RU2016152090A - Интраназальное введение - Google Patents
Интраназальное введение Download PDFInfo
- Publication number
- RU2016152090A RU2016152090A RU2016152090A RU2016152090A RU2016152090A RU 2016152090 A RU2016152090 A RU 2016152090A RU 2016152090 A RU2016152090 A RU 2016152090A RU 2016152090 A RU2016152090 A RU 2016152090A RU 2016152090 A RU2016152090 A RU 2016152090A
- Authority
- RU
- Russia
- Prior art keywords
- optionally
- patient
- day
- delivery
- pharmaceutical agent
- Prior art date
Links
- 238000000034 method Methods 0.000 claims 81
- 239000008177 pharmaceutical agent Substances 0.000 claims 30
- 239000012530 fluid Substances 0.000 claims 27
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 24
- ZISSAWUMDACLOM-UHFFFAOYSA-N triptane Chemical compound CC(C)C(C)(C)C ZISSAWUMDACLOM-UHFFFAOYSA-N 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 14
- 229940124597 therapeutic agent Drugs 0.000 claims 14
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 claims 13
- 239000002775 capsule Substances 0.000 claims 12
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 12
- 239000001569 carbon dioxide Substances 0.000 claims 12
- 229960003708 sumatriptan Drugs 0.000 claims 9
- 230000001276 controlling effect Effects 0.000 claims 8
- 208000002193 Pain Diseases 0.000 claims 7
- 239000000443 aerosol Substances 0.000 claims 6
- 230000009885 systemic effect Effects 0.000 claims 6
- 230000001225 therapeutic effect Effects 0.000 claims 6
- 150000003431 steroids Chemical class 0.000 claims 5
- 239000012458 free base Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229960000658 sumatriptan succinate Drugs 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 3
- 229960002714 fluticasone Drugs 0.000 claims 3
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 3
- 229960000289 fluticasone propionate Drugs 0.000 claims 3
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 230000035807 sensation Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 206010006784 Burning sensation Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 231100000862 numbness Toxicity 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 208000035824 paresthesia Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- -1 tingling sensation Chemical compound 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
- A61M15/0098—Activated by exhalation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/003—Particle size control by passing the aerosol trough sieves or filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0225—Carbon oxides, e.g. Carbon dioxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/315,132 | 2014-06-25 | ||
| US14/315,132 US11554229B2 (en) | 2013-03-26 | 2014-06-25 | Nasal administration |
| PCT/EP2015/064463 WO2015197798A1 (en) | 2014-06-25 | 2015-06-25 | Nasal administration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016152090A true RU2016152090A (ru) | 2018-07-27 |
| RU2016152090A3 RU2016152090A3 (cg-RX-API-DMAC7.html) | 2019-02-15 |
Family
ID=53489954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016152090A RU2016152090A (ru) | 2014-06-25 | 2015-06-25 | Интраназальное введение |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP3160556A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6785227B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102458964B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106470724A (cg-RX-API-DMAC7.html) |
| AU (3) | AU2015279154A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016029926A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2953207A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES3034743T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL249585B (cg-RX-API-DMAC7.html) |
| MX (1) | MX390453B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2016152090A (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201610685XA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015197798A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201608785B (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201713899D0 (en) * | 2017-08-30 | 2017-10-11 | Indosys Ltd | Multi-dose medicament delivery device |
| US11744967B2 (en) * | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| CN108421138A (zh) * | 2017-12-25 | 2018-08-21 | 宫本海 | 一种鼻腔雾化吸药器 |
| EP3793436B1 (en) * | 2018-05-16 | 2024-07-17 | Massachusetts Institute of Technology | Apparatus for passive, proportional, valveless gas sampling and delivery |
| EP4051107A4 (en) | 2019-10-28 | 2023-11-01 | The Research Foundation for The State University of New York | DEVICES, SYSTEMS AND METHODS FOR MONITORING ARTERIAL CARBON DIOXIDE |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9416884D0 (en) * | 1994-08-20 | 1994-10-12 | Danbiosyst Uk | Drug delivery compositions |
| JP4543553B2 (ja) | 1999-03-03 | 2010-09-15 | オプティノーズ アズ | 鼻用の送り込み装置 |
