RU2298923C2 - Preparation for treating dogs and cats against ectoparasites - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: the suggested preparation includes, weight%: "Proteide" 2-4, honeycomb's cuttings 55-65, lanolin 26-30, castor oil - the rest. The preparation is ecologically pure being of rapid protective action and prolonged residual action.

EFFECT: higher efficiency.

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Description

FIELD OF THE INVENTION

The invention relates to veterinary medicine, in particular to preparations for treating dogs and cats against ectoparasites.

State of the art

Known polymer-insecticidal preparation "Inplast" for prolonging insecticidal activity in wet conditions, the polymer-insecticidal composition includes an insecticide (permethrin or cypermethrin), a plasticizer (dibutyl phthalate, or dioctyl phthalate, or dibutyl sebacinate at a certain ratio of components), and also polyvinyl chloride iron oxide pigment in a final concentration of 0.08-0.12% (RU 2035861, A61K 31/00, 05/27/2005).

The disadvantage of this drug is the complexity of its preparation and the lack of environmental safety.

A known method for treating animal sarcoptoidosis, including treating animals with an acaricidal preparation, wherein the acaricidal preparation is mixed with a gel before treatment, where rare-cross-linked polyacrylic acid or hydroxyethyl cellulose is used as a polymer carrier in the ratio of acaricidal preparation and gel 1: 100-1: 5000, and the resulting preparation is used to treat the affected surface of the animal’s skin by the generally accepted method (RU 2035861, A61D 7/00, 09/10/1999).

The disadvantage of this drug is the complexity of preparing the drug and processing the animal.

The closest in technical essence and the achieved positive effect and adopted by the authors for the prototype is a drug according to the method of treatment and prevention of sarcoptidoses and demodecoses of animals, characterized in that they apply 2-3 times to the affected skin depending on the intensity of the invasion with an interval of 5-6 days pasty composition, including natural beeswax, stearin, castor oil, animal fat, dioctyl phthalate and diazinon in the following ratio of components, wt.%:

Natural Beeswax - 19-30

Stearin - 6-10

Castor Oil - 35

Animal Fat - 7-6

Dioctylphthalate - 18-19

Diazinon - the rest

(see RU 2216327, А61К 31/65, 11/15/2000).

The disadvantage of this drug is that it does not have a long enough residual effect.

Disclosure of invention

The task of the invention is to develop a drug with a quick protective and long-lasting residual effect, environmentally friendly.

The technical result, which can be obtained using the present invention, is reduced to a quick protective effect, environmental cleanliness and long-term residual effect.

The technical result is achieved using a preparation for treating dogs and cats against ectoparasites, including castor oil, the insectoacaricide Proteid (Vodyanov A. Proteid - against ticks // Bulletin of Veterinary Medicine. - 1998. - No. 1. - P. 94 -96) and natural beeswax, while it is additionally equipped with lanolin, and as a beeswax, the bee honeycombs are trimmed in the following ratio of components, wt.%:

"Proteid" 2-4 Bee honeycombs trimmed 55-65 Lanolin 26-30 Castor oil Rest

The essence of the preparation for the treatment of dogs and cats against ectoparasites

As a result of testing the drug’s formulation options, the best option was identified, which includes: Insectoacaricide "Proteid" 2-4%, bee honey trimmings 55-65%, lanolin 26-30%, castor oil 8-12%.

55-65 trimmings of bee honeycombs, 26-30 lanolin are placed in the thermostat at a temperature of 60 ° C (in wt.%), The rest is castor oil, kept until the wax melts, then when stirring, the temperature in the thermostat is reduced to 40 ° C and the proteid is added 2-4. The drug is Packed at a temperature of 40 ° C in plastic tubes with divisions and a piston. The volume of the tubes is 2 cm ³ (for cats) and 5; 10 cm ³ (for dogs), division value 0.2 cm ³ .

The implementation of the invention

Examples of specific performance of the method of preparation of the drug

Example 1

93 wt.% Water is placed in a heat-resistant flask, 2 wt.% Starch is dissolved in it, boiled until thickened, then cooled to room temperature and 2 wt.% Proteid insectoacaricide is added. All mix thoroughly.

The proposed composition for the treatment of dogs and cats - paste. The resulting preparation has a liquid consistency; apply it with a brush to animal hair. Disadvantages: short residual effect; In addition, it has a short shelf life.

Example 2

The ratio of components, wt.%:

"Proteid" 2 Bee honeycombs trimmed  Rest

The proposed composition for treating dogs and cats is a hard pencil. The drug was applied to the skin and coat of dogs and cats. This composition was considered unacceptable: the drug has a too hard consistency and is not applied to the skin and coat of animals, which also reduces its protective properties.

Example 3

The ratio of components, wt.%:

"Proteid" 2 Bee honeycombs trimmed 70 Lanolin Rest

The proposed composition for treating dogs and cats is a pencil. The composition introduced lanolin, which promotes the penetration of "Proteid" into the skin. Despite the softer consistency, the drug is also poorly applied to the skin and coat of animals, and the pencil itself breaks when applied.

Example 4

The ratio of components, wt.%:

"Proteid" 2 Bee honeycombs trimmed fifty Lanolin 28 Castor oil Rest

The proposed composition for treating dogs and cats is a soft pencil. Castor oil is introduced into the composition of the preparation, which has a softening effect on the skin and reduces the irritation caused by the Proteid insectoacaricide. The drug turns out to be a heterogeneous ointment-like consistency.

