RU2547423C2 - Medical and preventive agent for farm animals "rumisol" - Google Patents

Abstract

FIELD: veterinary medicine.

SUBSTANCE: medical and preventive agent for farm animals comprises salts of sodium, salts of potassium, potassium chloride and excipient. As salts of sodium and potassium the agent comprises sodium chloride, potassium chloride, and also sodium and potassium salts of one or more organic acids selected from the group of ascorbic, formic, acetic, valeric, octanoic, heptanoic, malic, tartaric, lactic, oxalic, succinic, propionic, citric, malonic, glutaric acid, and as the excipient - glucose and/or propylene glycol. All the components of the medical and preventive agent are taken in a certain ratio.

EFFECT: restoration of water and electrolyte balance, energy metabolism and regulation of pH of the digestive tract in dyspepsia of animals, ketosis and acidosis rumen of cows, sheep and goats, diarrhoea of various aetiologies, feed intoxication, mycotoxicosis, dewatering, heat stress, disorder of water and electrolyte balance, provides stimulation of digestion, increase in the overall tone and increase in milk production.

4 cl, 4 tbl, 4 ex

Description

The invention relates to veterinary medicine and can be used as a therapeutic and prophylactic means for correcting water-electrolyte balance, increasing resistance to heat stress, reducing the risk of feed intoxications and diarrhea of various etiologies, dyspepsia in young animals, prevention and treatment of postpartum complications, ketoses, acid correction Alkaline balance of the gastrointestinal tract in animals, increasing milk production and preservation of animals.

Known feed additive for gobies containing a feed mixture with Krezacin (SU 1655445 A1, 06/15/1991 [1]). The additive improves feed digestibility and reduces unit costs. The disadvantage of the analogue is the narrow specificity of the use of feed additives, only for gobies, and also use only to increase the digestibility of feed.

The closest analogue is a therapeutic and prophylactic agent for farm animals and birds - Electrosol (Catalog of veterinary drugs, Interchemistry, 2007, p.32 [2]). The disadvantage of the closest analogue is the narrow scope of its application - only for correcting fluid and salt losses in the body, restoring water-electrolyte balance, correcting acidosis with diarrhea, poisoning, and thermal damage. In addition, Electrosol contains predominantly inorganic salts of sodium and potassium, in particular sodium chloride and potassium chloride, which increases the risk of poisoning in farm birds, especially chickens, and also contributes to a more rapid change in the pH of the medium during acidosis, which may be accompanied by copious release of carbon dioxide and , in some cases, may lead to the opposite phenomenon.

The objective of the invention is to expand the range of highly effective and safe drugs for veterinary medicine.

The problem is solved in that the therapeutic and prophylactic agent for farm animals contains sodium salts, potassium salts, potassium chloride and an auxiliary substance. Moreover, as sodium and potassium salts it contains sodium and potassium salts of one or several organic acids selected from the group of ascorbic, formic, acetic, valerianic, caprylic, enanthic, malic, tartaric, lactic, oxalic, succinic, propionic, citric, malonic, glutaric acid, and as an adjuvant, glucose and / or propylene glycol and / or water in the following ratio of components, in 1 ml / mg: sodium salts of one or more organic acids selected from the group: ascorbic, ants nitric, acetic, valerianic, caprylic, enanthic, malic, tartaric, lactic, oxalic, succinic, propionic, citric, malonic, glutaric acid 10-800, potassium salts of one or more organic acids selected from the group: ascorbic, formic, acetic, valerianic, caprylic, enanthic, malic, tartaric, lactic, oxalic, succinic, propionic, citric, malonic, glutaric acid 10-800, sodium chloride 10-800, potassium chloride 10-800, excipient - glucose, propylene glycol and / or water 10-800.

The technical result is the restoration of water-electrolyte balance, energy metabolism and regulation of the pH of the digestive tract during dyspepsia of animals, ketosis and rumen acidosis in cows, sheep and goats, diarrhea of various etiologies, feed intoxications, mycotoxicosis, dehydration, heat stress, disturbances in water-salt balance , stimulation of digestion and an increase in general tone, an increase in milk productivity.

