RU2116783C1 - Cream for withering skin of face - Google Patents

Abstract

FIELD: medicine, in particular, cosmetic agents; may be used for face skin care. SUBSTANCE: besides auxiliary substances, cream contains biologically active additive separated from medicinal leech. Cream allows to smooth small and middle mimic wrinkles and prevent their formation. The proposed cream prevents early withering of dry skin of face and has soft antiinflammatory action. EFFECT: higher efficiency. 1 tbl

Description

 The invention relates to medicine, namely to cosmetics, and can be used for facial skin care.

 The prototype was taken cream for facial skin care (1).

 The objective of the invention is to increase the gerontological and gerontotherapeutic effectiveness of the cream, by introducing it into the composition of a biologically active additive isolated from a medical leech.

This goal is achieved by the fact that the composition of the cream includes components, with their following ratio, wt.%:
Lanolin - 1.0
Emulsion Wax - 2.5
DEG stearate - 4.0
Distilled monoglycerides - 1.2
Perfume oil - 7.5
Olive Oil - 3.5
Glycerin - 3.0
Dietary supplement isolated from a medical leech - 0.05 - 0.1
Ethyl Alcohol - 2.0
Paraform - 0.05
Methyl paraoxybenzoic acid ester - 0.3
Fragrance - Up to 1.0
Water - Up to 100.0
Anhydrous 1.0% lanolin was added to the cream as a consistent, nutritious, moisture-increasing additive. Introduction below 1.0% does not provide the desired consistency and moisture capacity, and above creates an excessive fat effect.

 Emulsifying mixtures - emulsion wax, glycerol monostearate, distilled monoglycerides in the indicated proportions give the cream high stability, soft texture and uniformity of structure. Changing the quantitative parameters either does not provide primary emulsification, or creates a more dense texture of the cream.

 As a fat component, a mixture of natural olive (can be sunflower, cotton, soybean) oil and perfume oil in the following concentrations: 7.5 and 3.5%. An increase in the amount of fat in this cream leads to poor absorption and a change in its consistency and instability of the emulsion, and a decrease in it leads to a deterioration in the nutritional properties of the cream.

 The cream contains a complex of preservatives: ethyl alcohol, methyl alcohol and propyl alcohol, paraoxybenzoic acid esters, paraforms. Their quantitative parameters are explained by the fact that introducing them in a smaller amount does not allow the cream to be kept from rancidity for a long time, and introducing them in a larger amount creates an irritating effect.

 As an emollient added glycerin distilled in an amount of 3.0%. The introduction of it in the specified amount creates the desired consistency of the cream and the optimal emollient effect.

 The cream formulation contains a dietary supplement isolated from a medical leech. It contains a complex of biologically active substances produced by medical leeches: hirudin, destabilization, a plasma kallikrein inhibitor, hyaluronidase, elastase, collagenase, prostacyclins, esterase, bdellina and aeglin. The additive is introduced into the cream in an amount of 0.05 - 0.1%. It is this concentration of biological additives that beneficially affects metabolic processes in the skin, stimulates not only proliferative processes, but also increases protein synthesis in cells, significantly increases metabolism and soluble collagen content.

 We give a method of obtaining a biologically active additive. Use medical leeches Hirudo medicinalis standard, sexually mature, grown in artificial conditions with a fasting period after feeding from 15 days to 6 months. The leeches and / or their parts are dried by wiping with a soft, moisture-absorbing material, then they are frozen and placed in a standard lyophilized chamber for lyophilization, which is carried out for 12-24 hours until the lyophilisate of medical leeches containing 10-40% of the liquid is obtained. The resulting mass is ground to a powder state, the powder is extracted with water, filtered and the supernatant is used as a biologically active additive. Dietary supplement is introduced in the version of Xenia cream in the amount of 0.1 and in the version of Anthony 0.05.

 The cream is prepared as follows.

 Refractory components: lanolin, emulsion wax, glycerol monostearate, monoglycerides, glycerin, paraoxybenzoic acid ester are introduced into the melting boiler, heated with steam, equipped with a stirrer. A measured amount of a mixture of olive and perfume oils is added.

