RU2014145270A - Способ и композиция для разрушения бактериальной биопленки - Google Patents
Способ и композиция для разрушения бактериальной биопленки Download PDFInfo
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- RU2014145270A RU2014145270A RU2014145270A RU2014145270A RU2014145270A RU 2014145270 A RU2014145270 A RU 2014145270A RU 2014145270 A RU2014145270 A RU 2014145270A RU 2014145270 A RU2014145270 A RU 2014145270A RU 2014145270 A RU2014145270 A RU 2014145270A
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- Prior art keywords
- composition
- paragraphs
- ulcer
- bacteria
- biofilm
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract 43
- 239000000203 mixture Substances 0.000 title claims abstract 37
- 230000001580 bacterial effect Effects 0.000 title claims abstract 13
- 230000006378 damage Effects 0.000 title 1
- 206010052428 Wound Diseases 0.000 claims abstract 10
- 208000027418 Wounds and injury Diseases 0.000 claims abstract 10
- 206010040943 Skin Ulcer Diseases 0.000 claims abstract 6
- 230000001338 necrotic effect Effects 0.000 claims abstract 6
- 210000001519 tissue Anatomy 0.000 claims abstract 6
- 230000035876 healing Effects 0.000 claims abstract 4
- 206010011985 Decubitus ulcer Diseases 0.000 claims abstract 2
- 208000008960 Diabetic foot Diseases 0.000 claims abstract 2
- 208000003790 Foot Ulcer Diseases 0.000 claims abstract 2
- 208000005230 Leg Ulcer Diseases 0.000 claims abstract 2
- 208000004210 Pressure Ulcer Diseases 0.000 claims abstract 2
- 206010039509 Scab Diseases 0.000 claims abstract 2
- 208000025865 Ulcer Diseases 0.000 claims abstract 2
- 208000000558 Varicose Ulcer Diseases 0.000 claims abstract 2
- 210000000988 bone and bone Anatomy 0.000 claims abstract 2
- 210000004087 cornea Anatomy 0.000 claims abstract 2
- 210000000959 ear middle Anatomy 0.000 claims abstract 2
- 239000012634 fragment Substances 0.000 claims abstract 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract 2
- 239000011159 matrix material Substances 0.000 claims abstract 2
- 210000000214 mouth Anatomy 0.000 claims abstract 2
- 210000004303 peritoneum Anatomy 0.000 claims abstract 2
- 210000002307 prostate Anatomy 0.000 claims abstract 2
- 210000005000 reproductive tract Anatomy 0.000 claims abstract 2
- 210000002345 respiratory system Anatomy 0.000 claims abstract 2
- 231100000075 skin burn Toxicity 0.000 claims abstract 2
- 231100000019 skin ulcer Toxicity 0.000 claims abstract 2
- 231100000397 ulcer Toxicity 0.000 claims abstract 2
- 210000001635 urinary tract Anatomy 0.000 claims abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 10
- 241000894006 Bacteria Species 0.000 claims 9
- 239000004599 antimicrobial Substances 0.000 claims 7
- 241000191967 Staphylococcus aureus Species 0.000 claims 6
- 239000000499 gel Substances 0.000 claims 4
- 235000011187 glycerol Nutrition 0.000 claims 4
- 241000192125 Firmicutes Species 0.000 claims 3
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 3
- 230000002421 anti-septic effect Effects 0.000 claims 3
- 230000003115 biocidal effect Effects 0.000 claims 3
- 239000006071 cream Substances 0.000 claims 3
- 230000000855 fungicidal effect Effects 0.000 claims 3
- 239000000417 fungicide Substances 0.000 claims 3
- 229960003085 meticillin Drugs 0.000 claims 3
- 239000002674 ointment Substances 0.000 claims 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 2
- 239000004264 Petrolatum Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008387 emulsifying waxe Substances 0.000 claims 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 2