This technical result is achieved due to the qualitative and quantitative selection of the components of the claimed funds. In contrast to the closest analogue of Electrosol [2], the composition of the claimed funds (composition) “Rumisol” contains mainly organic sodium salts, a specially selected ratio of sodium, potassium and chlorine. Organic sodium salts (sodium formate (formic acid), sodium acetate (acetic acid), sodium propionate (propionic acid)), organic potassium salts, and also potassium chloride form a buffer medium, which, reacting with acids, neutralizes them and stabilizes the pH of the gastrointestinal tract to physiological parameters. The reaction does not proceed violently, which does not cause side effects (as in the reaction of inorganic salts: sodium bicarbonate with acid), i.e. the reaction of neutralizing acids is not accompanied by the active release of carbon dioxide, foaming of the contents of the stomach, does not cause irritation of the gastric receptors. Anions of formic, propionic and acetic acids create favorable conditions for the development of beneficial lactic acid microflora and reduce the level of pathogenic microflora in animal feed and gastrointestinal tract, stimulate digestion and milk formation. A specially selected ratio of potassium, sodium, and chlorine ions is based on Stuart's theory of strong ion difference, which is determined by the formula Na ⁺ + K ⁺ -Cl ^- . SID is the difference between the sum of strong cations and the sum of strong anions in solution. The higher the SID value, the higher the alkaline properties and the better the acid is neutralized during acidosis. The optimal SID value for successful rehydration and pH correction ranges from 70-80 mmol / L of the prepared solution.

In addition, propylene glycol (1.2 propanediol) was added to the preparation. This substance effectively compensates for the lack of energy in the diet of lactating cows, and is also used for the prevention and treatment of ketosis. The energy value of propylene glycol is 4153.84 kcal or 17.38 mJ of exchange energy. Propylene glycol is quickly and completely absorbed in the rumen and is largely available for intermediate metabolism as a glucoplastic substance, and can be used for glucose synthesis and for direct energy production, is suitable for compensating for a possible energy deficit in the feeding of ruminants, and therefore can be used as an agent against ketosis, leads to an increase in milk yield, the content of fat and protein in milk, maintains the balance of cations (potassium and sodium) and anions (chlorine) in the body.

Glucose is the main and most universal source of energy for metabolic processes. Glucose is involved in the formation of glycogen, nutrition of brain tissue, working muscles. It is a universal antitoxic agent.

Water is a strongly polar solvent of organic and inorganic substances, in which the main biochemical processes of living organisms occur. Serves as a hydrostatic cell skeleton. Due to osmosis, water creates excess pressure inside the cell vacuoles. Due to its large heat capacity - 4200 J / (kg · K) - water provides an approximate temperature constancy inside the cell. Water transfers a large amount of heat, giving it where the temperature of the tissues is lower, and taking it where the temperature is higher.

In a particular embodiment of the claimed invention, the total sodium content may be from 28.75 to 115 mg / ml, potassium from 12.2 to 48.8 mg / ml, chlorine from 22 to 88 mg / ml.

The molar ratio of cations and anions of Na ⁺ , K ⁺ and Cl ^- can be: sodium - from 1.25 to 5.0 mmol / ml, potassium - from 0.3 to 1.24 mmol / ml and chlorine - from 0.625 to 2 5 mmol / ml, respectively.

The molar ratio of cations and anions of Na ⁺ , K ⁺ and Cl ^- in the prepared solution can be from 70 to 80 mmol / L.

Additionally, the claimed tool may contain fillers, solvents, stabilizers, preservatives and / or antioxidants.

In addition, the claimed tool as sodium salts may contain sodium chloride, sodium formate, sodium acetate, sodium propionate, as auxiliary substances - glucose, propylene glycol and water in the following ratio of components in 1 ml / mg: sodium chloride 32.85-40 , 15, sodium formate 38.6-46.75, sodium acetate 76.5-93.5, sodium propionate 54-66, potassium chloride 41.85-51.15, propylene glycol 180-220, glucose 144-176, water up to 1 ml.

Thus, the combined action of all components of the claimed funds allows you to use it not only as an antidiarrheal agent and to restore the water-salt balance, but also with ketoses and acidosis of the rumen in ruminants, to prevent postpartum complications in the uterine population, as well as to increase milk yield .

Table 1 shows comparative data on the use of the claimed funds and prototype.

The technology of obtaining the drug.

To 550 l of purified water (pH from 5.0 to 7.0 pH units), propylene glycol in an amount of 180-220 l and glucose in an amount of 144-176 kg are added. Then sodium chloride is dissolved in an amount of 32.85-40.15 g / L and potassium chloride in an amount of 41.85-51.15 g / L. Dissolution is carried out with stirring for at least 5-7 minutes.

Then, the sodium salts of one or more organic acids in an amount of 38.6-198.15 g / L and the potassium salts of one or more organic acids in an amount of 38.6-198.15 g / L are subsequently dissolved. Dissolution is carried out with stirring for at least 5-7 minutes.

The volume of the drug solution is adjusted to 1000 l with purified water. Set the concentration of hydrogen ions (pH) equal to 6.5-7.5 and then subjected to the prepared filtration solution.

