RU2134569C1 - Face cream "spyashchaya krasavitsa" - Google Patents

Abstract

FIELD: cosmetology, particularly, creams for face skin care. SUBSTANCE: cream contains lanolin, emulsion wax, distilled monoglycerides, perfume oil, olive oil, triethanolamide, biologically active additive from medicinal leeches, carbomer 150, tocopherol acetate, retinol acetate, ethyl alcohol, methyl ether of paraoxybenzoic acid, propyl ether of paraoxybenzoic acid, flavor and water. EFFECT: higher efficiency. 2 ex

Description

 The invention relates to medicine, namely to cosmetics, and can be used for facial skin care.

 The prototype was taken cream for facial skin care (1).

 The purpose of the invention is to increase the biological activity of the skin, the possibilities of its self-regeneration and improve its hydrant properties.

This goal is achieved by the fact that the composition of the cream contains lanolin, olive oil, triethanolamine, tocopherol acetate, retinol acetate, methyl paraoxybenzoic acid, emulsion wax, ethyl alcohol, perfume and water, distilled monoglycerides are additionally introduced, perfume oil, carbomer 150, biologically active additive from medical leeches in the following ratio of components, wt.%
Lanolin - 0.5 - 1.0
Emulsion wax - 2.0 - 4.0
Distilled monoglycerides - 1.0 - 2.0
Perfume oil - 8.0 - 9.0
Olive oil - 10.0 - 12.0
Dietary supplement - 3.0
Carbomer 150 - 0.2 - 0.4
Tocopherol acetate - 0.3
Retinol Acetate - 0.3
Ethyl alcohol - 2.0 - 3.0
Methyl paraoxybenzoic acid ester - 0.1 - 0.2
Propyl paraoxybenzoic acid ester - 0 - 0.05
Fragrance - Up to 1.0
Water - Up to 100.0
Anhydrous lanolin is added to the cream as a consistent, nutritious, moisture-increasing additive. The introduction of it below 0.5% does not provide the desired consistency and moisture capacity, and above - creates an excessive fat effect.

 Emulsifying mixtures - emulsion wax and monoglycerides distilled in the indicated proportions give the cream high stability, soft texture and uniformity of structure. Changing the quantitative parameters either does not provide primary emulsification, or creates a more dense texture of the cream.

 As a fat component, a mixture of natural olive (can be sunflower, cotton, soybean) oil and perfume oil is used.

 The cream contains a complex of preservatives - ethyl alcohol, methyl and propyl esters of para-hydroxybenzoic acid.

 Their quantitative parameters are explained by the fact that introducing them in a smaller amount does not allow the cream to be kept from rancidity for a long time, and introducing them in a larger amount creates an irritating effect.

 The presence of tocopherol acetate (vitamin E) enhances the stimulating effect of retinol acetate (vitamin A). At the same time, tocopherol acetate is an antioxidant, which helps preserve the hydration properties of the skin.

 The cream formulation contains a dietary supplement isolated from a medical leech. It contains a complex of biologically active substances produced by medical leeches: hirudin, destabilase, a plasma kallikrein inhibitor, hyaluronidase, elastase, collagenase, prostacyclins, esterase, bdellina and aeglin. The additive is introduced into the cream in an amount of 3.0%. It is this concentration of biological additives that beneficially affects the metabolic processes in the skin, contributes to increased penetration of substances into the cell.

 As an astringent component, carbomer 150 was introduced into the cream formulation.

 The choice of the number of components is justified as follows.

 When you enter the number of components below the minimum limit, the consistency of the cream becomes more liquid, which leads to a decrease in the positive effect on the physiological state of the skin due to a decrease in the time of exposure to the skin.

 When you enter the number of components above the upper limit, the consistency of the cream becomes more thick and viscous, which leads to a decrease in its penetrating ability through the skin barrier, which leads to a deterioration in the properties of the cream.

 The cream is prepared as follows. Refractory components: lanolin, emulsion wax, monoglycerides, olive oil and perfume oil are introduced into a melting boiler, heated with steam, equipped with a mixer, and melted.

