RU2132197C1 - Agent possessing antitumor and immunomodulating effect - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: new agent is used for treatment treatment of malignant tumors. It is represented by extract of leaves and flowers of common peach (Persica vulgaris mill). New agent advantage consists in prompt rehabilitation of patients and their recovery, as well as in prolongation of patients' life in late stage of tumoral process. EFFECT: enhanced efficiency of treatment. 1 tbl, 7 ex

Description

 The invention relates to medicine and can be used to treat malignant neoplasms.

 Known antitumor agent containing carotoline, which is an oil extract from the pulp of rose hips and vegetable oil (RF patent N 2007176, A 61 K 35/78, 1994).

 The closest analogue to the present invention is a tool for the prevention and postoperative treatment of malignant neoplasms (its variants), consisting of two tinctures and decoction, which include angelica root, vira root, ephedra grass, plantain grass, step root, decopus root, chaga , ledum, St. John's wort, sandwort, calendula, elecampane root, blueberry leaves, knotweed, horsetail, chicory, rose hips, bee honey (RF Patent N 2027441, A 61 K 35/78, 1995).

The disadvantages of both drugs is their inefficiency in the treatment of tumor patients in the 4th stage of the disease /
The problem is solved in that as an agent with antitumor and immunomodulatory effects, the extract of the leaves and flowers of common peach (Persica vulgaris mill) is used.

 The technical result consists in identifying herbal remedies for the treatment of malignant neoplasms and having immunomodulatory effects.

Based on studies, the leaves and flowers of common peach (Persica vulgaris mill) contain organic acids, tannin, carotenoids and flavonoids, including naringenin C ₁₅ H ₁₂ O ₅ , persicoside C ₂₂ H ₂₄ O ₁₁ . Carotenoids increase the body's overall resistance, promote tissue regeneration, intensify the healing process of wounds, stimulate the immune system. Organic acids with flavonoids have antiseptic, bactericidal and anti-inflammatory effects, reduce body intoxication, soothe pain, and reduce inflammation. Naringenin and persicoside have both a direct effect on tumor cells and indirect. Tannin has a capillary-strengthening, hemostatic effect.

 The preparation technology of the drug "Oleksin" is as follows.

Dry raw materials - the leaves and flowers of common peach are crushed, laid in a steam boiler and extracted with water at a temperature of 95 -100 ^o C for one hour from the moment of boiling. Extraction is carried out in several portions of water. Then all the hoods are drained and infused for 40 minutes at a temperature of 95-100 ^o C. the Combined hood is subjected to cleaning, filtering and evaporation.

 The obtained preparation "Oleksin" is dark brown in color with a pleasant smell of bitter taste, it is soluble in water, forming a solution of amber color. The drug is non-toxic, does not have side effects. Applied in the form of a liquid extract, diluting the obtained extract and preserving it with 20% ethyl alcohol.

 Liquid extract is used 2-3 times a day for 4-10 drops per tablespoon of water 1 hour before a meal, depending on the condition of the patient. The term of admission is from 30 days to several years, taking short breaks.

 The results of the use of Oleksin based on medical histories are as follows.

 Patient A., 49 years old. A trial laparotomy was performed in November 1993 for pancreatic cancer. Diagnosis: pancreatic cancer, stage IV.

2.02.94, objectively: the patient is exhausted (weight loss 25 kg), indifference, skin with a yellowish tint, the stomach is hard, painful, does not get out of bed, the temperature is 38 - 39 ^o C, the patient takes drugs (Promedol). After taking Oleksin, 10 drops 3 times a day, 3 days later sharp pains and nausea disappeared, after a week there was an appetite, after a month the temperature returned to normal. To date, "Oleksin" takes 7 drops 2 times a day. The condition is satisfactory.

 Patient N., 49 years old. Diagnosis: sarcoidosis of the II degree. Three-month conservative treatment with generally accepted methods did not give positive results. Treatment with Oleksin was carried out from February 1990 to January 1991. In the early days of treatment with the drug, profuse sputum appeared, which went away for a long time without coughing, and well-being improved. As a result of the treatment, shortness of breath, weakness disappeared, the patient stopped sweating. Blood tests are normal. In 1992, deregistered. In 1995, surveyed in February. The conclusion of the radiologist; there are no data on pathology.

