RU2015136683A - Иммуногенные композиции, содержащие силикатированный вирус, и способы применения - Google Patents

Иммуногенные композиции, содержащие силикатированный вирус, и способы применения Download PDF

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RU2015136683A
RU2015136683A RU2015136683A RU2015136683A RU2015136683A RU 2015136683 A RU2015136683 A RU 2015136683A RU 2015136683 A RU2015136683 A RU 2015136683A RU 2015136683 A RU2015136683 A RU 2015136683A RU 2015136683 A RU2015136683 A RU 2015136683A
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virus
hepatitis
silicate
coronavirus
immune response
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RU2015136683A
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RU2676083C2 (ru
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Кеннет М. СТЕДМАН
Джеймс Р. ЛЕЙДЛЕР
Кит БАХДЖАТ
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Портланд Стейт Юниверсити
Провиденс Хелс Энд Сервисез - Орегон
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Claims (24)

1. Способ индуцирования у субъекта вирус-специфического иммунного ответа, предусматривающий введение субъекту эффективного количества силикатированного вируса или силикатированных вирусных частиц, с индуцированием таким образом у субъекта вирус-специфического иммунного ответа.
2. Cпособ по п. 1, где вирус представляет собой вирус осповакцины, ротавирус, аденовирус, вирус гриппа, лентивирус, флавивирус, вирус гепатита, пикорнавирус или коронавирус.
3. Способ по п. 2, где лентивирус представляет собой вирус иммунодефицита.
4. Способ по п. 3, где вирус иммунодефицита представляет собой вирус иммунодефицита человека.
5. Способ по п. 2, где флавивирус представляет собой вирус Западного Нила, вирус японского энцефалита, вирус денге, вирус клещевого энцефалита, вирус желтой лихорадки или вирус энцефалита Сент-Луис.
6. Способ по п. 2, где вирус гепатита представляет собой вирус гепатита A, вирус гепатита В или вирус гепатита С.
7. Способ по п. 2, где пикорнавирус представляет собой полиовирус.
8. Способ по п. 2, где коронавирус представляет собой вирус тяжелого острого респираторного синдрома (SARS) или коронавирус ближневосточного респираторного синдрома (MERS).
9. Способ по п. 1, где вирус-специфический иммунный ответ предусматривает активацию вирус-специфических T-клеток, выработку вирус-специфических антител, выработку цитокинов или их любую их комбинацию.
10. Способ по п. 1, где введение представляет собой путь, выбранный из внутримышечного, подкожного, перорального и ингаляционного.
11. Иммуногенная композиция, содержащая (i) силикатированный вирус или силикатированную вирусную частицу и (ii) фармацевтически приемлемый носитель или адъювант, где вирус представляет собой вирус осповакцины, ротавирус, аденовирус, вирус гриппа, лентивирус, флавивирус, вирус гепатита, пикорнавирус или коронавирус.
12. Иммуногенная композиция по п. 11, где
лентивирус представляет собой вирус иммунодефицита; флавивирус представляет собой вирус Западного Нила, вирус японского энцефалита, вирус денге, вирус клещевого энцефалита, вирус желтой лихорадки или вирус энцефалита Сент-Луис; вирус гепатита представляет собой вирус гепатита A, вирус гепатита В или вирус гепатита С; пикорнавирус представляет собой полиовирус; или коронавирус представляет собой вирус SARS или вирус MERS.
13. Иммуногенная композиция по п. 12, где вирус иммунодефицита представляет собой вирус иммунодефицита человека.
14. Иммуногенная композиция по п. 11, где адъювант включает эмульсию вода в масле, неполный адъювант Фрейнда, квасцы, гидроксид алюминия, агонист толл-подобных рецепторов, иммуностимулирующий олигонуклеотид или биологический адъювант.
15. Иммуногенная композиция по п. 11, где фармацевтически приемлемый носитель включает физиологический солевой раствор, сбалансированный солевой раствор, буферизующее средство, суспендирующее средство, загуститель, неводный растворитель, водный носитель, консервант, антиоксидант, бактериостатическое средство или любую их комбинацию.
16. Иммуногенная композиция по п. 11, которая входит в состав единичной дозированной формы.
17. Способ усиления у субъекта вирус-специфического клеточно-опосредованного иммунного ответа, предусматривающий введение субъекту силикатированного вируса или силикатированных вирусных частиц, где вирус-специфический клеточно-опосредованный иммунный ответ повышается по сравнению с клеточно-опосредованным иммунным ответом после введения несиликатированного вируса или несиликатированных вирусных частиц.
18. Cпособ по п. 17, где вирус представляет собой вирус осповакцины, ротавирус, аденовирус, вирус гриппа, лентивирус, флавивирус, вирус гепатита, пикорнавирус или коронавирус.
19. Способ по п. 18, где
лентивирус представляет собой вирус иммунодефицита; флавивирус представляет собой вирус Западного Нила, вирус японского энцефалита, вирус денге, вирус клещевого энцефалита, вирус желтой лихорадки или вирус энцефалита Сент-Луис; вирус гепатита представляет собой вирус гепатита A, вирус гепатита В или вирус гепатита С; пикорнавирус представляет собой полиовирус; или коронавирус представляет собой вирус SARS или вирус MERS.
20. Способ по п. 19, где вирус иммунодефицита представляет собой вирус иммунодефицита человека.
21. Способ по п. 21, где повышение вирус-специфического клеточно-опосредованного иммунного ответа определяют по повышению числа вирус-специфических T-клеток, повышению активации вирус-специфических T-клеток, повышению выработки цитокинов или их любой комбинации.
22. Способ по п. 21, где T-клетки представляют собой CD8+ T-клетки, или цитокин представляет собой инетерферон-γ (IFN-γ), или и то, и другое.
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