RU2054288C1 - Method of prophylaxis and treatment of acute gastroenteric disease in newborn calves - Google Patents

Abstract

FIELD: veterinary. SUBSTANCE: method involves the use of furazol and, additionally, glucose-citrate blood injected by intraperitoneally or intravenously in the mixture with Ringer solution taken at the ratio 1:1 which is administrated at the dose 15-25 ml/kg animal mass at interval for 36-48 hr, 1-2 times; for treatment - at the dose 20-30 ml/kg animal mass at interval 18-36 hr up to recovery. EFFECT: improved method of prophylaxis and treatment. 2 cl, 2 tbl

Description

 The invention relates to veterinary medicine and can be used for the prevention and treatment of acute gastrointestinal diseases of newborn calves, accompanied by diarrhea and intoxication of the body.

 The pathogenesis of acute digestive disorders in newborn calves includes four groups of interrelated factors of impaired motor and secretory absorption function of the gastrointestinal tract; violations of water-salt metabolism leading to degradation, toxicosis and acidosis of the body; disorders associated with lack of nutrients and a high level of catabolism; disorders associated with exposure to opportunistic microflora, leading to dysbiosis and intoxication.

 Considering the pathogenesis of acute digestive disorders, for the prevention and treatment of diseases that occur as acute gastrointestinal disorders, agents are widely used that promote the restoration of water-salt metabolism and increase the body's resistance, stabilized blood, isotonic alkaline glucose-containing Schappath solution, as well as solutions of salt mixtures according to V.A. Alikayev, V.V. Mityushin and others.

 As antimicrobial agents, antibiotics, sulfonamides, nitrofurans, as well as complex antibacterial agents are widely used.

 Furazole is also promising, containing sulfanilamides, nitrofurans, glucose, vitamins and fodder yeast, which expands the antibacterial spectrum of the drug, and the presence of fodder yeast (containing vitamins, proteins, minerals) stimulates the secretory-enzymatic processes of the gastrointestinal tract, promotes increase non-specific resistance and improves the general condition of the body.

 Improving the effectiveness of treatment and prevention can be ensured by a complex effect on the body aimed at replenishing the animal’s body with nutrients, macro- and microelements, enzymes, hormones, as well as the use of water-salt mixtures that normalize water-salt metabolism and acid-base balance in animals .

 The purpose of the invention is to increase the effectiveness of methods of prevention and treatment.

 To achieve this goal, furazole and, in addition, a medicinal mixture consisting of glucose-citrated blood and Ringer’s water-salt solution in a ratio of 1: 1 are used. For therapeutic purposes, this mixture is used intraperitoneally or intravenously at a dose of 20-30 ml / kg of animal weight with an interval of 18-36 hours.

 In order to prevent acute digestive disorders, glucose-citrated blood in combination with Ringer's solution is used orally or intraperitoneally at a dose of 15-25 ml / kg of animal body weight 1-2 times with an interval of 36-48 hours.

 PRI me R 1. A method for the treatment of acute gastrointestinal diseases of newborn calves.

 On a farm that is disadvantageous in the dispersion and colibacillosis of calves, animals aged 1-7 days are divided into 8 groups according to the principle of analogues (7 experimental and 1 control). The animals of the first four experimental groups are injected with furazole at a dose of 0.8 g / kg of animal weight 2 times a day and at the same time intravenously with an interval of 12 hours until recovery, a mixture of glucose citrate blood with Ringer's water-salt solution in a ratio of 1: 1 in the following doses: the first group 15 ml / kg weight; second 20 ml / kg; third 25 ml / kg; fourth 30 ml / kg. Calves of 5-7 experimental groups are used inside furazole at a dose of 0.8 g / kg of mass and intraperitoneal glucose-citrated blood with Ringer's solution.

Glucose citrate blood is prepared by mixing fresh blood obtained from healthy cows and a glucose citrate diluent (sodium citrate 5.0 g, glucose 5.0 g, distilled water up to 100 ml). Glucose citrate blood is prepared in a ratio of 9: 1 (9 parts of blood + 1 part of diluent). Glyukozotsitratnuyu blood is filled into sterile vials with 250 and 500 yl and stored at 2-4 ^{° C} for 6-8 days.

 Ringer's solution is used in a biofactory production or prepared independently by dissolving the dry ingredients in distilled water, followed by filtration and boiling sterilization. The consumption of ingredients per 1000 ml of solution is, g: calcium chloride 0.1; potassium chloride 0.075; sodium biocarbonate 0.1; sodium chloride 8.0. The solution is stored in sterile vials with a capacity of 250, 500, 1000 ml at room temperature.

 The research results are presented in table 1.

 From the results of the studies it follows that the use of furazole in conjunction with a drug mixture consisting of glucose citrate blood and Ringer’s water-salt solution increases the therapeutic effectiveness of the method by 5-10% compared to the control, completely eliminates the occurrence of relapses and complications. The highest therapeutic effect was observed with the use of the drug mixture at a dose of 20-25 ml / kg of animal body weight.

 PRI me R 2. A method for the prevention of acute gastrointestinal diseases of calves.

 Calves aged 1-7 days in the farm, which is disadvantageous for acute gastrointestinal diseases of calves, are divided into 8 groups of 7 experimental groups and 1 control group, which is used furazole at a dose of 0.4 g / kg of animal weight 2 times a day.

 The calves of the first four experimental groups are treated with furazole and an additional intraperitoneal drug mixture consisting of equal amounts of glucose citrate blood and Ringer’s water-salt solution in the following doses: the first experimental group 15 ml / kg of animal weight, the second 20 ml, the third 25 ml, the fourth 30 ml / kg animal weight with an interval of 36 hours

 Calves of 5-7 experimental groups use a medicinal mixture of glucose-citrated blood with Ringer’s water-salt solution inside.

 Furazol calves of the control group (40 goals) are used in a dose of 0.4 g / kg of animal weight. The method of preparation of glucose-citrated blood and Ringer's solution, as in example 1.

 The research results are presented in table.2.

 The test results (table 2) show that the most optimal is the use of a medicinal mixture of glucose citrate blood with water-salt solution of Ringer in doses of 15-25 ml.

 The use of Ringer's solution with glucose-citrate solution has a new effect of enhancing protective and adaptive mechanisms and antitoxic activity due to improved hemodynamics and eliminating dehydration of the body when using Ringer's solution, which is complemented by a general sedative effect, reinforcing the beneficial effect of glucose on the central and autonomic nervous system and the stimulating effect of vitamins and blood on factors of body resistance.

 The appearance of a new effect due to the synergism of the components used is proved by production tests in various farms of the Non-chernozem zone of the RSFSR.

Claims (2)

 1. METHOD FOR PREVENTION AND TREATMENT OF ACUTE GASTROINTESTINAL DISEASES OF NEWBORN CALVES, including the introduction of furazole, characterized in that, in order to increase efficiency, glucose citrate blood is additionally mixed with Ringer's solution in a ratio of 1: 1.  2. The method according to claim 1, characterized in that glucose-citrated blood with Ringer's solution is administered intraperitoneally or intravenously for treatment, and for prevention, orally or intraperitoneally.

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