 Patient L., 44 years old. In 1978, she underwent a right-sided mastectomy for cancer of the right breast. In 1982, the patient complained: weakness, dizziness, lack of appetite, nausea, abdominal pain, in the right side of the chest, dry cough, shortness of breath, did not get out of bed.

 An X-ray examination in the right lung revealed a blackout of 1.5 x 3.5 cm. Diagnosis: metastasis of cancer of the right lung. Operations are not subject. After a 6-month course of treatment with Oleksin, the pain in the right side of the chest disappeared, a cough occurred, blood tests improved, she arrived in weight by 4 kg. An X-ray examination in the right lung showed no shadow. Lives in Perm.

 Patient V., 66 years old. In December 1982, a subtotal palliative gastric resection with a large omentum was performed. Diagnosis: gastric mucosa. After the operation, the condition improved slightly, but from the end of March 1983 the pain in the epigastric region and in the right hypochondrium intensified, weakness, nausea, burping rotten began to grow, there was an aversion to food, shortness of breath. After a course of taking the drug, pain in the epigastric region decreased, nausea, burping rotten, weakness, shortness of breath, appetite appeared, the patient arrived in weight. Conclusion of a radiologist in December 1987: an operated stomach with satisfactory anastomotic function. Blood test: hemoglobin - 80, leukocytes - 5.6, eosis - 2%, lymphocytes - 32%, ESR - 12 mm / h. He lives in Perm.

 Patient R., 78 years old, diagnosis: cancer of the body of the stomach, saucer form on the background of chronic gastric ulcer. She refused the proposed operation. After a 6-month course of treatment with Oleksin, pain, nausea, weakness disappeared, appetite appeared, stool returned to normal, the patient arrived in weight. Blood tests: hemoglobin - 74, white blood cells - 6.3, ESR - 27. Conclusion of the radiologist: no organic changes in the stomach were found, signs of relapse and metastases were not detected.

 Patient I., 8 years old, diagnosis: lymphoblastic leukemia. From 10.10.90 to 02.28.91, inpatient treatment - a course of chemotherapy. Since March 4, 91, he has been undergoing treatment with Oleksin to the present. As a result, bruises, lethargy, drowsiness disappeared on the body, appetite appeared, the liver decreased to normal sizes, arrived in weight. Blood tests: hemoglobin - 130, white blood cells - 5.8, lymphocytes - 7, ESR - 15, eosinophils - 2, blasts in the bone marrow are absent. Throughout the course of treatment, crises did not occur. ARI and ARVI were not sick.

 Patient K., 5 years old. Since 1988, the girl was repeatedly treated for hemolytic anemia. In May 1990, a splenectomy was performed. In August 1990, against the backdrop of acute respiratory viral infections, the crisis again, in-patient treatment with conventional therapy. The girl is sluggish, bruises, cough, runny nose are visible on her body, she eats poorly, complains of pain in her head. After the course of taking Oleksin, bruises, cough, runny nose, headaches disappeared on the body, a good appetite appeared, and blood tests improved. For 5 years, she regularly took the drug 2 drops per 1 tablespoon of water. During this time, acute respiratory infections and acute respiratory viral infections did not hurt, no crises arose, no other therapy was carried out. Disability removed. Blood tests from 08/18/94; hemoglobin - 130, white blood cells - 5.8, ESR - 8.

 The table shows the results of clinical observations for some malignant neoplasms in patients in the 4th stage.

 The drug "Oleksin" has a wide therapeutic spectrum of action, acts on the body as a whole, enhances its own defenses, with which it fights against a growing tumor, enhances the immune response, weakens endogenous intoxication, is convenient to use, does not have side effects, to it no addiction. The drug is applicable to extremely severe patients. Most effective in the treatment of patients with gastric cancer. The use of "Oleksin" makes it possible to reduce postoperative complications, promotes rapid rehabilitation of patients, lasting healing and prolongs the life of patients in the late stage of the tumor process. The softness and versatility of the action of the drug allows its successful use in the treatment of pulmonary tuberculosis, diseases of the gastrointestinal tract, colds, liver, chronic pancreatitis, and gynecology.

Claims (1)

 The use of an aqueous extract of the leaves and flowers of common peach (Persika vulgaris mill) as an agent with antitumor and immunomodulatory effects.

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