RU2015116485A - Антитела к рецептору альфа 2 интерлейкина-13 и конъюгаты антитело-лекарственное средство - Google Patents
Антитела к рецептору альфа 2 интерлейкина-13 и конъюгаты антитело-лекарственное средство Download PDFInfo
- Publication number
- RU2015116485A RU2015116485A RU2015116485A RU2015116485A RU2015116485A RU 2015116485 A RU2015116485 A RU 2015116485A RU 2015116485 A RU2015116485 A RU 2015116485A RU 2015116485 A RU2015116485 A RU 2015116485A RU 2015116485 A RU2015116485 A RU 2015116485A
- Authority
- RU
- Russia
- Prior art keywords
- seq
- antibody
- heavy chain
- variable region
- light chain
- Prior art date
Links
- 239000000611 antibody drug conjugate Substances 0.000 title claims 10
- 229940049595 antibody-drug conjugate Drugs 0.000 title claims 10
- 102000007482 Interleukin-13 Receptor alpha2 Subunit Human genes 0.000 title 1
- 108010085418 Interleukin-13 Receptor alpha2 Subunit Proteins 0.000 title 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims abstract 26
- 239000012634 fragment Substances 0.000 claims abstract 18
- 239000000427 antigen Substances 0.000 claims abstract 14
- 108091007433 antigens Proteins 0.000 claims abstract 14
- 102000036639 antigens Human genes 0.000 claims abstract 14
- 230000027455 binding Effects 0.000 claims abstract 14
- 101001003132 Homo sapiens Interleukin-13 receptor subunit alpha-2 Proteins 0.000 claims abstract 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 8
- 101710112634 Interleukin-13 receptor subunit alpha-2 Proteins 0.000 claims abstract 5
- 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 claims abstract 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims abstract 3
- 102000003816 Interleukin-13 Human genes 0.000 claims abstract 2
- 108090000176 Interleukin-13 Proteins 0.000 claims abstract 2
- 108020003175 receptors Proteins 0.000 claims abstract 2
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 239000000562 conjugate Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- 229940125644 antibody drug Drugs 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 206010018338 Glioma Diseases 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- -1 maleimide-polyethylene Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
- G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261723545P | 2012-11-07 | 2012-11-07 | |
| US61/723,545 | 2012-11-07 | ||
| US201361749610P | 2013-01-07 | 2013-01-07 | |
| US61/749,610 | 2013-01-07 | ||
| US201361886156P | 2013-10-03 | 2013-10-03 | |
| US61/886,156 | 2013-10-03 | ||
| US201361889179P | 2013-10-10 | 2013-10-10 | |
| US61/889,179 | 2013-10-10 | ||
| PCT/IB2013/059786 WO2014072888A1 (en) | 2012-11-07 | 2013-10-30 | Anti-il-13 receptor alpha 2 antibodies and antibody-drug conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015116485A true RU2015116485A (ru) | 2016-12-27 |
Family
ID=49955428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015116485A RU2015116485A (ru) | 2012-11-07 | 2013-10-30 | Антитела к рецептору альфа 2 интерлейкина-13 и конъюгаты антитело-лекарственное средство |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9828428B2 (OSRAM) |
| EP (1) | EP2916875A1 (OSRAM) |
