RU2019143780A - Наночастица, содержащее ее контрастное вещество для магнитно-резонансной томографии и лигандное соединение - Google Patents
Наночастица, содержащее ее контрастное вещество для магнитно-резонансной томографии и лигандное соединение Download PDFInfo
- Publication number
- RU2019143780A RU2019143780A RU2019143780A RU2019143780A RU2019143780A RU 2019143780 A RU2019143780 A RU 2019143780A RU 2019143780 A RU2019143780 A RU 2019143780A RU 2019143780 A RU2019143780 A RU 2019143780A RU 2019143780 A RU2019143780 A RU 2019143780A
- Authority
- RU
- Russia
- Prior art keywords
- metal
- particle
- nanoparticle
- nanoparticle according
- magnetic resonance
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Composite Materials (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (17)
1. Наночастица, содержащая:
металлосодержащую частицу, содержащую оксид железа; и
лиганд, который связан с атомом металла на поверхности металлосодержащей частицы и представлен формулой (3):
где m представляет собой целое число от 1 до 4, и штриховая линия представляет собой координационную связь с атомом металла на поверхности металлосодержащей частицы.
2. Наночастица по п. 1, в которой лиганд, связанный с атомом металла на поверхности металлосодержащей частицы, является лигандом, представленным формулой (1):
где штриховая линия представляет собой координационную связь с атомом металла на поверхности металлосодержащей частицы.
3. Наночастица по п. 1, в которой m составляет 1, 2 или 4 в формуле (3).
4. Наночастица по любому из пп. 1-3, в которой металлосодержащая частица, содержащая оксид железа, представляет собой частицу оксида железа.
5. Наночастица по любому из пп. 1-4, в которой металлосодержащая частица имеет средний диаметр частицы, составляющий 5 нм или менее.
6. Наночастица по п. 5, в которой металлосодержащая частица имеет средний диаметр частицы, составляющий 4 нм или менее.
7. Наночастица по п. 5, в которой металлосодержащая частица имеет средний диаметр частицы, составляющий 3 нм или менее.
8. Контрастное вещество для магнитно-резонансной томографии, содержащее наночастицу по любому из пп. 1-7.
9. Контрастное вещество по п. 8, причем контрастное вещество представляет собой позитивное контрастное вещество.
10. Применение (3,4-дигидроксифенил)(диметил)(3-сульфонатпропил)аммония для получения наночастицы по п. 2.
11. (3,4-Дигидроксифенил)(диметил)(3-сульфонатпропил)аммоний.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017-126755 | 2017-06-28 | ||
| JP2017126755 | 2017-06-28 | ||
| PCT/JP2018/024416 WO2019004297A1 (ja) | 2017-06-28 | 2018-06-27 | ナノ粒子、これを含む磁気共鳴イメージング用造影剤及びリガンド化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019143780A true RU2019143780A (ru) | 2021-06-25 |
| RU2019143780A3 RU2019143780A3 (ru) | 2021-08-27 |
| RU2767430C2 RU2767430C2 (ru) | 2022-03-17 |
Family
ID=64742350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019143780A RU2767430C2 (ru) | 2017-06-28 | 2018-06-27 | Наночастица, содержащее ее контрастное вещество для магнитно-резонансной томографии и лигандное соединение |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11389550B2 (ru) |
| EP (1) | EP3646888A4 (ru) |
| JP (1) | JP7107532B2 (ru) |
| KR (1) | KR20200018579A (ru) |
| CN (1) | CN110799219B (ru) |
| AU (1) | AU2018292927B2 (ru) |
| BR (1) | BR112019027478A2 (ru) |
| CA (1) | CA3068215A1 (ru) |
| CO (1) | CO2020000940A2 (ru) |
| IL (1) | IL271622A (ru) |