- 239000006072 paste Substances 0.000 claims 2
- 229940066842 petrolatum Drugs 0.000 claims 2
- 235000019271 petrolatum Nutrition 0.000 claims 2
- 229920000058 polyacrylate Polymers 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
Classifications
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21063—Oryzin (3.4.21.63)
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Materials Engineering (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261645815P | 2012-05-11 | 2012-05-11 | |
| US61/645,815 | 2012-05-11 | ||
| US201361820915P | 2013-05-08 | 2013-05-08 | |
| US61/820,915 | 2013-05-08 | ||
| PCT/US2013/040514 WO2013170128A1 (en) | 2012-05-11 | 2013-05-10 | Use of seaprose to remove bacterial biofilm |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014145270A true RU2014145270A (ru) | 2016-07-10 |
Family
ID=48468851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014145270A RU2014145270A (ru) | 2012-05-11 | 2013-05-10 | Способ и композиция для разрушения бактериальной биопленки |
Country Status (16)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0811530B1 (pt) | 2007-05-14 | 2019-01-02 | Research Foundation Of State Univ Of New York | composição compreendendo indutor(es) de resposta fisiológica à dispersão ácido decanóico, superfície, solução, método ex vivo de tratamento ou inibição da formação de um biofilme sobre uma superfície |
| CA2872530A1 (en) | 2012-05-11 | 2013-11-14 | Smith & Nephew, Inc. | Use of seaprose to remove bacterial biofilm |
| CN109260465A (zh) * | 2012-11-14 | 2019-01-25 | 史密夫和内修公司 | 稳定的嗜热菌蛋白酶水凝胶 |
| AU2014235578B2 (en) | 2013-03-15 | 2017-08-17 | Smith & Nephew, Inc. | Dissolvable gel-forming film for delivery of active agents |
| EP2857025A1 (en) * | 2013-10-02 | 2015-04-08 | Special Water Patents B.V. | Wound treatment composition |
| EP3120866A1 (en) | 2015-07-24 | 2017-01-25 | Zymetech ehf. | Use of marine serine proteases for removal, prevention and inhibition of formation and growth of biofilms |
| CA3031866A1 (en) | 2016-07-27 | 2018-02-01 | Smith & Nephew, Inc. | Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces |
| WO2018071506A1 (en) * | 2016-10-11 | 2018-04-19 | Sharklet Technologies, Inc | Composition for biofilm disruption, methods of manufacture thereof and articles comprising the same |
| WO2018140707A1 (en) | 2017-01-30 | 2018-08-02 | Smith & Nephew, Inc. | Synergistic combination of thermolysin and an antibacterial agent to reduce eliminate bacterial biofilms from surfaces |
| US20200289552A1 (en) * | 2017-07-04 | 2020-09-17 | Fluchem Ltd | Solid composition comprising iodine agent and sodium chloride having improved water solubility, and antiviral and antimicrobial composition for eye, oral cavity, nasal cavity or inhalation containing aqueous solution thereof |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| CN116057158A (zh) * | 2020-07-27 | 2023-05-02 | 联合利华知识产权控股有限公司 | 酶和表面活性剂用于抑制微生物的用途 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197291A (en) | 1974-01-08 | 1980-04-08 | Gerold K. V. Klein | Hydrolytic enzyme material |
| JPS5692217A (en) | 1979-12-26 | 1981-07-25 | Kowa Co | Easily absorbable enzyme preparation |
| IT1264322B (it) | 1992-07-30 | 1996-09-23 | Lanfranco Callegaro | Esteri di gellano autoreticolato, procedimento di preparazione e loro applicazioni farmaceutiche e biomedico-sanitarie |
| CA2106609A1 (en) * | 1992-09-28 | 1994-03-29 | Irene Yeatman Aldridge | Proteases to inhibit and remove biofilm |
