RU2018101261A - Многослойная тканевая структура непрерывной биопечати - Google Patents
Многослойная тканевая структура непрерывной биопечати Download PDFInfo
- Publication number
- RU2018101261A RU2018101261A RU2018101261A RU2018101261A RU2018101261A RU 2018101261 A RU2018101261 A RU 2018101261A RU 2018101261 A RU2018101261 A RU 2018101261A RU 2018101261 A RU2018101261 A RU 2018101261A RU 2018101261 A RU2018101261 A RU 2018101261A
- Authority
- RU
- Russia
- Prior art keywords
- specified
- living tissue
- synthetic
- paragraphs
- fabric according
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
- B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/14—Scaffolds; Matrices
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5061—Muscle cells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
- B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
- B29C64/118—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Sustainable Development (AREA)
- Manufacturing & Machinery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Toxicology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Mechanical Engineering (AREA)
- Optics & Photonics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Claims (16)
1. Синтетическая структура живой ткани, содержащая перекрывающиеся волокна клеток млекопитающих, нанесенных из биопринтера в затвердевшей биосовместимой матрице, способной поддерживать структурную целостность и правильность формы указанного волокна при нанесении, причем указанная затвердевшая биосовместимая матрица является однородной в радиальном поперечном сечении; и при этом указанное волокно непрерывно биопечатают на всем протяжении по меньшей мере двух слоев указанной структуры.
2. Синтетическая живая ткань по п. 1, отличающаяся тем, что указанное волокно непрерывно биопечатают на всем протяжении по меньшей мере трех, четырех, пяти, шести, семи, восьми, девяти, десяти или более слоев указанной структуры.
3. Структура синтетической живой ткани по п. 1, отличающаяся тем, что перекрывающиеся слои указанного волокна остаются структурно дискретными после биопечати.
4. Структура синтетической живой ткани по п. 1, отличающаяся тем, что указанная биосовместимая матрица физиологически совместима.
5. Синтетическая структура живых тканей по п. 2, отличающаяся тем, что указанная структура содержит цилиндр/трубку, причем указанная нить по существу проходит непрерывно через каждый слой указанного цилиндра.
6. Структура синтетической живой ткани по п. 2, отличающаяся тем, что указанная структура образует плоский лист, причем указанная нить по существу проходит непрерывно через указанный плоский лист.
7. Структура ткани по любому из пп. 1-6, отличающаяся тем, что указанные клетки млекопитающих представляют собой мышечные клетки.
8. Структура ткани по любому из пп. 1-6, отличающаяся тем, что указанные мышечные клетки представляют собой клетки гладкой мускулатуры, клетки скелетной мускулатуры или клетки сердечной мышцы.
9. Структура ткани по одному любому из пп. 7-8, отличающаяся тем, что указанная структура имеет сократительную функцию, причем указанная сократительная функциональность определяется изменением диаметра и/или окружности указанной структуры.
10. Структура ткани по любому из пп. 7-8, дополнительно содержащая по меньшей мере один дополнительный тип клеток.
11. Структура ткани по п. 10, отличающаяся тем, что по меньшей мере один указанный дополнительный тип клеток диспергирован в указанной нити.
12. Структура ткани по п. 10, отличающаяся тем, что по меньшей мере один указанный дополнительный тип клеток расположен снаружи указанной нити в качестве внешнего/второго слоя.
13. Структура ткани по любому из пп. 1-12, отличающаяся тем, что указанные клетки млекопитающих представляют собой клетки человека.
14. Набор, содержащий структуру ткани по любому из пп. 1-13.
15. Способ оценки влияния тестируемого агента и/или состояния на сократительную функцию мышечной клетки млекопитающего, включающий стадии: а) приведения в контакт синтетической структуры живой ткани по любому из пп. 7-8 с тестируемым агентом и/или состоянием; и b) определение влияния указанного агента и/или состояния на указанную мышечную клетку млекопитающего путем измерения изменения размеров в структуре.