| GB0121568D0 (en) * | 2001-09-06 | 2001-10-24 | Optinose As | Nasal delivery device |
| CA2375679C (en) | 1999-07-12 | 2008-09-23 | Capnia, Incorporated | Methods and apparatus for relieving headaches, rhinitis and other common ailments |
| US20070039615A1 (en) * | 1999-11-08 | 2007-02-22 | Capnia, Incorporated | Methods and apparatus for treating rhinitis |
| WO2001047493A1 (en) * | 1999-12-24 | 2001-07-05 | Glaxo Group Limited | Pharmaceutical aerosol formulation of salmeterol and fluticasone propionate |
| CA2400375A1 (en) | 2000-02-28 | 2001-09-07 | Capnia, Incorporated | Method and apparatus for transcutaneous infusion of carbon dioxide for local relief of pain and other ailments |
| ZA200306564B (en) * | 2001-02-26 | 2004-10-15 | Optinose As | Nasal devices. |
| GB2403154B (en) * | 2002-04-04 | 2007-01-24 | Optinose As | Nasal devices |
| US9808471B2 (en) * | 2003-04-16 | 2017-11-07 | Mylan Specialty Lp | Nasal pharmaceutical formulations and methods of using the same |
| GB0320171D0 (en) * | 2003-08-28 | 2003-10-01 | Optinose As | Delivery devices |
| AU2004270171A1 (en) * | 2003-08-29 | 2005-03-17 | Glaxo Group Limited | Pharmaceutical metered dose inhaler and methods relating thereto |
| MX2007001561A (es) * | 2004-08-04 | 2007-04-16 | Schering Corp | Formulacion farmaceutica que comprende pleconaril para tratamiento de enfermedades de vias aereas. |
| GB0503738D0 (en) * | 2005-02-23 | 2005-03-30 | Optinose As | Powder delivery devices |
| GB0602980D0 (en) * | 2006-02-14 | 2006-03-29 | Optinose As | Delivery device and method |
| GB0604319D0 (en) * | 2006-03-03 | 2006-04-12 | Optinose As | Nasal delivery |
| GB2440316A (en) * | 2006-07-25 | 2008-01-30 | Optinose As | Nasal inhaler with scrubber |
| JP5415769B2 (ja) | 2006-12-26 | 2014-02-12 | 株式会社新日本科学 | 経鼻投与用製剤 |
| GB2448193A (en) * | 2007-04-05 | 2008-10-08 | Optinose As | Nasal delivery device |
| GB0719299D0 (en) * | 2007-10-03 | 2007-11-14 | Optinose As | Nasal delivery devices |
| CA2728808A1 (en) | 2008-02-01 | 2009-08-06 | Vectura Limited | Pulmonary formulations of triptans |
| US20100196483A1 (en) * | 2009-02-04 | 2010-08-05 | Activaero Gmbh Research & Development | Method for treatmentof severe and uncontrollable asthma |
| DE102011103347B4 (de) * | 2011-05-27 | 2014-10-30 | Meda Pharma Gmbh & Co. Kg | Nasale pharmazeutische Formulierung |
| RU2636866C2 (ru) | 2012-02-16 | 2017-11-28 | Кэпниа, Инк. | Газовый диспенсер с распылительным наконечником |
| PL2978482T3 (pl) * | 2013-03-26 | 2022-10-03 | Optinose As | Podawanie donosowe |
-
2015
- 2015-06-25 JP JP2017519960A patent/JP6785227B2/ja active Active
- 2015-06-25 CA CA2953207A patent/CA2953207A1/en active Pending
- 2015-06-25 KR KR1020177002368A patent/KR102458964B1/ko active Active
- 2015-06-25 BR BR112016029926A patent/BR112016029926A2/pt not_active Application Discontinuation
- 2015-06-25 EP EP15731925.2A patent/EP3160556A1/en not_active Ceased
- 2015-06-25 SG SG11201610685XA patent/SG11201610685XA/en unknown
- 2015-06-25 MX MX2016017038A patent/MX390453B/es unknown
- 2015-06-25 EP EP23174517.5A patent/EP4233950B1/en active Active
- 2015-06-25 AU AU2015279154A patent/AU2015279154A1/en not_active Abandoned
- 2015-06-25 CN CN201580034749.0A patent/CN106470724A/zh active Pending
- 2015-06-25 WO PCT/EP2015/064463 patent/WO2015197798A1/en not_active Ceased
- 2015-06-25 RU RU2016152090A patent/RU2016152090A/ru not_active Application Discontinuation
- 2015-06-25 ES ES23174517T patent/ES3034743T3/es active Active
-
2016
- 2016-12-15 IL IL249585A patent/IL249585B/en active IP Right Grant
- 2016-12-20 ZA ZA201608785A patent/ZA201608785B/en unknown
-
2020
- 2020-03-20 AU AU2020202029A patent/AU2020202029A1/en not_active Abandoned
- 2020-07-03 JP JP2020115917A patent/JP7090124B2/ja active Active
-
2021
- 2021-08-13 AU AU2021215246A patent/AU2021215246A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201608785B (en) | 2019-10-30 |
| CA2953207A1 (en) | 2015-12-30 |
| JP7090124B2 (ja) | 2022-06-23 |
| ES3034743T3 (en) | 2025-08-22 |
| AU2021215246A1 (en) | 2021-09-09 |
| EP3160556A1 (en) | 2017-05-03 |
| EP4233950B1 (en) | 2025-06-25 |
| EP4233950A1 (en) | 2023-08-30 |
| RU2016152090A3 (cg-RX-API-DMAC7.html) | 2019-02-15 |
| JP2017520364A (ja) | 2017-07-27 |
| BR112016029926A2 (pt) | 2017-08-22 |
| MX2016017038A (es) | 2017-05-01 |
| WO2015197798A1 (en) | 2015-12-30 |
| SG11201610685XA (en) | 2017-01-27 |
| JP6785227B2 (ja) | 2020-11-18 |
| KR20170035919A (ko) | 2017-03-31 |
| EP4233950C0 (en) | 2025-06-25 |
| IL249585A0 (en) | 2017-02-28 |
| CN106470724A (zh) | 2017-03-01 |
| MX390453B (es) | 2025-03-19 |
| AU2015279154A1 (en) | 2017-01-12 |
| IL249585B (en) | 2021-04-29 |
| KR102458964B1 (ko) | 2022-10-25 |
| JP2020179191A (ja) | 2020-11-05 |
| AU2020202029A1 (en) | 2020-04-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20200421 |
|
| FZ9A | Application not withdrawn (correction of the notice of withdrawal) |
Effective date: 20210318 |