RU2016107313A - Способ сохранения и стабилизации протеинов - Google Patents
Способ сохранения и стабилизации протеинов Download PDFInfo
- Publication number
- RU2016107313A RU2016107313A RU2016107313A RU2016107313A RU2016107313A RU 2016107313 A RU2016107313 A RU 2016107313A RU 2016107313 A RU2016107313 A RU 2016107313A RU 2016107313 A RU2016107313 A RU 2016107313A RU 2016107313 A RU2016107313 A RU 2016107313A
- Authority
- RU
- Russia
- Prior art keywords
- proteins
- oil
- oil components
- hydrocynamate
- triisopropanolamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
Claims (5)
1. Способ сохранения и стабилизации протеинов, который может использоваться для промышленной разработки композиций, используемых в составе санитарной, фармацевтической и косметической продукции, в частности факторов роста клеток и/или протеинов, таких как эпидермальный фактор роста (EGF) и фактор роста фибробластов (bFGF), отличающийся тем, что он включает в себя фазу дисперсии при условии нормальной температуры и нормального давления, в которой протеины помещают в безводную среду, сформированную масляными компонентами, имеющими гидрофильные остатки и взаимодействующие с протеинами, сохраняя при этом нативную конформацию протеинов.
2. Способ по п. 1, отличающийся тем, что масляные компоненты включают в себя масло из виноградных косточек.
3. Способ по п. 1 или 2, отличающийся тем, что масляные компоненты включают в себя основу, в состав которой входят: триглецирид каприловой/каприновой кислоты, ПЭГ-18 диолеат касторового масла, пропиленгликоль, пентаэритритил тетра ди-Т-бензил гидрокси гидроцинамат, токоферол, триизопропаноламин.
4. Способ по п. 3, отличающийся тем, что масляные компоненты содержат бутил гидрокситолуол.
5. Способ по п. 1, отличающийся тем, что компонентами масляной фазы являются масло из виноградных косточек, бутил гидрокситолуол и основа, в состав которой входят: триглецирид каприловой/каприновой кислоты, ПЭГ-18 диолеат касторового масла, пропиленгликоль, пентаэритритил тетра ди-Т-бензил гидрокси гидроцинамат, токоферол, триизопропаноламин.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201331394A ES2502691B1 (es) | 2013-09-25 | 2013-09-25 | Método de conservación y estabilización de proteínas, aplicable para desarrollos industriales de formulaciones de productos sanitarios, farmacéuticos y cosméticos |
| ESP201331394 | 2013-09-25 | ||
| PCT/ES2014/000151 WO2015011308A1 (es) | 2013-09-25 | 2014-09-23 | Método de conservación y estabilización de proteínas, aplicable para desarrollos industriales de formulaciones de productos sanitarios, farmacéuticos y cosméticos |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016107313A true RU2016107313A (ru) | 2017-09-04 |
| RU2642277C2 RU2642277C2 (ru) | 2018-01-24 |
Family
ID=51626311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016107313A RU2642277C2 (ru) | 2013-09-25 | 2014-09-23 | Способ сохранения и стабилизации протеинов |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20160030584A1 (ru) |
| EP (2) | EP4241783A1 (ru) |
| JP (1) | JP6959002B2 (ru) |
| KR (1) | KR20160055720A (ru) |
| CN (2) | CN117402206A (ru) |
| BR (1) | BR112015020658B1 (ru) |
| CA (1) | CA2913394A1 (ru) |
| ES (1) | ES2502691B1 (ru) |
| MX (1) | MX2016001476A (ru) |
| RU (1) | RU2642277C2 (ru) |
| WO (1) | WO2015011308A1 (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105055265A (zh) * | 2015-07-21 | 2015-11-18 | 北京博士园科技发展有限公司 | 一种美容养颜产品及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998753A (en) * | 1974-08-13 | 1976-12-21 | Hoffmann-La Roche Inc. | Water dispersible carotenoid preparations and processes thereof |
| GB8604983D0 (en) * | 1986-02-28 | 1986-04-09 | Biocompatibles Ltd | Protein preservation |
| US4806343A (en) * | 1986-03-13 | 1989-02-21 | University Of Southwestern Louisiana | Cryogenic protectant for proteins |
