RU2016116257A - Способ нанесения покрытия и поверхность с покрытием, покрытие и имплант, содержащий такое покрытие - Google Patents

Способ нанесения покрытия и поверхность с покрытием, покрытие и имплант, содержащий такое покрытие Download PDF

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RU2016116257A
RU2016116257A RU2016116257A RU2016116257A RU2016116257A RU 2016116257 A RU2016116257 A RU 2016116257A RU 2016116257 A RU2016116257 A RU 2016116257A RU 2016116257 A RU2016116257 A RU 2016116257A RU 2016116257 A RU2016116257 A RU 2016116257A
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resin
biologically active
coated
web
fibers
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RU2016116257A
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RU2661994C2 (ru
RU2016116257A3 (ru
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Олли КАРХИ
Пекка ВАЛЛИТТУ
Юха-Пекка НУУТИНЕН
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Скулле Имплантс Ой
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C70/00Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
    • B29C70/68Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts by incorporating or moulding on preformed parts, e.g. inserts or layers, e.g. foam blocks
    • B29C70/86Incorporated in coherent impregnated reinforcing layers, e.g. by winding
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    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/80Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
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    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
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    • A61B17/84Fasteners therefor or fasteners being internal fixation devices
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    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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Claims (32)

1. Способ нанесения покрытия на поверхность, включающий этапы:
- абразивной обработки покрываемой поверхности частицами с образованием абразивно обработанной поверхности,
- формирования и/или размещения на абразивно обработанной поверхности композитной структуры, содержащей:
- первое полотно из волокон, пропитанное первой смолой,
- по меньшей мере один пучок волокон, пропитанный второй смолой, расположенный в соответствии с рисунком, образующим промежуточные пространства, и в контакте с первым полотном из волокон,
- частицы биологически активного материала, размещенные в упомянутых промежуточных пространствах пучка волокон и размещенные в контакте с первым полотном из волокон,
- второе полотно из волокон, пропитанное третьей смолой, размещенное в контакте с пучком волокон и по меньшей мере с частью частиц биологически активного материала, при этом размер ячеек второго полотна из волокон меньше среднего диаметра частиц биологически активного материала,
- полимеризации смол композитной структуры.
2. Способ по п.1, отличающийся тем, что этап размещения композитной структуры на абразивно обработанной поверхности включает этапы:
- нанесения первой смолы на абразивно обработанную поверхность с образованием поверхности, покрытой первой смолой,
- нанесения первого полотна из волокон на поверхность, покрытую первой смолой,
- полимеризации первой смолы при атмосферных условиях с образованием ингибированной кислородом поверхности,
- нанесения упомянутого по меньшей мере одного пучка волокон, пропитанного второй смолой, в соответствии с рисунком на ингибированную кислородом поверхность,
- нанесения частиц биологически активного материала на ингибированную кислородом поверхность в упомянутых промежуточных пространствах пучка волокон,
- полимеризации второй смолы с образованием полупокрытой поверхности,
- нанесения второго полотна из волокон, пропитанного третьей смолой, на полупокрытую поверхность, и
- полимеризации третьей смолы второго полотна из волокон с образованием поверхности с покрытием.
3. Способ по п.2, отличающийся тем, что первое полотно из волокон пропитывают первой смолой перед нанесением его на абразивно обработанную поверхность.
4. Способ по п.1, отличающийся тем, что композитную структуру формируют отдельно и размещают на абразивно обработанной поверхности.
5. Способ по любому из предыдущих пунктов, отличающийся тем, что этап абразивной обработки покрываемой поверхности осуществляют с помощью частиц, содержащих диоксид кремния, и тем, что он дополнительно включает, после абразивной обработки покрываемой поверхности и перед нанесением композитной структуры, этапы:
- нанесения раствора, содержащего агент для связывания силана, на абразивно обработанную поверхность с образованием поверхности, покрытой раствором, и
- полимеризации раствора с образованием силанизированной поверхности.
6. Способ по п.5, отличающийся тем, что раствору, содержащему агент для связывания силана, дают возможность гидролизоваться перед его нанесением на абразивно обработанную поверхность.
7. Способ по п.1, отличающийся тем, что вторая и третья смолы представляют собой фотополимеризуемые смолы, выбранные из группы, состоящей из диметакрилатных мономеров.
8. Способ по п.1, отличающийся тем, что волокна, используемые в полотнах и/или в ровингах, представляют собой стекловолокна.
9. Способ по п.8, отличающийся тем, что стекловолокна выполняют из композиции стекла из S-стекла, E-стекла или биологически активного стекла.
10. Способ по п.1, отличающийся тем, что биологически активный материал выбирается из группы, состоящей из биологически активного стекла, гидроксиапатита, трикальцийфосфата и их смесей.
11. Способ по п.1, отличающийся тем, что диаметр пучка волокон составляет 0,1-10 мм.
12. Способ по п.1, отличающийся тем, что средний размер частиц биологически активного материала составляет 10-1000 мкм.
13. Покрытие поверхности, получаемое способом по любому из пп.1-12.
14. Имплант, получаемый при по меньшей мере частичном покрытии его поверхности в соответствии со способом по любому из пп.1-12.
15. Имплант по п.14, отличающийся тем, что имплант выбирается из группы, состоящей из протезов тазобедренного сустава, ацетабулярных чашек, протезов коленного сустава, штифтов для остеосинтеза, пластин для фиксации переломов и стоматологических имплантов.
RU2016116257A 2013-09-27 2014-08-27 Способ нанесения покрытия и поверхность с покрытием, покрытие и имплант, содержащий такое покрытие RU2661994C2 (ru)

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