RU2018101261A - MULTILAYER FABRIC STRUCTURE OF CONTINUOUS BIOPRATING - Google Patents

MULTILAYER FABRIC STRUCTURE OF CONTINUOUS BIOPRATING Download PDF

Info

Publication number
RU2018101261A
RU2018101261A RU2018101261A RU2018101261A RU2018101261A RU 2018101261 A RU2018101261 A RU 2018101261A RU 2018101261 A RU2018101261 A RU 2018101261A RU 2018101261 A RU2018101261 A RU 2018101261A RU 2018101261 A RU2018101261 A RU 2018101261A
Authority
RU
Russia
Prior art keywords
specified
living tissue
synthetic
paragraphs
fabric according
Prior art date
Application number
RU2018101261A
Other languages
Russian (ru)
Inventor
Саймон БЕЙЕР
Тамер МОХАМЕД
Шен ПАНЬ
Сэм УЭДСВОРТ
Original Assignee
Эспект Байосистемз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эспект Байосистемз Лтд. filed Critical Эспект Байосистемз Лтд.
Publication of RU2018101261A publication Critical patent/RU2018101261A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061—Muscle cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B29C64/118—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Sustainable Development (AREA)
  • Manufacturing & Machinery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Optics & Photonics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (16)

1. Синтетическая структура живой ткани, содержащая перекрывающиеся волокна клеток млекопитающих, нанесенных из биопринтера в затвердевшей биосовместимой матрице, способной поддерживать структурную целостность и правильность формы указанного волокна при нанесении, причем указанная затвердевшая биосовместимая матрица является однородной в радиальном поперечном сечении; и при этом указанное волокно непрерывно биопечатают на всем протяжении по меньшей мере двух слоев указанной структуры.1. The synthetic structure of living tissue containing overlapping fibers of mammalian cells deposited from a bioprinter in a hardened biocompatible matrix capable of maintaining the structural integrity and correctness of the shape of said fiber when applied, said hardened biocompatible matrix being homogeneous in radial cross-section; and wherein said fiber is continuously bioprinted throughout at least two layers of said structure. 2. Синтетическая живая ткань по п. 1, отличающаяся тем, что указанное волокно непрерывно биопечатают на всем протяжении по меньшей мере трех, четырех, пяти, шести, семи, восьми, девяти, десяти или более слоев указанной структуры.2. Synthetic living tissue according to Claim. 1, characterized in that said fiber is continuously bio-printed all over at least three, four, five, six, seven, eight, nine, ten or more layers of said structure. 3. Структура синтетической живой ткани по п. 1, отличающаяся тем, что перекрывающиеся слои указанного волокна остаются структурно дискретными после биопечати.3. The structure of synthetic living tissue according to Claim. 1, characterized in that the overlapping layers of said fiber remain structurally discrete after bioprinting. 4. Структура синтетической живой ткани по п. 1, отличающаяся тем, что указанная биосовместимая матрица физиологически совместима.4. The structure of synthetic living tissue according to claim 1, characterized in that said biocompatible matrix is physiologically compatible. 5. Синтетическая структура живых тканей по п. 2, отличающаяся тем, что указанная структура содержит цилиндр/трубку, причем указанная нить по существу проходит непрерывно через каждый слой указанного цилиндра.5. The synthetic structure of living tissue under item 2, characterized in that the structure contains a cylinder / tube, and this thread essentially passes continuously through each layer of the specified cylinder. 6. Структура синтетической живой ткани по п. 2, отличающаяся тем, что указанная структура образует плоский лист, причем указанная нить по существу проходит непрерывно через указанный плоский лист.6. The structure of synthetic living tissue according to claim 2, characterized in that said structure forms a flat sheet, wherein said thread essentially passes continuously through said flat sheet. 7. Структура ткани по любому из пп. 1-6, отличающаяся тем, что указанные клетки млекопитающих представляют собой мышечные клетки.7. The structure of the fabric according to any one of paragraphs. 