RU2018127690A3 - - Google Patents
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- RU2018127690A3 RU2018127690A3 RU2018127690A RU2018127690A RU2018127690A3 RU 2018127690 A3 RU2018127690 A3 RU 2018127690A3 RU 2018127690 A RU2018127690 A RU 2018127690A RU 2018127690 A RU2018127690 A RU 2018127690A RU 2018127690 A3 RU2018127690 A3 RU 2018127690A3
- Authority
- RU
- Russia
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
- A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1077—Beam delivery systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1021—Radioactive fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511018353.5 | 2015-12-30 | ||
| CN201511018353 | 2015-12-30 | ||
| PCT/CN2016/111811 WO2017114316A1 (zh) | 2015-12-30 | 2016-12-23 | 用于消除β淀粉样蛋白的中子捕获治疗系统 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018127690A RU2018127690A (ru) | 2020-01-31 |
| RU2018127690A3 true RU2018127690A3 (ru) | 2020-01-31 |
| RU2721284C2 RU2721284C2 (ru) | 2020-05-18 |
Family
ID=58920104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018127690A RU2721284C2 (ru) | 2015-12-30 | 2016-12-23 | СИСТЕМА НЕЙТРОНОЗАХВАТНОЙ ТЕРАПИИ, ПРИМЕНЯЕМАЯ ДЛЯ УДАЛЕНИЯ β-АМИЛОИДНОГО БЕЛКА |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10709783B2 (ru) |
| EP (1) | EP3384960B1 (ru) |
| JP (1) | JP6709284B2 (ru) |
| CN (2) | CN106730414B (ru) |
| RU (1) | RU2721284C2 (ru) |
| TW (1) | TWI607756B (ru) |
| WO (1) | WO2017114316A1 (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3291884T3 (da) | 2015-05-06 | 2021-05-25 | Neutron Therapeuutics Inc | Neutronmål for behandling med boronneutronindfangning |
| CN108440584B (zh) * | 2015-12-30 | 2020-08-07 | 南京中硼联康医疗科技有限公司 | 用于制备和β淀粉样蛋白特异性结合的化合物的中间体的制备方法 |
| US10462893B2 (en) | 2017-06-05 | 2019-10-29 | Neutron Therapeutics, Inc. | Method and system for surface modification of substrate for ion beam target |
| EP3666336B1 (en) * | 2017-08-24 | 2021-06-16 | Neuboron Medtech Ltd. | Neutron capture therapy system |
| CN109464749B (zh) * | 2017-09-07 | 2024-02-23 | 南京中硼联康医疗科技有限公司 | 中子捕获治疗系统 |
| US11517769B2 (en) * | 2019-07-10 | 2022-12-06 | Ricoh Company, Ltd. | Neutron beam transmission adjusting device comprising a neutron beam transmission unit including a neutron reactant, method for producing neutron beam transmission adjusting device, and neutron beam adjusting method |
| WO2023100942A1 (ja) * | 2021-12-02 | 2023-06-08 | 国立大学法人 東京大学 | 光酸素化触媒用化合物及びこれを含有する医薬組成物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5630786A (en) * | 1994-06-27 | 1997-05-20 | Ionix Corporation | Boron neutron capture enhancement of fast neutron therapy |
| RU2191610C2 (ru) * | 2000-04-12 | 2002-10-27 | Медицинский радиологический научный центр РАМН | Способ формирования поглощенной дозы излучения при нейтронной терапии |
| EP1381604B1 (en) * | 2001-04-23 | 2006-12-27 | The Trustees Of The University Of Pennsylvania | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
