RU2018122564A - Применение флекаинида в качестве антиконнексинового средства и способ потенцирования эффектов психотропных лекарственных средств - Google Patents
Применение флекаинида в качестве антиконнексинового средства и способ потенцирования эффектов психотропных лекарственных средств Download PDFInfo
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Claims (10)
1. Применение Флекаинида в качестве антиконнексинового средства с целью потенцирования эффектов психотропного лекарственного стредства, предпочтительно для повышения эффективности, и/или безопасности, и/или продолжительности действия психотропного лекарственного средства.
2. Применение по п. 1, где указанное психотропное лекарственное средство выбрано из группы, состоящей из: дофаминергических, ГАМК-ергических, адренергических, ацетилхолинергических, серотонинергических, опиоидергических, аденозинергических, ионотропных, гистаминергических психотропных эффекторов; эффекторов моноаминооксидазы (ИМАО), катехол-O-метилтрансферазы, ДОФА-декарбоксилазы; норадренергических и глутаматергических психотропных эффекторов, а также молекул, оказывающих воздействие на систему гипокретинов/орексинов (включая гипокретин-1 и гипокретин-2).
3. Применение по п. 1, где указанное психотропное лекарственное средство выбрано из группы, состоящей из ГАМК-ергических, дофаминергических, норэпинефринергических, серотонинергических, гистаминергических и глутаматергических эффекторов, и эффекторов, оказывающих воздействие на систему гипокретинов/орексинов.
4. Применение по любому из пп. 1-3, где указанное психотропное лекарственное средство выбрано из группы, состоящей из: кофеина, мазиндола, натрия оксибата, питолисанта, амфетамина, метилфенидата, (R)-(бета-аминобензопропил)карбамата моногидрохлорида и армодафинила.
5. Применение по любому из пп. 1-4 с целью потенцирования эффектов, предпочтительно промнестического эффекта и/или эффекта пробуждения, психотропного лекарственного средства, выбранного из группы, состоящей из кофеина, мазиндола, натрия оксибата, питолисанта, амфетамина, метилфенидата, (R)-(бета-аминобензопропил)карбамата моногидрохлорида и армодафинила.
6. Применение по любому из пп. 1-5 с целью повышения эффективности и/или продолжительности действия психотропного лекарственного средства, выбранного из группы, состоящей из кофеина, мазиндола, натрия оксибата, питолисанта, амфетамина, метилфенидата, (R)-(бета-аминобензопропил)карбамата моногидрохлорида и армодафинила.
7. Терапевтическая композиция, включающая флекаинид и по меньшей мере одно психотропное лекарственное средство, которое не является флупиртином.
8. Терапевтическая композиция по п. 7, где указанное психотропное лекарственное средство выбрано из группы, состоящей из ГАМК-ергических, дофаминергических, норэпинефринергических, серотонинергических, гистаминергических и глутаматергических эффекторов, и эффекторов, оказывающих воздействие на систему гипокретинов/орексинов.
9. Терапевтическая композиция по п. 7 или п. 8, где указанное психотропное лекарственное средство представляет собой психотропное лекарственное средство, выбранное из группы, состоящей из: кофеина, мазиндола, натрия оксибата, питолисанта, амфетамина, метилфенидата, (R)-(бета-аминобензопропил)карбамата моногидрохлорида и армодафинила.
10. Применение Флекаинида в качестве антиконнексинового средства с целью лечения расстройства, выбранного из группы, состоящей из: ран, мигреней, инфекционных заболеваний, медикаментозного повреждения печени, индуцированной химиотерапевтическими средствами цитотоксичности и ишемии.
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| RU2016105971A RU2661026C2 (ru) | 2013-07-24 | 2014-07-24 | Применение флекаинида в качестве антиконнексинового средства и способ потенцирования эффектов психотропных лекарственных средств |
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| CA2992162A1 (en) * | 2015-07-15 | 2017-01-19 | Theranexus | Use of amitriptyline for blocking brain hemichannels and method for potentiating its effect in vivo |
| US10744087B2 (en) | 2018-03-22 | 2020-08-18 | Incarda Therapeutics, Inc. | Method to slow ventricular rate |
| WO2019204326A1 (en) * | 2018-04-16 | 2019-10-24 | Alsar Ltd Partnership | Compositions and methods for sustained release of flecainide |
| US20210255198A1 (en) * | 2018-06-11 | 2021-08-19 | The United States of America as Represented by the Department of Veterans Affairs Office | Methods for objective assessment of stress, early detection of risk for stress disorders, matching individuals with treatments, monitoring response to treatment, and new methods of use for drugs |
| US20190381056A1 (en) | 2018-06-17 | 2019-12-19 | Axsome Therapeutics, Inc. | Compositions for delivery of reboxetine |
| EP3593822A1 (en) | 2018-07-13 | 2020-01-15 | Theranexus | Therapeutic and diagnostic applications of a new method of monitoring of neuroglial interaction memri) |
| US11020402B2 (en) | 2018-10-15 | 2021-06-01 | Axsome Therapeutics, Inc. | Use of reboxetine to treat narcolepsy |
| US20200147093A1 (en) | 2018-10-15 | 2020-05-14 | Axsome Therapeutics, Inc. | Use of esreboxetine to treat nervous system disorders such as fibromyalgia |
| US11021410B2 (en) * | 2018-12-10 | 2021-06-01 | Purdue Research Foundation | Layer-wise agglomerated urea granules |
| US11020384B2 (en) | 2019-08-01 | 2021-06-01 | Incarda Therapeutics, Inc. | Antiarrhythmic formulation |
| WO2021025985A1 (en) * | 2019-08-02 | 2021-02-11 | Praxis Precision Medicines, Inc. | Methods of treating substance abuse disorder, dyspnea, tinnitus, and child and adolescent depression |
| CN111018694A (zh) * | 2019-12-12 | 2020-04-17 | 贵州省欣紫鸿药用辅料有限公司 | 一种氟卡尼的生产方法 |
| CN116096900A (zh) * | 2020-05-13 | 2023-05-09 | 阿库斯股份有限公司 | 用于治疗gjb2相关听力损失的组合物和方法 |
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| JP2001253825A (ja) | 2000-03-13 | 2001-09-18 | Masahiko Ichimada | 帯状疱疹後神経痛用鎮痛剤 |
| US7799832B2 (en) * | 2003-10-23 | 2010-09-21 | Valeant Pharmaceuticals North America | Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| KR20080067628A (ko) * | 2005-11-21 | 2008-07-21 | 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 알라바마 포 앤드 온 비하프 오브 더 유니버시티 오브 알라바마 | 신경보호를 위한 소분자 화합물의 사용 방법 |
| JP5960944B2 (ja) * | 2006-11-15 | 2016-08-02 | コーダ セラピューティクス， インコーポレイテッド | 創傷治癒のための改善された方法および組成物 |
| FR2935611B1 (fr) * | 2008-09-10 | 2010-10-15 | Commissariat Energie Atomique | Utilisation d'agents anti-connexines pour moduler l'effet therapeutique de molecules psychotropes |
| WO2012042541A2 (en) | 2010-09-30 | 2012-04-05 | Council Of Scientific & Industrial Research | Method for predicting and modeling anti-psychotic activity using virtual screening model |
| US20130096067A1 (en) | 2011-09-14 | 2013-04-18 | Norbert Perrimon | Drosophila tumor stem cell model and uses thereof |
| EP2586436A1 (en) * | 2011-10-31 | 2013-05-01 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Use of anti-connexin agents for enhancing the therapeutic effect of acetylcholinesterase inhibitor |
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