| JO (1) | JOP20190290A1 (ru) |
| MA (1) | MA49521A (ru) |
| MY (1) | MY201491A (ru) |
| PH (1) | PH12019502882A1 (ru) |
| RU (1) | RU2767430C2 (ru) |
| SG (1) | SG11201912664WA (ru) |
| UA (1) | UA125049C2 (ru) |
| WO (1) | WO2019004297A1 (ru) |
| ZA (1) | ZA202000265B (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3124753A1 (en) | 2018-12-27 | 2020-07-02 | Astellas Pharma Inc. | Method for producing nanoparticle having metal particle which contains iron oxide to which one or more hydrophilic ligands are coordination bonded |
| KR20210109574A (ko) * | 2018-12-27 | 2021-09-06 | 아스테라스 세이야쿠 가부시키가이샤 | 나노 입자, 이를 함유하는 자기 공명 영상용 조영제 및 양쪽성 이온 리간드 화합물 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3123542A (en) | 1960-10-13 | 1964-03-03 | Electrolytic marking medium | |
| US20100166664A1 (en) | 2008-12-29 | 2010-07-01 | General Electric Company | Nanoparticle contrast agents for diagnostic imaging |
| US8574549B2 (en) | 2008-12-29 | 2013-11-05 | General Electric Company | Nanoparticle contrast agents for diagnostic imaging |
| JP6063627B2 (ja) | 2008-12-29 | 2017-01-18 | ゼネラル・エレクトリック・カンパニイ | 診断イメージング用のナノ粒子造影剤 |
| US8728529B2 (en) | 2008-12-29 | 2014-05-20 | General Electric Company | Nanoparticle contrast agents for diagnostic imaging |
| US8728440B2 (en) | 2012-08-23 | 2014-05-20 | General Electric Company | Nanoparticulate compositions for diagnostic imaging |
| US9399075B2 (en) | 2008-12-29 | 2016-07-26 | General Electric Company | Nanoparticle contrast agents for diagnostic imaging |
| US9205155B2 (en) | 2009-10-30 | 2015-12-08 | General Electric Company | Treating water insoluble nanoparticles with hydrophilic alpha-hydroxyphosphonic acid conjugates, the so modified nanoparticles and their use as contrast agents |
| KR20130045647A (ko) * | 2011-10-26 | 2013-05-06 | 한국기초과학지원연구원 | 양쪽성 이온으로 코팅된 자기공명영상 조영제 |
| WO2013090601A2 (en) * | 2011-12-16 | 2013-06-20 | Massachusetts Institute Of Technology | Compact nanoparticles for biological applications |
| US8821838B2 (en) | 2012-08-23 | 2014-09-02 | General Electric Company | Nanoparticulate compositions for diagnostic imaging |
| CN104740654B (zh) | 2013-12-30 | 2017-12-29 | 中国科学院化学研究所 | 磁性纳米颗粒磁共振造影剂和增强磁性纳米颗粒弛豫率的方法 |
| HUE046306T2 (hu) | 2014-01-07 | 2020-02-28 | Colorobbia Italiana Spa | Katekollal funkcionalizált mágneses nanorészecskék, elõállításuk és alkalmazásuk |
| JP6471227B2 (ja) * | 2014-09-15 | 2019-02-13 | マサチューセッツ インスティテュート オブ テクノロジー | 磁気共鳴画像法用途のためのナノ粒子 |
| JP6577250B2 (ja) * | 2015-06-02 | 2019-09-18 | 国立大学法人 東京大学 | 複合半透膜 |
| CN106390146A (zh) | 2015-08-03 | 2017-02-15 | 天津大学 | 聚磺酸甜菜碱两性电解质修饰的磁性纳米粒子及其制备方法和应用 |
-
2018
- 2018-06-27 BR BR112019027478-2A patent/BR112019027478A2/pt unknown
- 2018-06-27 UA UAA202000282A patent/UA125049C2/uk unknown
- 2018-06-27 MA MA049521A patent/MA49521A/fr unknown
- 2018-06-27 CN CN201880041378.2A patent/CN110799219B/zh active Active
- 2018-06-27 WO PCT/JP2018/024416 patent/WO2019004297A1/ja active Application Filing
- 2018-06-27 MY MYPI2019007668A patent/MY201491A/en unknown
- 2018-06-27 CA CA3068215A patent/CA3068215A1/en active Pending
- 2018-06-27 KR KR1020207000498A patent/KR20200018579A/ko not_active Application Discontinuation
- 2018-06-27 US US16/624,946 patent/US11389550B2/en active Active
- 2018-06-27 EP EP18823223.5A patent/EP3646888A4/en not_active Withdrawn
- 2018-06-27 JP JP2019526990A patent/JP7107532B2/ja active Active
- 2018-06-27 RU RU2019143780A patent/RU2767430C2/ru active