16. Способ по п. 15, отличающийся тем, что указанная структура образует цилиндр/трубку, а упомянутый этап определения включает измерение изменения размеров площади, диаметра и/или окружности цилиндра.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562180174P | 2015-06-16 | 2015-06-16 | |
| US62/180,174 | 2015-06-16 | ||
| US201662305422P | 2016-03-08 | 2016-03-08 | |
| US62/305,422 | 2016-03-08 | ||
| PCT/CA2016/050707 WO2016201577A1 (en) | 2015-06-16 | 2016-06-16 | Continuously bioprinted multilayer tissue structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2018101261A true RU2018101261A (ru) | 2019-07-16 |
Family
ID=57545007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018101261A RU2018101261A (ru) | 2015-06-16 | 2016-06-16 | Многослойная тканевая структура непрерывной биопечати |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11746333B2 (ru) |
| EP (2) | EP3310902B1 (ru) |
| JP (1) | JP7026040B2 (ru) |
| KR (1) | KR20180042220A (ru) |
| CN (1) | CN108026508A (ru) |
| AU (1) | AU2016279941A1 (ru) |
| CA (1) | CA2989679C (ru) |
| DK (2) | DK3310902T3 (ru) |
| IL (1) | IL256306A (ru) |
| RU (1) | RU2018101261A (ru) |
| WO (1) | WO2016201577A1 (ru) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3310902B1 (en) | 2015-06-16 | 2022-08-10 | Aspect Biosystems Ltd. | Continuously bioprinted multilayer tissue structure |
| US10926000B2 (en) | 2016-05-13 | 2021-02-23 | Colorado School Of Mines | Deposition-conversion method for tunable calcium phosphate coatings on substrates and apparatus prepared thereof |
| EP3482260B1 (en) | 2016-07-08 | 2023-08-30 | Cypre, Inc. | Apparatus for patterning hydrogels into multi-well plates |
| US10596757B2 (en) * | 2016-12-06 | 2020-03-24 | Northeastern University | Three dimensional mineralization printer |
| US10967570B2 (en) * | 2018-01-18 | 2021-04-06 | Revotek Co., Ltd | Device for printing lumen tissue construct, method for using the same and 3D bioprinter |
| EP3517273A1 (en) * | 2018-01-18 | 2019-07-31 | Revotek Co., Ltd | Device for printing lumen tissue construct, method for using the same and 3d bioprinter |
| KR102083788B1 (ko) | 2018-09-04 | 2020-03-03 | 주식회사 티앤알바이오팹 | 인공 혈관 제조용 3d 프린팅 시스템 및 이를 이용한 인공 혈관의 제조 방법 |
| MX2021011780A (es) * | 2019-03-29 | 2021-11-12 | Tdbt Ip Inc | Reemplazos de tejidos y organos y metodos para elaborarlos. |
| EP4017413A4 (en) * | 2019-09-22 | 2022-11-02 | Steakholder Foods Ltd. | PHYSICAL MANIPULATION OF GROWN MUSCLE TISSUE |
| US20240267751A1 (en) | 2019-10-01 | 2024-08-08 | Telefonaktiebolaget Lm Ericsson (Publ) | Group Signalling Aspects for NR-NR Dual Connectivity (NR-DC) and Reconfiguration |
| KR102189959B1 (ko) | 2019-11-26 | 2020-12-11 | 주식회사 티앤알바이오팹 | 멀티 3d 프린팅 헤드 및 이를 포함하는 3d 프린터 |
| KR102253727B1 (ko) | 2019-11-26 | 2021-05-20 | 주식회사 티앤알바이오팹 | 바이오 클린 벤치 시스템 |
| KR102253724B1 (ko) | 2019-11-26 | 2021-05-20 | 주식회사 티앤알바이오팹 | 회전형 3d 프린팅 조형판 및 이를 포함하는 3d 프린터 |
| US20230119663A1 (en) * | 2020-03-26 | 2023-04-20 | Osaka University | Muscle tissue produced by bioprinting |
| US11559389B2 (en) * | 2020-05-05 | 2023-01-24 | International Business Machines Corporation | Bioprinted living tissue with therapy capability |