| JP (1) | JP2016503295A (OSRAM) |
| KR (1) | KR101763499B1 (OSRAM) |
| CN (1) | CN104936621A (OSRAM) |
| AU (1) | AU2013343111A1 (OSRAM) |
| CA (1) | CA2890256A1 (OSRAM) |
| HK (1) | HK1214161A1 (OSRAM) |
| IL (1) | IL238566A0 (OSRAM) |
| MX (1) | MX2015005582A (OSRAM) |
| PE (1) | PE20150891A1 (OSRAM) |
| PH (1) | PH12015500977A1 (OSRAM) |
| RU (1) | RU2015116485A (OSRAM) |
| SG (1) | SG11201503431TA (OSRAM) |
| WO (1) | WO2014072888A1 (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3111357A1 (en) | 2011-12-23 | 2013-06-27 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| CR20160319A (es) * | 2013-12-12 | 2016-11-08 | Jiangsu Hengrui Medicine Co | Anticuerpo pd-1, fragmento de union al antigeno de este y uso médico de este |
| KR102413079B1 (ko) | 2014-05-28 | 2022-06-24 | 어젠시스 인코포레이티드 | 돌라프로인-돌라이소류인 펩타이드의 유도체 |
| SG10201913324PA (en) | 2014-05-29 | 2020-03-30 | Macrogenics Inc | Tri-specific binding molecules and methods of use thereof |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| WO2016061562A2 (en) | 2014-10-17 | 2016-04-21 | Kodiak Sciences Inc. | Butyrylcholinesterase zwitterionic polymer conjugates |
| US10953106B2 (en) | 2015-02-16 | 2021-03-23 | Lonza Ltd | Antibodies |
| BR112018005573A2 (pt) * | 2015-09-21 | 2019-01-22 | Aptevo Research And Development Llc | ?polipeptídeos de ligação a cd3? |
| CA2949033C (en) * | 2015-11-30 | 2025-05-06 | Pfizer Inc. | ANTIBODIES AND ANTIBODY FRAGMENTS FOR SITE-SPECIFIC CONJUGATION |
| TWI778491B (zh) * | 2015-11-30 | 2022-09-21 | 美商輝瑞股份有限公司 | 位點專一性ｈｅｒ２抗體藥物共軛體 |
| AU2016370376B2 (en) | 2015-12-14 | 2023-12-14 | Macrogenics, Inc. | Bispecific molecules having immunoreactivity with PD-1 and CTLA-4, and methods of use thereof |
| CN107405408B (zh) * | 2015-12-21 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 一种抗体药物偶联物的制备方法 |
| AU2016381964B2 (en) * | 2015-12-30 | 2024-02-15 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| US20190086392A1 (en) | 2016-03-21 | 2019-03-21 | Inserm (Institut National De La Sante Et De La Recherch Medicale) | Methods for diagnosis and treatment of solar lentigo |
| EP3463464A4 (en) | 2016-06-07 | 2020-07-01 | MacroGenics, Inc. | ASSOCIATION TREATMENT |
| CN108456250B (zh) * | 2017-02-17 | 2025-11-28 | 恺兴生命科技(上海)有限公司 | 靶向il-13ra2的抗体及其应用 |
| CN107880131A (zh) * | 2017-08-14 | 2018-04-06 | 四川大学 | 一种抗IL‑13Rα2和CD3双特异抗体及其应用 |
| US11364303B2 (en) | 2017-09-29 | 2022-06-21 | Pfizer Inc. | Cysteine engineered antibody drug conjugates |
| SG11202005557TA (en) | 2017-12-12 | 2020-07-29 | Macrogenics Inc | Bispecific cd 16-binding molecules and their use in the treatment of disease |
| AU2019222666B2 (en) | 2018-02-15 | 2025-12-04 | Macrogenics, Inc. | Variant CD3-binding domains and their use in combination therapies for the treatment of disease |
| CN112203679A (zh) | 2018-03-02 | 2021-01-08 | 科达制药股份有限公司 | Il-6抗体及其融合构建体和缀合物 |
| CA3093791A1 (en) | 2018-03-14 | 2019-09-19 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Il-13 receptor alpha 2 targeted, zetakine directed t cell immunotherapy |
| EP3765041A4 (en) * | 2018-03-14 | 2021-12-22 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | IL-13 ALPHA 2 RECEPTOR CHEMICAL ANTIGENIC RECEPTOR (IL13RA2) FOR TUMOR-SPECIFIC T-LYMPHOCYTE IMMUNOTHERAPY |
