RU2016149370A - Способ хранения вакцины с эмульсионным адъювантом в смазанном медицинском инъекционном устройстве - Google Patents
Способ хранения вакцины с эмульсионным адъювантом в смазанном медицинском инъекционном устройстве Download PDFInfo
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- RU2016149370A RU2016149370A RU2016149370A RU2016149370A RU2016149370A RU 2016149370 A RU2016149370 A RU 2016149370A RU 2016149370 A RU2016149370 A RU 2016149370A RU 2016149370 A RU2016149370 A RU 2016149370A RU 2016149370 A RU2016149370 A RU 2016149370A
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- vaccine
- lubricating coating
- silicone oil
- injection device
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- 238000000034 method Methods 0.000 title claims 16
- 229960005486 vaccine Drugs 0.000 title claims 8
- 238000010999 medical injection Methods 0.000 title claims 7
- 239000002671 adjuvant Substances 0.000 title claims 6
- 239000000839 emulsion Substances 0.000 title claims 6
- 239000011248 coating agent Substances 0.000 claims 9
- 238000000576 coating method Methods 0.000 claims 9
- 230000001050 lubricating effect Effects 0.000 claims 9
- 229920002545 silicone oil Polymers 0.000 claims 8
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims 6
- 230000001590 oxidative effect Effects 0.000 claims 5
- 229910052786 argon Inorganic materials 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 238000009832 plasma treatment Methods 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 238000002310 reflectometry Methods 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
-
- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
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-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B7/00—Closing containers or receptacles after filling
- B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
- B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
- B65B7/2821—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers applying plugs or threadless stoppers
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- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M107/00—Lubricating compositions characterised by the base-material being a macromolecular compound
- C10M107/50—Lubricating compositions characterised by the base-material being a macromolecular compound containing silicon
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M177/00—Special methods of preparation of lubricating compositions; Chemical modification by after-treatment of components or of the whole of a lubricating composition, not covered by other classes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/438—Antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/452—Lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M2005/3131—Syringe barrels specially adapted for improving sealing or sliding
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- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2229/00—Organic macromolecular compounds containing atoms of elements not provided for in groups C10M2205/00, C10M2209/00, C10M2213/00, C10M2217/00, C10M2221/00 or C10M2225/00 as ingredients in lubricant compositions
- C10M2229/02—Unspecified siloxanes; Silicones
- C10M2229/025—Unspecified siloxanes; Silicones used as base material
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- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
- C10N2040/00—Specified use or application for which the lubricating composition is intended
- C10N2040/50—Medical uses
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- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Surgery (AREA)
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- Hematology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Mechanical Engineering (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
Claims (20)
1. Способ хранения вакцины с эмульсионным адъювантом в медицинском инъекционном устройстве, содержащем смазочное покрытие, включающий в себя этапы, на которых:
(a) берут медицинское инъекционное устройство (1), содержащее цилиндр (2), имеющий внутреннюю поверхность (21);
(b) формируют слой силиконового масла по меньшей мере на части внутренней поверхности (21) цилиндра, предназначенной для контактирования с вакциной;
(c) выполняют обработку окислительной плазмой указанного слоя, чтобы сшить по меньшей мере часть слоя силиконового масла и сформировать смазочное покрытие (5);
(d) заполняют цилиндр вакциной (6) с эмульсионным адъювантом.
2. Способ по п. 1, в котором эмульсия представляет собой эмульсию типа «масло в воде».
3. Способ по п. 2, в котором масляная фаза адъюванта содержит сквален.
4. Способ по любому из пп. 1-3, в котором цилиндр (2) изготовлен из стекла.
5. Способ по любому из пп. 1-3, в котором перед плазменной обработкой силиконовое масло имеет вязкость от 900 до 1200 сантистокс при температуре 25°C.
6. Способ по любому из пп. 1-3, в котором толщина смазочного покрытия (5), измеренная с помощью рефлектометрии, составляет от 90 до 400 нм.
