RU2017107715A - Производные имидазо[1,2-a]пиридина для применения в качестве ингибиторов репликации вируса иммунодефицита человека - Google Patents

Производные имидазо[1,2-a]пиридина для применения в качестве ингибиторов репликации вируса иммунодефицита человека Download PDF

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RU2017107715A
RU2017107715A RU2017107715A RU2017107715A RU2017107715A RU 2017107715 A RU2017107715 A RU 2017107715A RU 2017107715 A RU2017107715 A RU 2017107715A RU 2017107715 A RU2017107715 A RU 2017107715A RU 2017107715 A RU2017107715 A RU 2017107715A
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Prior art keywords
alkyl
inhibitors
substituted
phenyl
haloalkyl
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RU2017107715A
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English (en)
Russian (ru)
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RU2017107715A3 (https=
Inventor
Б. Нарасимхулу Наиду
Тимоти П. Коннолли
Кайл Дж. ИСТМАН
Кевин ПИЗ
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ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД
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Application filed by ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД filed Critical ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД
Publication of RU2017107715A publication Critical patent/RU2017107715A/ru
Publication of RU2017107715A3 publication Critical patent/RU2017107715A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2017107715A 2014-08-27 2015-08-25 Производные имидазо[1,2-a]пиридина для применения в качестве ингибиторов репликации вируса иммунодефицита человека RU2017107715A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462042300P 2014-08-27 2014-08-27
US62/042,300 2014-08-27
PCT/US2015/046648 WO2016033009A1 (en) 2014-08-27 2015-08-25 Imidazo[1,2-a]pyridine derivatives for use as inhibitors of human immunodeficiency virus replication

Publications (2)

Publication Number Publication Date
RU2017107715A true RU2017107715A (ru) 2018-09-27
RU2017107715A3 RU2017107715A3 (https=) 2019-03-04

Family

ID=54064588

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017107715A RU2017107715A (ru) 2014-08-27 2015-08-25 Производные имидазо[1,2-a]пиридина для применения в качестве ингибиторов репликации вируса иммунодефицита человека

Country Status (13)

Country Link
US (1) US10065953B2 (https=)
EP (1) EP3186254B1 (https=)
JP (1) JP2017526748A (https=)
KR (1) KR20170045308A (https=)
CN (1) CN107001357A (https=)
AU (1) AU2015306779B2 (https=)
BR (1) BR112017003663A2 (https=)
CA (1) CA2958591A1 (https=)
CL (1) CL2017000428A1 (https=)
IL (1) IL250561A0 (https=)
RU (1) RU2017107715A (https=)
WO (1) WO2016033009A1 (https=)
ZA (1) ZA201701214B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9975906B2 (en) 2014-05-16 2018-05-22 Shionogi & Co., Ltd. Tricyclic heterocycle derivatives having HIV replication inhibitory effect
TWI700284B (zh) 2015-05-29 2020-08-01 日商塩野義製藥股份有限公司 具有ｈｉｖ複製抑制作用之含氮３環性衍生物
US11541055B2 (en) * 2018-10-24 2023-01-03 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
CN109232562A (zh) * 2018-10-24 2019-01-18 康化（上海）新药研发有限公司 一种7-氮杂吲哚-5-氯-6-羧酸的合成方法
MY201239A (en) 2019-03-22 2024-02-13 Gilead Sciences Inc Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
PE20221569A1 (es) 2020-02-24 2022-10-06 Gilead Sciences Inc Compuestos tetraciclicos para el tratamiento de infecciones por vih
ES3064867T3 (en) 2020-09-30 2026-04-29 Gilead Sciences Inc Bridged tricyclic carbamoylpyridone compounds for a use in the treatment of hiv
US11613546B2 (en) 2021-01-19 2023-03-28 Gilead Sciences, Inc. Substituted pyridotriazine compounds and uses thereof
TW202446773A (zh) 2022-04-06 2024-12-01 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8338441B2 (en) * 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US8633200B2 (en) * 2010-09-08 2014-01-21 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
UA111841C2 (uk) * 2011-04-21 2016-06-24 Гіліад Сайєнсіз, Інк. Сполуки бензотіазолу та їх фармацевтичне застосування
US9034882B2 (en) * 2012-03-05 2015-05-19 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
UY34750A (es) * 2012-04-20 2013-11-29 Gilead Sciences Inc ?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?.
WO2014164409A1 (en) 2013-03-13 2014-10-09 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication

Also Published As

Publication number Publication date
EP3186254A1 (en) 2017-07-05
ZA201701214B (en) 2019-07-31
BR112017003663A2 (pt) 2017-11-28
CA2958591A1 (en) 2016-03-03
CN107001357A (zh) 2017-08-01
US20180222901A1 (en) 2018-08-09
KR20170045308A (ko) 2017-04-26
AU2015306779A1 (en) 2017-03-16
IL250561A0 (en) 2017-03-30
JP2017526748A (ja) 2017-09-14
WO2016033009A1 (en) 2016-03-03
AU2015306779B2 (en) 2017-11-02
US10065953B2 (en) 2018-09-04
RU2017107715A3 (https=) 2019-03-04
EP3186254B1 (en) 2019-03-06
CL2017000428A1 (es) 2017-08-18

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Effective date: 20190619