| KR102788989B1 (ko) | 2019-02-15 | 2025-03-31 | 우시 엑스디씨 싱가포르 프라이빗 리미티드 | 동질성이 개선된 항체-약물 콘쥬게이트의 제조방법 |
| US12109273B2 (en) | 2019-02-15 | 2024-10-08 | Wuxi Xdc Singapore Private Limited | Process for preparing antibody-drug conjugates with improved homogeneity |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN115279403A (zh) | 2020-02-21 | 2022-11-01 | 宏观基因有限公司 | Cd137结合分子及其用途 |
| KR20230010188A (ko) * | 2020-05-15 | 2023-01-18 | 엘리세라 테라퓨틱스 에이비 | 항-IL13Rα2 항체, 이의 항원 결합 단편 및 용도 |
| GB202011993D0 (en) * | 2020-07-31 | 2020-09-16 | Adc Therapeutics Sa | ANTI-IL 13Ra2 antibodies |
| CN117043192B (zh) * | 2021-02-19 | 2024-05-03 | 上海齐鲁制药研究中心有限公司 | 针对IL-13Rα2的抗体及其应用 |
| WO2023274380A1 (zh) * | 2021-07-01 | 2023-01-05 | 宁波茂行生物医药科技有限公司 | 靶向IL13Rα2的通用型CAR-T细胞及其制备方法和应用 |
| MX2023015153A (es) | 2021-07-01 | 2024-04-16 | Ningbo T Maximum Biopharmaceuticals Co Ltd | Polipéptido de unión a antígeno que se dirige a b7h3 y aplicación del mismo. |
| CN118843643A (zh) * | 2022-02-17 | 2024-10-25 | 上海礼新医药研发有限公司 | 抗il-13ra2单克隆抗体及其用途 |
| EP4577575A1 (en) * | 2022-08-25 | 2025-07-02 | Nanjing Legend Biotech Co., Ltd. | Chimeric antigen receptors targeting interleukin 13 receptor subunit alpha 2 and methods of use thereof |
| CN115960257B (zh) * | 2022-09-29 | 2023-10-27 | 卡瑞济(北京)生命科技有限公司 | 靶向IL13Rα2的经优化的嵌合抗原受体及其用途 |
| CN120882864A (zh) * | 2022-09-30 | 2025-10-31 | 国立大学法人 东京大学 | 靶向il13ra2的单纯疱疹病毒及抗il13ra2抗体或其抗原结合片段 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1257289A1 (en) | 2000-02-08 | 2002-11-20 | The Penn State Research Foundation | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
| WO2002017968A2 (en) | 2000-08-31 | 2002-03-07 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Sensitization of cancer cells to immunoconjugate-induced cell death by transfection with il-13 receptor alpha chain-2 |
| WO2004087758A2 (en) | 2003-03-26 | 2004-10-14 | Neopharm, Inc. | Il 13 receptor alpha 2 antibody and methods of use |
| WO2005042028A2 (en) | 2003-10-27 | 2005-05-12 | Neopharm, Inc. | Il-13 conjugated to an immunogen and uses thereof |
| EP2530090A3 (en) | 2006-10-19 | 2013-01-23 | CSL Limited | Anti-IL-13R alpha 1 antibodies and their uses thereof |
| AU2007319604B2 (en) | 2006-10-19 | 2011-03-24 | Csl Limited | High affinity antibody antagonists of interleukin-13 receptor alpha 1 |
| JP2010190572A (ja) | 2007-06-01 | 2010-09-02 | Sapporo Medical Univ | ＩＬ１３Ｒａ２に対する抗体およびこれを含む診断・治療薬 |
| PE20130643A1 (es) | 2010-07-12 | 2013-06-07 | Covx Technologies Ireland Ltd | Conjugados de anticuerpos multifuncionales |
| WO2013072813A2 (en) * | 2011-11-17 | 2013-05-23 | Pfizer Inc. | Cytotoxic peptides and antibody drug conjugates thereof |
| CA3111357A1 (en) | 2011-12-23 | 2013-06-27 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| EP3447071A1 (en) | 2012-01-09 | 2019-02-27 | Pfizer Healthcare Ireland | Mutant antibodies and conjugation thereof |
-
2013
- 2013-10-30 AU AU2013343111A patent/AU2013343111A1/en not_active Abandoned
- 2013-10-30 PE PE2015000568A patent/PE20150891A1/es not_active Application Discontinuation