1-6, characterized in that the mammalian cells are muscle cells. 8. Структура ткани по любому из пп. 1-6, отличающаяся тем, что указанные мышечные клетки представляют собой клетки гладкой мускулатуры, клетки скелетной мускулатуры или клетки сердечной мышцы.8. The structure of the fabric according to any one of paragraphs. 1-6, characterized in that the muscle cells are smooth muscle cells, skeletal muscle cells or heart muscle cells. 9. Структура ткани по одному любому из пп. 7-8, отличающаяся тем, что указанная структура имеет сократительную функцию, причем указанная сократительная функциональность определяется изменением диаметра и/или окружности указанной структуры.9. The structure of the fabric according to any one of paragraphs. 7-8, characterized in that the specified structure has a contractile function, and the specified contractile functionality is determined by changing the diameter and / or circumference of the specified structure. 10. Структура ткани по любому из пп. 7-8, дополнительно содержащая по меньшей мере один дополнительный тип клеток. 10. The structure of the fabric according to any one of paragraphs. 7-8, additionally containing at least one additional cell type. 11. Структура ткани по п. 10, отличающаяся тем, что по меньшей мере один указанный дополнительный тип клеток диспергирован в указанной нити.11. The structure of the tissue according to claim 10, characterized in that at least one specified additional cell type is dispersed in said strand. 12. Структура ткани по п. 10, отличающаяся тем, что по меньшей мере один указанный дополнительный тип клеток расположен снаружи указанной нити в качестве внешнего/второго слоя.12. The structure of the fabric according to claim 10, characterized in that at least one specified additional cell type is located outside the specified filament as an outer / second layer. 13. Структура ткани по любому из пп. 1-12, отличающаяся тем, что указанные клетки млекопитающих представляют собой клетки человека.13. The structure of the fabric according to any one of paragraphs. 1-12, characterized in that said mammalian cells are human cells. 14. Набор, содержащий структуру ткани по любому из пп. 1-13.14. A kit containing the structure of the fabric according to any one of paragraphs. 1-13. 15. Способ оценки влияния тестируемого агента и/или состояния на сократительную функцию мышечной клетки млекопитающего, включающий стадии: а) приведения в контакт синтетической структуры живой ткани по любому из пп. 7-8 с тестируемым агентом и/или состоянием; и b) определение влияния указанного агента и/или состояния на указанную мышечную клетку млекопитающего путем измерения изменения размеров в структуре.15. A method for evaluating the effect of a test agent and / or condition on the contractile function of a mammalian muscle cell, comprising the steps of: a) bringing into contact the synthetic structure of living tissue according to any one of claims. 7-8 with a test agent and / or condition; and b) determining the effect of said agent and / or state on said mammalian muscle cell by measuring dimensional changes in the structure. 16. Способ по п. 15, отличающийся тем, что указанная структура образует цилиндр/трубку, а упомянутый этап определения включает измерение изменения размеров площади, диаметра и/или окружности цилиндра.16. The method according to claim 15, characterized in that said structure forms a cylinder / tube, and said determining step involves measuring the change in dimensions of the area, diameter and / or circumference of the cylinder.
RU2018101261A 2015-06-16 2016-06-16 MULTILAYER FABRIC STRUCTURE OF CONTINUOUS BIOPRATING RU2018101261A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562180174P 2015-06-16 2015-06-16
US62/180,174 2015-06-16
US201662305422P 2016-03-08 2016-03-08
US62/305,422 2016-03-08
PCT/CA2016/050707 WO2016201577A1 (en) 2015-06-16 2016-06-16 Continuously bioprinted multilayer tissue structure

Publications (1)

Publication Number Publication Date
RU2018101261A true RU2018101261A (en) 2019-07-16

Family

ID=57545007

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018101261A RU2018101261A (en) 2015-06-16 2016-06-16 MULTILAYER FABRIC STRUCTURE OF CONTINUOUS BIOPRATING

Country Status (11)