7. Способ по любому из пп. 1-3, в котором медицинское инъекционное устройство (1) включает в себя шприц, внутренний объем которого составляет 1 мл.
8. Способ по п. 7, в котором слой силиконового масла имеет массу от 0,1 до 0,4 мг.
9. Способ по любому из пп. 1-3 или 8, в котором дополнительно обеспечивают наличие поршня (3), находящегося в скользящем контакте с внутренней поверхностью цилиндра (2), формируют слой силиконового масла по меньшей мере на части поршня (3), предназначенной для контактирования с вакциной (6), и воздействуют на этот слой силиконового масла посредством обработки окислительной плазмой, чтобы сформировать смазочное покрытие на указанной части поршня.
10. Способ по любому из пп. 1-3 или 8, в котором указанным смазочным покрытием (5) покрывают по меньшей мере 90% внутренней поверхности цилиндра (2).
11. Способ по любому из пп. 1-3 или 8, в котором обработку окислительной плазмой выполняют в атмосфере, содержащей кислород и аргон.
12. Способ по п. 11, в котором атмосфера указанной окислительной плазмы содержит кислород и аргон с соответствующими парциальными давлениями от 15 до 30% для кислорода и от 85 до 70% для аргона.
13. Способ по любому из пп. 1-3, 8 или 12, в котором воздействие плазмой на слой силиконового масла осуществляют в течение промежутка времени от 10 до 40 с.
14. Способ по любому из пп. 1-3, 8 или 12 в котором окислительную плазму генерируют при помощи радиочастоты, с мощностью от 50 до 300 ватт и в условиях вакуума в диапазоне от 1,33 до 13,3 Па (10-100 миллиторр) по абсолютной величине.
15. Медицинское инъекционное устройство (1), имеющее смазочное покрытие (5) и содержащее вакцину (6) с эмульсионным адъювантом в контакте со смазочным покрытием (5), полученное непосредственно способом по любому из пп. 1-14.
16. Применение силиконового масла, обработанного плазмой, в качестве смазочного покрытия (5) в медицинском инъекционном устройстве (1), содержащем цилиндр (2), для предотвращения миграции силикона из указанного смазочного покрытия (5) в вакцину (6) с эмульсионным адъювантом во время хранения вакцины (6) в медицинском инъекционном устройстве (1).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14305781 | 2014-05-26 | ||
| EP14305781.8 | 2014-05-26 | ||
| PCT/EP2015/061594 WO2015181173A1 (en) | 2014-05-26 | 2015-05-26 | Method for storing an emulsion-adjuvanted vaccine in a lubricated medical injection device |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016149370A true RU2016149370A (ru) | 2018-06-26 |
| RU2016149370A3 RU2016149370A3 (ru) | 2018-08-22 |
| RU2684400C2 RU2684400C2 (ru) | 2019-04-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016149370A RU2684400C2 (ru) | 2014-05-26 | 2015-05-26 | Способ хранения вакцины с эмульсионным адъювантом в смазанном медицинском инъекционном устройстве |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20170182252A1 (ru) |
| EP (1) | EP3148620A1 (ru) |
| JP (1) | JP2017519553A (ru) |
| KR (1) | KR20170008296A (ru) |
| CN (1) | CN106413782A (ru) |
| CA (1) | CA2949881A1 (ru) |
| MX (1) | MX2016015241A (ru) |
| RU (1) | RU2684400C2 (ru) |
| WO (1) | WO2015181173A1 (ru) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017137570A1 (en) * | 2016-02-10 | 2017-08-17 | Becton Dickinson France | Method to evaluate the stability of a protein-based formulation |
| MX2019000263A (es) * | 2016-07-11 | 2019-05-27 | Becton Dickinson France | Metodo para reducir una cantidad de particulas subvisibles en una composicion farmaceutica. |