- 2013-10-30 MX MX2015005582A patent/MX2015005582A/es unknown
- 2013-10-30 CN CN201380057103.5A patent/CN104936621A/zh active Pending
- 2013-10-30 EP EP13820931.7A patent/EP2916875A1/en not_active Withdrawn
- 2013-10-30 SG SG11201503431TA patent/SG11201503431TA/en unknown
- 2013-10-30 RU RU2015116485A patent/RU2015116485A/ru not_active Application Discontinuation
- 2013-10-30 WO PCT/IB2013/059786 patent/WO2014072888A1/en not_active Ceased
- 2013-10-30 CA CA2890256A patent/CA2890256A1/en not_active Abandoned
- 2013-10-30 US US14/439,897 patent/US9828428B2/en active Active
- 2013-10-30 JP JP2015540250A patent/JP2016503295A/ja active Pending
- 2013-10-30 KR KR1020157011436A patent/KR101763499B1/ko not_active Expired - Fee Related
- 2013-10-30 HK HK16102252.1A patent/HK1214161A1/zh unknown
-
2015
- 2015-04-30 PH PH12015500977A patent/PH12015500977A1/en unknown
- 2015-04-30 IL IL238566A patent/IL238566A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2890256A1 (en) | 2014-05-15 |
| KR20150060980A (ko) | 2015-06-03 |
| AU2013343111A1 (en) | 2015-05-14 |
| US20150266962A1 (en) | 2015-09-24 |
| HK1214161A1 (zh) | 2016-07-22 |
| MX2015005582A (es) | 2015-08-14 |
| CN104936621A (zh) | 2015-09-23 |
| EP2916875A1 (en) | 2015-09-16 |
| IL238566A0 (en) | 2015-06-30 |
| SG11201503431TA (en) | 2015-05-28 |
| PH12015500977A1 (en) | 2015-07-13 |
| WO2014072888A1 (en) | 2014-05-15 |
| KR101763499B1 (ko) | 2017-07-31 |
| JP2016503295A (ja) | 2016-02-04 |
| US9828428B2 (en) | 2017-11-28 |
| PE20150891A1 (es) | 2015-06-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015116485A (ru) | Антитела к рецептору альфа 2 интерлейкина-13 и конъюгаты антитело-лекарственное средство | |
| JP2016503295A5 (OSRAM) | ||
| RU2013142004A (ru) | Конъюгаты "антитело-лекарственное средство" | |
| ES2595091T3 (es) | Composiciones farmacéuticas con resistencia a CEA soluble | |
| RU2015116480A (ru) | Анти-notch3 антитела и конъюганты антител с лекарственным средством | |
| JP2022512132A (ja) | 抗クローディン抗体及びそれらの使用 | |
| RU2017107773A (ru) | Антитела, специфичные к ммр9 | |
| JP2009506790A5 (OSRAM) | ||
| JP2012100677A5 (OSRAM) | ||
| RU2014138038A (ru) | Фармацевтическая композиция для лечения профилактики рака | |
| JP2017532005A5 (OSRAM) | ||
| RU2008146922A (ru) | Антитела, связывающиеся с внеклеточным доменом тирозинкиназного рецептора (alk) | |
| TW202045536A (zh) | 抗ｃｄ２２８抗體及抗體－藥物共軛體 | |
| US11608378B2 (en) | Antibodies that bind integrin AVB8 and uses thereof | |
| RU2019104980A (ru) | Анти-icos антитела | |
| KR20220110495A (ko) | 클라우딘 18.2를 표적화하는 항체-약물 콘쥬게이트 | |
| JP2014515600A5 (OSRAM) | ||
| ES2818948T3 (es) | Composiciones para la supresión del cáncer por inhibición de TMCC3 | |
| JP2024514855A (ja) | Ｄｌｌ３に対する結合分子及びその使用 | |
| RU2013114783A (ru) | Anti-с-мет антитела и способы их применения | |
| EP3638309A1 (en) | Antibody drug conjugates that bind lgr5 | |
| Hong et al. | Rhamnose modified antibodies show improved immune killing towards EGFR-positive solid tumor cells | |
| JP7679380B2 (ja) | Ｃｄ２７６に特異的な抗体－薬物コンジュゲートおよびその使用 | |
| WO2024120526A1 (zh) | 抗ilt4抗体及其制备方法和应用 | |
| JPWO2023083846A5 (OSRAM) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20181224 |