| US5416242A (en) * | 1992-09-25 | 1995-05-16 | Nippon Hypox Laboratories Incorporated | Hydroquinone derivative |
| US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| KR100366439B1 (ko) * | 2000-02-21 | 2003-01-09 | 주식회사 대웅 | 상피세포 성장인자를 유효성분으로 하는 안정한 약제학적조성물 |
| FR2814672B1 (fr) * | 2000-10-03 | 2003-03-21 | Oreal | Composition cosmetique a phase continue lipophile comprenant un pigment goniochromatique multicouche et son utilisation en maquillage |
| AU3664102A (en) * | 2000-12-01 | 2002-06-11 | Battelle Memorial Institute | Method for stabilizing biomolecules in liquid formulations |
| ES2232305B1 (es) * | 2003-11-07 | 2006-07-16 | Miguel Angel Palomo S.A. | Procedimiento de obtencion de alimentos texturizados y termoestables a partir de materias primas naturales y productos obtenidos a partir del mismo. |
| US11039999B2 (en) * | 2004-06-25 | 2021-06-22 | Ferrosan Aps | Compositions suitable for treating cutaneous signs of aging |
| US20080102128A1 (en) * | 2006-07-28 | 2008-05-01 | Flamel Technologies, Inc. | Modified-release microparticles based on amphiphilic copolymer and on active principles(s) and pharmaceutical formulations comprising them |
| FR2910318B1 (fr) * | 2006-12-20 | 2009-07-03 | Flamel Technologies Sa | Dispersion de polyaminoacides dans une phase lipidique continue. |
| ES2319061B1 (es) * | 2007-09-11 | 2010-02-10 | Biomedal, S.L. | Metodo de conservacion de peptidos o proteinas. |
| US20110020519A1 (en) * | 2008-01-04 | 2011-01-27 | Aveka, Inc. | Encapsulation of oxidatively unstable compounds |
| IL188647A0 (en) * | 2008-01-08 | 2008-11-03 | Orina Gribova | Adaptable structured drug and supplements administration system (for oral and/or transdermal applications) |
| PT2343982T (pt) * | 2008-09-17 | 2017-07-04 | Chiasma Inc | Composições farmacêuticas e métodos de administração associados |
-
2013
- 2013-09-25 ES ES201331394A patent/ES2502691B1/es active Active
-
2014
- 2014-09-23 EP EP23175038.1A patent/EP4241783A1/en active Pending
- 2014-09-23 CA CA2913394A patent/CA2913394A1/en active Pending
- 2014-09-23 JP JP2016544774A patent/JP6959002B2/ja active Active
- 2014-09-23 WO PCT/ES2014/000151 patent/WO2015011308A1/es active Application Filing
- 2014-09-23 CN CN202311351237.XA patent/CN117402206A/zh active Pending
- 2014-09-23 US US14/759,320 patent/US20160030584A1/en not_active Abandoned
- 2014-09-23 MX MX2016001476A patent/MX2016001476A/es unknown
- 2014-09-23 CN CN201480028046.2A patent/CN105209476A/zh active Pending
- 2014-09-23 RU RU2016107313A patent/RU2642277C2/ru active
- 2014-09-23 KR KR1020157018008A patent/KR20160055720A/ko not_active IP Right Cessation
- 2014-09-23 EP EP14830029.6A patent/EP3050894A4/en not_active Ceased
- 2014-09-23 BR BR112015020658-1A patent/BR112015020658B1/pt active IP Right Grant
-
2017
- 2017-12-27 US US15/855,338 patent/US20180193467A1/en not_active Abandoned
-
2019
- 2019-05-14 US US16/411,782 patent/US11147882B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015020658B1 (pt) | 2023-12-05 |
| KR20160055720A (ko) | 2016-05-18 |
| CA2913394A1 (en) | 2015-01-29 |
| EP4241783A1 (en) | 2023-09-13 |
| US20180193467A1 (en) | 2018-07-12 |
| US20190290770A1 (en) | 2019-09-26 |
| MX2016001476A (es) | 2016-07-12 |
| ES2502691B1 (es) | 2015-07-07 |
| JP2017501206A (ja) | 2017-01-12 |
| WO2015011308A1 (es) | 2015-01-29 |
| EP3050894A1 (en) | 2016-08-03 |
| CN117402206A (zh) | 2024-01-16 |
| US20160030584A1 (en) | 2016-02-04 |
| US11147882B2 (en) | 2021-10-19 |
| RU2642277C2 (ru) | 2018-01-24 |
| ES2502691A1 (es) | 2014-10-03 |
| JP6959002B2 (ja) | 2021-11-02 |
| CN105209476A (zh) | 2015-12-30 |
| EP3050894A4 (en) | 2017-04-19 |
| BR112015020658A2 (pt) | 2017-07-18 |
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