| KR102525459B1 (ko) | 2021-01-22 | 2023-04-25 | 피피에스 주식회사 | Cps(cyber physical system)에 연결된 용량미달 불량품 식별 시스템 및 방법 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6176874B1 (en) | 1993-10-18 | 2001-01-23 | Masschusetts Institute Of Technology | Vascularized tissue regeneration matrices formed by solid free form fabrication techniques |
| US7051654B2 (en) | 2003-05-30 | 2006-05-30 | Clemson University | Ink-jet printing of viable cells |
| EP1690206A4 (en) * | 2003-11-14 | 2008-07-02 | Univ Drexel | METHOD AND DEVICE FOR COMPUTER-ASSISTED TISSUE TECHNOLOGY FOR MODELING, DEVELOPING AND FREEFORMING MANUFACTURING OF FABRIC SCAFFOLDING, CONSTRUCTIONS AND EQUIPMENT |
| US7368279B2 (en) | 2004-11-24 | 2008-05-06 | The Regents Of The University Of Michigan | Three dimensional bioengineered smooth muscle tissue and sphincters and methods therefor |
| WO2007124481A2 (en) * | 2006-04-21 | 2007-11-01 | Drexel University | Bioprinting three-dimensional structures onto microscale tissue analog devices for pharmacokinetic study and other uses |
| US8691274B2 (en) | 2008-02-14 | 2014-04-08 | Wake Forest University Health Sciences | Inkjet printing of tissues and cells |
| GB2489081B (en) | 2010-03-16 | 2013-03-27 | Organovo Inc | Multilayered vascular tubes |
| US20120089238A1 (en) | 2010-10-06 | 2012-04-12 | Hyun-Wook Kang | Integrated organ and tissue printing methods, system and apparatus |
| AU2015202836B2 (en) * | 2010-10-21 | 2016-11-03 | Organovo, Inc. | Devices, systems, and methods for the fabrication of tissue |
| DK2629975T3 (da) | 2010-10-21 | 2022-05-09 | Organovo Inc | Anordninger til fremstilling af væv |
| JP2014531204A (ja) * | 2011-09-12 | 2014-11-27 | オルガノボ，インク． | インビトロでの研究使用のための操作した組織、そのアレイ、およびその製造方法 |
| EP2755599B1 (en) | 2011-09-12 | 2020-04-01 | Organovo, Inc. | Platform for engineered implantable tissues and organs and methods of making the same |
| CA2863310C (en) * | 2012-01-31 | 2018-11-13 | Wake Forest University Health Sciences | Innervation of engineered structures |
| US9442105B2 (en) * | 2013-03-15 | 2016-09-13 | Organovo, Inc. | Engineered liver tissues, arrays thereof, and methods of making the same |
| KR102450885B1 (ko) * | 2013-06-13 | 2022-10-06 | 애스펙트 바이오시스템즈 리미티드 | 3차원 구조물의 첨삭 가공을 위한 장치 및 방법 |
| AU2014296246B2 (en) | 2013-07-31 | 2021-01-21 | Organovo, Inc. | Automated devices, systems, and methods for the fabrication of tissue |
| WO2015066705A1 (en) * | 2013-11-04 | 2015-05-07 | University Of Iowa Research Foundation | Bioprinter and methods of using same |
| US20160297104A1 (en) * | 2013-11-19 | 2016-10-13 | Guill Tool & Engineering | Coextruded, multilayer and multicomponent 3d printing inputs field |
| EP3310902B1 (en) | 2015-06-16 | 2022-08-10 | Aspect Biosystems Ltd. | Continuously bioprinted multilayer tissue structure |
| WO2017087904A1 (en) * | 2015-11-20 | 2017-05-26 | Organovo, Inc. | Rotating device and method for continuous fabrication of long biological tubes |
-
2016
- 2016-06-16 EP EP16810681.3A patent/EP3310902B1/en active Active
- 2016-06-16 RU RU2018101261A patent/RU2018101261A/ru not_active Application Discontinuation
- 2016-06-16 DK DK16810681.3T patent/DK3310902T3/da active
- 2016-06-16 DK DK22183540.8T patent/DK4130243T3/da active
- 2016-06-16 EP EP22183540.8A patent/EP4130243B1/en active Active
- 2016-06-16 CN CN201680035026.7A patent/CN108026508A/zh active Pending
- 2016-06-16 JP JP2018517465A patent/JP7026040B2/ja active Active