In a digester with a high-speed stirrer with a capacity of 100 liters, 300 g of carbomer 150 is placed and infused in 75 liters of water at a temperature of 50 ^o C.

Then the aqueous phase is heated in pairs to 70-75 ^o C, alcohol is added here, then the molten fat base is pumped from the melting pot, and pipelines are washed after pumping the molten mass. Emulsification of the cream mass is carried out within 25-30 minutes. Then the mixture is pumped into cooling tanks equipped with a stirrer. After cooling the cream to 50-40 ^° C, the ether and methyl esters of paraoxybenzoic acid and triethanolamine are added to the mass, and after cooling to 40-30 ^° C, the extract of the biologically active additive, and at 25 ^° C, perfume. The cream is left to ripen in a cooled pot with stirring for 4-5 hours. Then pumped to the packaging.

 Experimental and clinical trials of Sleeping Beauty cream have been conducted.

 Example 1

 Experimental studies of creams were carried out on three groups of sexually mature guinea pigs on the usual diet of vivarium. As a control in the III group of animals, a similar cream formulation was used without introducing a biologically active additive. The cream was applied daily, skin for 30 days. The following skin condition indicators were studied in all groups: the content of total soluble protein (according to the Bailey method), the content of total lipids (according to the Huergo method), the content of malondialdehyde, the content of soluble collagen (according to the Dmitrieva method), the effect on proteolytic activity. The irritating and allergenic effect of Sleeping Beauty cream and its subacute toxicity have been investigated.

 The results of a comparative study of long skin applications of the Sleeping Beauty cream and control allowed us to recommend it for clinical trials.

 Example 2

 A clinical study of the cream was carried out on patients aged 45 to 60 years with facial skin sensitive to external influences. Creams were applied daily in the morning and evening for 2 months. As a result of clinical trials, it was found that the cream does not have an allergenic and irritating effect on the skin, has a pleasant texture, is evenly applied to the skin, and is quickly absorbed without leaving a greasy shine. There was no toxic effect on the general condition of the subjects. When assessing the functional parameters of the skin, it was revealed that under the influence of the cream, the index of hydrant properties of the skin surface increased by 41.9%, and the skin elasticity index - by 8.2%.

 When studying microbiological contamination in 1 g of cream, no more than 80 colonies are detected. No pathogenic yeasts and molds, bacteria of the Enterobacteriae family, Stafilacoccus aureus, Preudomonas aeroginosa were found.

 Polarography recorded an increase in oxygen content in various layers of the skin by 9.7%.

 The cream significantly improves the self-regulating ability of the skin. It allows you to restore the level of collagen and elastin, has a softening, nourishing and slight anti-inflammatory effect, helps restore fluid balance in the skin.

Sources of information taken into account:
1. A.S. N 1163858, M. cl. A 61 K 7/00, June 30, 85 Bul. N 24.

Claims (1)

Face cream containing olive oil, emulsion wax, lanolin, perfume, water, tocopherol acetate, retinol acetate, paraoxybenzoic acid methyl ester, ethyl alcohol, characterized in that it additionally contains distilled monoglycerides, perfume oil, triethanolamine, carbomer 150, biologically active additive from a medical leech, propyl paraoxybenzoic acid ester in the following ratio of components, wt.%
Lanolin - 0.5-1.0
Emulsion wax - 2.0-4.0
Distilled monoglycerides - 1.0-2.0
Perfume oil - 8.0-9.0
Olive Oil - 10.0-12.0
Leech Dietary Supplement - 3.0
Triethanolamine - In an amount sufficient to provide the desired cream consistency
Carbomer 150 - 0.2-0.4
Tocopherol acetate - 0.3
Retinol Acetate - 0.3
Ethyl alcohol - 2.0-3.0
Methyl paraoxybenzoic acid ester - 0.1-0.2
Propyl paraoxybenzoic acid ester - Not more than 0.05
Fragrance - Not more than 1.0
Water - Up to 100