- 2018-06-27 SG SG11201912664WA patent/SG11201912664WA/en unknown
- 2018-06-27 AU AU2018292927A patent/AU2018292927B2/en active Active
- 2018-12-28 JO JOP/2019/0290A patent/JOP20190290A1/ar unknown
-
2019
- 2019-12-19 IL IL271622A patent/IL271622A/en unknown
- 2019-12-19 PH PH12019502882A patent/PH12019502882A1/en unknown
-
2020
- 2020-01-15 ZA ZA2020/00265A patent/ZA202000265B/en unknown
- 2020-01-27 CO CONC2020/0000940A patent/CO2020000940A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN110799219A (zh) | 2020-02-14 |
| RU2767430C2 (ru) | 2022-03-17 |
| CA3068215A1 (en) | 2019-01-03 |
| CO2020000940A2 (es) | 2020-02-18 |
| KR20200018579A (ko) | 2020-02-19 |
| JPWO2019004297A1 (ja) | 2020-04-30 |
| EP3646888A4 (en) | 2021-04-14 |
| US11389550B2 (en) | 2022-07-19 |
| IL271622A (en) | 2020-02-27 |
| PH12019502882A1 (en) | 2020-10-26 |
| ZA202000265B (en) | 2021-07-28 |
| MY201491A (en) | 2024-02-27 |
| US20200330617A1 (en) | 2020-10-22 |
| BR112019027478A2 (pt) | 2020-07-07 |
| MA49521A (fr) | 2020-05-06 |
| SG11201912664WA (en) | 2020-01-30 |
| CN110799219B (zh) | 2023-01-06 |
| AU2018292927A1 (en) | 2020-02-06 |
| JOP20190290A1 (ar) | 2019-12-19 |
| RU2019143780A3 (ru) | 2021-08-27 |
| UA125049C2 (uk) | 2021-12-29 |
| JP7107532B2 (ja) | 2022-07-27 |
| WO2019004297A1 (ja) | 2019-01-03 |
| EP3646888A1 (en) | 2020-05-06 |
| AU2018292927B2 (en) | 2021-11-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014149886A5 (ru) | ||
| RU2019143780A (ru) | Наночастица, содержащее ее контрастное вещество для магнитно-резонансной томографии и лигандное соединение | |
| JP2015518478A5 (ru) | ||
| JP2015180763A5 (ru) | ||
| CN109417863A8 (zh) | 用于emi屏蔽的二维金属碳化物、氮化物和碳氮化物膜和复合物 | |
| JP2015180767A5 (ru) | ||
| JP2017536332A5 (ru) | ||
| WO2012125693A3 (en) | Multifunctional metal nanoparticles having a polydopamine-based surface and methods of making and using the same | |
| MX2013009212A (es) | Agente de contraste mri para linfografia basada en nanoparticulas de oxido de hierro y metodo para formacion de imagenes del ganglio linfatico usando el mismo. | |
| WO2017131604A3 (en) | Magnetic nanoparticles and magnetorheological fluid comprising same | |
| RU2011126275A (ru) | Контрастные агенты на основе наночастиц для диагностической визуализации | |
| JP2015526527A5 (ru) | ||
| WO2012050810A3 (en) | Shape-controlled magnetic nanoparticles as t1 contrast agents for magnetic resonance imaging | |
| JP2017226652A5 (ru) | ||
| RU2020115068A (ru) | Способ получения нового азотсодержащего соединения или его соли и получение его промежуточного соединения | |
| JP2015157999A5 (ru) | ||
| JP2010079242A5 (ru) | ||
| WO2014197763A8 (en) | Molecular design toward dual-modality probes for radioisotope-based imaging (pet or spect) and mri | |
| PH12019501147A1 (en) | Metallic ore pellets | |
| MX2019007595A (es) | Compuestos de quelato de manganeso basados en tetra-azabiciclo-macrociclos adecuados como agentes de toma de imagenes mri. | |
| JP2014129317A5 (ru) | ||
| JP2015115140A5 (ru) | ||
| ZA202104733B (en) | Nanoparticle, contrast agent for magnetic resonance imaging comprising same and zwitterionic ligand compound | |
| TH2101003774A (th) | อนุภาคนาโน, สารให้ความต่างชัดสำหรับการสร้างภาพเรโซแนนซ์แม่เหล็ก ที่ประกอบรวมด้วย สิ่งเดียวกันนั้นและสารประกอบสวิตเตอไอออนิกลิแกนด์ | |
| Fortin | 13 Nanoparticles for magnetic resonance imaging (MRI) applications in medicine |