JOP20190290A1 - جسيم نانوي، عامل تباين للتصوير بالرنين المغناطيسي يحتوي عليه، ومركب ترابطي - Google Patents

جسيم نانوي، عامل تباين للتصوير بالرنين المغناطيسي يحتوي عليه، ومركب ترابطي

Info

Publication number
JOP20190290A1
JOP20190290A1 JOP/2019/0290A JOP20190290A JOP20190290A1 JO P20190290 A1 JOP20190290 A1 JO P20190290A1 JO P20190290 A JOP20190290 A JO P20190290A JO P20190290 A1 JOP20190290 A1 JO P20190290A1
Authority
JO
Jordan
Prior art keywords
nanoparticle
magnetic resonance
contrast agent
resonance imaging
ligand compound
Prior art date
Application number
JOP/2019/0290A
Other languages
English (en)
Inventor
Daigo Miyajima
Ichio Aoki
Takuzo Aida
Toshiaki Takeuchi
Seunghyun Sim
Original Assignee
Riken
National Institutes For Quantum And Radiological Science And Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riken, National Institutes For Quantum And Radiological Science And Tech filed Critical Riken
Publication of JOP20190290A1 publication Critical patent/JOP20190290A1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Abstract

يتعلق الاختراع الحالي بتوفير جسيم نانوي جديد، عامل تباين للتصوير بالرنين المغناطيسي الذي يحتوي عليه، ومركب ترابطي يستخدم لإنتاج الجسيم النانوي. يتعلق الاختراع الحالي بجسيم نانوي يتضمن: جسيم معدني يحتوي على أكسيد حديد؛ ومركب ترابطي مرتبط بذرة معدنية على سطح الجسيم المعدني ويتم تمثيله بالصيغة (3): حيث تكون m عبارة عن عدد صحيح من 1 إلى 4، ويمثل خط متقطع رابطة تناسقية مع ذرة معدنية على سطح الجسيم المعدني.
JOP/2019/0290A 2017-06-28 2018-12-28 جسيم نانوي، عامل تباين للتصوير بالرنين المغناطيسي يحتوي عليه، ومركب ترابطي JOP20190290A1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2017126755 2017-06-28

Publications (1)

Publication Number Publication Date
JOP20190290A1 true JOP20190290A1 (ar) 2019-12-19

Family

ID=64742350

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2019/0290A JOP20190290A1 (ar) 2017-06-28 2018-12-28 جسيم نانوي، عامل تباين للتصوير بالرنين المغناطيسي يحتوي عليه، ومركب ترابطي

Country Status (18)

Country Link
US (1) US11389550B2 (ar)
EP (1) EP3646888A4 (ar)
JP (1) JP7107532B2 (ar)
KR (1) KR20200018579A (ar)
CN (1) CN110799219B (ar)
AU (1) AU2018292927B2 (ar)
BR (1) BR112019027478A2 (ar)
CA (1) CA3068215A1 (ar)
CO (1) CO2020000940A2 (ar)
IL (1) IL271622A (ar)
JO (1) JOP20190290A1 (ar)
MA (1) MA49521A (ar)
PH (1) PH12019502882A1 (ar)
RU (1) RU2767430C2 (ar)
SG (1) SG11201912664WA (ar)
UA (1) UA125049C2 (ar)
WO (1) WO2019004297A1 (ar)
ZA (1) ZA202000265B (ar)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113227040A (zh) * 2018-12-27 2021-08-06 安斯泰来制药株式会社 纳米颗粒、包含该纳米颗粒的核磁共振成像造影剂及两性离子配体化合物
JOP20210167A1 (ar) 2018-12-27 2023-01-30 Astellas Pharma Inc طريقة لإنتاج جسيم نانوي يشتمل على جسيم معدني يحتوي على أكسيد حديد يرتبط به واحد أو أكثر من المركبات الترابطية الآلفة للماء تناسقيًا

Family Cites Families (16)

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US3123542A (en) 1960-10-13 1964-03-03 Electrolytic marking medium
US8574549B2 (en) 2008-12-29 2013-11-05 General Electric Company Nanoparticle contrast agents for diagnostic imaging
US8728440B2 (en) 2012-08-23 2014-05-20 General Electric Company Nanoparticulate compositions for diagnostic imaging
US9399075B2 (en) 2008-12-29 2016-07-26 General Electric Company Nanoparticle contrast agents for diagnostic imaging
US20100166664A1 (en) 2008-12-29 2010-07-01 General Electric Company Nanoparticle contrast agents for diagnostic imaging
US8728529B2 (en) 2008-12-29 2014-05-20 General Electric Company Nanoparticle contrast agents for diagnostic imaging
ES2647567T3 (es) * 2008-12-29 2017-12-22 General Electric Company Agentes de contraste de nanopartículas para el diagnóstico por imágenes
US9205155B2 (en) * 2009-10-30 2015-12-08 General Electric Company Treating water insoluble nanoparticles with hydrophilic alpha-hydroxyphosphonic acid conjugates, the so modified nanoparticles and their use as contrast agents
KR20130045647A (ko) * 2011-10-26 2013-05-06 한국기초과학지원연구원 양쪽성 이온으로 코팅된 자기공명영상 조영제
WO2013090601A2 (en) * 2011-12-16 2013-06-20 Massachusetts Institute Of Technology Compact nanoparticles for biological applications
US8821838B2 (en) 2012-08-23 2014-09-02 General Electric Company Nanoparticulate compositions for diagnostic imaging
CN104740654B (zh) * 2013-12-30 2017-12-29 中国科学院化学研究所 磁性纳米颗粒磁共振造影剂和增强磁性纳米颗粒弛豫率的方法
WO2015104664A1 (en) * 2014-01-07 2015-07-16 Colorobbia Italia S.P.A. Magnetic nanoparticles functionalized with cathecol, production and use thereof
CA2961358C (en) * 2014-09-15 2023-08-01 Massachusetts Institute Of Technology Nanoparticles for magnetic resonance imaging applications
JP6577250B2 (ja) * 2015-06-02 2019-09-18 国立大学法人 東京大学 複合半透膜
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Also Published As

Publication number Publication date
RU2019143780A3 (ar) 2021-08-27
US20200330617A1 (en) 2020-10-22
CN110799219A (zh) 2020-02-14
RU2019143780A (ru) 2021-06-25
CN110799219B (zh) 2023-01-06
IL271622A (en) 2020-02-27
CO2020000940A2 (es) 2020-02-18
PH12019502882A1 (en) 2020-10-26
AU2018292927A1 (en) 2020-02-06
RU2767430C2 (ru) 2022-03-17
ZA202000265B (en) 2021-07-28
CA3068215A1 (en) 2019-01-03
UA125049C2 (uk) 2021-12-29
US11389550B2 (en) 2022-07-19
MA49521A (fr) 2020-05-06
WO2019004297A1 (ja) 2019-01-03
JPWO2019004297A1 (ja) 2020-04-30
SG11201912664WA (en) 2020-01-30
BR112019027478A2 (pt) 2020-07-07
KR20200018579A (ko) 2020-02-19
AU2018292927B2 (en) 2021-11-25
EP3646888A4 (en) 2021-04-14
JP7107532B2 (ja) 2022-07-27
EP3646888A1 (en) 2020-05-06

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