Examples of the implementation of the claimed invention.

Example 1. Tests of the effectiveness of the drug for therapeutic and prophylactic purposes were carried out on 30 newborn piglets, 30 newborn calves and 30 newborn lambs. Young animals of each animal species were divided into 3 groups of 10 animals each. The first group (control) contained clinically healthy animals that did not use any prophylactic and therapeutic agents, and clean water was drunk. The second (experimental) group — clinically healthy animals — was given the drug orally at the rate of: calves - 80 ml per head, pigs - 10 ml per head, lambs - 40 ml per head. The drug was administered prophylactically twice a day, morning and evening. The third (experimental) group, which contained animals with signs of dyspepsia, dehydration against the background of diarrhea and water-salt balance, was given the drug orally from the calculation: calves - 100 ml per head, pigs - 40 ml per head, lambs - 80 ml of the drug on the head. The drug was used for therapeutic purposes twice a day, morning and evening.

The research results are presented in table 2.

As can be seen from table 2, the animals of the experimental groups were distinguished by higher safety indicators. Moreover, in group 2 (experiment), which was prescribed the drug for prophylactic purposes, low morbidity and mortality from dyspepsia were noted. And in group 3 (medical use), an almost complete restoration of the water-salt balance, the cessation of signs of dyspepsia and dehydration of the body were noted.

In addition, the drug had a positive effect on the growth rate of animals of the experimental groups. So in all experimental groups, higher average daily gains relative to the control were noted - an average of 5 to 13%. Studies have confirmed the positive effect of the proposed drug on the body of newborn animals.

Example 2. To test the prophylactic and therapeutic efficacy of the claimed agent for postpartum complications (postpartum bedding, ketoses, acidoses), 50 calving cows were selected, of which 3 groups were formed: one control and two experimental. Animals of the control group (20 animals) did not use any means of preventing postpartum complications. Animals of the 2nd group (20 goals) were used Rumisol for prophylactic purposes from the first day after calving at a dose of 200 ml per head twice a day for 3-5 days. In the 3rd group (10 goals) there were animals in which signs of postpartum complications (ketoses, acidoses, postpartum bedding) were already detected. In animals of this group, the drug was administered orally at a dose of 400 ml per head twice a day for 5 days. According to the results of the application, it was found that out of 10 animals of the first control group, postpartum deposits and 2 signs of ketosis were noted in 2 animals. Among animals of the second group for the entire period of use of the drug and further observation, signs of postpartum complications have not been established. Among the animals of the third group, which were used Rumisol for therapeutic purposes, two cows with signs of ketosis and one with signs of rumen acidosis recovered without the use of additional therapeutic agents. The data obtained indicate a high prophylactic effectiveness of the drug Rumisol for postpartum complications of cows. In addition, a therapeutic effect was established, which manifested itself in the complete recovery of animals.

Example 3. In order to determine the effect of the use of the claimed composition on lactation of cows, two groups of cows were formed by the first calving of 15 animals each. In the experimental group, Rumisol was used from the first day of lactation at a dose of 250 ml per head twice a day for 5 days. In the control group did not use similar means. At the beginning of the tests, the productivity of animals (average daily milk yield per cow) in the experimental group was 18.8 kg, and in the control group - 18.7 kg. 6 days after the start of the drug, the productivity per animal in the experimental group was 22.0 kg, and in the control group - 19.6 kg. Thus, the productivity of animals in the experimental group at the end of the tests was 12% higher than in the control.

A similar experiment was carried out on a livestock of cows 100 days of lactation. In the experimental group (48 goals), Rumisol was used in a dose of 250 ml per head twice a day for 5 days. In the control group (48 goals), no corrective therapy was used. The results are shown in table 3.

According to the data in Table 3, the productivity in animals of the experimental group after application of Rumisoli increased by 13.9%, while in the control it was only 0.6%. Thus, the drug Rumisol has a pronounced stimulating effect on lactation of cows.

Example 4. To study the effect of the claimed funds on metabolism, an experiment was conducted on piglets of the group of rearing at the age of 25-30 days. From the group of animals of 160 animals, two groups of 80 animals were formed. Animals of both groups were characterized by low weight at the beginning of the experiment (average weight of one head - 4.5 kg), slow growth energy. Piglets of the experimental group used Rumisol in a dose of 10-20 ml per head by batching by group method with water for 5 days. In the control group, pure water was evaporated. 10 days after the start of the drug, control measurements were carried out, the results of which are shown in table 4

The results shown in table 4 indicate that the use of the drug Rumisol has a positive effect on metabolic processes in the animal organism, which is manifested by a higher growth rate of piglets of the experimental group.

