RU2015156824A - Генетические методики получения животных с поддающимися сортировке сперматозоидами - Google Patents
Генетические методики получения животных с поддающимися сортировке сперматозоидами Download PDFInfo
- Publication number
- RU2015156824A RU2015156824A RU2015156824A RU2015156824A RU2015156824A RU 2015156824 A RU2015156824 A RU 2015156824A RU 2015156824 A RU2015156824 A RU 2015156824A RU 2015156824 A RU2015156824 A RU 2015156824A RU 2015156824 A RU2015156824 A RU 2015156824A
- Authority
- RU
- Russia
- Prior art keywords
- marker
- sperm
- animal
- chromosome
- toxin
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title claims 22
- 238000000034 method Methods 0.000 title claims 3
- 230000002068 genetic effect Effects 0.000 title 1
- 239000003550 marker Substances 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 108700012359 toxins Proteins 0.000 claims 8
- 210000001766 X chromosome Anatomy 0.000 claims 7
- 210000002593 Y chromosome Anatomy 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 239000000975 dye Substances 0.000 claims 6
- 239000003053 toxin Substances 0.000 claims 6
- 231100000765 toxin Toxicity 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 231100000331 toxic Toxicity 0.000 claims 5
- 230000002588 toxic effect Effects 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108010016529 Bacillus amyloliquefaciens ribonuclease Proteins 0.000 claims 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 3
- 239000000729 antidote Substances 0.000 claims 3
- 229910052791 calcium Inorganic materials 0.000 claims 3
- 239000011575 calcium Substances 0.000 claims 3
- 239000007850 fluorescent dye Substances 0.000 claims 3
- 238000009830 intercalation Methods 0.000 claims 3
- 238000012800 visualization Methods 0.000 claims 3
- 108090001008 Avidin Proteins 0.000 claims 2
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 2
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 2
- 101710163270 Nuclease Proteins 0.000 claims 2
- 108010039491 Ricin Proteins 0.000 claims 2
- 102000006601 Thymidine Kinase Human genes 0.000 claims 2
- 108020004440 Thymidine kinase Proteins 0.000 claims 2
- 230000001640 apoptogenic effect Effects 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- 231100000518 lethal Toxicity 0.000 claims 2
- 230000001665 lethal effect Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 229920002704 polyhistidine Polymers 0.000 claims 2
- 230000019100 sperm motility Effects 0.000 claims 2
- 102100030988 Angiotensin-converting enzyme Human genes 0.000 claims 1
- 101710183938 Barstar Proteins 0.000 claims 1
- 108050006400 Cyclin Proteins 0.000 claims 1
- 102000016736 Cyclin Human genes 0.000 claims 1
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims 1
- 102000007327 Protamines Human genes 0.000 claims 1
- 108010007568 Protamines Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 210000003495 flagella Anatomy 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000006543 gametophyte development Effects 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 229940048914 protamine Drugs 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829672P | 2013-05-31 | 2013-05-31 | |
| US61/829,672 | 2013-05-31 | ||
| US201361870586P | 2013-08-27 | 2013-08-27 | |
| US61/870,586 | 2013-08-27 | ||
| PCT/US2014/035851 WO2014193584A2 (en) | 2013-05-31 | 2014-04-29 | Genetic techniques for making animals with sortable sperm |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015156824A true RU2015156824A (ru) | 2017-07-05 |
Family
ID=51986778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015156824A RU2015156824A (ru) | 2013-05-31 | 2014-04-29 | Генетические методики получения животных с поддающимися сортировке сперматозоидами |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20140359795A1 (https=) |
| EP (1) | EP3003021A4 (https=) |
| JP (1) | JP2016519955A (https=) |
| KR (1) | KR20160015333A (https=) |
| CN (1) | CN105658050A (https=) |
| AP (1) | AP2015008966A0 (https=) |
| AU (1) | AU2014272107A1 (https=) |
| BR (1) | BR112015029905A2 (https=) |
| CA (1) | CA2913412A1 (https=) |
| MX (1) | MX2015016383A (https=) |
| PH (1) | PH12015502646A1 (https=) |
| RU (1) | RU2015156824A (https=) |
| WO (1) | WO2014193584A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3456831T3 (da) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| US20140359796A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetically sterile animals |
| US10779518B2 (en) | 2013-10-25 | 2020-09-22 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US10787684B2 (en) * | 2013-11-19 | 2020-09-29 | President And Fellows Of Harvard College | Large gene excision and insertion |
| KR102170502B1 (ko) | 2013-12-11 | 2020-10-28 | 리제너론 파마슈티칼스 인코포레이티드 | 게놈의 표적화된 변형을 위한 방법 및 조성물 |