- 2016-06-16 CA CA2989679A patent/CA2989679C/en active Active
- 2016-06-16 KR KR1020187001242A patent/KR20180042220A/ko unknown
- 2016-06-16 US US15/736,743 patent/US11746333B2/en active Active
- 2016-06-16 WO PCT/CA2016/050707 patent/WO2016201577A1/en active Application Filing
- 2016-06-16 AU AU2016279941A patent/AU2016279941A1/en not_active Abandoned
-
2017
- 2017-12-13 IL IL256306A patent/IL256306A/en unknown
-
2023
- 2023-08-31 US US18/240,744 patent/US20240158758A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240158758A1 (en) | 2024-05-16 |
| JP7026040B2 (ja) | 2022-02-25 |
| KR20180042220A (ko) | 2018-04-25 |
| DK3310902T3 (da) | 2022-11-14 |
| WO2016201577A1 (en) | 2016-12-22 |
| EP4130243A1 (en) | 2023-02-08 |
| US20180171304A1 (en) | 2018-06-21 |
| EP3310902A1 (en) | 2018-04-25 |
| AU2016279941A1 (en) | 2018-01-18 |
| CN108026508A (zh) | 2018-05-11 |
| US11746333B2 (en) | 2023-09-05 |
| CA2989679C (en) | 2023-11-28 |
| JP2018524022A (ja) | 2018-08-30 |
| EP3310902A4 (en) | 2018-12-12 |
| EP3310902B1 (en) | 2022-08-10 |
| IL256306A (en) | 2018-02-28 |
| DK4130243T3 (da) | 2024-09-30 |
| EP4130243B1 (en) | 2024-06-26 |
| CA2989679A1 (en) | 2016-12-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2018101261A (ru) | Многослойная тканевая структура непрерывной биопечати | |
| LANDE et al. | SUBSTANCE USE AND ABUSE IN THE | |
| Caliari et al. | The development of collagen-GAG scaffold-membrane composites for tendon tissue engineering | |
| Zhang et al. | Porous nerve guidance conduits reinforced with braided composite structures of silk/magnesium filaments for peripheral nerve repair | |
| Klinge et al. | ‘The Ideal Mesh?' | |
| ES2970484T3 (es) | Andamio electrohilado multiescala jerárquico para la regeneración y/o reemplazo del tejido tendinoso/ligamentoso y un método para su producción | |
| CN103361811B (zh) | 一种负泊松比纱线结构及其制造方法 | |
| RU2012137296A (ru) | Материал для ушивания раны | |
| TWI565845B (zh) | Production of Textile Machine and Its Textile Technology by Seamless Climbing and Quick Climbing | |
| RU2016134236A (ru) | Медицинское изделие и способ его изготовления | |
| RU2015149278A (ru) | Надувные медицинские баллоны с непрерывной намоткой волокна | |
| EA201301200A1 (ru) | Нить, способ изготовления нити и продукты, содержащие нить | |
| AR117385A1 (es) | Laminado de fibras no tejidas y procedimiento para la fabricación de un laminado de fibras no tejidas | |
| JP2015533090A5 (ru) | ||
| CN203829090U (zh) | 一种纳米纤维神经移植物 | |
| WO2011153340A3 (en) | Scaffolds and methods of forming the same | |
| JP2013541367A5 (ru) | ||
| TR201819937T4 (tr) | İnmenin önlenmesine yönelik 3D filtre. | |
| EP2135976A3 (en) | Crucible holding member and method for producing the same | |
| GB2557470A (en) | Fishing rod with graphene and method of manufacturing | |
| Kumar et al. | Study of the effect of composition and construction of material on sub-bandage pressure during dynamic loading of a limb in vitro | |
| CN207416163U (zh) | 仿竹纤维壁结构的空心木质单板层积材圆柱 | |
| ES2554490T3 (es) | Método de fabricar un estratificado elástico | |
| CN212293917U (zh) | 吸湿排汗复合纱线 | |
| RU2016104112A (ru) | Способ изготовления облегченной четырехосной хирургической сетки |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20190617 |