A measured amount of water is poured into the digester with a high-speed stirrer and heated in pairs to 70 - 75 ^o C, alcohol is added, then the molten fat base is pumped from the melting pot, and the pipelines are washed after pumping the molten mass. The emulsification of the cream mass is carried out for 25-30 minutes, after which the mixture is pumped into cooling tanks equipped with a stirrer. After cooling the cream to 50 - 40 ^o C, steam form is added to the mass, and after cooling to 40 - 30 ^o C - extract of biologically active additives, and at 25 ^o C - perfume. The cream is left to ripen in a cooling boiler with stirring for 4 to 5 hours. Then it is pumped to the packaging.

 Experimental and clinical trials of two versions of the cream were carried out: Xenia cream and Anthony cream. Experimental studies of creams were carried out on three groups of sexually mature guinea pigs on the usual diet of vivarium. As a control in the third group of animals, a similar cream formulation was used, without any biologically active additives. The cream was applied daily, skin for 30 days. The following skin condition indicators were studied in all groups: those containing total soluble protein (according to the Bailey method), the content of total lipids (according to the Huergo method), the content of malondialdehyde, the content of soluble collagen (according to the Dmitrieva method), and the effect on proteolytic activity. The irritating and allergenic effect of Xenia cream and its subacute toxicity have been investigated.

 The results of a comparative study of long skin applications of Anthony and Xenia creams and controls are shown in the table.

 Data from an experimental comparative study allow us to conclude that the proposed Xenia cream slightly increases the level of malondialdehyde in the skin of experimental animals. At the same time, the level of proteolytic activity is slightly lower than when using Anthony cream, which indicates its lower anti-inflammatory activity. At the same time, the indicators of the content of total lipids, soluble protein, soluble collagen are increased when using Xenia cream, both in comparison with the control and with Antonia cream, which indicates greater gerontological and gerontotherapeutic effectiveness of Xenia cream. At the same time, a change in these parameters when using the cream "Anthony", compared with the control, also indicates its gerontological orientation.

 Positive results from a comparative experimental study of creams have allowed clinical trials.

 A clinical study of the cream was conducted on patients aged 45 to 60 years with aging facial skin that is sensitive to external influences. The cream was applied daily in the morning and evening for 2 months. As a result of clinical trials, it was found that the cream does not have an allergenic and irritating effect on the skin, has a pleasant texture, is evenly applied to the skin, and is quickly absorbed without leaving a greasy shine. There was no toxic effect on the general condition of the subjects. When assessing the functional parameters of the skin, it was revealed that under the action of the cream, the index of hydrant properties of the skin surface increased by 38.9%, and the skin elasticity indicator - by 9.2%.

 The use of the cream allows you to smooth out small and medium expression wrinkles, prevent their formation, prevent premature withering of dry skin, has a mild anti-inflammatory effect.

 Both versions of the cream - Anthony cream and Xenia cream (0.05% biologically active additive is added to the Antonia cream formulation and 0.1% of Ksenia cream) have a pleasant smell and texture. It is easily and evenly applied to the skin, quickly absorbed without leaving a greasy film. Creams do not have an allergenic and irritating effect on the skin of the face, do not have a toxic effect on the general condition of the patient.

Claims (1)

A cream for aging skin containing olive oil, glycerin, emulsion wax, lanolin, perfume, water, characterized in that it additionally contains DEG stearate, distilled monoglycerides, perfume oil, ethyl alcohol, paraform, methyl paraoxybenzoic acid ether, dietary supplement isolated from a medical leech, in the following ratio of components, wt.%:
Lanolin - 1.0
Emulsion wax - 2.5
DEG stearate - 4.0
Distilled monoglycerides - 1.2
Perfume oil - 7.5
Olive Oil - 3.5
Glycerin - 3.0
Dietary supplement isolated from a medical leech - 0.05 - 0.1
Ethyl Alcohol - 2.0
Paraform - 0.05
Methyl paraoxybenzoic acid ester - 0.3
Fragrance - Up to 1.0
Water - Up to 100.00

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