RU2113789C1 - Insecticide preparation "cipam" - Google Patents

Abstract

FIELD: insecticides, veterinary science. SUBSTANCE: the following components are mixed for the preparation preparing, wt.-%: cypermethrin, 0.1-1.0; amitraz, 0.1-1.0; dimethylsulfoxide 0.001-20.0; and polyethylene oxide, the balance. Preparation provides the most effective action on all ectoparasite classes and complete recovery from broad disease spectrum. Preparation shows low toxicity and high effectiveness and can be used against mites, fleas, Trichodectes and other extoparasites. Preparation has fitness time up to 5 years. EFFECT: enhanced effectiveness of preparation.

Description

 The invention relates to veterinary medicine for the treatment of animals from ectoparasites, in particular from ticks, lice, fleas, lice-eaters, and to medicine.

 The known composition of a 4% (DV) aqueous solution of chlorophos for controlling sheep estrosis by treating animals with the method of irrigation of the nasal cavity (Mozgov I.E. Veterinary formulation with the basics of therapy and prevention. Handbook. -M.: Agropromizdat, 1988, p. 352 - 361).

 A disadvantage of the known composition is the high toxicity of chlorophos to animals when using this drug in the specified concentration.

 A known drug is activated creolin, which has an acaricidal effect from the causative agents of sheep psoroptosis. The method of its production includes mixing a medicinal product with coal oil and an emulsifier (Tretyakov A.D. Veterinary drugs. Handbook. - M.: Agropromizdat, 1985, p. 116 - 117, 249).

 This drug is toxic, contains exceeding the permissible norms (3%) of a harmful active substance - a pesticide - the gamma isomer of hexochloran, which negatively affects the body of an animal and a person.

 Known drug for the treatment and prevention of sheep psoroptosis, containing, wt.%: Coal oil 61.5 - 63.0; rosin 19.8 - 20.3; sodium ichthyol 6.0-6.9; sodium hydroxide 2.3 - 2.6 and the rest water (patent RU N 2074722, class A 61 K 35/06, 03/10/97).

 The specified drug causes toxicosis in animals.

 Known acaricidal preparation containing hexachloran, saponified pitch, rosin, sodium ichthyol and 23-27% caustic solution (ed. St. USSR N 911773, class A 61 K 31/05, 1980).

 The disadvantage of this acaricidal preparation is an unstable state of aggregation, which leads to a decrease in the period of use and effectiveness.

It is known to use 0.1% aqueous cypermethrin emulsion for treating animals from ectoparasites. Cypermethrin (C ₂₂ H ₁₉ Cl ₂ NO ₃ ) is a dense mass of brown color with a specific faint odor (Questions of veterinary toxicology, entomology and deratization. Proceedings of VNIIVS. - M .: 1987, p. 94)
When using a 0.1% emulsion of cypermethrin, a long term is observed for the completion of inflammatory processes after the destruction of ectoparasite larvae on the mucous membranes of the upper respiratory tract.

 The closest is the composition of the insecticidal preparation containing the active substances, wt.%: Cypermethrin 5 - 20; ethanol 7-9; Terpinghydrate 0.4 - 0.6 and auxiliary components else. As auxiliary components, the preparation contains PAV-OP-7 or OP-10, neonol, emulsogen and solvent - nefras or solvent, or a mixture thereof (patent RU N 2028802, class A 61 K 31/045, 1995).

 The specified drug has an insufficient duration of residual action, is ineffective for a number of diseases from ectoparasites, for example, with demodicosis of dogs, etc., and also has insufficiently high shelf life.

 The technical result of the proposed insecticidal preparation is the expansion of the possibilities of using carnivores to combat ectoparasites, increasing the effectiveness of the drug, increasing its shelf life, as well as medical use.

To achieve the technical result, an insecticidal preparation containing the active substance - cypermethrin and auxiliary components, additionally contains the active substance amitraz, and as auxiliary components contains dimethyl sulfoxide and polyethylene oxide in the following ratio, wt.%:
Amitraz - 0.1 - 1.0
Cypermethrin - 0.1 - 1.0
Dimethyl sulfoxide - 0.001 - 20.0
Polyethylene Oxide - Else
When checking the patentability of the invention, it was found that it meets the conditions of industrial applicability, since the indicated insecticidal preparation is effective in treating dogs, cats, fur-bearing animals and other animals with otodectosis (scabies), entomoses (lice, fleas, lice-eaters), with cathedosis in cats, with demodicosis in dogs, as well as for medical purposes. In addition, the shelf life of the drug was increased for 5 years.

 The invention is recognized to be consistent with the conditions of novelty, since the above composition of an insecticidal preparation containing amitraz and cypermethrin as active ingredients, and dimethyl sulfoxide and polyethylene oxide in the above ratio as auxiliary components are not known from the prior art.

 When conducting a comparative analysis, the invention was found to comply with the conditions of an inventive step, since the proposed insecticidal preparation differs from the closest analogue in the content of cypermethrin and amitrase as active substances, and dimethyl sulfoxide and polyethylene oxide in the above ratio as auxiliary components.

 The table shows the following components in wt.% For the preparation of the insecticidal preparation "Tsipam".

 The resulting preparation is a clear, colorless or light yellow liquid with a faint specific odor. The drug "Tsipam" refers to the group of compounds of low toxicity for warm-blooded animals (hazard class 3 according to GOST 12.1.007.-76).

 The drug is used to treat dogs, cats, fur-bearing animals and other animals with otodectosis (scabies), entomoses (lice, fleas, lice-eaters), with knothedrosis in cats, with demodicosis in dogs.

 When otodectosis in the auricle contribute 0.5 to 3 ml, depending on the size of the animal. The outer and inner surfaces of the ears are wiped with a swab moistened with the drug, the treatment is carried out 2 times with an interval of 6 to 7 days until complete recovery.

With entomoses, to destroy fleas, lice, animal lice, they are treated with the drug at the rate of 0.5 ml per 30 dm ² . The drug is applied in a thin stream to the skin under the hairline. After processing, allow the drug to dry, the animal's hair is combed.

When affected by sarcoptoid mites (notoedrosis) of the head, the drug is applied to the affected areas at the rate of 1 - 2 ml per 30 dm ² . Processing is carried out 2 to 3 times with an interval of 6 to 7 days.

For the treatment of dogs with demodicosis, the affected areas of the body are pre-cleaned of crusts and scabs with a swab. On the affected and adjacent areas of healthy skin, the preparation is uniformly applied at the rate of 1 - 2 ml per 30 dm ² . Processing is carried out 2 to 3 times a week until complete recovery.

When fleas are destroyed in rooms where animals are kept, walls are exposed to processing up to 1 m above the floor and floor. The drug is applied in a thin stream at the rate of 15 ml per 6 - 7 m ² . Processing is carried out 2 to 3 times with an interval of 14 days. After treatment, the drug is removed from the surface of the premises in a wet manner.

 Low toxic and effective insecticidal preparation "Tsipam" has a shelf life of up to 5 years.

 The drug provides the most effective effect on all classes of ectoparasites and a complete cure for a wide range of diseases. The auxiliary components used in the preparation contribute to its slow drying, which allows to increase the duration of the action of “Tsipam”.

Claims (1)

An insecticidal preparation containing the active substance cypermethrin and auxiliary components, characterized in that it additionally contains the active substance amitraz, and contains dimethyl sulfoxide and polyethylene oxide as auxiliary components in the following ratio, wt.%:
Cypermethrin - 0.1 - 1.0
Amitraz - 0.1 - 1.0
Dimethyl sulfoxide - 0.001 - 20.0
Polyethylene Oxide - Else

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