Country Link
US (2) US11746333B2 (en)
EP (2) EP3310902B1 (en)
JP (1) JP7026040B2 (en)
KR (1) KR20180042220A (en)
CN (1) CN108026508A (en)
AU (1) AU2016279941A1 (en)
CA (1) CA2989679C (en)
DK (1) DK3310902T3 (en)
IL (1) IL256306A (en)
RU (1) RU2018101261A (en)
WO (1) WO2016201577A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11746333B2 (en) 2015-06-16 2023-09-05 Aspect Biosystems Ltd. Continuously bioprinted multilayer tissue structure
US10926000B2 (en) 2016-05-13 2021-02-23 Colorado School Of Mines Deposition-conversion method for tunable calcium phosphate coatings on substrates and apparatus prepared thereof
WO2018009943A2 (en) 2016-07-08 2018-01-11 Cypre, Inc. Apparatus for patterning hydrogels into multi-well plates
US10596757B2 (en) * 2016-12-06 2020-03-24 Northeastern University Three dimensional mineralization printer
US11311368B2 (en) 2018-01-18 2022-04-26 Revotek Co., Ltd Device for printing lumen tissue construct, method for using the same and 3D bioprinter
US10967570B2 (en) * 2018-01-18 2021-04-06 Revotek Co., Ltd Device for printing lumen tissue construct, method for using the same and 3D bioprinter
KR102083788B1 (en) 2018-09-04 2020-03-03 주식회사 티앤알바이오팹 3D printing system for artificial blood vessel manufacturing and method of manufacturing artificial blood vessel using same
AU2020252072A1 (en) * 2019-03-29 2021-10-28 Tdbt Ip Inc. Tissue and organ replacements and methods of making thereof
BR112022004311A2 (en) * 2019-09-22 2022-06-21 Meatech 3D Ltd Physical manipulation of cultured muscle tissue
EP4039053A1 (en) 2019-10-01 2022-08-10 Telefonaktiebolaget LM Ericsson (publ) Group signalling aspects for nr-nr dual connectivity (nr-dc) and reconfiguration
KR102189959B1 (en) 2019-11-26 2020-12-11 주식회사 티앤알바이오팹 Multi 3d printing head and 3d printer thereof
KR102253727B1 (en) 2019-11-26 2021-05-20 주식회사 티앤알바이오팹 Bio clean bench system
KR102253724B1 (en) 2019-11-26 2021-05-20 주식회사 티앤알바이오팹 Rotational 3d printing base and 3d printer including thereof
CN115551995A (en) * 2020-03-26 2022-12-30 国立大学法人大阪大学 Muscle tissue produced by bioprinting
US11559389B2 (en) * 2020-05-05 2023-01-24 International Business Machines Corporation Bioprinted living tissue with therapy capability
KR102525459B1 (en) 2021-01-22 2023-04-25 피피에스 주식회사 A system and method for identifying defective products under capacity connected to CPS(CYBER PHYSICAL SYSTEM)

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6176874B1 (en) 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US7051654B2 (en) 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
EP1690206A4 (en) * 2003-11-14 2008-07-02 Univ Drexel Method and apparatus for computer-aided tissue engineering for modeling, design and freeform fabrication of tissue scaffolds, constructs, and devices
US7368279B2 (en) 2004-11-24 2008-05-06 The Regents Of The University Of Michigan Three dimensional bioengineered smooth muscle tissue and sphincters and methods therefor
WO2007124481A2 (en) * 2006-04-21 2007-11-01 Drexel University Bioprinting three-dimensional structures onto microscale tissue analog devices for pharmacokinetic study and other uses
US8691274B2 (en) 2008-02-14 2014-04-08 Wake Forest University Health Sciences Inkjet printing of tissues and cells
GB2478801B (en) 2010-03-16 2012-05-30 Organovo Inc Multilayered vascular tubes
US20120089238A1 (en) 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
CN105496601A (en) 2010-10-21 2016-04-20 奥加诺沃公司 Devices, systems, and methods for the fabrication of tissue
AU2015202836B2 (en) * 2010-10-21 2016-11-03 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue
BR112014005752A2 (en) 2011-09-12 2017-03-28 Organovo Inc platform for implantable tissues and organs produced by tissue engineering and methods for their production
WO2013040078A2 (en) * 2011-09-12 2013-03-21 Organovo, Inc. Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same
CA2863310C (en) 2012-01-31 2018-11-13 Wake Forest University Health Sciences Innervation of engineered structures
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
CN105579219B (en) 2013-06-13 2017-09-01 安斯百克特生物系统公司 System and method for the increasing material manufacturing of three-dimensional structure
KR20160036619A (en) 2013-07-31 2016-04-04 오가노보, 인크. Automated devices, systems, and methods for the fabrication of tissue
US11903612B2 (en) * 2013-11-04 2024-02-20 University Of Iowa Research Foundation Bioprinter and methods of using same
EP3970945A1 (en) * 2013-11-19 2022-03-23 Guill Tool & Engineering Filament for use in a 3d printer and method for producing the same
US11746333B2 (en) 2015-06-16 2023-09-05 Aspect Biosystems Ltd. Continuously bioprinted multilayer tissue structure
WO2017087904A1 (en) * 2015-11-20 2017-05-26 Organovo, Inc. Rotating device and method for continuous fabrication of long biological tubes