| US5902600A (en) | 1992-12-21 | 1999-05-11 | Healthpoint, Ltd. | Hydrogel polymer wound dressing |
| US6395529B1 (en) | 1998-11-10 | 2002-05-28 | Novozymes Biotech, Inc. | Polypeptides having lactonohydrolase activity and nucleic acids encoding same |
| US6399092B1 (en) | 2000-12-27 | 2002-06-04 | Healthpoint, Ltd. | Anhydrous, hydrophilic absorbent wound dressing (tube) with antimicrobials or other pharmaceutically active agents |
| US6548556B2 (en) | 2000-12-27 | 2003-04-15 | Healthpoint, Ltd. | Stable enzymatic wound debrider |
| US20030026794A1 (en) * | 2001-07-31 | 2003-02-06 | Howard Fein | Selective enzyme treatment of skin conditions |
| US6479060B1 (en) | 2001-09-04 | 2002-11-12 | Healthpoint, Ltd. | Elegant hydrogenated castor oil ointments |
| US20030198631A1 (en) | 2002-04-18 | 2003-10-23 | Healthpoint, Ltd. | Thermolysin enzymatic wound debrider |
| JP2006516889A (ja) | 2002-10-10 | 2006-07-13 | ダイヴァーサ コーポレイション | プロテアーゼ、それをコードする核酸並びにその製造および使用方法 |
| US20050079594A1 (en) | 2002-10-31 | 2005-04-14 | Karine Marion | Method of removing a biofilm |
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2013
- 2013-05-10 CA CA 2872530 patent/CA2872530A1/en not_active Abandoned
- 2013-05-10 BR BR112014027995A patent/BR112014027995A2/pt not_active IP Right Cessation
- 2013-05-10 EP EP13724135.2A patent/EP2849777B1/en not_active Not-in-force
- 2013-05-10 JP JP2015511734A patent/JP2015523330A/ja not_active Withdrawn
- 2013-05-10 US US14/399,124 patent/US11096992B2/en active Active
- 2013-05-10 KR KR20147034713A patent/KR20150013280A/ko not_active Withdrawn
- 2013-05-10 CN CN201380036705.2A patent/CN104602700A/zh active Pending
- 2013-05-10 NZ NZ701623A patent/NZ701623A/en not_active IP Right Cessation
- 2013-05-10 WO PCT/US2013/040514 patent/WO2013170128A1/en active Application Filing
- 2013-05-10 AU AU2013259360A patent/AU2013259360B2/en not_active Ceased
- 2013-05-10 MX MX2014013745A patent/MX2014013745A/es unknown
- 2013-05-10 RU RU2014145270A patent/RU2014145270A/ru not_active Application Discontinuation
- 2013-05-10 IN IN9412DEN2014 patent/IN2014DN09412A/en unknown
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2014
- 2014-11-10 IL IL235617A patent/IL235617A0/en unknown
- 2014-11-11 CL CL2014003059A patent/CL2014003059A1/es unknown
- 2014-11-11 CO CO14248773A patent/CO7250444A2/es unknown
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2018
- 2018-01-12 JP JP2018003062A patent/JP2018083830A/ja active Pending
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2019
- 2019-03-19 JP JP2019050562A patent/JP7118022B2/ja active Active
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|---|---|
| MX2014013745A (es) | 2016-05-05 |
| EP2849777B1 (en) | 2017-10-18 |
| IL235617A0 (en) | 2015-01-29 |
| JP2018083830A (ja) | 2018-05-31 |
| AU2013259360A1 (en) | 2014-11-20 |
| CO7250444A2 (es) | 2015-04-30 |
| US11096992B2 (en) | 2021-08-24 |
| JP7118022B2 (ja) | 2022-08-15 |
| AU2013259360B2 (en) | 2017-07-13 |
| WO2013170128A1 (en) | 2013-11-14 |
| CL2014003059A1 (es) | 2015-03-06 |
| JP2015523330A (ja) | 2015-08-13 |
| CA2872530A1 (en) | 2013-11-14 |
| EP2849777A1 (en) | 2015-03-25 |
| BR112014027995A2 (pt) | 2017-06-27 |
| US20150118219A1 (en) | 2015-04-30 |
| IN2014DN09412A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-07-17 |
| JP2019104757A (ja) | 2019-06-27 |
| NZ701623A (en) | 2016-12-23 |
| CN104602700A (zh) | 2015-05-06 |
| KR20150013280A (ko) | 2015-02-04 |
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