Example 5

The ratio of components, wt.%:

"Proteid" 2 Bee honeycombs trimmed 55 Lanolin 26 Castor oil Rest

The proposed composition for treating dogs and cats is a soft pencil. The drug is a homogeneous, moderately dense texture. Disadvantages: large, poorly controlled consumption of the drug.

Example 6

The ratio of components, wt.%:

"Proteid" four Bee honeycombs trimmed 65 Lanolin thirty Castor oil Rest

The proposed composition for treating dogs and cats is a pencil. The drug is a homogeneous, moderately dense consistency, is well applied to the skin and coat of dogs and cats in a given dosage, packaged in an applicator, which is a plastic tube with divisions and a piston.

Example 7

The ratio of components, wt.%:

"Proteid" four Bee honeycombs trimmed 70 Lanolin 35 Castor oil Rest

The proposed composition for treating dogs and cats is a pencil. The drug is a homogeneous, moderately dense consistency, is well applied to the skin and coat of dogs and cats in a given dosage. However, this ratio of components leads to a rise in the cost of the drug. The pencil is packaged in an applicator, which is a plastic tube with divisions and a piston.

Testing a drug for treating dogs and cats against ectoparasites

1. To test the proposed drug were formed 2 groups of animals. Each of them included 5 dogs affected by Ixodid ticks of the genus Dermacentor.

For the dogs of the first group, the proposed preparation, which included diazinon as an insectoacaricide, was applied in the withers, chest and along the spine at the rate of 0.2 ml per 10 kg of live weight. Ticks died after 18 hours, and the residual duration was 7 days.

For dogs of the 2nd group, the proposed preparation, which included the Proteid insectoacaricide, was applied in the withers, chest and along the spine at the rate of 0.2 ml per 10 kg of live weight. Ticks died after 12 hours, and the residual duration was 10 days.

Thus, when used in the composition of the proposed drug as an insecto-acaricide "Proteida" compared with diazinon, the duration of the residual action increases from 7 to 10 days.

2. Formed 2 groups of animals. Each of them included 5 dogs affected by Ixodid ticks of the genus Dermacentor.

Dogs of the 1st group were treated with the Proteid insect acacaricide emulsion using large-drop spraying. The death of ticks was observed 6 hours after spraying, and the duration of the residual effect was 7 days.

For dogs of the 2nd group, the proposed preparation, which included the Proteid insectoacaricide, was applied in the withers, chest and along the spine at the rate of 0.2 ml per 10 kg of live weight. Ticks died after 12 hours, and the residual duration was 10 days.

Thus, when using the traditional large-droplet spraying method, the residual action period was 7 days. In addition, when using the emulsion, environmental pollution occurs, there is a risk of colds in the animal, and the method of applying emulsions is laborious. When using the proposed drug, the duration of the residual action increases to 10 days. The drug is easy to dose, convenient to store, the applicator protects the skin of human hands when processing the animal.

3. To test the effectiveness of the proposed drug formed 2 groups of animals. 3 cats affected by fleas of the genus Ctenocephalides were included in each group. On average, up to 30 parasites were found on each animal.

The cats of the first group were treated with a 0.05% Protein emulsion by the bathing method. After treatment after 20 minutes, all three cats showed signs of toxicosis: profuse salivation, uncoordinated movements, then oppression; 1 cat fell. The remaining cats underwent treatment prescribed for poisoning with organophosphorus compounds. Fleas died within one hour. The residual period was 8 days.

For cats of the second group, the proposed drug, which includes the insecticide “Proteid”, was applied in the withers and along the spine at the rate of 0.2 ml per 10 kg of live weight (active substance consumption of 0.12 ml per head). Signs characteristic of organophosphate poisoning were not observed. Active fleas were not observed in animals after 3 hours. The residual period was 10 days.

Thus, the use of the Proteid pesticide by the bathing method for cats is unacceptable, as it leads to poisoning of animals of this species. When using the proposed composition of the drug, there are no signs of poisoning after treatment, in addition, the processing method is less time-consuming compared to the bathing method and provides a longer residual effect.

4. Formed 2 groups of animals. Each included 4 puppies of 3 months of age, affected by lice beetles. Over 50 parasites were found on each animal.

To the puppies of the 1st group, the insecticide “Proteid” was applied in the composition of the oil solution by the “Spot-on” method to the skin in the withers at a dose of 0.1 ml per kg of body weight. Insect death was observed 12 hours after application of the drug; the residual period is 7 days. Animals experienced mild anxiety and burning sensation in the area of application of the drug.

For puppies of the 2nd group, the proposed preparation, which included the Proteid insectoacaricide, was applied in the withers, chest and along the spine at the rate of 0.2 ml per 10 kg of live weight. After 6 hours, no active lice beetles were found in the animals. The residual period was 12 days.

Thus, when applying "Protein" in the composition of the oil solution using the "Spot-on" method, a pronounced local reaction was observed at the site of application of the drug, which was absent during the processing of the proposed drug, with a residual effect of 5 days longer.

The invention in comparison with the prototype and other known technical solutions has the following advantages:

- high insectoacaricidal activity of "Proteid"

- long term residual effects of the proposed drug;

- the exception of allergic reactions;

- a wide range of applications.

Claims (2)

1. A preparation for treating dogs and cats against ectoparasites, including castor oil, insecticide “Proteid” and natural beeswax, characterized in that it is additionally equipped with lanolin, and beeswax trimmings as beeswax in the following ratio of components, wt.% : "Proteid" 2-4 Bee honeycombs trimmed 55-65 Lanolin 26-30 Castor oil Rest 2. The drug according to claim 1, characterized in that the bee trimmings of honeycombs contains residues of honey.