RU2018118985A3 - - Google Patents
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- RU2018118985A3 RU2018118985A3 RU2018118985A RU2018118985A RU2018118985A3 RU 2018118985 A3 RU2018118985 A3 RU 2018118985A3 RU 2018118985 A RU2018118985 A RU 2018118985A RU 2018118985 A RU2018118985 A RU 2018118985A RU 2018118985 A3 RU2018118985 A3 RU 2018118985A3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
- G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Marine Sciences & Fisheries (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15199555.2 | 2015-12-11 | ||
| EP15199555 | 2015-12-11 | ||
| EP15201752.1 | 2015-12-21 | ||
| EP15201752 | 2015-12-21 | ||
| PCT/EP2016/080671 WO2017098051A2 (en) | 2015-12-11 | 2016-12-12 | Combined preparations of pkm2 modulators and hmgb1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018118985A RU2018118985A (ru) | 2020-01-13 |
| RU2018118985A3 true RU2018118985A3 (ru) | 2020-06-19 |
| RU2768186C2 RU2768186C2 (ru) | 2022-03-23 |
Family
ID=57944370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018118985A RU2768186C2 (ru) | 2015-12-11 | 2016-12-12 | Комбинированные лекарственные средства, содержащие модуляторы pkm2 и hmgb1 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11274132B2 (ru) |
| EP (2) | EP3386529A2 (ru) |
| JP (2) | JP7107839B2 (ru) |
| CN (2) | CN108367049A (ru) |
| AU (2) | AU2016366515A1 (ru) |
| CA (2) | CA3007877A1 (ru) |
| ES (1) | ES2922824T3 (ru) |
| PL (1) | PL3551649T3 (ru) |
| RU (1) | RU2768186C2 (ru) |
| WO (2) | WO2017098051A2 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11274132B2 (en) | 2015-12-11 | 2022-03-15 | Ruprecht-Karls-Universität Heidelberg | Combined preparations of PKM2 modulators and HMGB1 |
| US20210052598A1 (en) * | 2018-03-07 | 2021-02-25 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for treating cancer |
| JP2021519073A (ja) * | 2018-03-29 | 2021-08-10 | ジェネンテック， インコーポレイテッド | 哺乳動物細胞におけるラクトジェニック活性の制御 |
| CN113631180A (zh) | 2018-10-24 | 2021-11-09 | 英菲尼股份有限公司 | 用于确定代谢适应性的装置和方法 |
| US10610280B1 (en) | 2019-02-02 | 2020-04-07 | Ayad K. M. Agha | Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US7754217B2 (en) | 2001-03-16 | 2010-07-13 | Bio3 Research Srl | HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| CN1671742A (zh) | 2002-07-03 | 2005-09-21 | 塔博尔山圣拉弗尔基金中心 | Hmgb1在治疗组织损伤和/或促进组织修复中的用途 |
| US20060121047A1 (en) | 2002-11-20 | 2006-06-08 | Tracey Kevin J | Use of hmgb polypetides for increasing immune responses |
| WO2006024547A2 (en) | 2004-09-03 | 2006-03-09 | Creabilis Therapeutics S.P.A. | Protease resistant human and non-human hmgb1 box-a mutants and their therapeutic/diagnostic use |
| KR20080011011A (ko) | 2006-07-28 | 2008-01-31 | 주식회사 굿셀라이프 | 전구자연살해세포로부터 성숙자연살해세포로의 분화유도제 |
| CA2663300C (en) | 2006-09-15 | 2014-10-07 | Creabilis Therapeutics S.P.A. | Polymer conjugates of box-a of hmgb1 and box-a variants of hmgb1 |
| US20080103086A1 (en) | 2006-10-25 | 2008-05-01 | Jeon-Soo Shin | Methods for the treatment of diseases associated with the secretion of hmgb1 |
| US20110218176A1 (en) * | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| US8552050B2 (en) * | 2007-08-16 | 2013-10-08 | Beth Israel Deaconess Medical Center | Activators of pyruvate kinase M2 and methods of treating disease |