Thus, the claimed drug has a significant positive therapeutic and preventive effect on the animal organism, namely it improves the water-salt balance, prevents dyspepsia and dehydration, stimulates metabolism, prevents and effectively treats postpartum complications in cows (postpartum deposits, ketosis, acidosis) increases lactation.

The inventive tool is used for newborn calves, lambs, kids, piglets from the first day after birth in order to prevent diarrhea or when the first signs of dyspepsia appear. It is also used for young animals as a prophylactic in heat and feed stresses (transfer from one feed to another, feeding poor-quality feed, etc.), disorders of the gastrointestinal tract. It is used for cows, sheep and goats immediately after childbirth for 3-5 days as a means of preventing postpartum complications, in particular postpartum bedding, as well as ketoses and acidoses. The use of the claimed composition in the initial period of lactation allows you to increase milk yield by 10-13%. It is also used for all age and sex groups of animals when signs of feed intoxication, mycotoxicosis, dehydration, heat stress, disturbances in the water-salt balance appear, to stimulate digestion and increase overall tone.

Table 1 Indicators Rumisol Electric salt Structure sodium chloride - 36.5 mg, Glucose - 280 mg Sodium Chloride - 110 mg sodium formate - 42.5 mg, Glycine - 45 mg Sodium phosphate - 22 g sodium acetate - 85.0 mg sodium propionate - 60.0 mg (in terms of sodium - 57.5 mg), Potassium chloride - 13.5 mg Sodium Citrate - 5 mg potassium chloride - 46.5 mg (in terms of potassium - 24.4 mg), propylene glycol - 200 mg, glucose - 160 mg purified water - up to 1 ml. Biological action restoration of water-electrolyte balance, energy metabolism and regulation of the pH of the digestive tract during dyspepsia of calves and piglets, ketoses and rumen acidosis in cows, sheep and goats, diarrhea of various etiologies, feed intoxications, mycotoxicosis, dehydration, heat stress, disturbances of water-salt balance, to stimulate digestion and increase overall tone, to increase milk productivity Water-electrolyte balance restoration, acidosis correction for diarrhea, poisoning, and heat injuries

table 2 Animal species Calves Piglets Lambs Group 1 (control) 2 (experience prevention) 3 (treatment experience) 1 (control) 2 (experience prevention) 3 (treatment experience) 1 (control) 2 (experience prevention) 3 (treatment experience) The number of animals in the group goal. 10 10 10 10 10 10 10 10 10 The number of cases, goal. 7 2 - 8 0 - 3 one - Number of recovered, goal. 6 2 10 5 0 9 2 one 10 Preservation,% 90 one hundred one hundred 70 one hundred 90 90 one hundred one hundred The average daily gain, g 412 435 428 156.6 175.4 169.9 189 215 200 The average daily increase in% of control - 105.6 103.9 - 112.0 108,5 - 113.8 105.8

Table 3 Group of animals Productivity at the beginning of the experiment, kg Productivity at the end of the experiment, kg The dynamics of productivity growth,% Experience 15.25 17.38 +13.9 The control 12.90 12.98 +0.6

Table 4 Indicator Experienced group Control group Difference experience / control,% The age of the animals at the end of the experiment, days 30-35 30-35 - The weight of the animals at the end of the experiment, kg 5,4 5,0 +8 Preservation,% 97.5 95 +2.5 The average daily gain, g 270 200 +35

Claims (4)

1. Therapeutic and prophylactic agent for farm animals, containing sodium salts, potassium salts and auxiliary substances, characterized in that as sodium and potassium salts it contains sodium chloride, potassium chloride, sodium and potassium salts of one or more organic acids selected from the group ascorbic, formic, acetic, valerianic, caprylic, enanthic, malic, tartaric, lactic, oxalic, succinic, propionic, citric, malonic, glutaric acid, and as excipients - water, glucose and propylene glycol, and the molar ratio of cations and anions of Na ⁺ , K ⁺ and Cl ^- is: sodium - from 1.25 to 5.0 mmol / ml, potassium - from 0.3 to 1.24 mmol / ml and chlorine - from 0.625 up to 2.5 mmol / ml. 2. The tool according to claim 1, characterized in that the total sodium content is from 28.75 to 115 mg / ml, potassium from 12.2 to 48.8 mg / ml, chlorine from 22 to 88 mg / ml. 3. The tool according to claim 1, characterized in that it further comprises fillers, solvents, stabilizers, preservatives and / or antioxidants. 4. The tool according to claim 1, characterized in that the molar ratio of cations and anions Na ⁺ , K ⁺ and Cl ^- (the difference between the strong SID ions) is from 70 to 80 mmol / L.