc - 0.5 wt.% and lactose - 71.3 wt.%.

As a result of the tests, the claimed therapeutic and prophylactic agent showed high therapeutic efficacy in the treatment of calves with signs of dyspepsia, dehydration against the background of diarrhea and water-salt balance disorders (efficiency 93%). In the control group, where Diarax Light was used, the therapeutic efficacy was 80%. With the timely detection of sick animals, the appointment of a course of treatment of the feed additive according to the instructions, the recovery of the animals occurred within 1-3 days, both in the experimental and in the control groups. Complications during treatment and after the use of the supplement were not observed.

Also, production tests of the proposed therapeutic and prophylactic agent and the Nutrizan agent (Neolight S.A.S. LLC) were carried out.

Means were administered orally to sick animals once a day at a dose of 100 g per 2 liters of water for 1-2 days.

The composition of the proposed therapeutic and prophylactic agent, in wt.%: sodium chloride in the ratio of 4.3 wt.%, potassium chloride - 1.9 wt.%, sodium bicarbonate - 15.3 wt.%, glycine - 4.2 wt. %, citric acid - 9 wt.%, talc - 0.5 wt.% and lactose - 64.8 wt.%.

For the experiment, three groups of calves were formed: control, experimental-1 and experimental-2. The diagnosis was made taking into account anamnestic data, clinical and laboratory studies. In total, in the control (animals with signs of dyspepsia, Nutrizan), experimental-1 (clinically healthy animals, the claimed therapeutic and prophylactic agent) and experimental-2 (animals with signs of dyspepsia, the claimed therapeutic and prophylactic agent) groups, 10 heads were treated. Treatment continued until conditional recovery of the animal.

As a result of the tests, it was found that the animals of the experimental groups had higher survival rates. At the same time, in the experimental-1 group, in which the drug was given for prophylactic purposes, low morbidity and mortality from dyspepsia were noted. And in the experimental-2 group (application for therapeutic purposes), a complete restoration of the water-salt balance, the cessation of signs of dyspepsia and dehydration of the body were noted. In addition, the drug had a positive effect on the growth rate of animals in the experimental groups. The effectiveness of treatment of animals in the control group was 80%, and in the experimental groups it was 100% each.

Thus, the results were obtained confirming the effectiveness of the proposed therapeutic and prophylactic agent, high efficiency in a short time and increased digestibility, and a positive expert opinion by veterinarians of Tukaevsky LLC and Dusym LLC.

Advantages of the claimed invention:

Therapeutic and prophylactic agent for farm animals with a high content of potassium, sodium and glycine helps to stabilize the water and electrolyte balance in calves, lambs, goats, etc., ensures the restoration of energy metabolism and the regulation of the pH of the digestive tract in dyspepsia, ketosis and rumen acidosis in animals, diarrhea of various etiologies, feed intoxications, mycotoxicoses, dehydration, heat stress, stimulates digestion and improves overall tone.

The therapeutic and prophylactic agent is compatible with any feed ingredients, drugs and other feed additives.

Livestock products after the use of a therapeutic and prophylactic agent can be used for food purposes without restrictions.

The therapeutic and prophylactic agent is easily consumed by animals, completely dissolves in water for drinking the animal and does not cause disgust when consumed. When the therapeutic and prophylactic agent is dissolved in drinking water, it becomes sweetish, which favorably affects the animal's appetite, animal consumption improves due to the taste qualities of the therapeutic and prophylactic agent.

Claims (2)

Therapeutic and prophylactic agent for normalizing the water and electrolyte balance for farm animals, containing sodium chloride, potassium chloride, glycine, characterized in that it additionally contains sodium bicarbonate, citric acid, talc and lactose in the following ratio, wt. %: sodium chloride 3.5-5.5 potassium chloride 1.5-2.3 glycine 3.3-5.0 sodium bicarbonate 12.2-18.4 lemon acid 7.2-10.8 talc 0.4-0.6 lactose 57.4-71.9