| CA3079380A1 (en) * | 2017-10-18 | 2019-04-25 | Eli Lilly And Company | Accelerated testing method of silicone drainage in syringes |
| SG11202010549PA (en) * | 2018-04-24 | 2020-11-27 | Gore & Ass | Medical delivery devices with inhibited oxygen permeation |
| EP3824926B1 (en) * | 2019-11-21 | 2024-01-31 | SCHOTT Pharma AG & Co. KGaA | Receptacle for pharmaceutical packaging having a graduated lubricant layer |
| CN215230307U (zh) * | 2019-11-21 | 2021-12-21 | 肖特股份有限公司 | 用于药物包装的容器、套件及组件 |
| EP3824927A1 (en) * | 2019-11-21 | 2021-05-26 | Schott AG | Receptacle for pharmaceutical packaging with a thickness profile for a lubricant layer |
| EP3875131A1 (en) * | 2020-03-06 | 2021-09-08 | Schott AG | Pharmaceutical packaging receptacle with a lubricant layer for removal of a charge |
| EP4144653A1 (en) * | 2021-09-02 | 2023-03-08 | Steriline S.r.l. | Control method of an electromechanical apparatus for installing a bung element of a pharmaceutical container |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1271160A (en) * | 1985-05-16 | 1990-07-03 | Joel L. Williams | Ionizing plasma lubricant method |
| US5338312A (en) * | 1992-10-02 | 1994-08-16 | Becton, Dickinson And Company | Article having multi-layered lubricant and method therefor |
| FR2800713B1 (fr) * | 1999-11-05 | 2002-01-04 | Biodome | Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif |
| ES2397714T3 (es) * | 2006-10-12 | 2013-03-08 | Glaxosmithkline Biologicals S.A. | Vacuna que comprende un adyuvante de emulsión de aceite en agua |
| WO2009053947A2 (en) * | 2007-10-22 | 2009-04-30 | Becton Dickinson France | Surface coating to prevent cation leaching |
| WO2011092536A1 (en) * | 2010-01-26 | 2011-08-04 | Becton Dickinson France | Drug cartrigde different inner surface conditions |
| US8802603B2 (en) * | 2010-06-17 | 2014-08-12 | Becton, Dickinson And Company | Medical components having coated surfaces exhibiting low friction and low reactivity |
| ES2944088T3 (es) * | 2011-09-27 | 2023-06-19 | Becton Dickinson France | Uso de aceite de silicona tratado con plasma como recubrimiento en un dispositivo médico de inyección |
| MX2014013411A (es) * | 2012-05-29 | 2015-10-09 | Becton Dickinson France | Revestimiento lubricante y dispositivo de inyeccion medico que comprende dicho revestimiento. |
-
2015
- 2015-05-26 US US15/312,896 patent/US20170182252A1/en not_active Abandoned
- 2015-05-26 RU RU2016149370A patent/RU2684400C2/ru active
- 2015-05-26 JP JP2016569632A patent/JP2017519553A/ja active Pending
- 2015-05-26 WO PCT/EP2015/061594 patent/WO2015181173A1/en active Application Filing
- 2015-05-26 MX MX2016015241A patent/MX2016015241A/es unknown
- 2015-05-26 CA CA2949881A patent/CA2949881A1/en not_active Abandoned
- 2015-05-26 CN CN201580033298.9A patent/CN106413782A/zh active Pending
- 2015-05-26 EP EP15724671.1A patent/EP3148620A1/en active Pending
- 2015-05-26 KR KR1020167035796A patent/KR20170008296A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20170182252A1 (en) | 2017-06-29 |
| RU2684400C2 (ru) | 2019-04-09 |
| KR20170008296A (ko) | 2017-01-23 |
| CN106413782A (zh) | 2017-02-15 |
| EP3148620A1 (en) | 2017-04-05 |
| CA2949881A1 (en) | 2015-12-03 |
| JP2017519553A (ja) | 2017-07-20 |
| RU2016149370A3 (ru) | 2018-08-22 |
| MX2016015241A (es) | 2017-10-11 |
| WO2015181173A1 (en) | 2015-12-03 |
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