| CN102448951B (zh) * | 2009-04-06 | 2017-05-10 | 安吉奥斯医药品有限公司 | 丙酮酸激酶m2调节剂、治疗组合物和相关使用方法 |
| US20110123483A1 (en) * | 2009-11-23 | 2011-05-26 | Deutsches Krebsforschungszentrum | Hmgb1 for cancer treatment |
| EP2365332B1 (en) | 2010-03-10 | 2013-05-29 | Institut Pasteur | HMGB1 and anti-HMGB1 antibodies in HIV infected patients especially with neurological disorders |
| JP2015163592A (ja) * | 2012-10-31 | 2015-09-10 | アステラス製薬株式会社 | 抗癌剤の併用による癌治療方法 |
| US10626153B2 (en) * | 2012-07-26 | 2020-04-21 | Ospedale San Raffaele S.R.L. | HMGB1 variants and uses thereof |
| EP2821790A1 (en) | 2013-07-04 | 2015-01-07 | Universität Heidelberg | Tumor energy metabolism profiling |
| CA2925057A1 (en) * | 2013-10-01 | 2015-04-09 | Simon T. BARRY | Methods of treating and diagnosing alpha-v-beta-6 overexpressing cancer |
| CA2927794A1 (en) * | 2013-10-25 | 2015-04-30 | Pharmacyclics Llc | Treatment using bruton's tyrosine kinase inhibitors and immunotherapy |
| GB201508337D0 (en) * | 2015-05-15 | 2015-06-24 | Hmgbiotech S R L | Novel peptides |
| US11274132B2 (en) | 2015-12-11 | 2022-03-15 | Ruprecht-Karls-Universität Heidelberg | Combined preparations of PKM2 modulators and HMGB1 |
-
2016
- 2016-12-12 US US16/061,300 patent/US11274132B2/en active Active
- 2016-12-12 JP JP2018530152A patent/JP7107839B2/ja active Active
- 2016-12-12 CN CN201680072545.0A patent/CN108367049A/zh active Pending
- 2016-12-12 AU AU2016366515A patent/AU2016366515A1/en active Pending
- 2016-12-12 WO PCT/EP2016/080671 patent/WO2017098051A2/en active Application Filing
- 2016-12-12 CA CA3007877A patent/CA3007877A1/en active Pending
- 2016-12-12 EP EP16831815.2A patent/EP3386529A2/en not_active Ceased
- 2016-12-12 RU RU2018118985A patent/RU2768186C2/ru active
-
2017
- 2017-03-06 WO PCT/EP2017/055216 patent/WO2018108327A1/en unknown
- 2017-03-06 US US16/468,475 patent/US11072641B2/en active Active
- 2017-03-06 AU AU2017377124A patent/AU2017377124B2/en active Active
- 2017-03-06 EP EP17709417.4A patent/EP3551649B1/en active Active
- 2017-03-06 ES ES17709417T patent/ES2922824T3/es active Active
- 2017-03-06 JP JP2019531095A patent/JP6923650B2/ja active Active
- 2017-03-06 CA CA3045390A patent/CA3045390A1/en active Pending
- 2017-03-06 CN CN201780076967.XA patent/CN110392691A/zh active Pending
- 2017-03-06 PL PL17709417.4T patent/PL3551649T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2019115811A (ru) | 2021-01-12 |
| JP2020500544A (ja) | 2020-01-16 |
| WO2018108327A1 (en) | 2018-06-21 |
| AU2016366515A1 (en) | 2018-06-21 |
| JP2018538300A (ja) | 2018-12-27 |
| EP3551649A1 (en) | 2019-10-16 |
| CA3045390A1 (en) | 2018-06-21 |
| CA3007877A1 (en) | 2017-06-15 |
| CN110392691A (zh) | 2019-10-29 |
| US20200289560A1 (en) | 2020-09-17 |
| JP7107839B2 (ja) | 2022-07-27 |
| US11072641B2 (en) | 2021-07-27 |
| ES2922824T3 (es) | 2022-09-20 |
| CN108367049A (zh) | 2018-08-03 |
| US20190352360A1 (en) | 2019-11-21 |
| WO2017098051A3 (en) | 2018-02-15 |
| PL3551649T3 (pl) | 2023-02-06 |
| EP3551649B1 (en) | 2022-04-20 |
| AU2017377124A1 (en) | 2019-06-20 |
| EP3386529A2 (en) | 2018-10-17 |
| US11274132B2 (en) | 2022-03-15 |
| JP6923650B2 (ja) | 2021-08-25 |
| RU2768186C2 (ru) | 2022-03-23 |
| AU2017377124B2 (en) | 2021-12-23 |
| WO2017098051A2 (en) | 2017-06-15 |
| RU2018118985A (ru) | 2020-01-13 |