RU2019110955A - ЛЕЧЕНИЕ НЕХОДЖКИНСКОЙ ЛИМФОМЫ ЛИЛОТОМАБОМ И 177Lu-ЛИЛОТОМАБ САТЕТРАКСЕТАНОМ - Google Patents
ЛЕЧЕНИЕ НЕХОДЖКИНСКОЙ ЛИМФОМЫ ЛИЛОТОМАБОМ И 177Lu-ЛИЛОТОМАБ САТЕТРАКСЕТАНОМ Download PDFInfo
- Publication number
- RU2019110955A RU2019110955A RU2019110955A RU2019110955A RU2019110955A RU 2019110955 A RU2019110955 A RU 2019110955A RU 2019110955 A RU2019110955 A RU 2019110955A RU 2019110955 A RU2019110955 A RU 2019110955A RU 2019110955 A RU2019110955 A RU 2019110955A
- Authority
- RU
- Russia
- Prior art keywords
- lilotomab
- lymphoma
- administration
- satetraksetan
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1069—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from blood cells, e.g. the cancer being a myeloma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16189191.6 | 2016-09-16 | ||
| EP16189191 | 2016-09-16 | ||
| EP17164164.0 | 2017-03-31 | ||
| EP17164164 | 2017-03-31 | ||
| EP17170641 | 2017-05-11 | ||
| EP17170641.9 | 2017-05-11 | ||
| EP17175768.5 | 2017-06-13 | ||
| EP17175768 | 2017-06-13 | ||
| PCT/EP2017/073336 WO2018050851A1 (en) | 2016-09-16 | 2017-09-15 | Treatment of non-hodgkin lymphoma using lilotomab and 177lu-lilotomab satetraxetan |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019110955A true RU2019110955A (ru) | 2020-10-20 |
| RU2019110955A3 RU2019110955A3 (https=) | 2020-11-26 |
Family
ID=59895313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019110955A RU2019110955A (ru) | 2016-09-16 | 2017-09-15 | ЛЕЧЕНИЕ НЕХОДЖКИНСКОЙ ЛИМФОМЫ ЛИЛОТОМАБОМ И 177Lu-ЛИЛОТОМАБ САТЕТРАКСЕТАНОМ |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20190192703A1 (https=) |
| EP (1) | EP3512881A1 (https=) |
| JP (1) | JP2019529433A (https=) |
| KR (1) | KR20190054113A (https=) |
| CN (1) | CN109790219A (https=) |
| AU (1) | AU2017327772A1 (https=) |
| BR (1) | BR112019004838A2 (https=) |
| CA (1) | CA3035268A1 (https=) |
| IL (1) | IL265387A (https=) |
| MX (1) | MX2019003029A (https=) |
| PH (1) | PH12019550033A1 (https=) |
| RU (1) | RU2019110955A (https=) |
| SG (2) | SG11201901672RA (https=) |
| WO (1) | WO2018050851A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102688509B1 (ko) * | 2017-08-04 | 2024-07-24 | 브리스톨-마이어스 스큅 컴퍼니 | [1,2,4]트리아졸로[4,3-a]피리디닐 치환된 인돌 화합물 |
| CN111372613A (zh) * | 2017-11-22 | 2020-07-03 | 诺帝克纳诺维科特公司 | 放射免疫缀合物与其他药物联合治疗非霍奇金淋巴瘤 |
| KR20240083769A (ko) | 2022-12-05 | 2024-06-12 | 김원석 | 휴대할 수 있는 해수 정화 유닛용 물통 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100389825C (zh) * | 1999-08-11 | 2008-05-28 | 拜奥根Idec公司 | 用抗cd20抗体治疗累及骨髓的非霍奇金淋巴瘤患者 |
| NO331080B1 (no) * | 2010-01-29 | 2011-09-26 | Nordic Nanovector As | Radioimmunkonjugater, farmasøytiske sammensetninger og kit omfattende det samme og anvendelse derav |
| BR112014014258A2 (pt) * | 2011-12-13 | 2020-10-27 | Nordic Nanovector As. | molécula de anticorpo que se liga a cd37 humano; anticorpo; molécula de dna; vetor de expressão; célula hospedeira; método para produzir um anticorpo; composição farmacêutica; método de esgotamento de células b que expressam cd37 dentre uma população de células; radioimunoconjugado que se liga a cd37 humano; método de tratamento de uma malignidade de célula b; kit para a produção do radioimunoconjugado; e preparação injetável de anticorpo hh1 quimérico ou humanizado para uso no pré-tratamento de uma malignidade de célula b |
| WO2016138034A1 (en) * | 2015-02-24 | 2016-09-01 | The Regents Of The University Of California | Binding-triggered transcriptional switches and methods of use thereof |
-
2017
- 2017-09-15 SG SG11201901672RA patent/SG11201901672RA/en unknown
- 2017-09-15 RU RU2019110955A patent/RU2019110955A/ru unknown
- 2017-09-15 MX MX2019003029A patent/MX2019003029A/es unknown
- 2017-09-15 CA CA3035268A patent/CA3035268A1/en active Pending
- 2017-09-15 EP EP17768448.7A patent/EP3512881A1/en not_active Withdrawn
- 2017-09-15 US US16/329,661 patent/US20190192703A1/en not_active Abandoned
- 2017-09-15 JP JP2019515291A patent/JP2019529433A/ja active Pending
- 2017-09-15 BR BR112019004838A patent/BR112019004838A2/pt not_active IP Right Cessation
- 2017-09-15 WO PCT/EP2017/073336 patent/WO2018050851A1/en not_active Ceased
- 2017-09-15 AU AU2017327772A patent/AU2017327772A1/en not_active Abandoned
- 2017-09-15 KR KR1020197010585A patent/KR20190054113A/ko not_active Ceased
- 2017-09-15 SG SG10202102588QA patent/SG10202102588QA/en unknown
- 2017-09-15 CN CN201780055437.7A patent/CN109790219A/zh active Pending
-
2019
- 2019-03-07 PH PH12019550033A patent/PH12019550033A1/en unknown
- 2019-03-14 IL IL265387A patent/IL265387A/en unknown
-
2021
- 2021-06-22 US US17/304,541 patent/US20220160907A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PH12019550033A1 (en) | 2019-07-29 |
| CA3035268A1 (en) | 2018-03-22 |
| SG11201901672RA (en) | 2019-03-28 |
| AU2017327772A1 (en) | 2019-03-21 |
| IL265387A (en) | 2019-05-30 |
| RU2019110955A3 (https=) | 2020-11-26 |
| BR112019004838A2 (pt) | 2019-06-04 |
| EP3512881A1 (en) | 2019-07-24 |
| KR20190054113A (ko) | 2019-05-21 |
| US20190192703A1 (en) | 2019-06-27 |
| SG10202102588QA (en) | 2021-04-29 |
| WO2018050851A1 (en) | 2018-03-22 |
| US20220160907A1 (en) | 2022-05-26 |
| MX2019003029A (es) | 2019-09-13 |
| JP2019529433A (ja) | 2019-10-17 |
| CN109790219A (zh) | 2019-05-21 |
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