| BR112016024945A2 (pt) | 2014-04-28 | 2017-10-24 | Recombinetics Inc | edição de gene multiplex em suínos |
| SI3161128T1 (sl) | 2014-06-26 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Postopki in sestavki za ciljano genetsko spremembo in postopki uporabe |
| KR102531016B1 (ko) | 2014-11-21 | 2023-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물 |
| EP3303585A4 (en) | 2015-06-03 | 2018-10-31 | Board of Regents of the University of Nebraska | Dna editing using single-stranded dna |
| CN107315092B (zh) * | 2017-07-11 | 2019-03-19 | 上海市第一人民医院 | 一种快速评估睾丸生精功能的免疫荧光染色法及其试剂盒 |
| WO2020102565A2 (en) * | 2018-11-14 | 2020-05-22 | Flagship Pioneering Innovations V, Inc. | Systems and methods for nondestructive testing of gametes |
| CN111500530A (zh) * | 2020-04-30 | 2020-08-07 | 延安大学 | 一种通用型动物精子分选方法及x精子质控方法 |
| CN114015705A (zh) * | 2021-11-28 | 2022-02-08 | 华中科技大学同济医学院附属协和医院 | 一种小鼠体外受精繁育性别选择方法 |
| WO2024249570A2 (en) * | 2023-06-02 | 2024-12-05 | New York University | Single-sex chicken with toxin-antitoxin system |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1129205A1 (en) * | 1998-11-13 | 2001-09-05 | Cedars-Sinai Medical Center | Transfection of male germ cells for generation of selectable transgenic stem cells |
| GB9916810D0 (en) * | 1999-07-16 | 1999-09-22 | Cancer Res Campaign Tech | Killing cells |
| BR0016212A (pt) * | 1999-12-07 | 2002-08-27 | Univ Guelph | Proteìna especìfica do cromossoma sexual e sequência de ácido nucleico isolada e purificada, método para identificar moléculas especìficas de cromossomas sexuais associadas com membranas celulares de esperma animal, anticorpo contra um epìtopo de uma molécula especìfica de cromossomas sexuais, métodos de triagem para uma molécula especifica de cromossomas sexuais, e para separar esperma determinante de macho e fêmea de sêmen nativo kit para executar um método, contraceptivo, proteìna especìfica do cromossoma sexual isolada e purificada, e , molécula |
| US20010032340A1 (en) * | 1999-12-27 | 2001-10-18 | Chengyu Liu | Controlling offspring's sex ratio by targeting transgenes onto the sex chromosomes |
| CN1291010C (zh) * | 2000-02-24 | 2006-12-20 | 马萨诸塞大学 | 只生育单一性别后代的哺乳动物的生产 |
| CA2442019A1 (en) * | 2001-03-22 | 2002-10-03 | Infigen, Inc. | Sex-specific selection of sperm from transgenic animals |
| CN1313061C (zh) * | 2002-03-11 | 2007-05-02 | 刘凤鸣 | 一种动物精子的性别分选方法 |
| JP4271120B2 (ja) * | 2003-10-14 | 2009-06-03 | 独立行政法人科学技術振興機構 | Ｙ染色体標識トランスジェニック非ヒト動物 |
| CN101014350A (zh) * | 2004-03-29 | 2007-08-08 | 孟山都技术公司 | 用于授精的精子悬浮液 |
| US20060123489A1 (en) * | 2004-12-03 | 2006-06-08 | Envivo Pharmaceuticals, Inc. | Sex-specific automated sorting of non-human animals |
| CA2793945A1 (en) * | 2009-04-01 | 2011-10-21 | Biocern, Inc. | Sperm cell separation methods and compositions containing sperm cell targeting ligands for use therein |
| EP2470557A1 (en) * | 2009-08-28 | 2012-07-04 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Genetic vasectomy by overexpression of prml-egfp fusion protein in spermatids |
| MX363013B (es) * | 2011-02-25 | 2019-03-04 | Recombinetics Inc | Animales genéticamente modificados y métodos para su obtención. |
| CN102199606B (zh) * | 2011-03-09 | 2012-12-26 | 塔里木大学 | 一种筛选非人哺乳动物xy精子差异表达基因的方法 |
-
2014
- 2014-04-28 US US14/263,431 patent/US20140359795A1/en not_active Abandoned
- 2014-04-29 AP AP2015008966A patent/AP2015008966A0/xx unknown
- 2014-04-29 EP EP14804017.3A patent/EP3003021A4/en not_active Withdrawn
- 2014-04-29 BR BR112015029905A patent/BR112015029905A2/pt not_active Application Discontinuation
- 2014-04-29 CA CA2913412A patent/CA2913412A1/en not_active Abandoned
- 2014-04-29 MX MX2015016383A patent/MX2015016383A/es unknown
- 2014-04-29 RU RU2015156824A patent/RU2015156824A/ru not_active Application Discontinuation
- 2014-04-29 JP JP2016516662A patent/JP2016519955A/ja active Pending
- 2014-04-29 WO PCT/US2014/035851 patent/WO2014193584A2/en not_active Ceased
- 2014-04-29 CN CN201480042059.5A patent/CN105658050A/zh active Pending
- 2014-04-29 AU AU2014272107A patent/AU2014272107A1/en not_active Abandoned
- 2014-04-29 KR KR1020157037264A patent/KR20160015333A/ko not_active Withdrawn
-
2015
- 2015-11-26 PH PH12015502646A patent/PH12015502646A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2015016383A (es) | 2016-09-29 |
| PH12015502646A1 (en) | 2016-03-07 |
| AU2014272107A1 (en) | 2016-01-21 |
| BR112015029905A2 (pt) | 2017-09-26 |
| US20140359795A1 (en) | 2014-12-04 |
| EP3003021A4 (en) | 2016-11-02 |
| KR20160015333A (ko) | 2016-02-12 |
| CA2913412A1 (en) | 2014-12-04 |
| JP2016519955A (ja) | 2016-07-11 |
| AP2015008966A0 (en) | 2015-12-31 |
| EP3003021A2 (en) | 2016-04-13 |
| CN105658050A (zh) | 2016-06-08 |
| WO2014193584A3 (en) | 2015-08-06 |
| WO2014193584A2 (en) | 2014-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20180604 |