Also Published As

Publication number Publication date
AU2016279941A1 (en) 2018-01-18
US20240158758A1 (en) 2024-05-16
CA2989679A1 (en) 2016-12-22
EP4130243A1 (en) 2023-02-08
IL256306A (en) 2018-02-28
CA2989679C (en) 2023-11-28
DK3310902T3 (en) 2022-11-14
JP7026040B2 (en) 2022-02-25
US20180171304A1 (en) 2018-06-21
EP3310902A1 (en) 2018-04-25
JP2018524022A (en) 2018-08-30
KR20180042220A (en) 2018-04-25
EP3310902B1 (en) 2022-08-10
WO2016201577A1 (en) 2016-12-22
EP4130243B1 (en) 2024-06-26
CN108026508A (en) 2018-05-11
US11746333B2 (en) 2023-09-05
EP3310902A4 (en) 2018-12-12

Similar Documents

Publication Publication Date Title
RU2018101261A (en) MULTILAYER FABRIC STRUCTURE OF CONTINUOUS BIOPRATING
Caliari et al. The development of collagen-GAG scaffold-membrane composites for tendon tissue engineering
Klinge et al. ‘The Ideal Mesh?'
Zhang et al. Porous nerve guidance conduits reinforced with braided composite structures of silk/magnesium filaments for peripheral nerve repair
CN103361811B (en) A kind of negative poisson ratio yarn structure and manufacture method thereof
ES2970484T3 (en) Hierarchical multiscale electrospun scaffold for the regeneration and/or replacement of tendon/ligamentous tissue and a method for its production
RU2012137296A (en) Wound Suturing Material
RU2016134236A (en) MEDICAL PRODUCT AND METHOD FOR ITS PRODUCTION
RU2015149278A (en) INFLATABLE MEDICAL CYLINDERS WITH CONTINUOUS FIBER WINDING
JP2015533090A5 (en)
EA201301200A1 (en) THREAD, METHOD OF MANUFACTURING THREADS AND PRODUCTS CONTAINING THREAD
WO2011153340A3 (en) Scaffolds and methods of forming the same
JP2013541367A5 (en)
AR117385A1 (en) LAMINATE OF NON-WOVEN FIBERS AND PROCEDURE FOR THE MANUFACTURE OF A LAMINATE OF NON-WOVEN FIBERS
TW201525214A (en) Seamless rock climbing quickdraw, textile machine and textile technology thereof
TR201819937T4 (en) 3D filter for stroke prevention.
Kumar et al. Study of the effect of composition and construction of material on sub-bandage pressure during dynamic loading of a limb in vitro
GB2557470A (en) Fishing rod with graphene and method of manufacturing
AR110601A1 (en) NON-WOVEN FABRIC OF ENDLESS FILAMENTS
CN207416163U (en) The hollow wooden laminated veneer lumber cylinder of imitative bamboo fibre wall construction
ES2554490T3 (en) Method of manufacturing an elastic laminate
EA201690061A1 (en) HIGH-STRENGTH FABRIC AND METHOD OF ITS MANUFACTURE
RU2016104112A (en) METHOD FOR MANUFACTURING A LIGHTED FOUR-AXIS SURGICAL NET
Hunnakko et al. Towards chronic wound pads: Gradient nanofiber structure generated by ultrasound enhanced electrospinning (USES)
RU2005107865A (en) METHOD FOR PRODUCING COMPOSITE REINFORCEMENT

Legal Events

Date Code Title Description
FA93 Acknowledgement of application withdrawn (no request for examination)

Effective date: 20190617