RU2162844C2 - Производные 7-(2,2,2-трихлор-трет.бутоксикарбонил)-10-гидрокситаксана, способ их получения и промежуточные соединения в синтезе таксанов - Google Patents

Производные 7-(2,2,2-трихлор-трет.бутоксикарбонил)-10-гидрокситаксана, способ их получения и промежуточные соединения в синтезе таксанов Download PDF

Info

Publication number
RU2162844C2
RU2162844C2 RU98113957/04A RU98113957A RU2162844C2 RU 2162844 C2 RU2162844 C2 RU 2162844C2 RU 98113957/04 A RU98113957/04 A RU 98113957/04A RU 98113957 A RU98113957 A RU 98113957A RU 2162844 C2 RU2162844 C2 RU 2162844C2
Authority
RU
Russia
Prior art keywords
general formula
substituted
radical
taxane
side chain
Prior art date
Application number
RU98113957/04A
Other languages
English (en)
Russian (ru)
Other versions
RU98113957A (ru
Inventor
Шантелу Люк
Шово Брюно
Корбэн Кристин
Даль Робер
Ле Гэн Сония
Лами Арно
Лез Антуан
Робэн Жан-Пьер
Original Assignee
Сосьете Д'Этюд э де Решерш Ан Энженьери Фармасетик Серифарм
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сосьете Д'Этюд э де Решерш Ан Энженьери Фармасетик Серифарм filed Critical Сосьете Д'Этюд э де Решерш Ан Энженьери Фармасетик Серифарм
Publication of RU98113957A publication Critical patent/RU98113957A/ru
Application granted granted Critical
Publication of RU2162844C2 publication Critical patent/RU2162844C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
RU98113957/04A 1995-12-27 1996-12-27 Производные 7-(2,2,2-трихлор-трет.бутоксикарбонил)-10-гидрокситаксана, способ их получения и промежуточные соединения в синтезе таксанов RU2162844C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515557A FR2743074B1 (fr) 1995-12-27 1995-12-27 Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes
FR9515557 1995-12-27

Publications (2)

Publication Number Publication Date
RU98113957A RU98113957A (ru) 2000-06-20
RU2162844C2 true RU2162844C2 (ru) 2001-02-10

Family

ID=9486008

Family Applications (1)

Application Number Title Priority Date Filing Date
RU98113957/04A RU2162844C2 (ru) 1995-12-27 1996-12-27 Производные 7-(2,2,2-трихлор-трет.бутоксикарбонил)-10-гидрокситаксана, способ их получения и промежуточные соединения в синтезе таксанов

Country Status (25)

Country Link
US (1) US6180802B1 (cs)
EP (1) EP0889885B1 (cs)
JP (1) JP4068663B2 (cs)
KR (1) KR100510017B1 (cs)
CN (3) CN1244567C (cs)
AT (1) ATE218133T1 (cs)
AU (1) AU716876B2 (cs)
BR (1) BR9612242A (cs)
CA (1) CA2238889C (cs)
CZ (1) CZ20191998A3 (cs)
DE (1) DE69621463T2 (cs)
DK (1) DK0889885T3 (cs)
ES (1) ES2177825T3 (cs)
FR (1) FR2743074B1 (cs)
HK (2) HK1044765B (cs)
HU (1) HUP0000508A3 (cs)
IL (2) IL125049A (cs)
NO (1) NO982719L (cs)
NZ (1) NZ325323A (cs)
PL (1) PL327581A1 (cs)
PT (1) PT889885E (cs)
RU (1) RU2162844C2 (cs)
SK (1) SK88498A3 (cs)
TR (1) TR199801232T2 (cs)
WO (1) WO1997024345A1 (cs)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2437875C2 (ru) * 2006-03-21 2011-12-27 Др. Редди'С Лабораторис Лтд. Полиморфы доцетаксела и способы их получения