| JP2006075285A (ja) * | 2004-09-08 | 2006-03-23 | Sharp Corp | 物体の物性または機能を変化させる方法および細胞の生体機能を消失させる方法 |
| CU23592A1 (es) * | 2006-02-28 | 2010-11-11 | Ct Ingenieria Genetica Biotech | Método para prevenir y eliminar las fibrosis y otras formas de depósito patológico en los tejidos aplicando el péptido secretagogo ghrp-6 |
| EP2808020A1 (en) * | 2006-04-21 | 2014-12-03 | The Government Of The United States, As Represented by The Secretary Of Health And Human Services | Beta-Amyloid Pet Imaging Agents |
| JP5054335B2 (ja) * | 2006-07-18 | 2012-10-24 | 株式会社日立製作所 | ホウ素中性子捕捉療法用の医療装置 |
| CN102838532A (zh) * | 2006-11-24 | 2012-12-26 | Ac免疫有限公司 | 用于治疗与淀粉样物质或淀粉样蛋白有关的疾病的吡唑胺和噻唑胺衍生物 |
| JP5490651B2 (ja) * | 2010-09-01 | 2014-05-14 | 住友重機械工業株式会社 | 中性子線照射システム |
| US20130323166A1 (en) * | 2010-09-10 | 2013-12-05 | William Beaumont Hospital | Radiation Therapy for Treating Alzheimer's Disease |
| CN103127530B (zh) * | 2013-01-31 | 2014-09-10 | 中国人民解放军第三军医大学第二附属医院 | 靶向β淀粉样蛋白显像剂的应用 |
| CN103127877B (zh) * | 2013-03-05 | 2015-09-09 | 山东东岳高分子材料有限公司 | 一种含氟表面活性剂及其制备方法 |
| JP6042269B2 (ja) * | 2013-05-22 | 2016-12-14 | 住友重機械工業株式会社 | 中性子捕捉療法装置、及び中性子線の測定方法 |
| CA2913296A1 (en) * | 2013-05-23 | 2014-11-27 | Neurosn, Inc. | Diagnosing and treating alzheimer's disease using annexins with labeled with a radionuclide |
| CN104059028B (zh) * | 2014-06-06 | 2020-10-16 | 北京智博高科生物技术有限公司 | 与Aβ斑块具有亲和力的含手性侧链取代的氟代2-芳基苯并杂环化合物、其制备方法及应用 |
| CN107617169B (zh) * | 2014-12-08 | 2020-02-28 | 南京中硼联康医疗科技有限公司 | 用于中子捕获治疗的射束整形体 |
| EP3032927B1 (en) | 2014-12-08 | 2016-11-09 | Neuboron Medtech Ltd. | A beam shaping assembly for neutron capture therapy |
| CN108440584B (zh) * | 2015-12-30 | 2020-08-07 | 南京中硼联康医疗科技有限公司 | 用于制备和β淀粉样蛋白特异性结合的化合物的中间体的制备方法 |
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2016
- 2016-12-23 JP JP2018529662A patent/JP6709284B2/ja active Active
- 2016-12-23 CN CN201611207790.6A patent/CN106730414B/zh active Active
- 2016-12-23 CN CN201710609356.9A patent/CN108187044B/zh active Active
- 2016-12-23 EP EP16881105.7A patent/EP3384960B1/en active Active
- 2016-12-23 WO PCT/CN2016/111811 patent/WO2017114316A1/zh active Application Filing
- 2016-12-23 RU RU2018127690A patent/RU2721284C2/ru active
- 2016-12-29 TW TW105143856A patent/TWI607756B/zh active
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2018
- 2018-06-18 US US16/010,818 patent/US10709783B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN106730414A (zh) | 2017-05-31 |
| CN108187044B (zh) | 2021-03-09 |
| EP3384960A1 (en) | 2018-10-10 |
| CN106730414B (zh) | 2017-10-10 |
| US10709783B2 (en) | 2020-07-14 |
| EP3384960A4 (en) | 2018-12-19 |
| TWI607756B (zh) | 2017-12-11 |
| WO2017114316A1 (zh) | 2017-07-06 |
| US20180360963A1 (en) | 2018-12-20 |
| JP6709284B2 (ja) | 2020-06-10 |
| RU2018127690A (ru) | 2020-01-31 |
| TW201722441A (zh) | 2017-07-01 |
| CN108187044A (zh) | 2018-06-22 |
| JP2019506915A (ja) | 2019-03-14 |
| RU2721284C2 (ru) | 2020-05-18 |
| EP3384960B1 (en) | 2019-06-05 |