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE252569T1 (de) * 1997-05-02 2003-11-15 Pharmachemie Bv Verfahren zur herstellung von baccatin iii und seiner derivate ausgehend von 10-deacetylbaccatin iii.
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
EP2094643B1 (en) 2006-12-01 2012-02-29 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
CA2696856A1 (en) * 2007-08-22 2009-02-26 6570763 Canada Inc. Process for converting 9-dihydro-13-acetylbaccatin iii into docetaxel or paclitaxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
CN115260130A (zh) * 2022-07-07 2022-11-01 上海卓鼎生物技术有限公司 一种10-脱乙酰基紫杉醇的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
WO1995020582A1 (en) * 1994-01-28 1995-08-03 Pharmacia & Upjohn Company Δ12,13-iso-taxol analogs, antineoplastic use and pharmaceutical compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
WO1995020582A1 (en) * 1994-01-28 1995-08-03 Pharmacia & Upjohn Company Δ12,13-iso-taxol analogs, antineoplastic use and pharmaceutical compositions containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2437875C2 (ru) * 2006-03-21 2011-12-27 Др. Редди'С Лабораторис Лтд. Полиморфы доцетаксела и способы их получения

Also Published As

Publication number Publication date
NO982719D0 (no) 1998-06-12
CN1356325A (zh) 2002-07-03
CN1356326A (zh) 2002-07-03
PL327581A1 (en) 1998-12-21
CN1243745C (zh) 2006-03-01
IL125049A0 (en) 1999-01-26
CZ20191998A3 (cs) 1998-09-16
HK1044765A1 (en) 2002-11-01
EP0889885B1 (fr) 2002-05-29
CN1090625C (zh) 2002-09-11
DE69621463D1 (de) 2002-07-04
KR19990076733A (ko) 1999-10-15
HUP0000508A3 (en) 2001-05-28
DK0889885T3 (da) 2002-09-16
CA2238889A1 (fr) 1997-07-10
ES2177825T3 (es) 2002-12-16
BR9612242A (pt) 1999-07-13
DE69621463T2 (de) 2002-11-28
JP2000502696A (ja) 2000-03-07
CN1244567C (zh) 2006-03-08
JP4068663B2 (ja) 2008-03-26
IL138769A (en) 2006-04-10
KR100510017B1 (ko) 2005-12-16
HUP0000508A2 (en) 2000-07-28
IL125049A (en) 2003-10-31
HK1044765B (zh) 2006-09-29
PT889885E (pt) 2002-10-31
EP0889885A1 (fr) 1999-01-13
NO982719L (no) 1998-06-12
CN1206412A (zh) 1999-01-27
TR199801232T2 (xx) 1998-09-21
AU1381597A (en) 1997-07-28
HK1047099B (zh) 2006-09-29
FR2743074A1 (fr) 1997-07-04
US6180802B1 (en) 2001-01-30
AU716876B2 (en) 2000-03-09
WO1997024345A1 (fr) 1997-07-10
CA2238889C (fr) 2008-06-10
ATE218133T1 (de) 2002-06-15
NZ325323A (en) 1999-11-29
FR2743074B1 (fr) 1998-03-27
HK1047099A1 (en) 2003-02-07
SK88498A3 (en) 1998-11-04

Similar Documents

Publication Publication Date Title
US5808113A (en) Preparation of Taxol and docetaxel through primary amines
US20070027207A1 (en) Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
EP1786798B1 (en) One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
AU2003273671A1 (en) Novel taxanes and methods related to use and preparation thereof
RU2162844C2 (ru) Производные 7-(2,2,2-трихлор-трет.бутоксикарбонил)-10-гидрокситаксана, способ их получения и промежуточные соединения в синтезе таксанов
KR20010102444A (ko) 10-데아세틸바카틴 ⅲ으로부터 탁산류의 제조 방법
AU6170696A (en) Paclitaxel synthesis from precursor compounds and methods of producing the same
EP0837846A1 (en) C-2' hydroxyl-benzyl protected, n-carbamate protected (2r,3s)-3-phenylisoserine and production process therefor
KR100545436B1 (ko) 파크리탁셀과 그 동족체의 반합성에 유용한 중간체와 그제조방법
KR100846891B1 (ko) 파클리탁셀의 제조방법
RU2326876C2 (ru) Способ получения паклитаксела
SK1592003A3 (en) Process for the preparation of 14beta-hydroxy-1,14-carbonate- deacetyl baccatin III derivatives and intermediates
US20080262250A1 (en) Semi-Synthesis of Taxane Intermediates and Their Conversion to Paclitaxel and Docetaxel
WO2008032104A1 (en) One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
WO2016098015A1 (en) New efficient methods for the synthesis of taxane derivatives such as docetaxel and their structural analogous, and a method for the preparation thereof

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20091228